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Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy
Open accessAbstract
Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.
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“Primary age-related tauopathy (PART) and aging-related tau astrogliopathy (ARTAG) are independent tau pathologies commonly observed in patients over 80 years of age, and PART may account for a proportion of the misdiagnosed clinical AD cases in the elderly [130, 141, 142].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [141]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Perivascular, subpial, and periventricular p-tau immunoreactive NFTs and astrocytic tangles in the neocortex have been reported to be characteristic of both primary age-related tauopathy (PART) [35] and age-related tau astrogliopathy (ARTAG) [36].”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [36]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“PART refers to neuronal tau pathology and ARTAG is characterized by astrocytic tau pathology, although they are not mutually exclusive, and appear to be more a manifestation of age than a subtype of neurodegenerative disease.”
From The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features (2017) · cites this paper as [36]
Experimental — accuracy not yet measuredIn the citing paper
“Another exemplary phenomenon is age-related tau astrogliopathy (ARTAG), in which p-tau accumulates in astrocytes of various brain regions [79].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [79]
In the citing paper
“The panel did not ultimately accept all of the a priori criteria for CTE; they did not include pathology known to be associated with aging (i.e.primary age-related tauopathy [PART] [16] and aging-related tau astrogliopathy [ARTAG] [17]).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [17]
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Citations
Cites
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · cited 1×
“In addition to these differences, reaction of astrocytes varies considerably between distinct diseases of the nervous system [60].”
Self-citationAssociation of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · cited 2×
“Mutations in the tau gene (MAPT) can cause hereditary frontotemporal dementia and associate with frontotemporal lobar degeneration (FTLD) [23, 26, 51, 63].”
Self-citationGoedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492 · cited 1×
“The six isoforms differ from each other by the presence or absence of 29- or 58-amino acid inserts in the N-terminus domain and by the presence of either three (3R tau isoforms) or four (4R tau isoforms) tandem repeat sequences of 31 or 32 amino acids [24].”
Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · cited 1×
“Tauopathies are characterized by the accumulation of abnormal and hyper-phosphorylated tau protein in the brain and are also classified as primary or secondary [32, 37].”
Self-citationChronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury
McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098 · cited 12×
“On the other hand, tau pathology, including neuronal and astroglial, in CTE is more abundant in the depths of the convexity cerebral sulci, especially in early stages [41], an aspect that has not been reported in tau astrogliopathy in the aging brain [29, 34-36, 46, 57].”
InfluentialMutation in the tau gene in familial multiple system tauopathy with presenile dementia
Spillantini, M. G., Murrell, J. R., Goedert, M., Farlow, M. R., Klug, A., & Ghetti, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7737 · Cited by 1,474 · cited 2×
“Mutations in the tau gene (MAPT) can cause hereditary frontotemporal dementia and associate with frontotemporal lobar degeneration (FTLD) [23, 26, 51, 63].”
Primary age-related tauopathy (PART): a common pathology associated with human aging
Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1349-0 · Cited by 1,467 · cited 6×
“The recently introduced term ‘primary age-related tauopathy’ (PART) encompasses neuronal changes previously considered as “normal aging” as well as NFT-dementia [14].”
InfluentialSelf-citationTau is a candidate gene for chromosome 17 frontotemporal dementia
Poorkaj, P., Bird, T. D., Wijsman, E., Nemens, E., Garruto, R. M., Anderson, L., Andreadis, A., Wiederholt, W. C., Raskind, M., & Schellenberg, G. D. (1998) · Annals of Neurology · doi:10.1002/ana.410430617 · Cited by 1,374 · cited 2×
“Mutations in the tau gene (MAPT) can cause hereditary frontotemporal dementia and associate with frontotemporal lobar degeneration (FTLD) [23, 26, 51, 63].”
Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M.-Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0237-2 · Cited by 1,110 · cited 1×
“Tau pathology is characterized as 3R or 4R predominant or mixed 3R + 4R type [12, 30, 32].”
Cited by
Sorted by citations
Items 401–500 of 532
Brady, C. B., Robey, I., Stein, T. D., Huber, B. R., Riley, J., Rauf, N. A., Spencer, K. R., Walt, G. S., Adams, L., Averill, J. G., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11101349 · Cited by 4
“We perform assessments of vascular disease, Braak and Braak staging for neurofibrillary tangles, Braak staging and NIA-AA classification [37] for Lewy bodies, CERAD staging and Thal phasing for Aβ, and evaluation for TDP-43 pathology [38,39] and age-related tau astrogliopathy [40].”
