Cited by 384Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

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Osteocyte-Driven Bone Remodeling

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Bellido, Teresita·2014·Calcified Tissue International

DOI 10.1007/s00223-013-9774-yPMC PMC3947228

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Abstract

Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts. The discovery that the inhibitor of bone formation sclerostin is primarily expressed in osteocytes in bone and downregulated by anabolic stimuli provided a mechanism by which osteocytes influence the activity of osteoblasts. Advances of the last few years provided experimental evidence demonstrating that osteocytes also participate in the recruitment of osteoclasts and the initiation of bone remodeling. Apoptotic osteocytes trigger yet-to-be-identified signals that attract osteoclast precursors to specific areas of bone, which in turn differentiate to mature, bone-resorbing osteoclasts. Osteocytes are also the source of molecules that regulate the generation and activity of osteoclasts, such as OPG and RANKL; and genetic manipulations of the mouse genome leading to loss or gain of function or to altered expression of either molecule in osteocytes markedly affect bone resorption. This review highlights these investigations and discusses how the novel concept of osteocyte-driven bone resorption and formation impacts our understanding of the mechanisms by which current therapies control bone remodeling.

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Authors: Bellido, T.
Affiliations: Richard L. Roudebush VA Medical Center (US)
Corresponding author: Bellido, Teresita
ORCID: Bellido, Teresita
Venue: Calcified Tissue International
Publisher: Springer Science and Business Media LLC
Published: 2013-09-04
Volume: 94
Issue: 1
Pages: 25-34
ISSN: 0171-967X (ISSN-L)
1432-0827
DOI: 10.1007/s00223-013-9774-y
PMC: PMC3947228
OpenAlex: W2016390309
Cited by: 384
References: 84
Citations by year: 2026: 17 · 2025: 20 · 2024: 28 · 2023: 27 · 2022: 38 · 2021: 36 · 2020: 43 · 2019: 43 · 2018: 36 · 2017: 29 · 2016: 23 · 2015: 28 · 2014: 14 · 2013: 1
FWCI: 2.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Calcified Tissue International (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: U.S. Department of Veterans Affairs (IK6 BX004596, I01 BX002104)
National Institute on Aging (P01 AG-13918, P01AG013918)
Fogarty International Center (R03TW006919)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076007)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059357, KO2-AR-02127, K02AR002127, R01AR053643)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: osteocytes, bone remodeling, sclerostin, osteoblasts, osteoclasts, bone resorption, osteocyte apoptosis, RANKL, OPG, mechanical stimulation, bone formation
MeSH terms: Animals, Bone and Bones, Cell Differentiation, Humans, Osteoclasts, Osteocytes, Osteogenesis, Bone Remodeling

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