Biomedical applications of nisin
Open accessAbstract
Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin is classified as a Type A (I) lantibiotic that is synthesized from mRNA and the translated peptide contains several unusual amino acids due to post-translational modifications. Over the past few decades, nisin has been used widely as a food biopreservative. Since then, many natural and genetically modified variants of nisin have been identified and studied for their unique antimicrobial properties. Nisin is FDA approved and generally regarded as a safe peptide with recognized potential for clinical use. Over the past two decades the application of nisin has been extended to biomedical fields. Studies have reported that nisin can prevent the growth of drug-resistant bacterial strains, such as methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Enterococci and Clostridium difficile. Nisin has now been shown to have antimicrobial activity against both Gram-positive and Gram-negative disease-associated pathogens. Nisin has been reported to have anti-biofilm properties and can work synergistically in combination with conventional therapeutic drugs. In addition, like host-defence peptides, nisin may activate the adaptive immune response and have an immunomodulatory role. Increasing evidence indicates that nisin can influence the growth of tumours and exhibit selective cytotoxicity towards cancer cells. Collectively, the application of nisin has advanced beyond its role as a food biopreservative. Thus, this review will describe and compare studies on nisin and provide insight into its future biomedical applications.
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Lactococcus lactis produces nisin, a bacteriocin that has been shown to reduce oral tumorigenesis and extend the life span of mice with tumors.
“Lactococcus lactis, a commensal of the oral microbiota, produces nisin, a bacteriocin that has been shown to reduce oral tumorigenesis and extend the life span of mice with tumors.165, 166”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [165]
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The oral microbiome: Role of key organisms and complex networks in oral health and disease
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Kamarajan, P., Ateia, I., Shin, J. M., Fenno, J. C., Le, C., Zhan, L., Chang, A., Darveau, R., & Kapila, Y. L. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008881 · Cited by 134 · see citing works
Self-citationModulation of pathogenic oral biofilms towards health with nisin probiotic
Radaic, A., Ye, C., Parks, B., Gao, L., Kuraji, R., Malone, E., Kamarajan, P., Zhan, L., & Kapila, Y. L. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1809302 · Cited by 59 · see citing works
Self-citation
- Authors
- Shin, J. M., Gwak, J. W., Kamarajan, P., Fenno, J. C., Rickard, A. H., & Kapila, Y. L.
- Affiliations
- University of Michigan (US)
- Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Ann Arbor MI USA
- Corresponding author
- Kapila, Y.L.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-02-12
- Volume
- 120
- Issue
- 6
- Pages
- 1449-1465
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- PMC
- PMC4866897
- OpenAlex
- W2233236537
- Cited by
- 607
- References
- 159
- Citations by year
- 2026: 35 · 2025: 66 · 2024: 93 · 2023: 87 · 2022: 78 · 2021: 75 · 2020: 66 · 2019: 36 · 2018: 39 · 2017: 24 · 2016: 8
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Applied Microbiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- IADR/GlaxoSmithKline Innovation in Oral Care Award
- NIH T-32 Training (5 T32 DE 7057-38)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- nisin, bacteriocins, lantibiotics, antimicrobial peptides, food biopreservatives, antimicrobial resistance, methicillin-resistant Staphylococcus aureus, antibiofilm activity, drug synergy, immunomodulation, anticancer activity, Gram-positive pathogens
- MeSH terms
- Anti-Bacterial Agents, Antineoplastic Agents, Bacterial Infections, Bacteriocins, Gram-Positive Bacteria, Nisin, Preservation, Biological, Virus Diseases, Biofilms, Drug Resistance, Bacterial
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