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Cited by 86

Prior medical conditions and the risk of amyotrophic lateral sclerosis

Seelen, Meinie, van Doormaal, Perry T. C., Visser, Anne E., Huisman, Mark H. B., Roozekrans, Margot H. J., de Jong, Sonja W., van der Kooi, Anneke J., de Visser, Marianne +3 more·2014·Journal of Neurology
DOI 10.1007/s00415-014-7445-1
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Abstract

Sporadic amyotrophic lateral sclerosis (ALS) is believed to be a complex disease in which multiple exogenous and genetic factors interact to cause motor neuron degeneration. Elucidating the association between medical conditions prior to the first symptoms of ALS could lend support to the theory that specific subpopulations are at risk of developing ALS and provide new insight into shared pathogenic mechanisms. We performed a population-based case-control study in the Netherlands, including 722 sporadic ALS patients and 2,268 age and gender matched controls. Data on medical conditions and use of medication were obtained through a structured questionnaire. Multivariate analyses showed that hypercholesterolemia (OR 0.76, 95% CI 0.63-0.92, P = 0.006), the use of statins (OR 0.45, 95% CI 0.35-0.59, P = 1.86 × 10(-9)) or immunosuppressive drugs (OR 0.26, 95% CI 0.08-0.86, P = 0.03) were associated with a decreased risk of ALS. Head trauma was associated with an increased ALS susceptibility (OR 1.95, 95% CI 1.11-3.43, P = 0.02). No association was found with autoimmune diseases, cancer, psychiatric disorders or cardiovascular diseases, or survival. The lower frequency of hypercholesterolemia and less use of statins in ALS patients indicate a favorable lipid profile prior to symptom onset in at least a subpopulation of ALS. Prior head trauma is a risk factor for ALS and the significantly lower use of immunosuppressive drugs in ALS patients could suggest a protective effect. The iden…

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Crossref · 10.1007/s00415-014-7445-1

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  • In a case-control study of 722 ALS patients and 2268 controls in the Netherlands, Seelen et al. found that head injuries were associated with a 95% odds of developing ALS.

    “In a case–control study of 722 ALS patients and 2268 controls in the Netherlands, Seelen et al. also found that head injuries were associated with a 95% odds of developing ALS [58].”

    From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [58]

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Authors
Seelen, M., van Doormaal, P. T. C., Visser, A. E., Huisman, M. H. B., Roozekrans, M. H. J., de Jong, S. W., van der Kooi, A. J., de Visser, M., Voermans, N. C., Veldink, J. H., & van den Berg, L. H.
Venue
Journal of Neurology
Publisher
Springer Science and Business Media LLC
Published
2014-07-25
Volume
261
Issue
10
Pages
1949-1956
ISSN
  • 0340-5354
  • 1432-1459
DOI
10.1007/s00415-014-7445-1
Cited by
86
References
6
Language
en
Licence
www.springer.com/tdm (tdm)

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