MethodPathological Assessment of Chronic Traumatic Encephalopathy
Ommeren, R. V., & Hazrati, L. (2018) · Academic Forensic Pathology · doi:10.1177/1925362118797729 · Cited by 4
Iverson, G. L., Luoto, T. M., & Castellani, R. J. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa047.001 · Cited by 4
““the diagnosis of CTE was defined by the presence of the following criteria (Table 1 and Figures 1 and 2): (1) perivascular foci of p-tau-immunoreactive astrocytic tangles and neurofibrillary tangles; (2) irregular cortical distribution of p-tau-immunoreactive neurofibrillary tangles and astrocytic tangles with a pred…”
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Tremblay, C., Beach, T. G., Intorcia, A. J., Walker, J. E., Arce, R. A., Sue, L. I., Nelson, C. M., Borja, C. I., Suszczewicz, K. E., Cline, M. P., et al. (2021) · medRxiv · doi:10.1101/2021.12.21.21268119 · Cited by 4
Age-related differences in cerebral morphology and microstructure in rhesus macaques
Weiss, A. R., Grigorian, A., Dash, S., Kroenke, C. D., Urbanski, H. F., & Kohama, S. G. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.06.004 · Cited by 3
Association of Subjective Memory Complaints With Neuropathologic Changes at Age 90 or Older
Melikyan, Z. A., Al‐Darsani, Z., Colcord, K. A., Paganini‐Hill, A., Jiang, L., Bukhari, S. A., Montine, T. J., Kawas, C. H., & Corrada, M. M. (2025) · Neurology · doi:10.1212/wnl.0000000000213948 · Cited by 3
Chronic traumatic encephalopathy neuropathologic change in former Australian rugby players
Shepherd, C. E., McCann, H., McLean, C. A., Iverson, G. L., & Gardner, A. J. (2024) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12972 · Cited by 3
“The presence of thorn-shaped or granular/fuzzy astrocytes indicating age-related tau astrogliopathy (ARTAG) [32] was also assessed and the distribution noted, specifically whether it was situated in the cortex, basal ganglia and brainstem and whether the arrangement was subpial, subependymal,…”
BackgroundA case of argyrophilic grain disease with an initial clinical diagnosis of Parkinson’s disease
Arakawa, A., Murayama, S., Morimoto, S., Matsubara, T., Sengoku, R., Kameyama, M., Tokumaru, A. M., Tarutani, A., Hasegawa, M., Iwata, A., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12688-4 · Cited by 3
Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration
Rodríguez-Carreiro, S., Nogales, M. D. C., Jiménez-Galán, D., Carmona-Lorenzo, S., Caro-Martín, A., Navarro, E., & Esteras, N. (2024) · Regenerative medicine reports . · doi:10.4103/regenmed.regenmed-d-24-00005 · Cited by 2
Contribution of α‐synuclein cytopathologies to distinct seeding of misfolded α‐synuclein
Kim, A., Martínez-Valbuena, I., Danics, K., Forrest, S. L., & Kovács, G. G. (2025) · Brain Pathology · doi:10.1111/bpa.70024 · Cited by 3
The interaction between resilience framework and neuron-astrocyte-synapse dynamics in AD
Ma, H., Zhao, H., Feng, X., & Gao, F. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1644532 · Cited by 4
“Aging is also associated with tau astrogliopathy, a disease that serves as the basis for various neurodegenerative pathologies related to cognitive impairment (Schultz et al., 2000; Kovacs et al., 2016; Verkhratsky and Zorec, 2024).”
A Practical Approach to Differentiate the Frontotemporal Tauopathy Subtypes
Forrest, S. L., Halliday, G. M., Sizemova, A., van Roijen, M., McGinley, C. V., Bright, F., Kapur, M., McGeachie, A. B., McCann, H., Shepherd, C. E., et al. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa100 · Cited by 3
Alzheimer’s Disease Pathology Outside of the Cerebrum Is Related to a Higher Odds of Dementia
Buchman, A. S., Leurgans, S. E., Kim, N., Agrawal, S., Oveisgharan, S., Zammit, A. R., VanderHorst, V., Nag, S., & Bennett, D. A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230223 · Cited by 3
Chronic Traumatic Encephalopathy
Muñoz, D. G., & Mackenzie, I. R. (2022) · Springer eBooks · doi:10.1007/978-3-030-93813-0_11 · Cited by 3
Presymptomatic anterior frontal involvement in corticobasal degeneration
Kobylecki, C., & Mann, D. M. A. (2016) · Brain · doi:10.1093/brain/aww267 · Cited by 3
Klotz, S., König, T., Erdler, M., Ulram, A., Nguyen, A., Ströbel, T., Zimprich, A. A., Stögmann, E., Regelsberger, G., Höftberger, R., et al. (2020) · European Journal of Neurology · doi:10.1111/ene.14621 · Cited by 3
Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline
Thom, M., & Koepp, M. J. (2021) · Progress in inflammation research · doi:10.1007/978-3-030-67403-8_7 · Cited by 3
