Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction
Abstract
Study question Does prenatal exposure to perfluoroalkyl substances (PFASs) have long-term effects on female reproductive function?. Summary answer Our results suggest an association between in utero exposure to perfluorooctanoic acid (PFOA) and delay in age of menarche. What is known already Previous cross-sectional studies have reported possible effects of PFASs on female reproduction including reduced fecundity, delayed puberty and accelerated age at menopause. Only limited data exist from follow-up studies on long-term implications of prenatal exposure to PFASs. Study design, size, duration In this study we used data from a Danish population-based cohort established in 1988-1989. Of 1212 eligible pregnant women, 965 participated. Follow-up was initiated in 2008 on the female offspring at ∼20 years of age. Three hundred and sixty seven (84%) daughters answered a questionnaire and 267 (61%) daughters furthermore attended clinical examinations which were conducted in 2008-2009. Participants/materials, setting, methods The final study population consisted of 343 daughters of which 254 had attended the clinical examinations and 89 had answered the questionnaire only. Levels of PFASs in maternal serum from pregnancy week 30 were used as a measure of prenatal exposure and related to age of menarche, menstrual cycle length, levels of reproductive hormones and follicle number of the daughters. Data were divided into three groups according to tertiles of maternal concentrations of P…
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Human epidemiological studies report delayed puberty in exposed females.
“these findings are supported by human epidemiological studies reporting delayed puberty in exposed females.33,34”
From A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? (2017) · cites this paper as [33]
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- Authors
- Kristensen, S. L., Ramlau-Hansen, C. H., Ernst, E., Olsen, S. F., Bonde, J. P., Vested, A., Halldorsson, T. I., Becher, G., Haug, L. S., & Toft, G.
- Affiliations
- Aarhus University Hospital (DK)
- Aarhus University (DK)
- Statens Serum Institut (DK)
- University of Copenhagen (DK)
- Norwegian Institute of Public Health (NO)
- Corresponding author
- Kristensen, S. L.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-10-15
- Volume
- 28
- Issue
- 12
- Pages
- 3337-3348
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2114076003
- Cited by
- 151
- References
- 44
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 18 · 2023: 17 · 2022: 10 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 7 · 2015: 13 · 2014: 3
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Norwegian Institute of Public Health
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- perfluorinated compounds, perfluorooctanoic acid, prenatal exposure, female reproduction, age at menarche, delayed menarche, menstrual cycle length, reproductive hormones, ovarian follicle count, placental transfer, endocrine disruptors, puberty onset, age at menopause
- MeSH terms
- Adolescent, Caprylates, Female, Fluorocarbons, Follow-Up Studies, Humans, Menarche, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, Young Adult
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