Neuroprotective effects of an engineered commensal bacterium in the 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine Parkinson disease mouse model via producing glucagon‐like peptide‐1

Trimmomatic: a flexible trimmer for Illumina sequence data

Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works

QIIME allows analysis of high-throughput community sequencing data

Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works

UPARSE: highly accurate OTU sequences from microbial amplicon reads

Edgar, R. C. (2013) · Nature Methods · doi:10.1038/nmeth.2604 · Cited by 16,587 · see citing works

Measuring Biological Diversity

Reid, J. R. W. (2005) · Austral Ecology · doi:10.1111/j.1442-9993.2005.01502.x · Cited by 4,471 · see citing works

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Li, W., Björklund, T., Wang, Z.-Y., Roybon, L., Melki, R., & Li, J.-Y. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1343-6 · Cited by 925 · see citing works

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

During, M. J., Cao, L., Zuzga, D. S., Francis, J. S., Fitzsimons, H. L., Jiao, X., Bland, R. J., Klugmann, M., Banks, W. A., Drucker, D. J., et al. (2003) · Nature Medicine · doi:10.1038/nm919 · Cited by 851 · see citing works

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works

Toll-like receptor signaling in neural plasticity and disease

Okun, E., Griffioen, K. J. S., & Mattson, M. P. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.005 · Cited by 513 · see citing works

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works

Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease

Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445 · see citing works

Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease

Ghosh, A., Roy, A., Liu, X., Kordower, J. H., Mufson, E. J., Hartley, D. M., Ghosh, S., Mosley, R. L., Gendelman, H. E., & Pahan, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704908104 · Cited by 438 · see citing works

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

Langston, J. W., Irwin, I., Langston, E. B., & Forno, L. S. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90293-3 · Cited by 435 · see citing works

Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula

Xu, J. Y., Lian, F., Zhao, L., Zhao, Y., Chen, X., Zhang, X., Guo, Y., Zhang, C., Zhou, Q., Xue, Z., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.177 · Cited by 423 · see citing works

Current pharmacotherapy for obesity

Srivastava, G., & Apovian, C. M. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.122 · Cited by 406 · see citing works

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

Catorce, M. N., & Gevorkian, G. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151204122017 · Cited by 361 · see citing works

Gut-Brain Cross-Talk in Metabolic Control

Clemmensen, C., Müller, T. D., Woods, S. C., Berthoud, H., Seeley, R. J., & Tschöp, M. H. (2017) · Cell · doi:10.1016/j.cell.2017.01.025 · Cited by 296 · see citing works

Engineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetes

Duan, F. F., Liu, J. H., & March, J. C. (2015) · Diabetes · doi:10.2337/db14-0635 · Cited by 263 · see citing works

The Roles of Inflammation, Nutrient Availability and the Commensal Microbiota in Enteric Pathogen Infection

Stecher, B. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mbp-0008-2014 · Cited by 235 · see citing works

Interactions of innate and adaptive immunity in brain development and function

Filiano, A. J., Gadani, S. P., & Kipnis, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.050 · Cited by 217 · see citing works

Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism

Soto, M., Herzog, C., Pacheco, J. A., Fujisaka, S., Bullock, K., Clish, C. B., & Kahn, C. R. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0086-5 · Cited by 216 · see citing works

Measuring biological diversity

Solow, A. R., & Polasky, S. (1994) · Environmental and Ecological Statistics · doi:10.1007/bf02426650 · Cited by 211 · see citing works

Inflammation and gut-brain axis link obesity to cognitive dysfunction: plausible pharmacological interventions

Solas, M., Milagro, F. I., Ramírez, M. J., & Martínez, J. A. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.10.005 · Cited by 173 · see citing works

Neuroprotective properties of GLP-1: theoretical and practical applications

Holst, J. J., Burcelin, R., & Nathanson, E. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.549466 · Cited by 152 · see citing works

Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve with insulin resistance?