Beach, T. G., Deture, M. A., Walker, J. E., Arce, R. A., Glass, M. J., Sue, L. I., Intorcia, A. J., Nelson, C. M., Suszczewicz, K. E., Borja, C. I., et al. (2021) · medRxiv · doi:10.1101/2021.12.16.21266656 · Cited by 3
Zhang, M., Ganz, A. B., Rohde, S. K., Rozemüller, A. J. M., Bank, N. B., Reinders, M. J. T., Scheltens, P., Hulsman, M., Hoozemans, J. J. M., & Holstege, H. H. (2022) · medRxiv · doi:10.1101/2022.08.28.22279304 · Cited by 3
Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaPreprint
Iyer, A. K., Vermunt, L., Mirfakhar, F. S., Minaya, M., Acquarone, M., Koppisetti, R. K., Renganathan, A., You, S., Danhash, E., Verbeck, A. C., et al. (2024) · medRxiv · doi:10.1101/2024.05.15.24307444 · Cited by 3
Star-shaped TDP-43 inclusions in the oldest-old
Connolly, E. E., Ervin, J. F., Plassman, B. L., Welsh-Bohmer, K. A., & Wang, S. J. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae116 · Cited by 2
van Wetering, J., Deshayes, N. A. C., Boone, J., Fernandes, I., Hepp, D. H., Berendse, H. W., Jonkman, L. E., Rozemüller, A. J. M., & van de Berg, W. D. J. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02940-0 · Cited by 2
“…amyloid angiopathy (CAA) type and stage [38], the presence of neuritic plaques assessed by Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) score [39], and the presence of aging-related tau astrogliopathy (ARTAG) [40] and argyrophilic grain disease (AGD) [41] was reported.”
Selmanovic, E., Seifert, A. C., Delman, B. N., Pruyser, A., Thorn, E. L., Nolan, A., Keene, C. D., Walker, J. M., Crary, J. F., Hof, P. R., et al. (2025) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaf117 · Cited by 3
“37,49 Its more recent detection among younger people with a variety of disorders, including IPV in women in their third to fifth decades, 20 has prompted consideration of modifying the term to “tau astrogliopathy”; however, this has not been adopted formally.”
CTE-type tau filaments in Alzheimer’s disease with co-morbid LATE-NC
Rana, J. K., Pinarbasi, E. S., Fernandez, M. G., Navratna, V., Conway, K. S., Lieberman, A. P., Barmada, S. J., & Mosalaganti, S. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03052-z · Cited by 2
“Aging-related tau astrogliopathy (ARTAG 36 ) was also noted in the medial temporal lobe, lobar, subcortical, and brainstem regions.”
Reframing TDP‐43 in Alzheimer's disease: From co‐pathology to neurovascular culprit
Donna, M. G. D., Motta, C., Bonomi, C. G., Bernocchi, F., Ricci, F., Poli, M., Koch, G., & Martorana, A. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70988 · Cited by 2
“33 AQP4 mislocalization, and barrier disruption.”
Castellani, R. J., Bharadwaj, R. A., Fisher‐Hubbard, A., Deep‐Soboslay, A., Hyde, T. M., Kleinman, J. E., Hazrati, L., & Iverson, G. L. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877251411332 · Cited by 2
“13 17 A β accumulates in the brain, in the form of plaques of varying morphology and types, 18 in association with age 3,19 and/or with Alzheimer ’ s disease.”
Richardson, T. E., Cherry, J. D., Kandoi, S., Rohde, S. K., Uretsky, M., Tuz‐Zahra, F., Bieniek, K. F., Farrell, K. W., Hefti, M. M., Miller, M. B., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03031-4 · Cited by 3
Expanding the Clinical Phenotypes of Corticobasal Degeneration
Wetmore, E. L., Uruk, G., Bhaskaran, J. G., Duffy, J. R., Knopman, D. S., Boeve, B. F., Petersen, R. C., Nguyen, A. T., Reichard, R. R., Dickson, D. W., et al. (2026) · Neurology Open Access · doi:10.1212/wn9.0000000000000110 · Cited by 2
Tanaka, H., Hird, M. A., Tang‐Wai, D. F., & Kovács, G. G. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac117 · Cited by 2
Pathology vs pathogenesis: Rationale and pitfalls in the clinicopathology model of neurodegeneration
Donadio, V. A., Sturchio, A., Rizzo, G., Abu‐Rumeileh, S., Liguori, R., & Espay, A. J. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85538-9.00001-8 · Cited by 2
Prevalence and Distribution of Lewy Pathology in a Homeless Population
Danics, K., Visanji, N. P., Ichimata, S., Mathur, S., Sára-Klausz, G., & Kovács, G. G. (2023) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2023.291 · Cited by 2
“All 44 cases were stained and assessed for 5G4 immunoreactivity in the brain regions required for Braak staging of Lewy-related pathology as well as in the olfactory bulb, submandibular gland, parotid gland, esophagus, and stomach, regions 1 – 23 shown in supplemental table 2.”
