Cited by 92Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsDementia and Cognitive Impairment Research

Relationships between brain metabolism decrease in normal aging and changes in structural and functional connectivity

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Chételat, Gaël, Landeau, Brigitte, Salmon, Eric, Yakushev, Igor, Bahri, Mohamed Ali, Mézenge, Florence, Perrotin, Audrey, Bastin, Christine +6 more·2013·NeuroImage

Abstract

Normal aging is characterized by brain glucose metabolism decline predominantly in the prefrontal cortex. The goal of the present study was to assess whether this change was associated with age-related alteration of white matter (WM) structural integrity and/or functional connectivity. FDG-PET data from 40 young and 57 elderly healthy participants from two research centers (n=49/48 in Center 1/2) were analyzed. WM volume from T1-weighted MRI (Center 1), fractional anisotropy from diffusion-tensor imaging (Center 2), and resting-state fMRI data (Center 1) were also obtained. Group comparisons were performed within each imaging modality. Then, positive correlations were assessed, within the elderly, between metabolism in the most affected region and the other neuroimaging modalities. Metabolism decline in the elderly predominated in the left inferior frontal junction (LIFJ). LIFJ hypometabolism was significantly associated with macrostructural and microstructural WM disturbances in long association fronto-temporo-occipital fibers, while no relationship was found with functional connectivity. The findings offer new perspectives to understand normal aging processes and open avenues for future studies to explore causality between age-related metabolism and connectivity changes.

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Crossref · 10.1016/j.neuroimage.2013.03.009

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  1. Pfefferbaum A., Sullivan E.V., Hedehus M., Lim K.O., Adalsteinsson E., Moseley M. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn. Reson. Med. 2000, 44:259-268.

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Authors
Chételat, G., Landeau, B., Salmon, E., Yakushev, I., Bahri, M. A., Mézenge, F., Perrotin, A., Bastin, C., Manrique, A., Scheurich, A., Scheckenberger, M., Desgranges, B., Eustache, F., & Fellgiebel, A.
Affiliations
  • Inserm (FR)
  • University Medical Center of the Johannes Gutenberg University Mainz (DE)
  • University of Liège (BE)
  • Centre Hospitalier Universitaire de Caen Normandie (FR)
Corresponding author
Chételat, Gaël
Venue
NeuroImage
Publisher
Elsevier BV
Published
2013-08
Volume
76
Pages
167-177
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2072418095
Cited by
92
References
68
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 8
FWCI
4.92
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • mediaTUM (Technical University of Munich) (submittedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
normal aging, brain glucose metabolism, white matter integrity, fractional anisotropy, functional connectivity, structural connectivity, inferior frontal junction, resting-state fMRI, FDG-PET, diffusion tensor imaging
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Positron-Emission Tomography, Young Adult

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