Esteve, E., Ricart, W., & Fernández-Real, J.-M. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328348c06d · Cited by 133 · see citing works

Gut-brain and brain-gut axis in Parkinson’s disease models: effects of a uridine and fish oil diet

Perez-Pardo, P., Dodiya, H. B., Broersen, L. M., Douna, H., van Wijk, N., Lopes da Silva, S., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1294555 · Cited by 111 · see citing works

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

Ji, C., Xue, G., Cao, L., Feng, P., Li, D., Li, L., Li, G., & Hölscher, C. (2015) · Brain Research · doi:10.1016/j.brainres.2015.09.035 · Cited by 101 · see citing works

Glucagon-like peptides 1 and 2 in health and disease: A review

Marathe, C. S., Rayner, C. K., Jones, K. L., & Horowitz, M. (2013) · Peptides · doi:10.1016/j.peptides.2013.01.014 · Cited by 100 · see citing works

Treatment of Advanced Parkinson's Disease

Varanese, S., Birnbaum, Z. E., Rossi, R. P., & Rocco, A. D. (2010) · Parkinson s Disease · doi:10.4061/2010/480260 · Cited by 100 · see citing works

Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers

Li, B., Guo, K., Zeng, L., Zeng, B., Huo, R., Luo, Y., Wang, H., Dong, M.-X., Zheng, P., Zhou, C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0078-2 · Cited by 91 · see citing works

Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

Li, Y., Liu, W., Li, L., & Hölscher, C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.002 · Cited by 80 · see citing works

The intricate association between gut microbiota and development of Type 1, Type 2 and Type 3 diabetes

Bekkering, P., Jafri, I., van Overveld, F. J., & Rijkers, G. T. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.848793 · Cited by 77 · see citing works

Neurobiology of l-DOPA induced dyskinesia and the novel therapeutic strategies

Sharma, S., Singh, S., Sharma, V., Singh, V. P., & Deshmukh, R. R. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.01.029 · Cited by 56 · see citing works

Analysis of the intestinal microbial community structure of healthy and long-living elderly residents in Gaotian Village of Liuyang City

Yu, X., Wu, X., Qiu, L., Wang, D., Gan, M., Chen, X., Wei, H., & Xu, F. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6888-3 · Cited by 54 · see citing works

Engineered commensal bacteria prevent systemic inflammation-induced memory impairment and amyloidogenesis via producing GLP-1

Chen, T., Tian, P., Huang, Z., Zhao, X., Wang, H., Xia, C., Wang, L., & Wei, H. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9155-6 · Cited by 52 · see citing works

Anti-cancer and Sensibilisation Effect of Triptolide on Human Epithelial Ovarian Cancer

Hu, H., Luo, L., Liu, F., Zou, D., Zhu, S., Tan, B., & Chen, T. (2016) · Journal of Cancer · doi:10.7150/jca.16178 · Cited by 49 · see citing works

Hedgehog signaling pathway regulates ovarian cancer invasion and migration via adhesion molecule CD24

Zeng, C., Chen, T., Zhang, Y., & Chen, Q. (2017) · Journal of Cancer · doi:10.7150/jca.17712 · Cited by 45 · see citing works

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease

Hansen, H. H., Fabricius, K., Barkholt, P., Mikkelsen, J. D., Jelsing, J., Pyke, C., Knudsen, L. B., & Vrang, N. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.038 · Cited by 39 · see citing works

Neuropathology of Movement Disorders

Jellinger, K. A. (1998) · Neurosurgery Clinics of North America · doi:10.1016/s1042-3680(18)30262-6 · Cited by 30 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson’s disease via gut microbiota-GLP-1 pathway

Sun, J., Li, H., Jin, Y., Yu, J., Mao, S., Su, K.-P., Ling, Z., & Liu, J. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.10.014 · Cited by 264 · see citing works

Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies

Zhang, X., Tang, B., & Guo, J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00392-8 · Cited by 205 · see citing works

The Gut–Brain Axis and Its Relation to Parkinson’s Disease: A Review

Klann, E. M., Dissanayake, U., Gurrala, A., Farrer, M. J., Shukla, A. W., Ramirez‐Zamora, A., Mai, V., & Vedam‐Mai, V. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.782082 · Cited by 191 · see citing works

