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Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy
Open accessAbstract
Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.
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“Primary age-related tauopathy (PART) and aging-related tau astrogliopathy (ARTAG) are independent tau pathologies commonly observed in patients over 80 years of age, and PART may account for a proportion of the misdiagnosed clinical AD cases in the elderly [130, 141, 142].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [141]
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“Perivascular, subpial, and periventricular p-tau immunoreactive NFTs and astrocytic tangles in the neocortex have been reported to be characteristic of both primary age-related tauopathy (PART) [35] and age-related tau astrogliopathy (ARTAG) [36].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [36]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“PART refers to neuronal tau pathology and ARTAG is characterized by astrocytic tau pathology, although they are not mutually exclusive, and appear to be more a manifestation of age than a subtype of neurodegenerative disease.”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [36]
Experimental — accuracy not yet measuredIn the citing paper
“Another exemplary phenomenon is age-related tau astrogliopathy (ARTAG), in which p-tau accumulates in astrocytes of various brain regions [79].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [79]
In the citing paper
“The panel did not ultimately accept all of the a priori criteria for CTE; they did not include pathology known to be associated with aging (i.e.primary age-related tauopathy [PART] [16] and aging-related tau astrogliopathy [ARTAG] [17]).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [17]
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Citations
Cites
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InfluentialSelf-citationTau is a candidate gene for chromosome 17 frontotemporal dementia
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“The morphological spectrum of tau immunoreactivity as present in glial cells of the aging human brain is described by ARTAG, regardless of the existence of any concurrent neurological disorders [13].”
BackgroundBaiardi, S., Mammana, A., Rossi, M., Ladogana, A., Carlà, B., Gambetti, P. L., Capellari, S., & Parchi, P. (2022) · Viruses · doi:10.3390/v14020367 · Cited by 13
“Moreover, focal and widespread fine granular deposits into the astrocytic processes were detected in both the gray and white matter with subpial, subependymal, and perivascular distribution, co siste tl it i ‐ l t t t li t ( ) ( i r 3 ) [29].”
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“The significance of these glial inclusions is unclear, but similarities between granular or fuzzy astrocytes in ALS/PDC and aging-related tau astrogliopathy have been noticed (7, 21).”
BackgroundParkinson's Progression Markers Initiative brain autopsy program
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Age-Related Pathology in Corticobasal Degeneration
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“…tangle stage, CERAD neuritic plaque score, LBD (McKeith DLB), limbic-predominant age-related TDP-43 encephalopathy neurological change (LATE-NC), small vessel disease, and age-related tau astrogliopathy (ARTAG) were performed according to published guidelines [12, 65, 75, 79, 83, 86, 104, 113].”
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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“Regression models and remaining comparisons among all study groups can be found in Supplementary Tables 33–41.”
InfluentialArakawa, A., Goto, R., Higashihara, M., Hiroyoshi, Y., Shioya, A., Hara, M., Orita, M., Matsubara, T., Sengoku, R., Kameyama, M., et al. (2024) · Neuropathology · doi:10.1111/neup.12973 · Cited by 10
“3B), subiculum, and tran-sentorhinal gyrus alongside bush-like astrocytes, 35 now referred to as granular fuzzy astrocytes (GFAs) 36 and pretangles (PTs), 3,16 which are diffuse neuronal fi ne granular AT8/RD4 immunoreactive intracytoplasmic structures.”
Comorbid neuropathology and atypical presentation of Alzheimer's disease
Piña‐Escudero, S. D., Joie, R. L., Spina, S., Hwang, J., Miller, Z., Huang, E. J., Grant, H. E., Mundada, N. S., Boxer, A. L., Gorno‐Tempini, M., et al. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12602 · Cited by 10
Brain aging and Alzheimer’s disease, a perspective from non-human primates
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Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
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Cognitive deficit, and neuropathological correlates, in the oldest-old
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“Each brain region was reviewed for TSA and GFA pathologies from 3 anatomical locations consisting of the gray matter, white matter, and subpial cortex (29).”
