Novel pentablock copolymer (PLA–PCL–PEG–PCL–PLA)-based nanoparticles for controlled drug delivery: effect of copolymer compositions on the crystallinity of copolymers and in vitro drug release profile from nanoparticles
Open accessAbstract
The purpose of this investigation was to design novel pentablock copolymers (polylatide-polycaprolactone-polyethylene glycol- polycaprolactone-polylatide) (PLA-PCL-PEG-PCL-PLA) to prepare nanoparticle formulations which provide continuous delivery of steroids over a longer duration with minimal burst effect. Another purpose was to evaluate the effect of poly (L-lactide) (PLLA) or poly (D, L-lactide) (PDLLA) incorporation on crystallinity of pentablock copolymers and in vitro release profile of triamcinolone acetonide (selected as model drug) from nanoparticles. PLA-PCL-PEG-PCL-PLA copolymers with different block ratio of PCL/PLA segment were synthesized. Release of triamcinolone acetonide from nanoparticles was significantly affected by crystallinity of the copolymers. Burst release of triamcinolone acetonide from nanoparticles was significantly minimized with incorporation of proper ratio of PDLLA in the existing triblock (PCL-PEG-PCL) copolymer. Moreover, pentablock copolymer based nanoparticles exhibited continuous release of triamcinolone acetonide. Pentablock copolymer based nanoparticles can be utilized to achieve continuous near zero-order delivery of corticosteroids from nanoparticles without any burst effect.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549 · see citing works
Self-porating polymersomes of peg–pla and peg–pcl: Hydrolysis-triggered controlled release vesicles
Ahmed, F., & Discher, D. E. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.12.021 · Cited by 667 · see citing works
Preparation and characterization of biodegradable PLA polymeric blends
Chen, C.-C., Chueh, J.-Y., Tseng, H., Huang, H.-M., & Lee, S.-Y. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00466-0 · Cited by 583 · cited 1× · see citing works
“Literature suggests that crystallinity of PCL can be modulated by conjugating with PLA segment [23, 24].”
BackgroundNanotechnology in ocular drug delivery
Sahoo, S. K., Dilnawaz, F., & Krishnakumar, S. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.10.021 · Cited by 554 · see citing works
Applications of nanoparticles in ophthalmology
Diebold, Y., & Calonge, M. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.08.002 · Cited by 396 · see citing works
Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery
Gupta, H., Aqil, M., Khar, R. K., Ali, A., Bhatnagar, A., & Mittal, G. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.10.004 · Cited by 367 · see citing works
Nanotechnology in Ocular Drug Delivery
Patel, D. H., Pathak, D., & Giradkar, P. (2021) · Springer eBooks · doi:10.1007/978-981-33-4497-6_18 · Cited by 362 · see citing works
Safety and efficacy of intravitreal triamcinolone for cystoid macular oedema in uveitis
Young, S. H., Larkin, G. B., Branley, M. G., et al. (2001) · Clinical and Experimental Ophthalmology · doi:10.1046/j.1442-9071.2001.00360.x · Cited by 354 · see citing works
Hu, Y., Xie, J., Tong, Y. W., & Wang, C. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.11.028 · Cited by 351 · see citing works
Biodegradable Polymers for Microencapsulation of Drugs
Park, J. H., Ye, M., & Park, K. (2005) · Molecules · doi:10.3390/10010146 · Cited by 318 · see citing works
Ghoroghchian, P. P., Li, G., Levine, D. H., Davis, K. P., Bates, F. S., Hammer, D. A., & Therien, M. J. (2006) · Macromolecules · doi:10.1021/ma0519009 · Cited by 266 · see citing works
Hu, Y., Jiang, X., Ding, Y., Zhang, L., Yang, C., Zhang, J., Chen, J., & Yang, Y. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00021-8 · Cited by 261 · see citing works
Encapsulation of dexamethasone into biodegradable polymeric nanoparticles
Gómez-Gaete, C., Tsapis, N., Besnard, M., Bochot, A., & Fattal, E. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.028 · Cited by 260 · see citing works
Tamura, H., Miyamoto, K., Kiryu, J., Miyahara, S., Katsuta, H., Hirose, F., Musashi, K., & Yoshimura, N. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0905 · Cited by 250 · see citing works
