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Cited by 223Exercise and Physiological ResponsesCardiovascular and exercise physiologyAdipokines, Inflammation, and Metabolic Diseases

Exercise and interleukin-6

Pedersen, Bente Klarlund, Steensberg, Adam, Schjerling, Peter·2001·Current Opinion in Hematology
DOI 10.1097/00062752-200105000-00002
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Abstract

Strenuous exercise induces increased levels in a number of pro-and anti-inflammatory cytokines, natural occurring cytokine inhibitors, and chemokines. Thus, increased plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-1 receptor antagonist (IL-1ra), TNF-receptors (TNF-R), IL-10, IL-8, and macrophage inflammatory protein (MIP)-1 are found after strenuous exercise. The concentration of IL-6 increases as much as 100-fold after a marathon race. It has recently been demonstrated that IL-6 is produced locally in contracting skeletal muscles and that the net release from the muscle can account for the exercise-induced increase in arterial concentration. Larger amounts of IL-6 are produced in response to exercise than any other cytokine, IL-6 is produced locally in the skeletal muscle in response to exercise, and IL-6 is known to induce hepatic glucose output and to induce lipolysis. These facts indicate that IL-6 may represent an important link between contracting skeletal muscles and exercise-related metabolic changes.

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Crossref · 10.1097/00062752-200105000-00002

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37 of 37 references verified0 citation errors · 0 not checkable

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  • Circulating IL-6 increases in an exponential fashion up to 100 fold in response to exercise and declines in the postexercise period.

    “The level of circulating IL-6 increases in an exponential fashion (up to 100 fold) in response to exercise, and declines in the postexercise period [60–62].”

    From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [62]

  • The magnitude by which plasma IL-6 increases is related to exercise duration, intensity, and muscle mass involved in the mechanical work.

    “The magnitude by which plasma IL-6 increases is related to exercise duration, intensity, and muscle mass involved in the mechanical work [13, 18, 60, 62].”

    From Exercise as a Mean to Control Low‐Grade Systemic Inflammation (2008) · cites this paper as [62]

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Authors
Pedersen, B. K., Steensberg, A., & Schjerling, P.
Affiliations
University of Copenhagen (DK)
Corresponding author
  • Pedersen, Bente Klarlund
  • Steensberg, Adam
  • Schjerling, Peter
ORCID
Venue
Current Opinion in Hematology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-05
Volume
8
Issue
3
Pages
137-141
ISSN
1065-6251 (ISSN-L)
DOI
10.1097/00062752-200105000-00002
OpenAlex
W2044381640
Cited by
223
References
37
Citations by year
2026: 10 · 2025: 12 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 17 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 4 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 10 · 2012: 7
FWCI
1.28
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Hematology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Danmarks Grundforskningsfond
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
interleukin-6, strenuous exercise, cytokines, inflammatory cytokines, anti-inflammatory cytokines, TNF-α, IL-1β, interleukin-1 receptor antagonist, TNF receptor, IL-10, interleukin-8, MIP-1, skeletal muscle, local cytokine production, hepatic glucose production, lipolysis, exercise metabolism
MeSH terms
Humans, Exercise, Interleukin-6, Cytokines, Muscle, Skeletal

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