MethodAgeing‐related tau astrogliopathy severely affecting the substantia nigra
Tanaka, H., Lee, S., Martínez-Valbuena, I., Couto, B., Tartaglia, M. C., de Gordoa, J. S., Erro, M. E., Lang, A. E., Forrest, S. L., & Kovács, G. G. (2024) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.13000 · Cited by 9
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Yokota, O., Miki, T., Ikeda, C., Ishizu, H., Haraguchi, T., Miyashita, A., Ikeuchi, T., Takenoshita, S., & Terada, S. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-4285 · Cited by 9
“[1], and later they were classified as one of the agerelated tau astrogliopathies and re-named granular fuzzy astrocytes (GFAs) [2].”
BackgroundVerkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00012-2 · Cited by 10
Understanding the Relevance of Aging-Related Tau Astrogliopathy (ARTAG)
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Robinson, A., Chew-Graham, S., Davidson, Y. S., Horan, M. A., Roncaroli, F., Minshull, J., du Plessis, D., Pal, P., Payton, A., Pendleton, N., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190580 · Cited by 9
“Other pathological diagnoses were made in accordance with published criteria or descriptions for frontotemporal lobar degeneration (FTLD) [24, 25], corticobasal degeneration (CBD) [26], progressive supranuclear palsy (PSP) [27], multiple system atrophy (MSA) [28], argyrophilic grain disease (AGD) [29], primary age-rel…”
MethodClinical and Pathological Phenotypes of LRP10 Variant Carriers with Dementia
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Robinson, A., Roncaroli, F., Chew-Graham, S., Davidson, Y. S., Minshull, J., Horan, M. A., Payton, A., Pendleton, N., & Mann, D. M. A. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200339 · Cited by 9
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Iverson, G. L., Jamshidi, P., Fisher‐Hubbard, A., Deep‐Soboslay, A., Hyde, T. M., Kleinman, J. E., deJong, J. L., Shepherd, C. E., Hazrati, L., & Castellani, R. J. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1143882 · Cited by 9
Arafuka, S., Fujishiro, H., Torii, Y., Sekiguchi, H., Habuchi, C., Miwa, A., Yoshida, M., Iritani, S., Iwasaki, Y., Ikeda, M., et al. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13597 · Cited by 10
“Geser et al . reported that 29% of patients with schizophrenia had TDP-43 pathology, 46 but no study was conducted concerning the incidence of AGs and ARTAG in early-onset schizophrenia (<40 years old at the onset).”
MethodInfluentialNiedowicz, D. M., Katsumata, Y., & Nelson, P. T. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad085 · Cited by 8
“Astrocytes and their pathologies are foci of interest in the dementia research world (32–35).”
BackgroundOrlandi, F., Carlos, A. F., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Botha, H., Machulda, M. M., Stephens, Y. C., Schwarz, C. G., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae113 · Cited by 8
“45 The presence of cerebral amyloid angiopathy and arteriolosclerosis was also assessed using slides stained with haematoxylin and eosin.”
MethodMontoliu‐Gaya, L., Valeriano-Lorenzo, E., Ashton, N. J., López‐González, F. J., Lantero‐Rodriguez, J., Ruiz-González, A., Pastor, A. B., Frades, B., Zea‐Sevilla, M. A., Valentí, M., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70562 · Cited by 11
“32 The latter was registered as present or absent, both in the medial temporal lobe and the cerebral neocortex/juxtacortical white matter.”
Ramsay, D. S. C., Miller, A., Baykeens, B., Hassan, H., & Gentleman, S. (2023) · Cureus · doi:10.7759/cureus.34279 · Cited by 8
“This is further reflected by the presence of ageing-related tau astrogliopathy (ARTAG), which shares features seen in CTE, and the two pathologies may well coexist [50].”