Chin, H.-S., PARK, T.-S., Moon, Y. S., et al. (2005) · Retina · doi:10.1097/00006982-200507000-00002 · Cited by 247 · see citing works
Kwak, H. W. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080140115038 · Cited by 230 · see citing works
Nanomedicines for ocular NSAIDs: safety on drug delivery
Araújo, J., González‐Mira, E., Egea, M. A., et al. (2009) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2009.02.003 · Cited by 224 · see citing works
Controlled release from bioerodible polymers: Effect of drug type and polymer composition
Frank, A., Rath, S. K., & Venkatraman, S. S. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.019 · Cited by 201 · see citing works
Kister, G., Cassanas, G., Bergounhon, M., Hoarau, D., & Vert, M. (2000) · Polymer · doi:10.1016/s0032-3861(99)00223-2 · Cited by 163 · see citing works
Triamcinolone Acetonide in Ocular Therapeutics
Jermak, C. M., DELLACROCE, J. T., Heffez, J. L., et al. (2007) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2007.06.004 · Cited by 150 · see citing works
Müller, A. J., Albuerne, J., Marquez, L., Raquez, J.-M., Degée, P., Dubois, P., Hobbs, J., & Hamley, I. W. (2005) · Faraday Discuss. · doi:10.1039/b403085k · Cited by 141 · see citing works
Huang, M., Li, S., Hutmacher, D. W., Schantz, J., Vacanti, C. A., Braud, C., & Vert, M. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30008 · Cited by 139 · see citing works
Micelle-like nanoparticles of PLA–PEG–PLA triblock copolymer as chemotherapeutic carrier
Venkatraman, S. S., Pan, J., Feng, M., Boey, Y. C. F., & Leong-Huat, G. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.023 · Cited by 133 · see citing works
Huang, M., Li, S., Coudane, J., & Vert, M. (2003) · Macromolecular Chemistry and Physics · doi:10.1002/macp.200350054 · Cited by 120 · see citing works
Liang, H., Yang, T.-F., Huang, C.-T., Chen, M., & Sung, H. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.03.021 · Cited by 112 · see citing works
Gou, M., Zheng, L., Peng, X.-Y., Men, K., Zheng, X., Zeng, S., Guo, G. F., Luo, F., Zhao, X., Chen, L., et al. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.04.007 · Cited by 111 · see citing works
Poly(ε-Caprolactone) Nanocapsules in Carteolol Ophthalmic Delivery
Marchal‐Heussler, L., Sirbat, D., Hoffman, M., & Maincent, P. (1993) · Pharmaceutical Research · doi:10.1023/a:1018936205485 · Cited by 110 · see citing works
Nanoparticle applications in ocular gene therapy
Cai, X., Conley, S. M., & Naash, M. I. (2007) · Vision Research · doi:10.1016/j.visres.2007.07.012 · Cited by 106 · see citing works
Degradation characteristics of poly(ϵ‐caprolactone)‐based copolymers and blends
Huang, M., Li, S., Hutmacher, D. W., Coudane, J., & Vert, M. (2006) · Journal of Applied Polymer Science · doi:10.1002/app.24196 · Cited by 104 · see citing works
Effect of polymer crystallinity on papaverine release from poly (l-lactic acid) matrix
Miyajima, M., Koshika, A., Okada, J., Ikeda, M., & Nishimura, K. J. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00081-3 · Cited by 88 · see citing works
Preparation and evaluation of PEG–PCL nanoparticles for local tetradrine delivery
Li, R., Li, X., Li, X., Ding, D., Hu, Y., Qian, X., Yu, L., Ding, Y., Jiang, X., & Liu, B. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.007 · Cited by 87 · see citing works
Li, S., Dobrzyński, P., Kasperczyk, J., Bero, M., Braud, C., & Vert, M. (2004) · Biomacromolecules · doi:10.1021/bm049458+ · Cited by 84 · see citing works
van Kooij, B., Rothová, A., & de Vries, P. (2006) · Ocular Immunology and Inflammation · doi:10.1080/09273940500545684 · Cited by 78 · see citing works
Jonas, J. B., Kreissig, I., & Degenring, R. F. (2002) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-002-0547-y · Cited by 72 · see citing works
Fang, F., Gong, C., Qian, Z., et al. (2009) · ACS Nano · doi:10.1021/nn900785b · Cited by 72 · see citing works
Jia, W. J., Gu, Y. C., Gou, M. L., et al. (2008) · Drug Delivery · doi:10.1080/10717540802321727 · Cited by 72 · see citing works
Intraocular Sustained-Release Delivery Systems for Triamcinolone Acetonide
