Cited by 375Treatment of Major DepressionTryptophan and brain disordersNerve injury and regeneration

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Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients

Gonul, A. Saffet, Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., Vahip, S.·2005·European Archives of Psychiatry and Clinical Neuroscience

DOI 10.1007/s00406-005-0578-6

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Abstract

Researchers have reported that serum brain-derived neurotrophic factor (sBDNF) of drug-free depressed patients are lower than those of healthy controls and proposed that low sBDNF levels might reflect failure of neuronal plasticity in depression. In this study, we compared sBDNF levels of depressed patients (n = 28) before and after 8 weeks of antidepressant treatment, with those of healthy controls (n = 18) to test the hypothesis that initially low sBDNF levels of drug-free depressed patients will increase parallel with their clinical response to antidepressant treatment. The severity of depression and response to treatment were assessed with Hamilton Rating Scale for Depression (HAM-D). sBDNF was assayed with the sandwich ELISA method. Baseline sBDNF levels of patients (mean, 20.8 ng/ml; [S.D., 6.7]) were significantly lower than those of controls (mean, 26.8 ng/ml; [S.D., 9.3]; p = 0.015), and were negatively correlated with HAM-D scores (r = -0.49, p = 0.007). After 8 weeks of treatment, sBDNF levels of patients had increased significantly (mean, 33.3 ng/ml; [S.D., 9.9]; p < 0.001) and no longer differed from those of controls. These results support the hypothesis that BDNF might play a critical role in the pathophysiology of major depressive disorder and successful antidepressant treatment increases the attenuated BDNF levels in depressed patients.

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Authors: Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S.
Affiliations: Ege University (TR)
Manisa Celal Bayar University (TR)
ORCID: Taneli, F.
Vahip, S.
Venue: European Archives of Psychiatry and Clinical Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-04-06
Volume: 255
Issue: 6
Pages: 381-386
ISSN: 0003-9373 (ISSN-L)
0940-1334
1433-8491
DOI: 10.1007/s00406-005-0578-6
OpenAlex: W2055040288
Cited by: 375
References: 50
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 23 · 2014: 18 · 2013: 29 · 2012: 25
FWCI: 15.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Ege Üniversitesi
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: brain-derived neurotrophic factor, serum BDNF, major depressive disorder, antidepressant response, depression pathophysiology, neuroplasticity, treatment response biomarkers, depression severity
MeSH terms: Adult, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Brain-Derived Neurotrophic Factor

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Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients

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