BackgroundThe Adult Neurogenesis Theory of Alzheimer’s Disease
Abbate, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221279 · Cited by 11
Carlos, A. F., Sekiya, H., Koga, S., Gatto, R. G., Casey, M. C., Pham, N. T. T., Sintini, I., Machulda, M. M., Jack, C. R., Lowe, V. J., et al. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad105 · Cited by 8
Kovács, G. G., Respondek, G., van Eimeren, T., Holler, E., Levin, J., Müller, U., Schwarz, S. C., Rösler, T. W., Schweyer, K., & Höglinger, G. U. (2018) · Der Nervenarzt · doi:10.1007/s00115-018-0584-3 · Cited by 8
Tau seeding activity in various regions of down syndrome brain assessed by two novel assays
Jin, N., Gu, J., Wu, R., Chu, D., Tung, Y. C., Węgiel, J., Wısnıewskı, T., Gong, C., Iqbal, K., & Liu, F. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01436-2 · Cited by 8
“The diagnosis of these cases was confirmed histopathologically by TW (a board-certified neuropathologist), using standard neuropathological criteria [3, 6, 30, 33, 39, 45, 57].”
MethodIncidental corticobasal degeneration
Martínez-Maldonado, A., Luna‐Muñoz, J., & Ferrer, I. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12339 · Cited by 8
Traumatic brain injury or head impacts from contact sports are associated with tau astrogliopathy
Arena, J. D., Stewart, W. B., Jr., Kovács, G. G., Lee, E. B., Robinson, J. L., Lee, V. M. ‐., Trojanowski, J. Q., Schneider, A. L. C., Smith, D. H., & Johnson, V. E. (2025) · Brain · doi:10.1093/brain/awaf073 · Cited by 8
Argyrophilic grain disease: epidemiology and association with cognitive decline and parkinsonism
Arakawa, A., Matsubara, T., Shioya, A., Hara, M., Hiroyoshi, Y., Kurihara, M., Morimoto, S., Kato, T., Higashihara, M., Sengoku, R., et al. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf352 · Cited by 7
DYRK1A in the physiology and pathology of the neuron-astrocyte axis
Cisternas, P., Kim, J.-Y., Ashfeld, B. L., & Zartman, J. J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1626062 · Cited by 7
Relationships between regional burden of tau pathology and age at death and disease duration in PSP
Badihian, N., Tosakulwong, N., Weigand, S. D., Ali, F., Clark, H. M., Stierwalt, J. A. G., Botha, H., Savica, R., Dickson, D. W., Whitwell, J. L., et al. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.107109 · Cited by 7
Astrocyte–Neuron Interactions in Alzheimer’s Disease
Muñoz‐Castro, C., & Serrano‐Pozo, A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_14 · Cited by 7
The prevalence of chronic traumatic encephalopathy in a historical epilepsy post‐mortem collection
Ryniejska, M., Hachami, H. E., Mrzyglod, A., Liu, J. Y. W., & Thom, M. (2024) · Brain Pathology · doi:10.1111/bpa.13317 · Cited by 6
“Ageing-related tau astrogliopathy (ARTAG) pathological tau accumulation is restricted to astroglia and comprised of 4R isoforms, but without a clearly defined cognitive syndrome [51,52].”
InfluentialNeuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease
Lim, D., Matute, C., Cavaliere, F., & Verkhratsky, A. (2025) · Handbook of Clinical Neurology · doi:10.1016/b978-0-443-19102-2.00012-0 · Cited by 8
Neuropathology of McLeod Syndrome
Deutschlander, A. B., Dickson, D. W., & Wszołek, Z. K. (2021) · Movement Disorders · doi:10.1002/mds.28882 · Cited by 7
The tauopathies: Neuroimaging characteristics and emerging experimental therapies
Riley, K. J., Graner, B. D., & Veronesi, M. C. (2022) · Journal of Neuroimaging · doi:10.1111/jon.13001 · Cited by 8
Iacono, D., Geraci-Erck, M., Peng, H., & Bouffard, J. (2016) · Journal of Visualized Experiments · doi:10.3791/54602 · Cited by 8
Lewis, A. J., van den Heuvel, L., Fabrizio, M. D., Bandelier, K., Proniakova, D., Burger, D., Shafiei, N., Ekundayo, K., Offringa, S., Huisman, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.25.605088 · Cited by 7
Neuropathological comorbidity, genetics and cognition in a Chinese community-based autopsy cohort
Wu, W., Wang, X. L., Xu, Y., Ma, C., Qian, X., & Qiu, W. (2025) · Brain · doi:10.1093/brain/awaf039 · Cited by 6
“ARTAG was considered with the presence of pTDP-43-positive thorn-shaped astrocytes or granular/fuzzy astrocytes, 22 which were needed to distinguish it from chronic traumatic encephalopathy.”
