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PET imaging of neural activity, β-amyloid, and tau in normal brain aging

Zhang, Kai, Mizuma, Hiroshi, Zhang, Xiaohui, Takahashi, Kayo, Jin, Chentao, Song, Fahuan, Gao, Yuanxue, Kanayama, Yousuke, Wu, Yuping, Li, Yuting, Ma, Lijuan, Tian, Mei, Zhang, Hong, Watanabe, Yasuyoshi·2021·European Journal of Nuclear Medicine and Molecular Imaging
DOI 10.1007/s00259-021-05230-5
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Abstract

Normal brain aging is commonly associated with neural activity alteration, β-amyloid (Aβ) deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly individuals. Positron emission tomography (PET) with radiotracers targeting these age-related changes has been increasingly employed to clarify the sequence of their occurrence and the evolution of clinically cognitive deficits. Herein, we reviewed recent literature on PET-based imaging of normal human brain aging in terms of neural activity, Aβ, and tau. Neural hypoactivity reflected by decreased glucose utilization with PET imaging has been predominately reported in the frontal, cingulate, and temporal lobes of the normal aging brain. Aβ PET imaging uncovers the pathophysiological association of Aβ deposition with cognitive aging, as well as the potential mechanisms. Tau-associated cognitive changes in normal aging are likely independent of but facilitated by Aβ as indicated by tau and Aβ PET imaging. Future longitudinal studies using multi-radiotracer PET imaging combined with other neuroimaging modalities, such as magnetic resonance imaging (MRI) morphometry, functional MRI, and magnetoencephalography, are essential to elucidate the neuropathological underpinnings and interactions in normal brain aging.

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  • Our findings are consistent with reduced neuronal activity in tau transgenic mice and the negative correlation of tauopathy measured by PET tau tracer with neuronal activity measured with FDG PET.

    “Our findings are also consistent with reduced neuronal activity in tau transgenic mice53 and the negative correlation of tauopathy measured by PET tau tracer with neuronal activity measured with FDG PET87.”

    From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [87]

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Metadata

Authors
Zhang, K., Mizuma, H., Zhang, X., Takahashi, K., Jin, C., Song, F., Gao, Y., Kanayama, Y., Wu, Y., Li, Y., Ma, L., Tian, M., Zhang, H., & Watanabe, Y.
Venue
European Journal of Nuclear Medicine and Molecular Imaging
Publisher
Springer Science and Business Media LLC
Published
2021-03-05
Volume
48
Issue
12
Pages
3859-3871
ISSN
  • 1619-7070
  • 1619-7089
DOI
10.1007/s00259-021-05230-5
Cited by
49
References
13
Language
en
Licence
Funders
  • National Key Research and the Development Program of China (2016YFA0100900)
  • National Natural Science Foundation of China (81725009, 81761148029, 21788102, 32027802, 82030049)
  • Fundamental Research Funds for the Central Universities (2020FZZX001-05)
  • Japan Society for the Promotion of Science

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