Cited by 87Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systemsbiodegradable polymer synthesis and properties

Novel pentablock copolymer (PLA–PCL–PEG–PCL–PLA)-based nanoparticles for controlled drug delivery: effect of copolymer compositions on the crystallinity of copolymers and in vitro drug release profile from nanoparticles

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Tamboli, Viral, Mishra, Gyan P., Mitra, Ashim K.·2013·Colloid and Polymer Science

Abstract

The purpose of this investigation was to design novel pentablock copolymers (polylatide-polycaprolactone-polyethylene glycol- polycaprolactone-polylatide) (PLA-PCL-PEG-PCL-PLA) to prepare nanoparticle formulations which provide continuous delivery of steroids over a longer duration with minimal burst effect. Another purpose was to evaluate the effect of poly (L-lactide) (PLLA) or poly (D, L-lactide) (PDLLA) incorporation on crystallinity of pentablock copolymers and in vitro release profile of triamcinolone acetonide (selected as model drug) from nanoparticles. PLA-PCL-PEG-PCL-PLA copolymers with different block ratio of PCL/PLA segment were synthesized. Release of triamcinolone acetonide from nanoparticles was significantly affected by crystallinity of the copolymers. Burst release of triamcinolone acetonide from nanoparticles was significantly minimized with incorporation of proper ratio of PDLLA in the existing triblock (PCL-PEG-PCL) copolymer. Moreover, pentablock copolymer based nanoparticles exhibited continuous release of triamcinolone acetonide. Pentablock copolymer based nanoparticles can be utilized to achieve continuous near zero-order delivery of corticosteroids from nanoparticles without any burst effect.

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Authors
Tamboli, V., Mishra, G. P., & Mitra, A. K.
Affiliations
University of Missouri–Kansas City (US)
Corresponding author
Mitra, Ashim K.
Venue
Colloid and Polymer Science
Published
2012-11-21
Volume
291
Issue
5
Pages
1235-1245
ISSN
  • 0303-402X (ISSN-L)
  • 1435-1536
OpenAlex
W1991148038
Cited by
87
References
45
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 6 · 2014: 2 · 2013: 1
FWCI
1.17
Type
journal article
Language
en
Open access
Locations
  • Colloid & Polymer Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Missouri-Kansas City
  • National Institutes of Health
  • National Eye Institute (R01EY009171, R01EY010659)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
pentablock copolymers, polymeric nanoparticles, controlled drug delivery, triamcinolone acetonide, corticosteroid delivery, crystallinity, burst release, zero-order release, block copolymer composition, polycaprolactone, polyethylene glycol, poly(L-lactic acid), poly(D,L-lactide), sustained drug release

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