Nasir, A. R., & Nouh, C. D. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1671419 · Cited by 8
“Atypical star-shaped TDP-43 inclusions have been recently identified, primarily in the subpial medial region of the amygdala, and they colocalize with tau in superagers (Geser et al., 2010; Kovacs et al., 2016; Nelson et al., 2018; Carlos et al., 2023a).”
Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study
Salman, Y., Goloubeva, J., Huyghe, L., Quenon, L., Tomé, S. O., Hanseeuw, B. J., & Initiative, A. D. N. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02200-y · Cited by 6
“The presence of Lewy body pathology (LBD), aging-related tau astrogliopathy (ARTAG), argyrophilic grain disease (AGD), small vessel disease, and microinfarcts was classified using pre-established criteria, respectively [3, 4, 7, 28].”
Stable ubiquitin conjugation for biological interrogation of ubiquitinated tau repeat domain
Viola, G., Trivellato, D., Meulli, L., Tira, R., Lauriola, A., Munari, F., Montagnana, M., Buffelli, M., Assfalg, M., & D’Onofrio, M. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107549 · Cited by 6
Rusina, R., Bajtošová, R., Cséfalvay, Z., Keller, J., Kavková, A., Kukal, J., & Matěj, R. (2022) · Behavioural Neurology · doi:10.1155/2022/6075511 · Cited by 6
“astrogliopathy (ARTAG) and limbic-predominant age-related TDP-43 encephalopathy (LATE) [40, 41].”
InfluentialUemura, M. T., Suh, E. R., Robinson, J. L., Brunden, K. R., Grossman, M., Irwin, D. J., Lee, V. M. ‐., Trojanowski, J. Q., Lee, E. B., & Deerlin, V. M. V. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12865 · Cited by 6
“Ageing-related tau astrogliopathy (ARTAG) describes a pathological accumulation of abnormally phosphorylated tau protein in astrocytes with the morphological subtypes of (1) thorn-shaped astrocytes (TSA) and (2) granular/fuzzy astrocytes (GFA).15 ARTAG occurs in the brain during normal ageing as well as in most neurod…”
BackgroundInfluential18F ‐Florzolotau PET Imaging Unveils Tau Pathology in Dementia with Lewy Bodies
Tang, G., Lu, J., Li, X., Yao, R., Yang, Y., Jiao, F., Chen, M., Liang, X., Ju, Z., Ge, J., et al. (2024) · Movement Disorders · doi:10.1002/mds.30055 · Cited by 6
“58 Given these complexities, further investigation into tau PET imaging using next-generation tracers is imperative to fully understand and differentiate these tau pathologies.”
