The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
The effects of physical exercise in schizophrenia and affective disorders.
Abstract
Affective and non-affective psychoses are severe and frequent psychiatric disorders. Amongst others, they not only have a profound impact on affected individuals through their symptomatology, but also regarding cognition, brain structure and function. Cognitive impairment influences patients' quality of life as well as their ability to work and being employed. While exercise therapy has been implemented in the treatment of psychiatric conditions since the days of Kraepelin and Bleuler, the underlying mechanisms have never been systematically studied. Since the early 1990s, studies emerged examining the effect of physical exercise in animal models, revealing stimulation of neurogenesis, synaptogenesis and neurotransmission. Based on that body of work, clinical studies have been carried out in both healthy humans and in patient populations. These studies differ with regard to homogenous study samples, sample size, type and duration of exercise, outcome variables and measurement techniques. Based on their review, we draw conclusions regarding recommendations for future research strategies showing that modern therapeutic approaches should include physical exercise as part of a multimodal intervention programme to improve psychopathology and cognitive symptoms in schizophrenia and affective disorders.
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“Despite this, there is a distinct lack of systematic investigations (both animal and human) into the relationship between AE and neuroplasticity, hippocampal functioning, and its impact on cognitive dysfunctions in psychiatric disorders such as MDD (Malchow et al., 2013) or schizophrenia (Sommer and Kahn, 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Malchow et al., 2013
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“In a longitudinal epidemiological study, subjects with regular physical activity had lower incidence of mental diseases in general, anxiety, somatoform and dysthymic disorder, while the incidence of bipolar disorder was increased B. Malchow (&) D. Reich-Erkelenz A. Hasan A. Schmitt P. Falkai Department of Psychiatry a…”
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Cited by
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Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies
Solé, B., Jiménez, E., Torrent, C., Reinares, M., Bonnin, C. D. M., Torres, I., Varo, C., Grande, I., Valls, E., Salagre, E., et al. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx032 · Cited by 299
“The results obtained across other psychiatric or neurological conditions, as well as on aging, suggest that aerobic physical exercise may also have unequivocal beneficial effects on cognitive functioning in BD, though no studies are available in this population (Kucyi et al., 2010; Malchow et al., 2013).”
ResultOertel-Knöchel, V., Mehler, P., Thiel, C., Steinbrecher, K., Malchow, B., Tesky, V., Ademmer, K., Prvulovic, D., Banzer, W., Zopf, Y., et al. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0485-9 · Cited by 185
“[43] summarized in their review of current clinical studies the effect of exercise on affective and schizophrenia patients and revealed positive effects in both disorders.”
BackgroundSelf-citationKandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155
“…there is a distinct lack of systematic investigations (both animal and human) into the relationship between AE and neuroplasticity, hippocampal functioning, and its impact on cognitive dysfunctions in psychiatric disorders such as MDD (Malchow et al., 2013) or schizophrenia (Sommer and Kahn, 2015).”
Malchow, B., Keller, K., Hasan, A., Dörfler, S., Schneider-Axmann, T., Hillmer-Vogel, U., Honer, W. G., Schulze, T. G., Niklas, A., Wobrock, T., et al. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv020 · Cited by 103
Self-citationSchmitt, A., Maurus, I., Rossner, M. J., Röh, A., Lembeck, M., von Wilmsdorff, M., Takahashi, S., Rauchmann, B., Keeser, D., Hasan, A., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00690 · Cited by 111
“In later endurance training studies, a minimum of 30min per training session and at least three sessions per week were recommended in schizophrenia patients (75).”
BackgroundSelf-citation
Metadata
- Authors
- Malchow, B., Reich-Erkelenz, D., Oertel-Knöchel, V., Keller, K., Hasan, A., Schmitt, A., Scheewe, T. W., Cahn, W., Kahn, R. S., & Falkai, P.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- University of Göttingen (DE)
- Universidade de São Paulo (BR)
- Windesheim University of Applied Sciences (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Malchow, Berend
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2013-07-20
- Volume
- 263
- Issue
- 6
- Pages
- 451-467
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2052275405
- Cited by
- 111
- References
- 158
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 17 · 2016: 12 · 2015: 15 · 2014: 6 · 2013: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- physical activity, schizophrenia, mood disorders, exercise therapy, cognitive impairment, neurogenesis, synaptogenesis, neurotransmission, multimodal intervention, animal models of psychosis, quality of life
- MeSH terms
- Brain, Humans, Schizophrenia, Exercise, Mood Disorders, Neurogenesis, Neuroimaging
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