Cited by 375Treatment of Major DepressionTryptophan and brain disordersNerve injury and regeneration

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Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients

Gonul, A. Saffet, Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., Vahip, S.·2005·European Archives of Psychiatry and Clinical Neuroscience

DOI 10.1007/s00406-005-0578-6

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Abstract

Researchers have reported that serum brain-derived neurotrophic factor (sBDNF) of drug-free depressed patients are lower than those of healthy controls and proposed that low sBDNF levels might reflect failure of neuronal plasticity in depression. In this study, we compared sBDNF levels of depressed patients (n = 28) before and after 8 weeks of antidepressant treatment, with those of healthy controls (n = 18) to test the hypothesis that initially low sBDNF levels of drug-free depressed patients will increase parallel with their clinical response to antidepressant treatment. The severity of depression and response to treatment were assessed with Hamilton Rating Scale for Depression (HAM-D). sBDNF was assayed with the sandwich ELISA method. Baseline sBDNF levels of patients (mean, 20.8 ng/ml; [S.D., 6.7]) were significantly lower than those of controls (mean, 26.8 ng/ml; [S.D., 9.3]; p = 0.015), and were negatively correlated with HAM-D scores (r = -0.49, p = 0.007). After 8 weeks of treatment, sBDNF levels of patients had increased significantly (mean, 33.3 ng/ml; [S.D., 9.9]; p < 0.001) and no longer differed from those of controls. These results support the hypothesis that BDNF might play a critical role in the pathophysiology of major depressive disorder and successful antidepressant treatment increases the attenuated BDNF levels in depressed patients.

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Diagnostic and Statistical Manual of Mental Disorders
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A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525

