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Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients
Abstract
Researchers have reported that serum brain-derived neurotrophic factor (sBDNF) of drug-free depressed patients are lower than those of healthy controls and proposed that low sBDNF levels might reflect failure of neuronal plasticity in depression. In this study, we compared sBDNF levels of depressed patients (n = 28) before and after 8 weeks of antidepressant treatment, with those of healthy controls (n = 18) to test the hypothesis that initially low sBDNF levels of drug-free depressed patients will increase parallel with their clinical response to antidepressant treatment. The severity of depression and response to treatment were assessed with Hamilton Rating Scale for Depression (HAM-D). sBDNF was assayed with the sandwich ELISA method. Baseline sBDNF levels of patients (mean, 20.8 ng/ml; [S.D., 6.7]) were significantly lower than those of controls (mean, 26.8 ng/ml; [S.D., 9.3]; p = 0.015), and were negatively correlated with HAM-D scores (r = -0.49, p = 0.007). After 8 weeks of treatment, sBDNF levels of patients had increased significantly (mean, 33.3 ng/ml; [S.D., 9.9]; p < 0.001) and no longer differed from those of controls. These results support the hypothesis that BDNF might play a critical role in the pathophysiology of major depressive disorder and successful antidepressant treatment increases the attenuated BDNF levels in depressed patients.
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“Both MDD patients [57–59] and animal models of depression [60, 61] show a remarkable reduction in serum BDNF levels.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [57]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Neurotrophins and Neuronal Plasticity
Thoenen, H. (1995) · Science · doi:10.1126/science.270.5236.593 · Cited by 1,927
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
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Molendijk, M. L., Spinhoven, P., Polak, M., Bus, B. A. A., Penninx, B. W. J. H., & Elzinga, B. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.105 · Cited by 702
Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 662
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Lee, B.-H., & Kim, Y. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.4.231 · Cited by 466
Serum and plasma BDNF levels in major depression: A replication study and meta-analyses
Bocchio-Chiavetto, L., Bagnardi, V., Zanardini, R., Molteni, R., Gabriela Nielsen, M., Placentino, A., Giovannini, C., Rillosi, L., Ventriglia, M., Riva, M. A., et al. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622971003611319 · Cited by 435
Goodman, A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 445
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Groves, J. O. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002075 · Cited by 412
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Schmidt, H. D., & Duman, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.114 · Cited by 403
Hashimoto, K. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02113.x · Cited by 388
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Maletic, V., Robinson, M., Oakes, T. M. M., Iyengar, S., Ball, S. G., & Russell, J. D. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01602.x · Cited by 414
Brain-derived neurotrophic factor: role in depression and suicide
Dwivedi, Y. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s5700 · Cited by 355
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Lee, B.-H., Kim, H., Park, S., & Kim, Y. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.11.005 · Cited by 327
Post, R. M. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.003 · Cited by 312
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Notaras, M., Hill, R., & van den Buuse, M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.27 · Cited by 274
Zoladz, J. A., & Pilc, A. (2010) · PubMed · Cited by 269
The Hippocampus, Neurotrophic Factors and Depression
Masi, G., & Brovedani, P. (2011) · CNS Drugs · doi:10.2165/11595900-000000000-00000 · Cited by 271
Hwang, J., Tsai, S., Hong, C., Yang, C.-H., Lirng, J., & Yang, Y.-M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.013 · Cited by 253
Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression
Mößner, R., Mikova, O., Koutsilieri, E., Saoud, M., Ehlis, A., Müller, N., Fallgatter, A. J., & Riederer, P. F. (2007) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701263303 · Cited by 254