α‐synuclein astrogliopathy: A possible specific feature in α‐synucleinopathy
Koga, S., Kasanuki, K., & Dickson, D. W. (2017) · Neuropathology · doi:10.1111/neup.12371 · Cited by 6
“The morphology and location of this astrocytic pathology are reminiscent of aging-related tau astrogliopathy (ARTAG), which is characterized by thorn-shaped astrocytes (TSA) or granular/fuzzy astrocytes in subependymal, subpial, perivascular, gray matter and white matter regions.(2) We previously reported that 7% of M…”
BackgroundJung, N.-Y., Lee, J.-H., Lee, Y.-M., Shin, J.-H., Shin, M., Lee, M., Pak, K., Hwang, C., Ahn, J., Sung, S., et al. (2018) · Neurocase · doi:10.1080/13554794.2018.1494290 · Cited by 6
“gliopathy (Kovacs et al., 2016) and TDP-43 immunoreactive”
Homma, T., Mochizuki, Y., Tobisawa, S., Komori, T., & Takahashi, K. (2021) · Neuropathology · doi:10.1111/neup.12779 · Cited by 6
“They had concentric p-tau-positive fine processes with tree-shaped branching,(4,14) which was a different morphology from granular/fuzzy astrocytes and other aging-related tau astrogliopathies (ARTAG)-associated astrocytes.(15) However, TuALG were localized only in the cerebral cortex of Pt2 and in the cerebral cortex…”
BackgroundMacroscopic diagnostic clue for parkinsonism
Yoshida, M., Akagi, A., Miyahara, H., Riku, Y., Ando, T., Ikeda, T., Yabata, H., Moriyoshi, H., Koizumi, R., & Iwasaki, Y. (2022) · Neuropathology · doi:10.1111/neup.12853 · Cited by 6
Kawakami, I., Arai, T., Ikeda, K., Niizato, K., Oshima, K., & Akiyama, H. (2022) · Neuropathology · doi:10.1111/neup.12870 · Cited by 6
“The pathology is partially consistent with PART(4) and ARTAG.(7) There were no pathological features suggestive of other tauopathies such as AD, PSP, CBD, AGD, GGT, PiD, or DLB.”
BackgroundAli, F., & Josephs, K. A. (2019) · Seminars in Neurology · doi:10.1055/s-0039-1678584 · Cited by 5
Celebrating 40 years of the University of Kentucky Alzheimer's Disease Research Center
Schmitt, F. A., Abner, E. L., Fardo, D. W., Gold, B. T., Jicha, G. A., Kryscio, R. J., Lee, D. C., Nelson, P. T., & Eldik, L. J. V. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70181 · Cited by 7
Mapping multipathology via spatial omic integration
Palaganas, R. G., Sidiropoulos, D. N., Morris, M., & Stein-O’Brien, G. (2025) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2025.103398 · Cited by 6
Bigio, M. R. D., Krawitz, S., & Sinha, N. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad079 · Cited by 5
“Immunoreactivity for p-tau was also occasionally found in granular eosinophilic bodies adjacent to old contusions or in an ARTAG-like pattern at sites of superficial siderosis (Supplementary Data).”
Making tau amyloid models in vitro: a crucial and underestimated challenge
Broc, J., Piersson, C., & Fichou, Y. (2025) · FEBS Letters · doi:10.1002/1873-3468.70022 · Cited by 5
The China Brain Multi-omics Atlas Project (CBMAP)
Zhou, D., Zhou, Y., Sun, Z., Ji, F., Zhang, D., Wang, Q., Ruan, Y., Wang, Y., Zhu, Y., Sun, X., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03250-3 · Cited by 6
Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
Fischer, D. L., Grinberg, L. T., Ahrendsen, J. T., Beach, T. G., Bieniek, K. F., Castellani, R. J., Chkheidze, R., Cobos, I., Cohen, M. L., Crary, J. F., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70734 · Cited by 6
Zhang, L., Toyoshima, Y., Takeshima, A., Shimizu, H., Tomita, I., Onodera, O., Takahashi, H., & Kakita, A. (2020) · Neuropathology · doi:10.1111/neup.12707 · Cited by 5
“We also paid attention to the presence or absence of ARTAG, in which TSAs and GFAs are the two major forms.(26) ARTAG may be encountered in tauopathies or other neurodegenerative disorders.”
BackgroundNeuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study
Melikyan, Z. A., Kawas, C. H., Paganini‐Hill, A., Jiang, L., Bukhari, S. A., Montine, T. J., Mander, B. A., & Corrada, M. M. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13798 · Cited by 5
Salem, S., Kilgore, M. D., Anwer, M., Maxan, A., Child, D. D., Bird, T. D., Keene, C. D., Cicchetti, F., & Latimer, C. S. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106542 · Cited by 5
“Journal Pre-proof tauopathy and the glial tau fits descriptions of age-related tau astrogliopathy [41,42]. f Tau pathology is a common feature of many neurodegenerative processes, including those related to chronic repetitive neurotrauma and those associated with aging.”