Lactobacillus Plantarum PS128 Alleviates Neurodegenerative Progression in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Models of Parkinson’s Disease

Liao, J.-F., Cheng, Y.-F., You, S.-T., Kuo, W.-C., Huang, C.-W., Chiou, J.-J., Hsu, C.-C., Hsieh-Li, H.-M., Wang, S., & Tsai, Y.-C. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.036 · Cited by 159 · see citing works

Engineering probiotics for therapeutic applications: recent examples and translational outlook

Aggarwal, N., Breedon, A. M. E., Davis, C. M., Hwang, I. Y., & Chang, M. W. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.02.016 · Cited by 158 · see citing works

Short-chain fatty acids-producing probiotics: A novel source of psychobiotics

Cheng, Y., Liu, J., & Ling, Z. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1920884 · Cited by 155 · see citing works

Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases

Diz-Chaves, Y., Mastoor, Z., Spuch, C., González-Matías, L. C., & Mallo, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179583 · Cited by 148 · see citing works

Probiotics for Parkinson's disease: Current evidence and future directions

Tan, A. H., Hor, J. W., Chong, C. W., & Lim, S. (2020) · JGH Open · doi:10.1002/jgh3.12450 · Cited by 101 · see citing works

The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment

Varesi, A., Campagnoli, L. I. M., Fahmideh, F., Pierella, E., Romeo, M., Ricevuti, G., Nicoletta, M., Chirumbolo, S., & Pascale, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012289 · Cited by 88 · see citing works

Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease

Fang, X., Zhou, X., Miao, Y., Han, Y., Wei, J., & Chen, T. (2020) · AMB Express · doi:10.1186/s13568-020-01014-6 · Cited by 70 · see citing works

Neurotrophic Role of the Next-Generation Probiotic Strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson’s Disease via Inhibiting Ferroptosis

Yue, M., Wei, J., Chen, W., Hong, D., Chen, T., & Fang, X. (2022) · Nutrients · doi:10.3390/nu14224886 · Cited by 62 · see citing works

Are We What We Eat? Impact of Diet on the Gut–Brain Axis in Parkinson’s Disease

Alfonsetti, M., Castelli, V., & d’Angelo, M. (2022) · Nutrients · doi:10.3390/nu14020380 · Cited by 60 · see citing works

Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP ‐1 and modulating gut microbiota

Wu, H., Wei, J., Zhao, X., Liu, Y., Chen, Z., Wei, K., Lu, J., Chen, W., Jiang, M., Li, S., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10351 · Cited by 57 · see citing works

Current perspectives on microglia-neuron communication in the central nervous system: Direct and indirect modes of interaction

Hu, Y., & Tao, W. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.01.006 · Cited by 61 · see citing works

Sodium butyrate ameliorates gut dysfunction and motor deficits in a mouse model of Parkinson’s disease by regulating gut microbiota

Zhang, Y., Xu, S., Qian, Y., Mo, C., Ai, P., Yang, X., & Xiao, Q. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1099018 · Cited by 49 · see citing works

Engineered probiotics Clostridium butyricum ‐pMTL007‐GLP ‐1 improves blood pressure via producing GLP ‐1 and modulating gut microbiota in spontaneous hypertension rat models

Wang, X., Chen, W., Jin, R., Xu, X., Wei, J., Huang, H., Tang, Y., Zou, C., & Chen, T. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.14196 · Cited by 46 · see citing works

Anti-aging effect of the combination of Bifidobacterium longum and B. animalis in a d-galactose-treated mice

Xia, C., Cao, X., Cui, L., Liu, H., Wang, S., & Chen, T. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103938 · Cited by 42 · see citing works

Engineered Bacteria of MG1363-pMG36e-GLP-1 Attenuated Obesity-Induced by High Fat Diet in Mice

Wang, L., Chen, T., Wang, H., Wu, X., Cao, Q. N., Wen, K., Deng, K., & Xin, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.595575 · Cited by 40 · see citing works