Tsuji, K., Nakayama, Y., Taruya, J., & Ito, H. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad113 · Cited by 2
Robinson, A., Rizwan, T. B., Davidson, Y. S., Minshull, J., Tinkler, P., Payton, A., Mann, D. M. A., & Roncaroli, F. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231429 · Cited by 2
Iverson, G. L., Jamshidi, P., Deep‐Soboslay, A., Hyde, T. M., Kleinman, J. E., Hazrati, L., & Castellani, R. J. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251351524 · Cited by 2
“P-tau lesions in 3-repeat and 4-repeat tauopathies (e.g., Pick ’ s disease, progressive supranuclear palsy, and corticobasal degeneration), 13 and astroglial tauopathy, 14 are relevant and important, but not the focus of this study.”
The Heidenhain variant of Creutzfeldt–Jakob disease and concomitant tau pathology: A case report
Ehler, E., Pipka, M., Meleková, A., Mandysová, P., Johanidesová, S., Matěj, R., & Rusina, R. (2017) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2017.01.011 · Cited by 2
“Recently, these conditions have been characterized as primary age-related tauopathy (PART) and, more recently, aging-related tau astrogliopathy (ARTAG) [5].”
BackgroundInfluentialNeurodegeneration and the Ordered Assembly of Tau
Goedert, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811304-2.00004-3 · Cited by 3
Fathy, Y. Y., de Jong, F. J., van Dam, A., Rozemüller, A. J. M., & van de Berg, W. D. J. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/156984 · Cited by 1
“Glial tauopathies such as age related tauopathy of the astroglia (ARTAG) and primary age related tauopathy (PART) were assessed primarily in the temporal cortex and amygdala in all donors [20, 31].”
BackgroundKovács, G. G. (2017) · Brain Pathology · doi:10.1111/bpa.12544 · Cited by 2
Epigenetic signatures of regional tau pathology and cognition in the aging and pathological brainPreprint
Goldberg, D. C., Wadhwani, A. R., Dehghani, N., Sreepada, L. P., Fu, H., Jager, P. L. D., Bennett, D. A., Wolk, D. A., Lee, E. B., White, C. L., et al. (2024) · medRxiv · doi:10.1101/2024.11.07.24316933 · Cited by 2
Anatomic and Histological Changes of the Aging Brain
Yachnis, A. T. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108554350.002 · Cited by 1
Severe cerebrovascular pathology of the first supercentenarian to be autopsied in the world
Iwase, T., Yoshida, M., Hashizume, Y., Inagaki, T., & Iwasaki, Y. (2022) · Neuropathology · doi:10.1111/neup.12874 · Cited by 1
“ARTAG, determined in 2016, is a pathological astrocytic condition involving tau accumulation.(12) The distribution pattern of subpial or white matter ARTAG, or TSA, shows involvement of basal brain regions, the brainstem, and lobar regions.”
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Forrest, S. L., & Kovács, G. G. (2025) · Advances in neurobiology · doi:10.1007/978-3-031-87919-7_14 · Cited by 2
The Role of Neuroglia in Cognitive Longevity
Zorec, R., Verkhratsky, A., & Parpura, V. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04545-1 · Cited by 1
Tracing neuropathological signatures: TARDBP and C9orf72 double mutations in a Sicilian family
Masrori, P., Tomé, S. O., Dedeene, L., Remiche, G., Esch, H. V., Thal, D. R., & Damme, P. V. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf147 · Cited by 1
Ichimata, S., Yoshida, K., & Tanaka, R. (2025) · Brain Pathology · doi:10.1111/bpa.70051 · Cited by 1
Clinicopathological study of chronic traumatic encephalopathy pathology in a population-based cohort
Rodriguez, R. D., Nowinski, C. J., Suemoto, C. K., Leite, R. E. P., Ferretti‐Rebustini, R. E. D. L., Filho, W. J., Pasqualucci, C. A., Nitríni, R., & Grinberg, L. T. (2025) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaf150 · Cited by 2
Shahidehpour, R. K., Neltner, A. M., Klusty, M. A., Corbett, W. C., Gonzalez, A. D., Gutman, D. A., Fardo, D. W., Bachstetter, A. D., Bumgardner, C., Flanagan, M. E., et al. (2026) · Brain Pathology · doi:10.1111/bpa.70102 · Cited by 1
Aguilar, L. F., Zaikos, T. D., Rivera, I., Wright, S. T., Lou, J., Gawronski, B., Gonzalez, L., Berry, J. V., Rouanet, J. P., Edwards, N. C., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03028-z · Cited by 1
Astrocytic contributions to the pathogenesis of chronic traumatic encephalopathy: a scoping review
Kubiak, A., Hahn, K., Powers, N., Arroyo, E., Vandello, C., Martins, J., & He, L. (2026) · Chinese Neurosurgical Journal · doi:10.1186/s41016-026-00434-w · Cited by 1
“Kovacs et al. [29] defined ARTAG as an age-associated astrocytic tauopathy characterized by subpial and periventricular astrocytic tau deposition that follows anatomical distributions independent of traumatic exposure [29].”
