Cited by 52Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsProbiotics and Fermented Foods

Engineered commensal bacteria prevent systemic inflammation-induced memory impairment and amyloidogenesis via producing GLP-1

Chen, Tingtao, Tian, Puyuan, Huang, Zhixiang, Zhao, Xiaoxiao, Wang, Huan, Xia, Chaofei, Wang, Le, Wei, Hua·2018·Applied Microbiology and Biotechnology

Abstract

The anti-obesity drug GLP-1 has been proven to have an impact on central nervous system, while its extremely short half-life greatly limited its use. In this study, our group constructed two engineering strains MG1363-pMG36e-GLP-1 and VNP20009-pLIVE-GLP-1 to continuously express GLP-1, and supplementation of these strains, especially MG1363-pMG36e-GLP-1, had significantly restored the spatial learning and memory impairment of mice caused by LPS (p < 0.05), suppressed glia activation and Aβ accumulation, and downregulated inflammatory expressions of COX-2, TLR-4, TNF-a, and IL-1β. In addition, MG1363-pMG36e-GLP-1 had significantly blocked the translocation of NF-κB signal and inhibited the phosphorylation of redox-sensitive cytoplasmic signalings of MAPKs and PI3K/AKT. These data suggest that MG1363-pMG36e-GLP-1 could be used as a safe and effective nonabsorbed oral treatment for neuroinflammation-related diseases such as Alzheimer's disease (AD).

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Crossref · 10.1007/s00253-018-9155-6

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Authors
Chen, T., Tian, P., Huang, Z., Zhao, X., Wang, H., Xia, C., Wang, L., & Wei, H.
Affiliations
Nanchang University (CN)
Corresponding author
Wei, Hua
Venue
Applied Microbiology and Biotechnology
Published
2018-06-28
Volume
102
Issue
17
Pages
7565-7575
ISSN
  • 0175-7598 (ISSN-L)
  • 1432-0614
OpenAlex
W2810315921
Cited by
52
References
41
Citations by year
2026: 6 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 1
FWCI
2.25
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Microbiology and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
glucagon-like peptide-1, LPS-induced neuroinflammation, memory impairment, amyloid-beta deposition, Alzheimer's disease, spatial learning and memory, NF-κB signaling, MAPK signaling, PI3K/Akt signaling, anti-obesity drugs, oral probiotic supplementation, VNP20009
MeSH terms
Microorganisms, Genetically-Modified, Animals, Bacteria, Lipopolysaccharides, Memory Disorders, Mice, Glucagon-Like Peptide 1

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