Alkaloids extracted from Uncaria rhynchophylla demonstrate neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the PI3K/Akt/mTOR signaling pathway

Zheng, M., Chen, M., Liu, C., Fan, Y., & Shi, D. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113451 · Cited by 39 · see citing works

Liraglutide Regulates Mitochondrial Quality Control System Through PGC-1α in a Mouse Model of Parkinson’s Disease

Wu, P., Dong, Y., Chen, J., Guan, T., Cao, B., Zhang, Y., Qi, Y., Guan, Z., & Wang, Y. (2022) · Neurotoxicity Research · doi:10.1007/s12640-021-00460-9 · Cited by 38 · see citing works

Glucagon-like peptide 1 receptor activation: anti-inflammatory effects in the brain

Diz-Chaves, Y., Mastoor, Z., Spuch, C., Lamas, J. A., González-Matías, L. C., & Mallo, F. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389626 · Cited by 39 · see citing works

Improvement effect of a next-generation probiotic L. plantarum -pMG36e-GLP-1 on type 2 diabetes mellitus via the gut–pancreas–liver axis

Hu, H., Luo, J., Liu, Y., Li, H., Jin, R., Li, S., Wei, J., Hong Kui, W. E. I., & Chen, T. (2023) · Food & Function · doi:10.1039/d3fo00044c · Cited by 34 · see citing works

The role of the microbiota-gut-brain axis and intestinal microbiome dysregulation in Parkinson’s disease

Li, Q., Meng, L., Chen, L., Shi, X., Tu, L., Zhou, Q. G., Yu, J.-L., Liao, X., Zeng, Y., & Yuan, Q. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1185375 · Cited by 36 · see citing works

Engineered Akkermansia muciniphila: A promising agent against diseases (Review)

Zou, Y., & Chen, T. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9415 · Cited by 34 · see citing works

Modes of therapeutic delivery in synthetic microbiology

Alexander, L. M., & van Pijkeren, J. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.09.003 · Cited by 35 · see citing works

Meta-analysis of randomized controlled trials of the effects of probiotics in Parkinson's disease

Chu, C., Yu, L., Li, Y. H., Guo, H., Zhai, Q., Chen, W., & Tian, F. (2023) · Food & Function · doi:10.1039/d2fo03825k · Cited by 32 · see citing works

Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e -GLP-1 in monkey model

Luo, J., Zhang, H., Lu, J., Ma, C., & Chen, T. (2021) · Synthetic and Systems Biotechnology · doi:10.1016/j.synbio.2021.09.009 · Cited by 32 · see citing works

Gut microbiome-based strategies for host health and disease

Wang, C., Bai, J., Chen, X., Song, J., Zhang, Y., Wang, H., & Suo, H. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2176464 · Cited by 29 · see citing works

Gut microbiota: Candidates for a novel strategy for ameliorating sleep disorders

Li, L., Liang, T., Jiang, T., Li, Y., Yang, L., Wu, L., Yang, J., Ding, Y., Wang, J., Chen, M., et al. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2228409 · Cited by 30 · see citing works

Synthetic Biology-Driven Microbial Therapeutics for Disease Treatment

Kim, T. H., Cho, B., & Lee, D. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2407.07004 · Cited by 31 · see citing works

Advanced microbiome therapeutics for oral delivery of peptides and proteins: Advances, challenges, and opportunities

Gelli, H. P., Vazquez-Uribe, R., Buckley, S. T., Andersen, J. T., & Sommer, M. O. A. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115603 · Cited by 28 · see citing works

Fibre-rich diet attenuates chemotherapy-related neuroinflammation in mice

Cross, C., Davies, M. R., Bateman, E. H., Crame, E. E., Joyce, P., Wignall, A. D., Ariaee, A., Gladman, M. A., Wardill, H. R., & Bowen, J. M. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.018 · Cited by 27 · see citing works