Lavrova, A., Satoh, R., Pham, N. T. T., Nguyen, A. T., Jack, C. R., Petersen, R. C., Ross, R. R., Dickson, D. W., Lowe, V. J., Whitwell, J. L., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14301 · Cited by 6
Rábano, A., Márquez, C. G., Juste, R. A., Geijó, M., & Calero, M. (2021) · Biomolecules · doi:10.3390/biom11030413 · Cited by 5
“Aging-related tau astrogliopathy (ARTAG) will not be here discussed due to its primary glial involvement, which suggests different spreading mechanisms [17].”
BackgroundDifferences in Tau Seeding in Newborn and Adult Wild-Type Mice
Ferrer, I., Andrés‐Benito, P., Garcia‐Esparcia, P., López‐González, I., Valiente, D., Jordán, M., Carmona, M., Sala‐Jarque, J., Gil, V., & del Rı́o, J. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094789 · Cited by 5
Fenouil, T., Fourier, A., Quadrio, I., Streichenberger, N., Bernardini, S., Zima, T., Perret‐Liaudet, A., & Meyronet, D. (2019) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2019.06.004 · Cited by 5
AD and its comorbidities: An obstacle to develop a clinically efficient treatment?
Baker, J., & Schott, J. M. (2022) · Revue Neurologique · doi:10.1016/j.neurol.2022.03.001 · Cited by 5
Lavrova, A., Pham, N. T. T., Vernon, C. J., Graff‐Radford, J., Boeve, B. F., Knopman, D. S., Kantarci, K., Jack, C. R., Nguyen, A. T., Ross, R. R., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70568 · Cited by 4
“TDP-43, HpScl, ARTAG, and AGD pathology frequencies remained relatively stable across Braak NFT stages.”
Zaikos, T. D., Guo, H., Barrett, A., Dastgheyb, R. M., Rubin, L. H., Troncoso, J. C., & Morris, M. (2025) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaf102 · Cited by 4
“27 Classification and staging of Alzheimer disease neuropathologic change (ADNC) and primary age-related tauopathy were performed in accordance with consensus neuropathological criteria.”
Curing the brain: in search for new astrocyte-specific therapies
Verkhratsky, A., Lee, C. J., Chun, H., Göritz, C., Harkany, T., Lee, J., Lee, S., Lindskog, M., Koh, W., Mulder, J., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01712-4 · Cited by 8
“Finally, thorn-shaped and granular-fuzzy astrocytes are found in aging-related tau astrogliopathy, ARTAG 257 .”
Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis
Yuan, Y., Mao, X., Pan, X., Zhang, R., & Su, W. (2024) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.3c01211 · Cited by 4
Characterization of neurodegenerative pathologies in adult and pediatric subjects with Down syndrome
Canan, F., Wick, N., Raisanen, J. M., Burns, D. K., Hatanpaa, K. J., Richardson, T. E., White, C. L., & Daoud, E. V. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251362762 · Cited by 4
“28 Only 12% of ADNC + cases in our institutional dataset and 4.9% in the combined dataset (age range: 54 – 70 years) were found to have comorbid ARTAG.”
InfluentialMenšíková, K., Matěj, R., Parobková, E., Smětáková, M., & Kaňovský, P. (2021) · Prion · doi:10.1080/19336896.2021.1946378 · Cited by 4
“in various anatomical regions in subpial, subependymal, perivascular and grey or white matter predominant localizations [9].”