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Schneider, B., Prvulovic, D., Oertel‐Knöchel, V., Knöchel, C., Reinke, B., Grexa, M., Weber, B., & Hampel, H. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.001 · Cited by 45
Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD)
Katsuki, A., Yoshimura, R., Kishi, T., Hori, H., Umene‐Nakano, W., Ikenouchi, A., Hayashi, K., Atake, K., Iwata, N., & Nakamura, J. (2012) · CNS Spectrums · doi:10.1017/s109285291200051x · Cited by 44
The Role of Brain-Derived Neurotrophic Factor Genotype, Parental Depression, and Relationship Discord in Predicting Early-Emerging Negative Emotionality
Hayden, E. P., Klein, D. N., Dougherty, L. R., Olino, T. M., Dyson, M. W., Durbin, C. E., Sheikh, H. I., & Singh, S. M. (2010) · Psychological Science · doi:10.1177/0956797610385357 · Cited by 48
Hemodialysis Decreases Serum Brain-Derived Neurotrophic Factor Concentration in Humans
Zoladz, J. A., Śmigielski, M., Majerczak, J., Nowak, Ł. R., Zapart-Bukowska, J., Smoleński, O., Kulpa, J., Duda, K., Drzewińska‐Chańko, J., & Bartosz, G. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0862-6 · Cited by 42
Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors
Schulz, K. M., Pearson-Smith, J. N., Gasparrini, M. E., Brooks, K. F., Drake-Frazier, C., Zajkowski, M. E., Kreisler, A. D., Adams, C. E., Leonard, S. S., & Stevens, K. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.031 · Cited by 41
Atorvastatin Protects from Aβ1–40-Induced Cell Damage and Depressive-Like Behavior via ProBDNF Cleavage
Ludka, F. K., Cunha, M. P., Dal-Cim, T. A., Binder, L. B., Constantino, L. C., Massari, C. M., Martins, W. C., Rodrigues, A. L. S., & Tasca, C. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0134-6 · Cited by 42
BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder
Tseng, M., Alda, M., Xu, L., Sun, X., Wang, J., Grof, P., Turecki, G., Rouleau, G. A., & Young, L. T. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0843 · Cited by 41
Effects of Music Aerobic Exercise on Depression and Brain-Derived Neurotrophic Factor Levels in Community Dwelling Women
Yeh, S., Lin, L.-W., Chuang, Y.-K., Liu, C.-L., Tsai, L.-J., Tsuei, F.-S., Lee, M.-T., Hsiao, C.-Y., & Yang, K. D. (2015) · BioMed Research International · doi:10.1155/2015/135893 · Cited by 34
Effects of electroconvulsive therapy on serum levels of brain-derived neurotrophic factor and nerve growth factor in treatment resistant major depression
Bilgen, A. E., Zincir, S. B., Zincir, S., Özdemir, B. H., Ak, M., Aydemir, E., & Şener, İ. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.04.005 · Cited by 46
Measurement Methods of BDNF Levels in Major Depression: A Qualitative Systematic Review of Clinical Trials
Teche, S. P., Nuernberg, G. L., Sordi, A. O., de Souza, L. H., Remy, L., Ceresér, K. M. M., & da Rocha, N. S. (2013) · Psychiatric Quarterly · doi:10.1007/s11126-013-9261-7 · Cited by 41
Targeting TrkB neurotrophin receptor to treat depression
Rantamäki, T., & Castrén, E. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.6.705 · Cited by 40
From depressive symptoms to depression in people with epilepsy: Contribution of physical exercise to improve this picture
Arida, R. M., Cavalheiro, É. A., & Scorza, F. A. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.10.012 · Cited by 39
Brain-Derived Neurotrophic Factor Serum Concentrations in Acute Depressive Patients Increase During Lithium Augmentation of Antidepressants
Ricken, R., Adli, M., Lange, C., Krusche, E., Stamm, T. J., Gaus, S., Koehler, S., Nase, S., Bschor, T., Richter, C., et al. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3182a412b8 · Cited by 38
Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder
Huuhka, K., Sami, A., Huuhka, M., Esa, L., Rontu, R., Mattila, K. J., & Lehtimäki, T. J. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0679-x · Cited by 37
Potentiation of omega-3 fatty acid antidepressant-like effects with low non-antidepressant doses of fluoxetine and mirtazapine
Laino, C. H., Fonseca, C., Sterin-Speziale, N. B., Slobodianik, N., & Reinés, A. G. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.08.047 · Cited by 35
Relationships between stress, social adaptation, personality traits, brain-derived neurotrophic factor and 3-methoxy-4-hydroxyphenylglycol plasma concentrations in employees at a publishing company in Japan
Okuno, K., Yoshimura, R., Ueda, N., Ikenouchi, A., Umene‐Nakano, W., Hori, H., Hayashi, K., Katsuki, A., Chen, H., & Nakamura, J. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.07.023 · Cited by 35
Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats.
Rogóż, Z., Skuza, G., & Legutko, B. (2008) · PubMed · Cited by 36
Electroconvulsive Therapy Improves Clinical Manifestation with Plasma BDNF Levels Unchanged in Treatment-Resistant Depression Patients
Lin, C., Chen, M., Lee, W., Chen, C., Huang, C.-H., & Lane, H. (2013) · Neuropsychobiology · doi:10.1159/000352013 · Cited by 38
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Pietro, M. J. S., Marks, D. R., & Mullen, A. (2019) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-019-09608-4 · Cited by 35
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Francazio (2015) · doi:10.1016/j.psychres.2015.04.009 · Cited by 35
Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia
Bartlett, M. J., Flores, A. J., Ye, T., Smidt, S. I., Dollish, H. K., Stancati, J. A., Farrell, D. C., Parent, K. L., Doyle, K. P., Besselsen, D. G., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113413 · Cited by 36
Diagnostic accuracy of serum brain derived neurotrophic factor concentration in antidepressant naïve patients with first major depression episode
Karlović, D., Serretti, A., Jevtović, S., Vrkić, N., Šerić, V., & Peleš, A. M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.09.017 · Cited by 36
Serum Brain-derived neurotrophic factor (BDNF): the severity and symptomatic dimensions of depression.
Jevtović, S., Karlović, D., Mihaljević-Peleš, A., Šerić, V., Vrkić, N., & Jakšić, N. (2011) · PubMed · Cited by 34
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Alterations of BDNF and trkB mRNA Expression in the 6-Hydroxydopamine-Induced Model of Preclinical Stages of Parkinson’s Disease: An Influence of Chronic Pramipexole in Rats
Berghauzen-Maciejewska, K., Wardas, J., Kosmowska, B., Głowacka, U., Kuter, K. Z., & Ossowska, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117698 · Cited by 34
The functional BDNF Val66Met polymorphism affects functions of pre-attentive visual sensory memory processes
Beste, C., Schneider, D. A., Epplen, J. T., & Arning, L. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.028 · Cited by 33
Brain-Derived Neurotrophic Factor in Neuroimmunology: Lessons Learned from Multiple Sclerosis Patients and Experimental Autoimmune Encephalomyelitis Models
Lühder, F., Gold, R., Flügel, A., & Linker, R. A. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-012-0211-0 · Cited by 33
Comparison of efficacy, safety and brain derived neurotrophic factor (BDNF) levels in patients of major depressive disorder, treated with fluoxetine and desvenlafaxine
Ghosh, R., Gupta, R., Bhatia, M. S., Tripathi, A. K., & Gupta, L. K. (2015) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2015.10.006 · Cited by 33
Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance
Kim, S. J., Cho, S., Jang, H. M., Shin, J., Park, P.-W., Lee, Y. J., Cho, I. H., Choi, J.-E., & Lee, H. (2009) · Neuropsychobiology · doi:10.1159/000258639 · Cited by 31
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Konishi, K., Cherkerzian, S., Aroner, S. A., Jacobs, E. G., Rentz, D. M., Remington, A., Aizley, H. G., Hornig, M., Klibanski, A., & Goldstein, J. M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.12.014 · Cited by 33
Effects of escitalopram on serum BDNF levels in elderly patients with depression: a preliminary report
Martocchia, A., Curto, M., Scaccianoce, S., Comite, F., Xenos, D., Nasca, C., Falaschi, G. M., Ferracuti, S., Girardi, P., Nicoletti, F., et al. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0194-2 · Cited by 31

Authors: Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S.
Affiliations: Ege University (TR)
Manisa Celal Bayar University (TR)
ORCID: Taneli, F.
Vahip, S.
Venue: European Archives of Psychiatry and Clinical Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-04-06
Volume: 255
Issue: 6
Pages: 381-386
ISSN: 0003-9373 (ISSN-L)
0940-1334
1433-8491
DOI: 10.1007/s00406-005-0578-6
OpenAlex: W2055040288
Cited by: 375
References: 50
Citations by year: 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 23 · 2014: 18 · 2013: 29 · 2012: 25
FWCI: 15.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Ege Üniversitesi
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: brain-derived neurotrophic factor, serum BDNF, major depressive disorder, antidepressant response, depression pathophysiology, neuroplasticity, treatment response biomarkers, depression severity
MeSH terms: Adult, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Brain-Derived Neurotrophic Factor

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Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients

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