Peptide GLP-1 receptor agonists: From injection to oral delivery strategies

Ke, Z., Ma, Q., Ye, X., Wang, Y., Jin, Y., Zhao, X., & Su, Z. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116471 · Cited by 24 · see citing works

Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition

Deng, X., Zheng, C., Wang, S., Yang, R. L., Liu, Z., & Chen, T. (2020) · Oncology Reports · doi:10.3892/or.2020.7463 · Cited by 23 · see citing works

Gut Microbial Alteration in MPTP Mouse Model of Parkinson Disease is Administration Regimen Dependent

Aktaş, B. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01319-7 · Cited by 23 · see citing works

Multidirectional associations between the gut microbiota and Parkinson’s disease, updated information from the perspectives of humoral pathway, cellular immune pathway and neuronal pathway

Jia, X., Chen, Q., Zhang, Y., & Asakawa, T. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1296713 · Cited by 22 · see citing works

Gut Microbiota-Based Interventions for Parkinson’s Disease: Neuroprotective Mechanisms and Current Perspective

Kumar, D., Bishnoi, M., Kondepudi, K. K., & Sharma, S. S. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10433-x · Cited by 21 · see citing works

Lactobacillus fermentum HFY06 attenuates d -galactose-induced oxidative stress and inflammation in male Kunming mice

Li, F., Huang, H. Y., Wu, Y., Lu, Z., Zhou, X., Tan, F., & Zhao, X. (2021) · Food & Function · doi:10.1039/d1fo00982f · Cited by 21 · see citing works

GLP-1/Sigma/RAGE receptors: An evolving picture of Alzheimer's disease pathology and treatment

Neha, N., Wali, Z., Pinky, P., Hattiwale, S. H., Jamal, A., & Parvez, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102134 · Cited by 19 · see citing works

Neuroprotective Effects of Bifidobacterium animalis subsp. lactis NJ241 in a Mouse Model of Parkinson’s Disease: Implications for Gut Microbiota and PGC-1α

Dong, Y., Qi, Y., Chen, J., Han, S., Su, W., Ma, X., Yu, Y., & Wang, Y. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04038-2 · Cited by 18 · see citing works

Microbiota- Brain-Gut-Axis Relevance to Parkinson’s Disease: Potential Therapeutic Effects of Probiotics

Raj, K., Singh, S., Chib, S., & Mallan, S. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666221003112300 · Cited by 16 · see citing works

Parkinson’s Disease, It Takes Guts: The Correlation between Intestinal Microbiome and Cytokine Network with Neurodegeneration

Xiromerisiou, G., Marogianni, C., Androutsopoulou, A., Ntavaroukas, P., Mysiris, D. S., & Papoutsopoulou, S. (2023) · Biology · doi:10.3390/biology12010093 · Cited by 17 · see citing works

Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1α pathway

Qi, Y., Dong, Y., Chen, J., Xie, S., Ma, X., Yu, X., Yu, Y., & Wang, Y. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115001 · Cited by 17 · see citing works

Parkinson’s disease and the gut-brain connection: unveiling pathways, mechanisms and promising therapies

Hajare, S., & Kulkarni, Y. A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149975 · Cited by 16 · see citing works

Regulation of Pain Perception by Microbiota in Parkinson Disease

Manjarres, Z., Calvo, M., & Pacheco, R. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000674 · Cited by 15 · see citing works

Gut-directed therapy in Parkinson’s disease

Benvenuti, L., Salvo, C. D., Bellini, G., Seguella, L., Rettura, F., Esposito, G., Antonioli, L., Ceravolo, R., Bernardini, N., Pellegrini, C., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1407925 · Cited by 13 · see citing works

Prebiotics and probiotics and Parkinson's disease

Amani, R., & Mehrabani, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90052-2.00034-2 · Cited by 9 · see citing works

Advice to People with Parkinson’s in My Clinic: Probiotics and Prebiotics

Hor, J. W., Toh, T. S., Lim, S., & Tan, A. H. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-240172 · Cited by 9 · see citing works

