Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation
Open accessAbstract
PURPOSE: The aim of this study is to evaluate the long-term influence of L-arginine intake on mineral concentration in patients with obesity and to assess the changes in lipid serum levels, fat content, and insulin resistance that result. METHODS: A randomized double-blind placebo-controlled study was conducted. 88 obese patients were randomly assigned to receive either 9 g of L-arginine or placebo daily, for 6 months. At baseline and after 6 months, selected anthropometrical measurements and blood biochemical analyses were performed and mineral levels were assessed. To assess insulin sensitivity, the gold-standard euglycemic clamp methodology was used. RESULTS: We found that 6 months of L-arginine supplementation resulted in significant increases in insulin sensitivity (Δ1.1 mg/kg/min, P < 0.01) and zinc levels (Δ1.5 μmol/L, P < 0.001). Moreover, a positive correlation between the change in zinc concentration in serum and the change in insulin sensitivity was observed (R = 0.80, P < 0.01). In the group of patients treated with L-arginine, a negative correlation between the change in zinc concentration in serum and the change in body fat content was noted (R = -0.38, P < 0.05). CONCLUSIONS: L-Arginine supplementation affects zinc status in obese patients. One beneficial influence is related to the improvements in insulin sensitivity.
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Human studies have repeatedly shown that L-arginine supplementation has favorable effects on body composition and insulin sensitivity.
“However, human studies have repeatedly shown that L-arginine supplementation has favorable effects on body composition and insulin sensitivity [271-277].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [276]
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- Authors
- Suliburska, J., Bogdanski, P., Szulinska, M., Pupek-Musialik, D., & Jablecka, A.
- Affiliations
- Poznań University of Life Sciences (PL)
- Corresponding author
- Suliburska, Joanna
- ORCID
- Suliburska, Joanna
- Venue
- European Journal of Nutrition
- Published
- 2013-05-25
- Volume
- 53
- Issue
- 2
- Pages
- 387-393
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- PMC
- PMC3925292
- OpenAlex
- W2020207257
- Cited by
- 47
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 2 · 2022: 9 · 2021: 2 · 2020: 7 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 1
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Journal of Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- arginine supplementation, obesity, insulin sensitivity, zinc status, serum minerals, body fat content, insulin resistance, euglycemic clamp
- MeSH terms
- Adult, Arginine, Blood Glucose, Body Composition, Copper, Double-Blind Method, Female, Humans, Insulin, Insulin Resistance, Lipids, Male, Middle Aged, Minerals, Obesity, Placebos, Zinc, Body Mass Index, Dietary Supplements
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