Engineered commensal bacteria prevent systemic inflammation-induced memory impairment and amyloidogenesis via producing GLP-1
Abstract
The anti-obesity drug GLP-1 has been proven to have an impact on central nervous system, while its extremely short half-life greatly limited its use. In this study, our group constructed two engineering strains MG1363-pMG36e-GLP-1 and VNP20009-pLIVE-GLP-1 to continuously express GLP-1, and supplementation of these strains, especially MG1363-pMG36e-GLP-1, had significantly restored the spatial learning and memory impairment of mice caused by LPS (p < 0.05), suppressed glia activation and Aβ accumulation, and downregulated inflammatory expressions of COX-2, TLR-4, TNF-a, and IL-1β. In addition, MG1363-pMG36e-GLP-1 had significantly blocked the translocation of NF-κB signal and inhibited the phosphorylation of redox-sensitive cytoplasmic signalings of MAPKs and PI3K/AKT. These data suggest that MG1363-pMG36e-GLP-1 could be used as a safe and effective nonabsorbed oral treatment for neuroinflammation-related diseases such as Alzheimer's disease (AD).
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An engineered strain MG1363-pMG36e-GLP-1 was constructed that continuously expresses GLP-1 and overcomes the short half-life of GLP-1.
“An engineered strain MG1363-pMG36e-GLP-1 is constructed which continuously express GLP-1, and overcome the problem of the short half-life of GLP-1.”
From Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease (2020) · cites this paper as Chen et al. 2018
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- Authors
- Chen, T., Tian, P., Huang, Z., Zhao, X., Wang, H., Xia, C., Wang, L., & Wei, H.
- Affiliations
- Nanchang University (CN)
- Corresponding author
- Wei, Hua
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2018-06-28
- Volume
- 102
- Issue
- 17
- Pages
- 7565-7575
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W2810315921
- Cited by
- 52
- References
- 41
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 1
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Applied Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- glucagon-like peptide-1, LPS-induced neuroinflammation, memory impairment, amyloid-beta deposition, Alzheimer's disease, spatial learning and memory, NF-κB signaling, MAPK signaling, PI3K/Akt signaling, anti-obesity drugs, oral probiotic supplementation, VNP20009
- MeSH terms
- Microorganisms, Genetically-Modified, Animals, Bacteria, Lipopolysaccharides, Memory Disorders, Mice, Glucagon-Like Peptide 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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