Effects of nicotine on social cognition, social competence and self-reported stress in schizophrenia patients and healthy controls
Abstract
More than 80 % of patients diagnosed with schizophrenia are nicotine-dependent. Self-medication of cognitive deficits and an increased vulnerability to stress are discussed as promoting factors for the development of nicotine dependence. However, the effects of nicotine on social cognition and subjective stress responses in schizophrenia are largely unexplored. A 2 × 2-factorial design (drug × group) was used to investigate the effects of nicotine versus placebo in smoking schizophrenia patients and healthy controls after 24 h of abstinence from smoking. Participants performed a facial affect recognition task and a semi-standardized role-play task, after which social competence and self-reported stress during social interaction were assessed. Data analysis revealed no significant group differences in the facial affect recognition task. During social interaction, healthy controls showed more non-verbal expressions and a lower subjective stress level than schizophrenia patients. There were no significant effects of nicotine in terms of an enhanced recognition of facial affect, more expressive behaviour or reduced subjective stress during social interaction. While schizophrenia patients unexpectedly recognized facial affect not significantly worse than healthy controls, the observed group differences in subjective stress and non-verbal expression during social interaction in the role-play situation are in line with previous findings. Contrary to expectations derived from the self-medication hypothesis, nicotine showed no significant effects on the dependent variables, perhaps because of the dosage used and the delay between the administration of nicotine and the performance of the role-play.
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Evidence supporting a significant but complex role of nicotine and nicotinic receptors in ARBS can be gleaned from clinical studies with different primary outcomes that also report on these data, as well as well-conducted case series.
“evidence supporting a significant but complex role of nicotine and nicotinic receptors in these syndromes can be gleaned from a variety of clinical studies with different primary outcomes that also report on these data (Arnold et al., 2012; Conners et al., 1996; Drusch et al., 2013; Newhouse et al., 1994), as well as well-conducted case series (Mayer et al., 2001; Rosin et al., 2001)”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Drusch et al., 2013
Other work has found nicotine to be similarly ineffective in improving social cognition and subjective stress responses.
“Other work has found nicotine to be similarly ineffective in improving social cognition and subjective stress responses (Drusch et al., 2013).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Drusch et al., 2013
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- Authors
- Drusch, K., Lowe, A., Fisahn, K., Brinkmeyer, J., Musso, F., Mobascher, A., Warbrick, T., Shah, J., Ohmann, C., Winterer, G., & Wölwer, W.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Johannes Gutenberg University Mainz (DE)
- Forschungszentrum Jülich (DE)
- University of Cologne (DE)
- Corresponding author
- Drusch, Katharina
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2012-10-19
- Volume
- 263
- Issue
- 6
- Pages
- 519-527
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2087659246
- Cited by
- 25
- References
- 63
- Citations by year
- 2024: 1 · 2023: 2 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 3
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine, schizophrenia, social cognition, social competence, self-reported stress, facial expression recognition, nonverbal expression, social interaction, nicotine dependence, self-medication hypothesis, smoking abstinence, role play
- MeSH terms
- Adult, Analysis of Variance, Cognition Disorders, Cotinine, Double-Blind Method, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Nicotine, Schizophrenia, Schizophrenic Psychology, Smoking, Social Behavior, Statistics as Topic, Stress, Psychological, Nicotinic Agonists, Young Adult, Self Report
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