Torii, Y., Sekiguchi, H., Habuchi, C., Miwa, A., Arafuka, S., Takeda, K., Fujishiro, H., Yoshida, M., Iwasaki, Y., Iritani, S., et al. (2026) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70079 · Cited by 1
“43 Arteriolosclerosis was evaluated in the white matter of the occipital cortex and classi fi ed as none, mild, moderate, or severe according to the classi fi cation sys-tem of Blevins et al .”
Stage-dependent tau-PET signatures in Huntington’s disease revealed by [¹⁸F]PI-2620
Martínez‐Horta, S., Pérez‐Pérez, J., Puig‐Davi, A., Camacho, V., Pérez‐Carasol, L., Franch-Martí, C., Olmedo‐Saura, G., Fernández‐León, Á., Flotats, A., Kolinger, G. D., et al. (2026) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-026-08003-0 · Cited by 1
“Historically, tau pathology in HD has often been interpreted as a secondary consequence of neurodegeneration or attributed to concomitant Alzheimer-type pathology, primary age-related tauopathy (PART), aging-related tau astrogliopathy (ARTAG), or other age-related copathological processes [22–28 ].”
Shafiei, N., Proniakova, D., Simjanoska, M., Sjødal, A. M. R., Stähli, D. A., van den Heuvel, L., Fabrizio, M. D., Aaron, E., Kasas, S., Krause, M. S., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03039-w · Cited by 3
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APP /Aβ Signaling Orchestrates Reactive Astrocyte Networks in Alzheimer's Disease
Jáuregui, G. V., Coomes, S., Emmett, E., Thatcher, A., Oyelakin, N., Čarná, M., Zelinková, J., Novotný, J., Polakova, N., Kuruvilla, T., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70526 · Cited by 1
“This pathogenic signature may be shared across other disorders featuring prominent astroglial pathology, including ischemic stroke, glial tumors, demyelinating disease, or conditions with primary astrocytic drives such as autoimmune GFAP astrocytopathy (Fang et al. 2016; Kunchok et al. 2019; Toda et al. 2007), Alexand…”
Villareal, J. A. B., Bathe, T., de la Rosa, A., Sharma, R. V., Gómez, E. O. H., Ryan, A. M., Hawkinson, T. R., Tuzzolo, A. M., Medina-Parrilla, E., Phillips, J. L., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102968 · Cited by 1
“…disease, progressive supranuclear palsy (PSP), spinocerebellar ataxia (SCA), aging-related tau astrogliopathy (ARTAG), and cerebral amyloid angiopathy (CAA), were evaluated by a board-certified neuropathologist according to current guidelines 18,61–66 and as defined previously within our lab.”
Artificial intelligence–based 3D segmentation of tangle‐associated TDP ‐43 in neurodegeneration
Uruk, G., Youssef, H., Gatto, R. G., Hossain, N., Whitwell, J. L., Reichard, R. R., & Josephs, K. A. (2026) · Brain Pathology · doi:10.1111/bpa.70131 · Cited by 1
Majidi, M., Rajabi, A., & Ahmadi, S. (2021) · Scientific Journal of Kurdistan University of Medical Sciences · doi:10.52547/sjku.26.3.129 · Cited by 1
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Labos, E., Bavec, C. V., Cristalli, D. O., Deschle, F., Isaac, C. F., Dorman, G. S., Ollari, J., Rubiño, V., & Russo, M. J. (2023) · Vertex Revista Argentina de Psiquiatría · doi:10.53680/vertex.v34i160.460 · Cited by 4
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Gentleman, S., & Liu, A. K. L. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3774-6_15 · Cited by 1
López, A. G., López‐Muñoz, S., Caballero, G., de Anta, N. C., Rojo, L., Vidal‐Robau, N., Muñoz, A., Ortiz, E., Archilla, I., Díaz, S., et al. (2024) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-024-03781-0 · Cited by 1
“…disease or frequently with conditions such as Lewy body disease (LBD), cerebrovascular disease (CVD), and vascular brain injury (VBI) [2], as well as with limbic age-related TDP43 encephalopathy (LATE) [6, 7] aging-related Tau astrogliopathy (ARTAG) [8] and argyrophilic grain diseases (AGD) [9].”
