Effects of various sodium bicarbonate loading protocols on the time-dependent extracellular buffering profile
Abstract
Although much research has investigated the types of exercise that are enhanced with sodium bicarbonate (NaHCO3) ingestion, to date, there has been limited research on the dosage and timing of ingestion that optimizes the associated ergogenic effects. This study investigated the effects of various NaHCO3 loading protocols on the time-dependent blood-buffering profile. Eight male volunteers (age, 22.4 +/- 5.7 yr; height, 179.8 +/- 9.6 cm, body mass, 76.3 +/- 14.1 kg) completed Part A, measures of alkalosis throughout 120 minutes after ingestion of various single NaHCO3 dosages (0.3 gxkg-1, 0.2 gxkg-1, 0.1 gxkg-1, and placebo); and Part B, similar profiles after alternative NaHCO3 loading protocols (single morning dosage [SMD], single evening dosage [SED], and dosages ingested on 3 consecutive evenings [CED]). Results from Part A are as follows. Blood buffering in the 0.1 gxkg-1 condition was significantly lower than the 0.2 g.kg-1 and 0.3 gxkg-1 conditions (p < 0.002), but there was no significant differences between the 0.2 gxkg -1and 0.3 g.kg-1 conditions (p = 0.34). Although the blood buffering was relatively constant in the 0.1 and 0.2 conditions, it was significantly higher at 60 minutes than at 100 minutes and 120 minutes in the 0.3 gxkg-1 condition (p < 0.05). Results from Part B are as follows. Blood buffering for SMD was significantly higher than for SED and CED (p < 0.05). Blood buffering in the SMD condition was significantly lower at 17:00 hours than at 11:00 hours…
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The increase in buffering capacity achieved by ingesting sodium bicarbonate before exercise has previously been well documented.
“The increase in buffering capacity achieved by ingesting sodium bicarbonate before exercise has previously been well documented (Siegler et al., 2010).”
From Acute enteric-coated sodium bicarbonate has negligible effect on anaerobic performance but affects metabolomics and attenuates the gastrointestinal response (2022) · cites this paper as Siegler et al., 2010
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“Because the use of NaHCO3 loading as a supplement appears widespread (4,8,25), we also recommend that athletes generally should not ingest single NaHCO3 dosages greater than 0.”
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“In the control protocol, the NaCl dose administered was used as a placebo substance, according to previous studies (Cameron et al., 2010; Siegler et al., 2010).”
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“The increase in buffering capacity achieved by ingesting sodium bicarbonate before exercise has previously been well documented (Siegler et al., 2010).”
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- Authors
- Siegler, J. C., Midgley, A. W., Polman, R. C. J., & Lever, R.
- Affiliations
- University of Hull (GB)
- University of Lancashire (GB)
- Corresponding author
- Siegler, Jason C
- Venue
- Journal of Strength and Conditioning Research
- Published
- 2010-09
- Volume
- 24
- Issue
- 9
- Pages
- 2551-2557
- ISSN
- 1064-8011 (ISSN-L)
- OpenAlex
- W2091966313
- Cited by
- 63
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 1 · 2014: 2 · 2013: 7 · 2012: 6
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Strength and Conditioning Research (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- Edge Hill University Research Information Repository (Edge Hill University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- sodium bicarbonate, blood buffering, alkalosis, loading protocols, ergogenic aids, exercise performance
- MeSH terms
- Acid-Base Equilibrium, Alkalosis, Respiratory, Dose-Response Relationship, Drug, Drug Administration Schedule, Humans, Male, Plasma, Time Factors, Single-Blind Method, Sodium Bicarbonate, Young Adult
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