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Osteocyte-Driven Bone Remodeling
Open accessAbstract
Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts. The discovery that the inhibitor of bone formation sclerostin is primarily expressed in osteocytes in bone and downregulated by anabolic stimuli provided a mechanism by which osteocytes influence the activity of osteoblasts. Advances of the last few years provided experimental evidence demonstrating that osteocytes also participate in the recruitment of osteoclasts and the initiation of bone remodeling. Apoptotic osteocytes trigger yet-to-be-identified signals that attract osteoclast precursors to specific areas of bone, which in turn differentiate to mature, bone-resorbing osteoclasts. Osteocytes are also the source of molecules that regulate the generation and activity of osteoclasts, such as OPG and RANKL; and genetic manipulations of the mouse genome leading to loss or gain of function or to altered expression of either molecule in osteocytes markedly affect bone resorption. This review highlights these investigations and discusses how the novel concept of osteocyte-driven bone resorption and formation impacts our understanding of the mechanisms by which current therapies control bone remodeling.
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“Moreover, osteocyte apoptosis has been recognized as a chemotactic signal to osteoclastic bone resorption [70–73].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [73]
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“High mobility group box protein 1 (HMGB1) [198–200] and M-CSF [201] have also been suggested to be produced by osteocytes that stimulate osteoclast recruitment during bone remodeling [72, 73].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [73]
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Metadata
- Authors
- Bellido, T.
- Affiliations
- Richard L. Roudebush VA Medical Center (US)
- Corresponding author
- Bellido, Teresita
- ORCID
- Bellido, Teresita
- Venue
- Calcified Tissue International
- Published
- 2013-09-04
- Volume
- 94
- Issue
- 1
- Pages
- 25-34
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- PMC
- PMC3947228
- OpenAlex
- W2016390309
- Cited by
- 384
- References
- 84
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 28 · 2023: 27 · 2022: 38 · 2021: 36 · 2020: 43 · 2019: 43 · 2018: 36 · 2017: 29 · 2016: 23 · 2015: 28 · 2014: 14 · 2013: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK6 BX004596, I01 BX002104)
- National Institute on Aging (P01 AG-13918, P01AG013918)
- Fogarty International Center (R03TW006919)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076007)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059357, KO2-AR-02127, K02AR002127, R01AR053643)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteocytes, bone remodeling, sclerostin, osteoblasts, osteoclasts, bone resorption, osteocyte apoptosis, RANKL, OPG, mechanical stimulation, bone formation
- MeSH terms
- Animals, Bone and Bones, Cell Differentiation, Humans, Osteoclasts, Osteocytes, Osteogenesis, Bone Remodeling
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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