Lochner, R. H., Arumanayagam, A. S., Powell, S. Z.-E., Masdeu, J. C., Pascual, B., & Cykowski, M. D. (2024) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlae027 · Cited by 2
Yokota, O., Miki, T., Nakashima‐Yasuda, H., Ishizu, H., Haraguchi, T., Miyashita, A., Ikeuchi, T., Hasegawa, M., Nishikawa, N., Takenoshita, S., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02875-6 · Cited by 1
Neurodegeneration: 2021 update
Crary, J. F. (2021) · Free Neuropathology · doi:10.17879/freeneuropathology-2021-3317 · Cited by 1
Brain pathological changes from population-based studies
Cao, Y., Huang, M., Shu, M.-J., & Zhu, Y. (2022) · Human Brain · doi:10.37819/hb.001.001.0205 · Cited by 1
Terry, D. P., Zuckerman, S. L., Yengo-Kahn, A. M., Kuhn, A. W., Brett, B. L., & Davis, G. A. (2022) · Neurosurgery · doi:10.1227/neu.0000000000001979 · Cited by 1
Nelson, P. T., & Jicha, G. A. (2023) · Neurology · doi:10.1212/wnl.0000000000208071 · Cited by 1
Ferrer, I. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170609
The endolysosomal system in neuronal physiology and pathology
Sanchez, S. V. (2019)
Liu, B., Wang, M., Zhang, S., Gao, L., & Yang, L. (2019) · International Conference on Medical and Health Informatics (ICMHI) · doi:10.1145/3340037.3340041
“Astrocytes have been proved to be very important in structure and pathology of Central Nervous System [1-3].”
BackgroundCerebral Amyloid Angiopathy: Emerging Evidence for Novel Pathophysiology and Pathogenesis
Yamada, M., Sakai, K., Hamaguchi, T., & Noguchi‐Shinohara, M. (2020) · Stroke revisited · doi:10.1007/978-981-10-1430-7_7
The Role of DNA Damage-induced Cellular Senescence in the Pathophysiology of mTBI
Schwab, N. (2019) · TSpace (University of Toronto)
The aging brain and brain banking
Jeżewski, R. C., Halliday, G. M., & Shepherd, C. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818000-6.00010-x
Jadhav, V. (2021) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2086
Tau Biomarkers for Long-Term Effects of Neurotrauma: Technology Versus the Null Hypothesis
Castellani, R. J. (2021) · Neuromethods · doi:10.1007/978-1-0716-1712-0_13
Bellessi, D. (2006) · Revista de la Casa de las Américas
Chronic Traumatic Encephalopathy: Past, Present, and Future
Patel, A., Abou‐Al‐Shaar, H., Mathkour, M., & Maroon, J. C. (2022) · Springer eBooks · doi:10.1007/978-3-030-88227-3_15
The 2020 Incentive Award of the Okayama Medical Association in Neuroscience (2020 Niimi Prize)
Miki, T. (2021) · Okayama Igakkai Zasshi (Journal of Okayama Medical Association) · doi:10.4044/joma.133.147
Age-related cytoskeletal pathologies
Wijesinghe, P. (2020) · doi:10.26481/dis.20202508pk
Fathy, Y. Y., Jonkman, L. E., Bol, J. G. J. M., Timmermans, E., Jonker, A. J., Rozemüller, A. J. M., & van de Berg, W. D. J. (2022) · Research Square · doi:10.21203/rs.3.rs-1767866/v1
Ubiquitin-positive astrogliopathy clinically mimicking Parkinson’s disease
Morris, M., Moghekar, A., Guo, H., Pletniková, O., Redding‐Ochoa, J., Albert, M., Resnick, S. M., & Chen, L. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01464-y
The Spectrum of Tau Pathology in Human Prion Disease
Kovács, G. G., & Budka, H. (2023) · Springer eBooks · doi:10.1007/978-3-031-20565-1_21
Nordberg, A. K., Semyanov, A. V., Parpura, V., & Zorec, R. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03894-z
Lindemann, H. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9889
The ubiquitin-proteasome system in neurodegenerative diseases
Verheijen, L. (2023) · Research Publications (Maastricht University) · doi:10.26481/dis.20231024lv · Cited by 1
Geut, H., van den Berg, E., Boon, B. D. C., Hoozemans, J. J. M., Tunold, J., Pihlstrøm, L., Jonkman, L. E., Rozemüller, A. J. M., Lemstra, A. W., & van de Berg, W. D. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.02.573857
Jankovská, N., Waishaupt, J., Holada, K., & Matěj, R. (2024) · Neurologie pro praxi · doi:10.36290/neu.2024.001
Geut, A. J. (2024) · doi:10.5463/thesis.484
Towards in vivo MRI-based diagnostics and tracking of dementia
Ortega‐Cruz, D. (2024) · UPM Digital Archive (Technical University of Madrid) · doi:10.20868/upm.thesis.81334
Degenerazioni lobari frontotemporali: neuropatologia, genetica e classificazione
Saracino, D., Ber, I. L., & Deramecourt, V. (2024) · EMC - Neurologia · doi:10.1016/s1634-7072(24)49339-2
Evolutionary Aspects of Glial Cells
Calì, C., Ackermans, N. L., Hof, P. R., & Magistretti, P. J. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197676592.003.0003
Sala‐Jarque, J., Gil, V., Andrés‐Benito, P., Martínez-Soria, I., Picón-Pagès, P., Hernández, F., Ávila, J., Lanciego, J. L., Nuvolone, M., Aguzzi, A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-72232-2
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Gong, S., & Gan, L. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0056
Selmanovic, E., Pruyser, A., Seifert, A. C., Delman, B. N., Thorn, E. L., Folkerth, R. D., & Dams-O’Connor, K. (2025) · medRxiv · doi:10.1101/2025.02.24.25322800
Berrocal, M., Alvarez, A. M., & Mata, A. M. (2025) · FEBS Open Bio · doi:10.1002/2211-5463.70046 · Cited by 1
“Endogenous tau is also expressed in astrocytes, as firstly reported by [62] in rats, and more recently in mice [63,64] and humans [44,65 – 68], although at much lower levels than in neurons [63,69].”
