Neuron-Astrocyte Interactions in Parkinson’s Disease

Neurotoxic reactive astrocytes are induced by activated microglia

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Astrocyte-endothelial interactions at the blood-brain barrier

Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

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GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons

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Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774 · see citing works

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

Sidransky, E., Nalls, M. A., Aasly, J. O., Aharon-Peretz, J., Annesi, G., Barbosa, E. R., Bar-Shira, A., Berg, D., Bras, J., Brice, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901281 · Cited by 2,135 · see citing works

Non-motor features of Parkinson disease

Schapira, A. H. V., Chaudhuri, K. R., & Jenner, P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.62 · Cited by 2,053 · see citing works

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947 · see citing works

Tripartite synapses: astrocytes process and control synaptic information

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Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

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β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518 · see citing works

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208 · see citing works

Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones

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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

Yun, S. P., Kam, T.-I., Panicker, N., Kim, S., Oh, Y., Park, J.-S., Kwon, S.-H., Park, Y. J., Karuppagounder, S. S., Park, H., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0051-5 · Cited by 1,123 · see citing works

Gastrointestinal Dysfunction in Parkinson’s Disease

Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016 · see citing works

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307301101 · Cited by 986 · see citing works

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

Lee, H.-J., Suk, J.-E., Patrick, C., Bae, E.-J., Cho, J.-H., Rho, S., Hwang, D., Masliah, E., & Lee, S.-J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.081125 · Cited by 877 · see citing works

Mechanisms of Disease: astrocytes in neurodegenerative disease

Maragakis, N., & Rothstein, J. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0355 · Cited by 834 · see citing works

DJ-1, a cancer- and Parkinson’s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818 · see citing works

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 786 · see citing works

Glutathione metabolism in brain

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Dopamine covalently modifies and functionally inactivates parkin

LaVoie, M. J., Ostaszewski, B. L., Weihofen, A., Schlossmacher, M. G., & Selkoe, D. J. (2005) · Nature Medicine · doi:10.1038/nm1314 · Cited by 722 · see citing works

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

Sofroniew, M. V. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.004 · Cited by 721 · see citing works

Neuroinflammation as a common feature of neurodegenerative disorders

Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702 · see citing works

Glial reactions in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders · doi:10.1002/mds.21751 · Cited by 701 · see citing works

Transcellular degradation of axonal mitochondria

Davis, C.-H. O., Kim, K.-Y., Bushong, E. A., Mills, E. A., Boassa, D., Shih, T., Kinebuchi, M., Phan, S., Zhou, Y., Bihlmeyer, N. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404651111 · Cited by 673 · see citing works

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

Klingelhoefer, L., & Reichmann, H. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.197 · Cited by 598 · see citing works

A timeline for Parkinson's disease

Hawkes, C. H., Del Tredici, K., & Braak, H. (2010) · Parkinsonism &amp; Related Disorders · doi:10.1016/j.parkreldis.2009.08.007 · Cited by 594 · see citing works

Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione

Dringen, R., Pfeiffer, B., & Hamprecht, B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00562.1999 · Cited by 589 · see citing works

Inflammation, glutamate, and glia: a trio of trouble in mood disorders

Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584 · see citing works

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte

Chen, P.-C., Vargas, M. R., Pani, A. K., Smeyne, R. J., Johnson, D. A., Kan, Y. W., & Johnson, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813361106 · Cited by 579 · see citing works

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Joshi, A. U., Minhas, P. S., Liddelow, S. A., Haileselassie, B., Andreasson, K. I., Dorn, G. W., & Mochly-Rosen, D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0486-0 · Cited by 571 · see citing works

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Choi, I., Zhang, Y., Seegobin, S. P., Pruvost, M., Wang, Q., Purtell, K., Zhang, B., & Yue, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15119-w · Cited by 549 · see citing works

Zinc Metabolism in the Brain: Relevance to Human Neurodegenerative Disorders

Cuajungco, M. P., & Lees, G. J. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0163 · Cited by 540 · see citing works

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

Kang, M.-I., Kobayashi, A., Wakabayashi, N., Kim, S.-G., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308347100 · Cited by 536 · see citing works

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury

Yi, J., & Hazell, A. S. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.001 · Cited by 477 · see citing works

NLRP3 inflammasome in neurological diseases, from functions to therapies

Song, L., Pei, L., Yao, S., Wu, Y., & Shang, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00063 · Cited by 467 · see citing works

Glutathione peroxidase, glial cells and Parkinson's disease

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The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

Bandopadhyay, R. (2004) · Brain · doi:10.1093/brain/awh054 · Cited by 466 · see citing works

Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease

Braak, H., Sastre, M., & Del Tredici, K. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0244-3 · Cited by 462 · see citing works

Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

Orimo, S., Uchihara, T., Nakamura, A., Mori, F., Kakita, A., Wakabayashi, K., & Takahashi, H. (2007) · Brain · doi:10.1093/brain/awm302 · Cited by 462 · see citing works