BackgroundTaniguchi, D., Shimonaka, S., Ahmed, I., Elahi, M., Hatano, T., Imai, Y., & Hattori, N. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106686 · Cited by 5
Yagita, K., Honda, H., Ohara, T., Hamasaki, H., Koyama, S., Noguchi, H., Mihara, A., Nakazawa, T., Hata, J., Ninomiya, T., et al. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab126 · Cited by 4
Structures of tau and α-synuclein filaments from brains of patients with neurodegenerative diseases
Kametani, F., & Hasegawa, M. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105362 · Cited by 3
Carlos, A. F., Koga, S., Graff‐Radford, N. R., Baker, M., Rademakers, R., Ross, O. A., Dickson, D. W., & Josephs, K. A. (2023) · Neuropathology · doi:10.1111/neup.12938 · Cited by 4
“43 ARTAG, another age-related pathology with unclear clinical signi fi cance, 22 was also found.”
Background
Metadata
- Authors
- Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., Halliday, G. M., Ironside, J. W., Love, S., Mackenzie, I. R., Munoz, D. G., Murray, M. E., Nelson, P. T., Takahashi, H., Trojanowski, J. Q., Ansorge, O., Arzberger, T., Baborie, A., Beach, T. G., Bieniek, K. F., Bigio, E. H., Bodi, I., Dugger, B. N., Feany, M., Gelpi, E., Gentleman, S. M., Giaccone, G., Hatanpaa, K. J., Heale, R., Hof, P. R., Hofer, M., Hortobágyi, T., Jellinger, K., Jicha, G. A., Ince, P., Kofler, J., Kövari, E., Kril, J. J., Mann, D. M., Matej, R., McKee, A. C., McLean, C., Milenkovic, I., Montine, T. J., Murayama, S., Lee, E. B., Rahimi, J., Rodriguez, R. D., Rozemüller, A., Schneider, J. A., Schultz, C., Seeley, W., Seilhean, D., Smith, C., Tagliavini, F., Takao, M., Thal, D. R., Toledo, J. B., Tolnay, M., Troncoso, J. C., Vinters, H. V., Weis, S., Wharton, S. B., White, C. L., Wisniewski, T., Woulfe, J. M., Yamada, M., & Dickson, D. W.
- Affiliations
- Universidade de São Paulo (BR)
- Uppsala University (SE)
- Newcastle University (GB)
- University Hospital Zurich (CH)
- Washington University in St. Louis (US)
- Icahn School of Medicine at Mount Sinai (US)
- Sorbonne Université (FR)
- Indiana University School of Medicine (US)
- UNSW Sydney (AU)
- University of Edinburgh (GB)
- Southmead Hospital (GB)
- University of British Columbia (CA)
- Mayo Clinic (US)
- University of Kentucky (US)
- Brain Research Institute, Niigata University (JP)
- University of Pennsylvania (US)
- John Radcliffe Hospital (GB)
- Institut für Neuropathologie (DE)
- Walton Centre (GB)
- Banner Sun Health Research Institute (US)
- Northwestern University (US)
- University of California, San Francisco (US)
- Brigham and Women's Hospital (US)
- Imperial College London (GB)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- The University of Texas Southwestern Medical Center (US)
- University of Debrecen (HU)
- University of Sheffield (GB)
- University of Pittsburgh (US)
- The University of Sydney (AU)
- University of Manchester (GB)
- Boston University (US)
- The Alfred Hospital (AU)
- University of Washington (US)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Vienna General Hospital (AT)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Rush University Medical Center (US)
- Heidelberg University (DE)
- Saitama International Medical Center (JP)
- Universität Ulm (DE)
- University Hospital of Basel (CH)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- Johannes Kepler University of Linz (AT)
- University of Ottawa (CA)
- Kanazawa University (JP)
- Corresponding author
- Dickson, Dennis W.
- ORCID
- Grinberg, Lea T.
- Alafuzoff, Irina
- Attems, Johannes
- Budka, Herbert
- Cairns, Nigel J.
- Crary, John F.
- Duyckaerts, Charles
- Ghetti, Bernardino
- Halliday, Glenda M.
- Ironside, James W.
- Love, Seth
- Mackenzie, Ian R.
- Murray, Melissa E.
- Nelson, Peter T.
- Takahashi, Hitoshi
- Trojanowski, John Q.
