Cited by 71Immune cells in cancerCancer, Stress, Anesthesia, and Immune ResponseBreast Cancer Treatment Studies

Circulating myeloid-derived suppressor cells increase in patients undergoing neo-adjuvant chemotherapy for breast cancer

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Wesolowski, Robert, Duggan, Megan C., Stiff, Andrew, Markowitz, Joseph, Trikha, Prashant, Levine, Kala M., Schoenfield, Lynn, Abdel-Rasoul, Mahmoud +10 more·2017·Cancer Immunology, Immunotherapy

Abstract

This study sought to evaluate whether myeloid-derived suppressor cells (MDSC) could be affected by chemotherapy and correlate with pathologic complete response (pCR) in breast cancer patients receiving neo-adjuvant chemotherapy. Peripheral blood levels of granulocytic (G-MDSC) and monocytic (M-MDSC) MDSC were measured by flow cytometry prior to cycle 1 and 2 of doxorubicin and cyclophosphamide and 1st and last administration of paclitaxel or paclitaxel/anti-HER2 therapy. Of 24 patients, 11, 6 and 7 patients were triple negative, HER2+ and hormone receptor+, respectively. 45.8% had pCR. Mean M-MDSC% were <1. Mean G-MDSC% and 95% confidence intervals were 0.88 (0.23-1.54), 5.07 (2.45-7.69), 9.32 (4.02-14.61) and 1.97 (0.53-3.41) at draws 1-4. The increase in G-MDSC by draw 3 was significant (p < 0.0001) in all breast cancer types. G-MDSC levels at the last draw were numerically lower in patients with pCR (1.15; 95% CI 0.14-2.16) versus patients with no pCR (2.71; 95% CI 0-5.47). There was no significant rise in G-MDSC from draw 1 to 3 in African American patients, and at draw 3 G-MDSC levels were significantly lower in African Americans versus Caucasians (p < 0.05). It was concluded that G-MDSC% increased during doxorubicin and cyclophosphamide therapy, but did not significantly differ between patients based on pathologic complete response.

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Authors
Wesolowski, R., Duggan, M. C., Stiff, A., Markowitz, J., Trikha, P., Levine, K. M., Schoenfield, L., Abdel-Rasoul, M., Layman, R., Ramaswamy, B., Macrae, E. R., Lustberg, M. B., Reinbolt, R. E., Mrozek, E., Byrd, J. C., Caligiuri, M. A., Mace, T. A., & Carson, W. E.
Affiliations
  • The Ohio State University (US)
  • The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
  • The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Carson, William E.
Venue
Cancer Immunology, Immunotherapy
Published
2017-07-07
Volume
66
Issue
11
Pages
1437-1447
ISSN
  • 0340-7004 (ISSN-L)
  • 1432-0851
OpenAlex
W2729175670
Cited by
71
References
31
Citations by year
2026: 2 · 2025: 9 · 2024: 3 · 2023: 8 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 7 · 2018: 8
FWCI
3.34
Type
journal article
Language
en
Open access
Locations
  • Cancer Immunology Immunotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (2P01CA095426-11, T32 GM068412, K12 CA 133250)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
myeloid-derived suppressor cells, breast cancer, neoadjuvant chemotherapy, pathological complete response, granulocytic MDSCs, monocytic MDSCs, doxorubicin, cyclophosphamide, paclitaxel, HER2-targeted therapy, triple-negative breast cancer, HER2-positive breast cancer, hormone receptor-positive breast cancer, racial differences, African American patients, circulating immune cells
MeSH terms
Myeloid-Derived Suppressor Cells, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Black or African American, Breast Neoplasms, Cell Count, Cyclophosphamide, Doxorubicin, Female, Granulocytes, Humans, Middle Aged, Monocytes, Pilot Projects, Cytokines, Treatment Outcome, Chemotherapy, Adjuvant, Paclitaxel, Neoadjuvant Therapy, White People

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