The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Osteocyte-Driven Bone Remodeling
Open accessAbstract
Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts. The discovery that the inhibitor of bone formation sclerostin is primarily expressed in osteocytes in bone and downregulated by anabolic stimuli provided a mechanism by which osteocytes influence the activity of osteoblasts. Advances of the last few years provided experimental evidence demonstrating that osteocytes also participate in the recruitment of osteoclasts and the initiation of bone remodeling. Apoptotic osteocytes trigger yet-to-be-identified signals that attract osteoclast precursors to specific areas of bone, which in turn differentiate to mature, bone-resorbing osteoclasts. Osteocytes are also the source of molecules that regulate the generation and activity of osteoclasts, such as OPG and RANKL; and genetic manipulations of the mouse genome leading to loss or gain of function or to altered expression of either molecule in osteocytes markedly affect bone resorption. This review highlights these investigations and discusses how the novel concept of osteocyte-driven bone resorption and formation impacts our understanding of the mechanisms by which current therapies control bone remodeling.
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“Moreover, osteocyte apoptosis has been recognized as a chemotactic signal to osteoclastic bone resorption [70–73].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [73]
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“High mobility group box protein 1 (HMGB1) [198–200] and M-CSF [201] have also been suggested to be produced by osteocytes that stimulate osteoclast recruitment during bone remodeling [72, 73].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [73]
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Cites
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778
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“It is now recognized that decreased osteocyte viability accompanies not only the bone fragility syndrome that characterizes estrogen withdrawal but also glucocorticoid excess, mechanical disuse, and aging [34, 50, 51].”
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin
Robling, A. G., Niziolek, P. J., Baldridge, L. A., Condon, K. W., Allen, M. R., Alam, I., Mantila, S. M., Gluhak-Heinrich, J., Bellido, T. M., Harris, S. E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705092200 · Cited by 1,350
Self-citationMatrix-embedded cells control osteoclast formation
Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304
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Manolagas, S. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0024 · Cited by 1,234
Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors
Kousteni, S., Bellido, T., Plotkin, L. I., O’Brien, C. A., Bodenner, D., Li, H., Han, K., Gregorio, G. B. D., Katzenellenbogen, J. A., Katzenellenbogen, B. S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00268-9 · Cited by 1,163
Self-citationIncreased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
Balemans, W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.537 · Cited by 1,147 · cited 1×
“Loss of SOST expression in humans causes the high–bone mass disorders Van Buchem’s disease [16] and sclerosteosis [17].”
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
Winkler, D. G., Sutherland, M. K., Geoghegan, J. C., Yu, C., Hayes, T., Skonier, J. E., Shpektor, D., Jonas, M., Kovacevich, B. R., Staehling‐Hampton, K., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg599 · Cited by 1,114
Research works printed but not linked: 1
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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044
Inflammation, fracture and bone repair
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Oxidative stress in bone remodeling: role of antioxidants
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Metadata
- Authors
- Bellido, T.
- Affiliations
- Richard L. Roudebush VA Medical Center (US)
- Corresponding author
- Bellido, Teresita
- ORCID
- Bellido, Teresita
- Venue
- Calcified Tissue International
- Published
- 2013-09-04
- Volume
- 94
- Issue
- 1
- Pages
- 25-34
- ISSN
- 0171-967X (ISSN-L)
- 1432-0827
- PMC
- PMC3947228
- OpenAlex
- W2016390309
- Cited by
- 384
- References
- 84
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 28 · 2023: 27 · 2022: 38 · 2021: 36 · 2020: 43 · 2019: 43 · 2018: 36 · 2017: 29 · 2016: 23 · 2015: 28 · 2014: 14 · 2013: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Calcified Tissue International (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK6 BX004596, I01 BX002104)
- National Institute on Aging (P01 AG-13918, P01AG013918)
- Fogarty International Center (R03TW006919)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076007)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059357, KO2-AR-02127, K02AR002127, R01AR053643)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteocytes, bone remodeling, sclerostin, osteoblasts, osteoclasts, bone resorption, osteocyte apoptosis, RANKL, OPG, mechanical stimulation, bone formation
- MeSH terms
- Animals, Bone and Bones, Cell Differentiation, Humans, Osteoclasts, Osteocytes, Osteogenesis, Bone Remodeling
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