Gut neuropeptide involvement in Parkinson’s disease

Templeton, H., Tobet, S. A., & Schwerdtfeger, L. (2025) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2024 · Cited by 9 · see citing works

Potential applications of engineered bacteria in disease diagnosis and treatment

Luo, Z., Qi, Z., Luo, J., & Chen, T. (2024) · Microbiome Research Reports · doi:10.20517/mrr.2024.57 · Cited by 9 · see citing works

Growth differentiation factor 11 delivered by dairy Lactococcus lactis strains modulates inflammation and prevents mucosal damage in a mice model of intestinal mucositis

Américo, M. F., Freitas, A. D. S., da Silva, T. F., de Jesus, L. C. L., Barroso, F. A. L., Campos, G. M., Santos, R. C. V., Gomes, G. C., de Assis, R. R., Ferreira, E. F., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1157544 · Cited by 8 · see citing works

Systematic review and meta-analysis of microbiota-gut-astrocyte axis perturbation in neurodegeneration, brain injury, and mood disorders

Radford-Smith, D. E., Oke, K., Costa, C. F. F. A., & Anthony, D. (2025) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2025.101013 · Cited by 7 · see citing works

The role of gut-derived short-chain fatty acids in Parkinson's disease

Saadh, M. J., Mustafa, A. N., Mustafa, M. A., Renuka Jyothi, S., Dabis, H. K., Prasad, G. V. S., Mohammad, I. J., Adnan, A., & Idan, A. H. (2024) · Neurogenetics · doi:10.1007/s10048-024-00779-3 · Cited by 9 · see citing works

The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s disease

Yue, M., Chen, T., Chen, W., Wei, J., Liao, B., Zhang, J., Li, F., Hong, D., & Fang, X. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00702 · Cited by 8 · see citing works

Engineered Bacteria as Living Materials for Oral Delivery of Peptide Drugs

Yu, L. J., Han, X., Liu, J., Yan, X., & Li, T. F. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6c06551 · Cited by 5 · see citing works

Probiotic Influences on Motor Skills: A Review

Lalonde, R., & Strazielle, C. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230807150523 · Cited by 5 · see citing works

The engineered probiotics for the treatment of chronic diseases: A systematic review

Barati, M., Jabbari, M., Ghavidel, A. A., Nikmehr, P., Arzhang, P., Aynehchi, A., Babashahi, M., Mosharkesh, E., Roshanravan, N., Shabani, M., et al. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14343 · Cited by 4 · see citing works

Gut Microbes in Parkinson's Disease

Markidi, A., Elford, J. D., Berkers, C. R., Kraneveld, A. D., & Perez‐Pardo, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00002-3 · Cited by 4 · see citing works

Gut Microbiota Modification via Glucagon-like Peptide-1 with Beneficial Neuroprotective Effects

Sayehmiri, F., Samadian, M. M., Mohamadkhani, A., Tafakhori, A., Haghighat, S., Rahmatian, A., Mohammadkhani, M. A., Fazli, H. R., & Rezaei–Tavirani, M. (2022) · Middle East Journal of Digestive Diseases · doi:10.34172/mejdd.2022.278 · Cited by 4 · see citing works

Potential Role of Probiotics and Fecal Microbiota Transplantation in the Treatment of Parkinson's Disease

El‐Mansoury, B., Smimih, K., Khiat, A. E., Fatimi, H. E., Aimrane, A., Baz, S. E., Elmourid, A., Saad, F. E.-Z., Ghachi, H. E., Khanouchi, M., et al. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-5156-4.ch017 · Cited by 4 · see citing works

Optimization of ultrasound-mediated DNA transfer for bacteria and preservation of frozen competent cells

Zhang, M., Tang, R., Li, F.-X., Jin, W.-Y., Guo, J., Teng, L.-Z., Meng, G., Sansonetti, P. J., & Gao, Y. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00978-24 · Cited by 3 · see citing works

Gut bacteria composition in animal models of Parkinson’s disease: a systematic review and meta-analysis

