Involvement of Hydra achaete–scute gene CnASH in the differentiation pathway of sensory neurons in the tentacles
Abstract
The proneural genes of achaete-scute (ac-sc) family that encodes the bHLH class transcription factors play a variety of roles in neurogenesis. In Hydra, the ac-sc homologue CnASH is involved in nematocyte differentiation. In the present study, we found that sensory neurons in the tentacles expressed CnASH, in addition to differentiating nematocytes in the body column of Hydra. Neuron precursors that migrated to the tentacle base did not express CnASH, and it took 1 day for them to become CnASH-expressing neurons. Thus, the CnASH-positive cells at the tentacle base appeared to be sensory cells at early stages of differentiation. Furthermore, the CnASH-positive neurons distributed from the base to the tip of tentacles suggest that the gene is also involved in maintenance of the differentiated state. In addition, we found that the sensory neurons in the tentacles consist of at least two subpopulations. The comparison of the CnASH expression with Nv1 expression in sensory cells that is detected by monoclonal antibody Nv1 showed that at least Nv1-positive/ CnASH-positive and Nv1-negative/ CnASH-positive sensory neurons existed in the tentacles.
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Certain differentiation gene batteries composed of orthologous effector genes and the regulatory state drivers that activate them are known in all bilaterian animals investigated and even in cnidarians, e.g., in muscle cells, neurons, photoreceptor cells, and neurosecretory cells.
“Certain differentiation gene batteries composed of orthologous effector genes and the regulatory state drivers that activate them are known in all bilaterian animals investigated and even in cnidarians, e.g., in muscle cells (5) neurons (13), photoreceptor cells (14 -17), and neurosecretory cells (17).”
From Transphyletic conservation of developmental regulatory state in animal evolution (2011) · cites this paper as [13]
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- Authors
- Hayakawa, E., Fujisawa, C., & Fujisawa, T.
- Affiliations
- The Graduate University for Advanced Studies, SOKENDAI (JP)
- National Institute of Genetics (JP)
- Corresponding author
- Fujisawa, Toshitaka
- ORCID
- Hayakawa, Eisuke
- Venue
- Development Genes and Evolution
- Published
- 2004-09-18
- Volume
- 214
- Issue
- 10
- Pages
- 486-492
- ISSN
- 0043-5546 (ISSN-L)
- 0949-944X
- 1432-041X
- OpenAlex
- W2074825208
- Cited by
- 53
- References
- 48
- Citations by year
- 2025: 2 · 2023: 1 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 8 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Development Genes and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Hydra, proneural genes, sensory neurons, tentacles, nematocytes, bHLH transcription factors, neuronal differentiation
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Extremities, Hydra, Immunohistochemistry, Morphogenesis, Neurons, Afferent, Transcription Factors, In Situ Hybridization, Gene Expression Regulation, Developmental
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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