Visual short-term memory binding in Alzheimer's disease and depression
Open accessAbstract
The differential diagnosis between Alzheimer's disease (AD) and major depression (MD) in the elderly can be problematic because the cognitive profile of the two conditions overlaps. Associative learning tasks seem to separate AD from MD. However, they are sensitive to the effects of normal ageing. Short-term memory-binding tasks have proved insensitive to the effects of normal ageing and highly sensitive to AD. However, they have not been used to differentiate AD from MD. The present study was aimed at investigating visual short-term memory binding in AD and MD. Fourteen AD patients, 14 patients with MD, and 14 healthy older adults were asked to perform a visual short-term memory binding task that investigated the retention of shapes, colors, or combinations of shapes and colors. Participants were to recognize changes occurring between two consecutive displays either in a single dimension (i.e., shape or color only) or in two dimensions (i.e., shape-color binding). Short-term memory performance for shape or color only was equivalent across groups. The only significant effect found was in short-term memory for shape-color binding and this was due to AD patients performing poorly in this condition only. The results extend previous findings in AD to visual short-term memory and suggest that the specific impairment in binding information in memory differentiates between the performance of AD and patients with MD.
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Abnormal functional connectivity of the inferior temporal gyrus might contribute to working memory impairment in depressed patients.
“Abnormal functional connectivity of the inferior temporal gyrus may contribute to working memory dysfunction in depressed patients (Axmacher et al., 2008;Parra et al., 2010).”
From Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis (2012) · cites this paper as Parra et al., 2010
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- Authors
- Parra, M. A., Abrahams, S., Logie, R. H., & Della Sala, S.
- Affiliations
- University of Edinburgh (GB)
- Corresponding author
- Parra, Mario A.
- Venue
- Journal of Neurology
- Published
- 2010-02-17
- Volume
- 257
- Issue
- 7
- Pages
- 1160-1169
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2125754969
- Cited by
- 115
- References
- 94
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 4
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- Alzheimer's disease, major depressive disorder, visual short-term memory, binding, differential diagnosis, normal aging, associative learning, older adults, memory impairment
- MeSH terms
- Aged, Alzheimer Disease, Brain, Depressive Disorder, Diagnosis, Differential, Disability Evaluation, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Neuropsychological Tests, Pattern Recognition, Visual, Photic Stimulation, Visual Perception
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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