Elford, J. D., Heesbeen, E. J., van der Plaats, N. A., Garssen, J., Kraneveld, A. D., Groenink, L., & Perez‐Pardo, P. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-025-01236-0 · Cited by 2 · see citing works

Akkermansia muciniphila: A double-edged sword in life-stage-specific nutritional modulation of Parkinson’s disease via the gut-brain axis

Chen, N., Pang, D., & Shang, H. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128436 · Cited by 3 · see citing works

New insights in non-motor symptoms in Parkinson’s disease

Falup‐Pecurariu, C., Fanciulli, A., Borgohain, R., Chaudhuri, К. R., & Metta, V. (2024) · Frontiers research topics · doi:10.3389/978-2-8325-4722-9 · Cited by 1 · see citing works

Long-term Probiotics Intervention Facilitates Recovery of Motor and Non-motor Functions by Regulating Inflammation and Modulating Gut-brain Axis in 6-OHDA Rat Model of Parkinson’s Disease

Sharma, S., Jain, S., Chittora, R., Chaudhry, R., Nag, T. C., Elavarasi, A., Radhakrishnan, D. M., Pandey, S., Das, S., Bamola, V. D., et al. (2025) · Annals of Neurosciences · doi:10.1177/09727531251335746 · Cited by 1 · see citing works

Synthetic Biology Toolbox: Developing Microbial Therapeutics

Singh, B., Mal, G., Kalra, R. S., & Marotta, F. (2024) · Springer eBooks · doi:10.1007/978-3-031-65459-6_22

The Gut-Brain Axis in Parkinson’s Disease: Probiotic Interventions and Mechanistic Insights

Hasnain, M. A., Bashir, H. H., & Moon, G. (2025) · Current Topic in Lactic Acid Bacteria and Probiotics · doi:10.35732/ctlabp.2025.11.2.41

Engineered bacteria: a novel era for metabolic, cardiovascular and cerebrovascular diseases therapy

Wu, Y., Sang, R., Chen, X., & Wang, S. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1757348

Non-pharmacological interventions modulating immune response in Parkinson's disease: where do we stand for future preventive approaches

Pirovano, E., Silva, I. P., Camacho, M., Canak, A., Aktaş, B., Crompton, D., Gökçe, E., Tan, F.-M., Marino, F., Domingos, J., et al. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106211

Sex-specific gut microbiota and metabolite signatures in Parkinson’s disease: implications for personalized therapeutics

Sharma, S. A., & Patri, M. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01924-7

Gut microbiota–nanoparticle interactions in Parkinson’s disease: mechanistic insights and therapeutic perspective

Kafshdooz, L., & Safaralizadeh, R. (2026) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2026.2694921

Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP ‐1 and modulating gut microbiota

Wu, H., Wei, J., Zhao, X., Liu, Y., Chen, Z., Wei, K., Lu, J., Chen, W., Jiang, M., Li, S., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10351 · Cited by 57 · see citing works

The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson’s disease

Yue, M., Chen, T., Chen, W., Wei, J., Liao, B., Zhang, J., Li, F., Hong, D., & Fang, X. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00702 · Cited by 8 · see citing works

Neurotrophic Role of the Next-Generation Probiotic Strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson’s Disease via Inhibiting Ferroptosis

Yue, M., Wei, J., Chen, W., Hong, D., Chen, T., & Fang, X. (2022) · Nutrients · doi:10.3390/nu14224886 · Cited by 62 · see citing works

Neuroprotective effect of engineered Clostridium butyricum‐pMTL007‐GLP ‐1 on Parkinson's disease mice models via promoting mitophagy

Wang, Y., Chen, W., Han, Y., Xu, X., Yang, A., Wei, J., Hong, D., Fang, X., & Chen, T. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10505 · Cited by 52 · see citing works

Neuroprotective Effects of a GLP-2 Analogue in the MPTP Parkinson’s Disease Mouse Model

Zhang, Z., Li, H., Shi, M., Yu, Z., Shao, S., Yuan, Y., Zhang, Z., & Hölscher, C. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-202318 · Cited by 19 · see citing works