Matrisciano, F., Bonaccorso, S., Ricciardi, A., Scaccianoce, S., Panaccione, I., Wang, L. H.-C., Ruberto, A., Tatarelli, R., Nicoletti, F., Girardi, P., et al. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.014 · Cited by 252
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Aydemir, Ç., Yalçın, E. S., Aksaray, S., Kısa, C., Yildirim, S. G., Uzbay, T. I., & Göka, E. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.025 · Cited by 214
Kozisek, M. E., Middlemas, D. S., & Bylund, D. B. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.07.001 · Cited by 211
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Li, Y., Xu, M., Zong-hua, G., Wang, Y., Yue, Z., Zhang, Y.-X., Li, X., Zhang, C. M., Xie, S., & Wang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063648 · Cited by 206
Zhou, C., Zhong, J., Zou, B., Fang, L., Chen, J., Deng, X., Zhang, L., Zhao, X., Qu, Z., Lei, Y., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172270 · Cited by 187
Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression
Peng, G.-J., Tian, J., Gao, X., Zhou, Y., & Qin, X. (2015) · Current Neuropharmacology · doi:10.2174/1570159x1304150831120428 · Cited by 189
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Youssef, M. M., Underwood, M. D., Huang, Y.-Y., Hsiung, S.-C., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy008 · Cited by 183
Bocchio‐Chiavetto, L., Zanardini, R., Bortolomasi, M., Abate, M., Segala, M., Giacopuzzi, M., Riva, M. A., Marchina, E., Pasqualetti, P., Pérez, J., et al. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.04.010 · Cited by 189
Yoshimura, R., Mitoma, M., Sugita, A., Hori, H., Okamoto, T., Umene, W., Ueda, N., & Nakamura, J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.03.001 · Cited by 179
Almeida, R. N. D., Galvão, A. C. D. M., da Silva, F. S., Silva, E. A. D. S., Palhano-Fontes, F., Maia-de-Oliveira, J. P., de Araújo, L.-S. B., Lobão-Soares, B., & Galvão-Coelho, N. L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01234 · Cited by 177
Rahbardar, M. G., & Hosseinzadeh, H. (2020) · PubMed Central · doi:10.22038/ijbms.2020.45269.10541 · Cited by 202
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Larsen, M. H., Mikkelsen, J. D., Hay-Schmidt, A., & Sandi, C. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.01.005 · Cited by 165
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Teixeira, A. L., Barbosa, I. G., Diniz, B. S., & Kümmer, A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.111 · Cited by 164
Michael, J. R. (2009) · Frontiers in bioscience · doi:10.2741/3585 · Cited by 167
Hu, Y., & Russek, S. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05237.x · Cited by 164
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Pattwell, S. S., Bath, K. G., Perez-Castro, R., Lee, F. S., Chao, M. V., & Ninan, I. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5205-11.2012 · Cited by 156
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Zanardini, R., Gazzoli, A., Ventriglia, M., PEREZ, J., Bignotti, S., MARIAROSSINI, P., Gennarelli, M., & Bocchio‐Chiavetto, L. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.029 · Cited by 147
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Leyhe, T., Stransky, E., Eschweiler, G. W., Buchkremer, G., & Laske, C. (2007) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-007-0764-9 · Cited by 140
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Drzyzga, Ł. R., Marcinowska, A., & Obuchowicz, E. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.03.009 · Cited by 90
Mosiołek, A., Mosiołek, J., Jakima, S., Pięta, A., & Szulc, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153377 · Cited by 87
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Metadata
- Authors
- Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S.
- Affiliations
- Ege University (TR)
- Manisa Celal Bayar University (TR)
- ORCID
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2005-04-06
- Volume
- 255
- Issue
- 6
- Pages
- 381-386
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2055040288
- Cited by
- 375
- References
- 50
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 16 · 2017: 11 · 2016: 16 · 2015: 23 · 2014: 18 · 2013: 29 · 2012: 25
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ege Üniversitesi
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- brain-derived neurotrophic factor, serum BDNF, major depressive disorder, antidepressant response, depression pathophysiology, neuroplasticity, treatment response biomarkers, depression severity
- MeSH terms
- Adult, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Brain-Derived Neurotrophic Factor
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