Multiscale analysis of myelin alterations in skin biopsies from synucleinopathiesPreprint
Fabrizio, M. D., van der Gaag, B., Terzi, M., Aaron, E., Steerenberg, N. B., Bol, J. G. J. M., van de Berg, W. D. J., Stahlberg, H., & Lewis, A. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.15.654285
Application of consensus criteria
Castellani, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99651-8.00014-4
Aging and disease-related astrocytic tau
Castellani, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99651-8.00013-2
Castellani, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99651-8.00018-1
Castellani, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99651-8.00016-8
Atypical Frontotemporal Dementia Associated With SQSTM1 Gene Mutation: A Clinicopathological Case
Espinoza‐Vinces, C., Zelaya, M. V., Pueyo, V. C., Montoya‐Murillo, G., Patiño‐García, A., Villino‐Rodríguez, R. A., Atorrasagasti-Villar, A., Arbizu, J., & Riverol, M. (2025) · Neuropathology · doi:10.1111/neup.70029
Metadata
- Authors
- Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., Halliday, G. M., Ironside, J. W., Love, S., Mackenzie, I. R., Munoz, D. G., Murray, M. E., Nelson, P. T., Takahashi, H., Trojanowski, J. Q., Ansorge, O., Arzberger, T., Baborie, A., Beach, T. G., Bieniek, K. F., Bigio, E. H., Bodi, I., Dugger, B. N., Feany, M., Gelpi, E., Gentleman, S. M., Giaccone, G., Hatanpaa, K. J., Heale, R., Hof, P. R., Hofer, M., Hortobágyi, T., Jellinger, K., Jicha, G. A., Ince, P., Kofler, J., Kövari, E., Kril, J. J., Mann, D. M., Matej, R., McKee, A. C., McLean, C., Milenkovic, I., Montine, T. J., Murayama, S., Lee, E. B., Rahimi, J., Rodriguez, R. D., Rozemüller, A., Schneider, J. A., Schultz, C., Seeley, W., Seilhean, D., Smith, C., Tagliavini, F., Takao, M., Thal, D. R., Toledo, J. B., Tolnay, M., Troncoso, J. C., Vinters, H. V., Weis, S., Wharton, S. B., White, C. L., Wisniewski, T., Woulfe, J. M., Yamada, M., & Dickson, D. W.
- Affiliations
- Universidade de São Paulo (BR)
- Uppsala University (SE)
- Newcastle University (GB)
- University Hospital Zurich (CH)
- Washington University in St. Louis (US)
- Icahn School of Medicine at Mount Sinai (US)
- Sorbonne Université (FR)
- Indiana University School of Medicine (US)
- UNSW Sydney (AU)
- University of Edinburgh (GB)
- Southmead Hospital (GB)
- University of British Columbia (CA)
- Mayo Clinic (US)
- University of Kentucky (US)
- Brain Research Institute, Niigata University (JP)
- University of Pennsylvania (US)
- John Radcliffe Hospital (GB)
- Institut für Neuropathologie (DE)
- Walton Centre (GB)
- Banner Sun Health Research Institute (US)
- Northwestern University (US)
- University of California, San Francisco (US)
- Brigham and Women's Hospital (US)
- Imperial College London (GB)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- The University of Texas Southwestern Medical Center (US)
- University of Debrecen (HU)
- University of Sheffield (GB)
- University of Pittsburgh (US)
- The University of Sydney (AU)
- University of Manchester (GB)
- Boston University (US)
- The Alfred Hospital (AU)
- University of Washington (US)
- Tokyo Metropolitan Institute of Gerontology (JP)
- Vienna General Hospital (AT)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Rush University Medical Center (US)
- Heidelberg University (DE)
- Saitama International Medical Center (JP)
- Universität Ulm (DE)
- University Hospital of Basel (CH)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- Johannes Kepler University of Linz (AT)
- University of Ottawa (CA)
- Kanazawa University (JP)
- Corresponding author
- Dickson, Dennis W.