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles

Sulzer, D. L., Bogulavsky, J. J., Larsen, K. E., Behr, G. G., Karatekin, E., Kleinman, M. H., Turro, N. J., Krantz, D. E., Edwards, R. H., Greene, L. A., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.22.11869 · Cited by 460 · see citing works

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

Craig, K. J. T., McCoy, M. K., Blackinton, J. G., Beilina, A. G., van der Brug, M., Matton, A., Miller, D. W., Maric, D., Cedazo-Mı́nguez, Á., & Cookson, M. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq430 · Cited by 455 · see citing works

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Lindholm, P., Voutilainen, M. H., Laurén, J., Peränen, J., Leppänen, V., Andressoo, J., Lindahl, M., Janhunen, S. K., Kalkkinen, N., Timmusk, T., et al. (2007) · Nature · doi:10.1038/nature05957 · Cited by 444 · see citing works

NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains

Wakabayashi, K., Hayashi, S., Yoshimoto, M., Kudo, H., & Takahashi, H. (2000) · Acta Neuropathologica · doi:10.1007/pl00007400 · Cited by 439 · see citing works

DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

Bonifati, V., Rizzu, P., Squitieri, F., Krieger, E., Vanacore, N., Swieten, J. C. V., Brice, A., van Duijn, C. M., Oostra, B. A., Meco, G., et al. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0108-0 · Cited by 427 · see citing works

Neuropathology underlying clinical variability in patients with synucleinopathies

Halliday, G. M., Holton, J. L., Révész, T., & Dickson, D. W. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0852-9 · Cited by 426 · see citing works

Potential oxidative pathways of brain catecholamines

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TNFα potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NFκB inhibition

Zou, J., & Crews, F. T. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.014 · Cited by 410 · see citing works

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

Gray, M. T., & Woulfe, J. M. (2015) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2015.32 · Cited by 409 · see citing works

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

Freeman, L., Guo, H., David, C. N., Brickey, W. J., Jha, S., & Ting, J. P.-Y. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20150237 · Cited by 397 · see citing works

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

Xiong, H., Wang, D., Chen, L., Choo, Y. S., Ma, H., Tang, C., Xia, K., Jiang, W. B., Ronai, Z. A., Zhuang, X., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37617 · Cited by 394 · see citing works

Lipopolysaccharide Intranigral Injection Induces Inflammatory Reaction and Damage in Nigrostriatal Dopaminergic System

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Neuroinflammation and regulation of glial glutamate uptake in neurological disorders

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Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

di Domenico, A., Carola, G., Calatayud, C., Pons-Espinal, M., Muñoz, J. P., Richaud-Patin, Y., Fernandez-Carasa, I., Gut, M., Faella, A., Parameswaran, J., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.011 · Cited by 372 · see citing works

Neuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transport

Freundt, E. C., Maynard, N., Clancy, E. K., Roy, S., Bousset, L., Sourigues, Y., Covert, M. W., Melki, R., Kirkegaard, K., & Brahic, M. (2012) · Annals of Neurology · doi:10.1002/ana.23747 · Cited by 370 · see citing works

MANF: A New Mesencephalic, Astrocyte-Derived Neurotrophic Factor with Selectivity for Dopaminergic Neurons

Petrova, P. S., Raibekas, A. A., Pevsner, J., Vigo, N. T., Anafi, M., Moore, M. K., Peaire, A. E., Shridhar, V., Smith, D. I., Kelly, J., et al. (2003) · Journal of Molecular Neuroscience · doi:10.1385/jmn:20:2:173 · Cited by 353 · see citing works

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

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The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

Niranjan, R. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8483-x · Cited by 331 · see citing works

The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease

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DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Kahle, P. J., Waak, J., & Gasser, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.003 · Cited by 324 · see citing works

Cystine/Glutamate Exchange Modulates Glutathione Supply for Neuroprotection from Oxidative Stress and Cell Proliferation

Shih, A. Y., Erb, H., Sun, X., Toda, S., Kalivas, P. W., & Murphy, T. H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3178-06.2006 · Cited by 315 · see citing works

The neurotrophic effects of fibroblast growth factors on dopaminergic neurons in vitro are mediated by mesencephalic glia [published erratum appears in J Neurosci 1992 Mar;12(3):685]

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Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

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The Nrf2–ARE cytoprotective pathway in astrocytes

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Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

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Astrocytes Provide Cysteine to Neurons by Releasing Glutathione

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Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease

Voutilainen, M. H., Bäck, S., Pörsti, E., Toppinen, L., Lindgren, L., Lindholm, P., Peränen, J., Saarma, M., & Tuominen, R. K. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0833-09.2009 · Cited by 269 · see citing works

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

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α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

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Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

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Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death

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Copper pathology in vulnerable brain regions in Parkinson's disease

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NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy

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Degeneration in Different Parkinsonian Syndromes Relates to Astrocyte Type and Astrocyte Protein Expression

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Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

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Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2

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RAISED CEREBROSPINAL-FLUID COPPER CONCENTRATION IN PARKINSON'S DISEASE

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Environmental Exposures and Parkinson’s Disease

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Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist

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