Mansoor, S., Kuppermann, B. D., & Kenney, M. C. (2009) · Pharmaceutical Research · doi:10.1007/s11095-008-9812-z · Cited by 66 · see citing works
Okabe, K., Kimura, H., Okabe, J., et al. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0956 · Cited by 61 · see citing works
Molecular Mobilities in Biodegradable Poly( dl -lactide)/Poly(ε-caprolactone) Blends
Newman, D., Laredo, E., Bello, A., Grillo, A. M., Feijoo, J. L., & Müller, A. J. (2009) · Macromolecules · doi:10.1021/ma9007303 · Cited by 51 · see citing works
Li, S., Molina, I., Bueno, M., & Vert, M. (2002) · Journal of Materials Science Materials in Medicine · doi:10.1023/a:1013651022431 · Cited by 49 · see citing works
Mishra, G. P., Tamboli, V., & Mitra, A. K. (2011) · Colloid & Polymer Science · doi:10.1007/s00396-011-2476-y · Cited by 40 · see citing works
Self-citationDalwadi, G., & Sunderland, B. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.08.004 · Cited by 30 · see citing works
Havlíková, L., Matysová, L., Hájková, R., et al. (2008) · Talanta · doi:10.1016/j.talanta.2008.03.048 · Cited by 22 · see citing works
Wu, D., & Chu, C. (2008) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856208783719536 · Cited by 18 · see citing works
Ge, H., Hu, Y., Yang, S., Jiang, X., & Yang, C. (2000) · Journal of Applied Polymer Science · doi:10.1002/(sici)1097-4628(20000214)75:7
Flagged first, then by citations
Cited by
Sorted by citations
PCL and PCL-based materials in biomedical applications
Malikmammadov, E., Tanir, T. E., Kiziltay, A., Hasirci, V., & Hasirci, N. (2018) · Journal of Biomaterials Science, Polymer Edition · doi:10.1080/09205063.2017.1394711 · Cited by 894 · see citing works
Redox Switchable Copolymerization of Cyclic Esters and Epoxides by a Zirconium Complex
Quan, S. M., Wang, X., Zhang, R., & Diaconescu, P. L. (2016) · Macromolecules · doi:10.1021/acs.macromol.6b00997 · Cited by 93 · see citing works
Alami-Milani, M., Zakeri-Milani, P., Valizadeh, H., Fathi, M., Salatin, S., Salehi, R., & Jelvehgari, M. (2020) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2020.1733606 · Cited by 36 · see citing works
Zwitterionic light-responsive polymeric micelles for controlled drug delivery
Shen, H., Zhou, M., Zhang, Q., Keller, A., & Shen, Y. (2015) · Colloid and Polymer Science · doi:10.1007/s00396-015-3550-7 · Cited by 36 · see citing works
Kamali, H., Khodaverdi, E., Kaffash, E., Saffari, A. S., Shiadeh, S. N. R., Nokhodchi, A., & Hadizadeh, F. (2021) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-020-09480-y · Cited by 24 · see citing works
Palacios, J. K., Mugica, A., Zubitur, M., & Müller, A. J. (2018) · Crystallization in Multiphase Polymer Systems · doi:10.1016/b978-0-12-809453-2.00006-2 · Cited by 18 · see citing works
Matxinandiarena, E., Múgica, A., Tercjak, A., Ladelta, V., Zapsas, G., Hadjichristidis, N., Cavallo, D., Flores, A., & Müller, A. J. (2021) · Macromolecules · doi:10.1021/acs.macromol.1c01186 · Cited by 16 · see citing works
Palacios, J. K., Liu, G., Wang, D., Hadjichristidis, N., & Müller, A. J. (2019) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201900292 · Cited by 15 · see citing works
- Authors
- Tamboli, V., Mishra, G. P., & Mitra, A. K.
- Affiliations
- University of Missouri–Kansas City (US)
- Corresponding author
- Mitra, Ashim K.
- Venue
- Colloid and Polymer Science
- Published
- 2012-11-21
- Volume
- 291
- Issue
- 5
- Pages
- 1235-1245
- ISSN
- 0303-402X (ISSN-L)
- 1435-1536
- PMC
- PMC3633208
- OpenAlex
- W1991148038
- Cited by
- 87
- References
- 45
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 6 · 2014: 2 · 2013: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Colloid & Polymer Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Missouri-Kansas City
- National Institutes of Health
- National Eye Institute (R01EY009171, R01EY010659)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- pentablock copolymers, polymeric nanoparticles, controlled drug delivery, triamcinolone acetonide, corticosteroid delivery, crystallinity, burst release, zero-order release, block copolymer composition, polycaprolactone, polyethylene glycol, poly(L-lactic acid), poly(D,L-lactide), sustained drug release
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review