- Ansorge, Olaf
- Arzberger, Thomas
- Beach, Thomas G.
- Bieniek, Kevin F.
- Bigio, Eileen H.
- Dugger, Brittany N.
- Feany, Mel
- Giaccone, Giorgio
- Hatanpaa, Kimmo J.
- Heale, Richard
- Hof, Patrick R.
- Hofer, Monika
- Hortobágyi, Tibor
- Jellinger, Kurt
- Jicha, Gregory A.
- Ince, Paul
- Kofler, Julia
- Kril, Jillian J.
- Mann, David M.
- McKee, Ann C.
- McLean, Catriona
- Montine, Thomas J.
- Murayama, Shigeo
- Lee, Edward B.
- Rodriguez, Roberta D.
- Rozemüller, Annemieke
- Schneider, Julie A.
- Schultz, Christian
- Seeley, William
- Seilhean, Danielle
- Smith, Colin
- Tagliavini, Fabrizio
- Takao, Masaki
- Thal, Dietmar Rudolf
- Toledo, Jon B.
- Tolnay, Markus
- Troncoso, Juan C.
- Vinters, Harry V.
- Weis, Serge
- Wharton, Stephen B.
- White, Charles L.
- Woulfe, John M.
- Yamada, Masahito
- Dickson, Dennis W.
- Venue
- Acta Neuropathologica
- Published
- 2015-12-10
- Volume
- 131
- Issue
- 1
- Pages
- 87-102
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4879001
- OpenAlex
- W2195527239
- Cited by
- 532
- References
- 69
- Citations by year
- 2026: 37 · 2025: 49 · 2024: 66 · 2023: 48 · 2022: 57 · 2021: 56 · 2020: 54 · 2019: 51 · 2018: 49 · 2017: 38 · 2016: 25 · 2015: 1
- FWCI
- 27.47
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Explore Bristol Research (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- Lirias (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- FP7 EU Project (Develage No. 278486)
- National Institutes of Health (NIH P30 AG10133, R01 AG040311, P01 AG019724-03, P50 AG023501, AG010124, AG017586, P50 AG005138, AG028383, P50AG05146, grants P50 AG05136 and P50 NS062684, P50 AG016574 and P50 NS072187)
- NIA Grant (P50 AG05681, P01 AG03991)
- Nelson Family Foundation
- Alzheimer’s Research UK
- Alzheimer's Society, National Institute for Health Research
- Medical Research Council (G0400074, MR/L016400/1, MR/L016400/1 Edinburgh Brain Bank)
- National Health and Medical Research Council of Australia (Senior Principal Research Fellow (#630434))
- Grant Agency of Ministry of Health of Czech Republic (IGA NT12094-5)
- NIA P50 (P50 AG005133)
- National Institute of Neurological Disorders and Stroke (1U01NS086659-01)
- National Institute of Aging Boston University Alzheimer’s Disease Center (P30AG13846; supplement 0572063345–5)
- MRC (MC-PC-13044)
- National Brain Research Program, Hungary (KTIA_13_NAP-A-II/7)
- Grant-in-Aid (KAKEN 26250017)
- NIH (P30AG12300)
- DFG Grant (SFB 1134/A03)
- Alzheimer's Disease Core Center (P30AG008051-26)
- Grant (AG13854)
- JSPS KAKENHI (26430060)
- Italian Ministry of Health
- Vienna KIN-Neurobiobank and VITA–study
- France Alzheimer, France Parkinson, Fondacion ARSEP and CSC (GIE NeuroCEB)
- Neuroscience Research Australia and the University of New South Wales (Sydney Brain Bank)
- Sheffield and Cambridge Brain Banks (Brain Banks)
- Parkinson's UK (Parkinson's UK Tissue Bank at Imperial College)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau phosphorylation, astrocytes, glia limitans, white matter, gray matter, primary tauopathies, nomenclature, brain aging, clinical biomarkers
- MeSH terms
- Aging, Animals, Astrocytes, Brain, Humans, Neuroglia, tau Proteins, Tauopathies
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