Cited by 375Dementia and Cognitive Impairment ResearchPsychological Testing and AssessmentHistorical and Modern Theater Studies

Early Detection and Differential Diagnosis of Alzheimer’s Disease and Depression with Neuropsychological Tasks

Swainson, R., Hodges, J.R., Galton, C.J., Semple, J., Michael, A., Dunn, B.D., Iddon, J.L., Robbins, T.W. +1 more·2001·Dementia and Geriatric Cognitive Disorders

Abstract

The development of novel treatments for Alzheimer’s disease (AD), aimed at ameliorating symptoms and modifying disease processes, increases the need for early diagnosis. Neuropsychological deficits such as poor episodic memory are a consistent feature of early-in-the-course AD, but they overlap with the cognitive impairments in other disorders such as depression, making differential diagnosis difficult. Computerised and traditional tests of memory, attention and executive function were given to four subject groups: mild AD (n = 26); questionable dementia (QD; n = 43); major depression (n = 37) and healthy controls (n = 39). A visuo-spatial associative learning test accurately distinguished AD from depressed/control subjects and revealed an apparent sub-group of QD patients who performed like AD patients. QD patients’ performance correlated with the degree of subsequent global cognitive decline. Elements of contextual and cued recall may account for the task’s sensitivity and specificity for AD.

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Crossref · 10.1159/000051269

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Authors
Swainson, R., Hodges, J. R., Galton, C. J., Semple, J., Michael, A., Dunn, B. D., Iddon, J. L., Robbins, T. W., & Sahakian, B. J.
Affiliations
  • University of Cambridge (GB)
  • Addenbrooke's Hospital (GB)
  • West Suffolk Hospital (GB)
Venue
Dementia and Geriatric Cognitive Disorders
Publisher
S. Karger AG
Published
2001
Volume
12
Issue
4
Pages
265-280
ISSN
  • 1420-8008 (ISSN-L)
  • 1421-9824
OpenAlex
W1980584599
Cited by
375
References
65
Citations by year
2026: 4 · 2025: 6 · 2024: 14 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 14 · 2019: 17 · 2018: 12 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 18
FWCI
8.37
Type
journal article
Language
en
Open access
closed
Locations
  • Dementia and Geriatric Cognitive Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
Alzheimer's disease, depression, differential diagnosis, early detection, episodic memory, cognitive decline, cued recall, neuropsychological assessment
MeSH terms
Aged, Alzheimer Disease, Analysis of Variance, Dementia, Major Depressive Disorder, Diagnosis, Differential, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Logistic Models, Case-Control Studies

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