- ORCID
- Grinberg, Lea T.
- Alafuzoff, Irina
- Attems, Johannes
- Budka, Herbert
- Cairns, Nigel J.
- Crary, John F.
- Duyckaerts, Charles
- Ghetti, Bernardino
- Halliday, Glenda M.
- Ironside, James W.
- Love, Seth
- Mackenzie, Ian R.
- Murray, Melissa E.
- Nelson, Peter T.
- Takahashi, Hitoshi
- Trojanowski, John Q.
- Ansorge, Olaf
- Arzberger, Thomas
- Beach, Thomas G.
- Bieniek, Kevin F.
- Bigio, Eileen H.
- Dugger, Brittany N.
- Feany, Mel
- Giaccone, Giorgio
- Hatanpaa, Kimmo J.
- Heale, Richard
- Hof, Patrick R.
- Hofer, Monika
- Hortobágyi, Tibor
- Jellinger, Kurt
- Jicha, Gregory A.
- Ince, Paul
- Kofler, Julia
- Kril, Jillian J.
- Mann, David M.
- McKee, Ann C.
- McLean, Catriona
- Montine, Thomas J.
- Murayama, Shigeo
- Lee, Edward B.
- Rodriguez, Roberta D.
- Rozemüller, Annemieke
- Schneider, Julie A.
- Schultz, Christian
- Seeley, William
- Seilhean, Danielle
- Smith, Colin
- Tagliavini, Fabrizio
- Takao, Masaki
- Thal, Dietmar Rudolf
- Toledo, Jon B.
- Tolnay, Markus
- Troncoso, Juan C.
- Vinters, Harry V.
- Weis, Serge
- Wharton, Stephen B.
- White, Charles L.
- Woulfe, John M.
- Yamada, Masahito
- Dickson, Dennis W.
- Venue
- Acta Neuropathologica
- Published
- 2015-12-10
- Volume
- 131
- Issue
- 1
- Pages
- 87-102
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4879001
- OpenAlex
- W2195527239
- Cited by
- 532
- References
- 69
- Citations by year
- 2026: 37 · 2025: 49 · 2024: 66 · 2023: 48 · 2022: 57 · 2021: 56 · 2020: 54 · 2019: 51 · 2018: 49 · 2017: 38 · 2016: 25 · 2015: 1
- FWCI
- 27.47
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Explore Bristol Research (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- Lirias (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Purdue University Indianapolis (Indiana University) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- FP7 EU Project (Develage No. 278486)
- National Institutes of Health (NIH P30 AG10133, R01 AG040311, P01 AG019724-03, P50 AG023501, AG010124, AG017586, P50 AG005138, AG028383, P50AG05146, grants P50 AG05136 and P50 NS062684, P50 AG016574 and P50 NS072187)
- NIA Grant (P50 AG05681, P01 AG03991)
- Nelson Family Foundation
- Alzheimer’s Research UK
- Alzheimer's Society, National Institute for Health Research
- Medical Research Council (G0400074, MR/L016400/1, MR/L016400/1 Edinburgh Brain Bank)
- National Health and Medical Research Council of Australia (Senior Principal Research Fellow (#630434))
- Grant Agency of Ministry of Health of Czech Republic (IGA NT12094-5)
- NIA P50 (P50 AG005133)
- National Institute of Neurological Disorders and Stroke (1U01NS086659-01)
- National Institute of Aging Boston University Alzheimer’s Disease Center (P30AG13846; supplement 0572063345–5)
- MRC (MC-PC-13044)
- National Brain Research Program, Hungary (KTIA_13_NAP-A-II/7)
- Grant-in-Aid (KAKEN 26250017)
- NIH (P30AG12300)
- DFG Grant (SFB 1134/A03)
- Alzheimer's Disease Core Center (P30AG008051-26)
- Grant (AG13854)
- JSPS KAKENHI (26430060)
- Italian Ministry of Health
- Vienna KIN-Neurobiobank and VITA–study
- France Alzheimer, France Parkinson, Fondacion ARSEP and CSC (GIE NeuroCEB)
- Neuroscience Research Australia and the University of New South Wales (Sydney Brain Bank)
- Sheffield and Cambridge Brain Banks (Brain Banks)
- Parkinson's UK (Parkinson's UK Tissue Bank at Imperial College)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau phosphorylation, astrocytes, glia limitans, white matter, gray matter, primary tauopathies, nomenclature, brain aging, clinical biomarkers
- MeSH terms
- Aging, Animals, Astrocytes, Brain, Humans, Neuroglia, tau Proteins, Tauopathies
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