FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian
Open accessAbstract
The fibroblast growth factor (FGF) signal transduction pathway serves as one of the key regulators of early metazoan development, displaying conserved roles in the specification of endodermal, mesodermal, and neural fates during vertebrate development. FGF signals also regulate gastrulation, in part, by triggering epithelial to mesenchymal transitions in embryos of both vertebrates and invertebrates. Thus, FGF signals coordinate gastrulation movements across many different phyla. To help understand the breadth of FGF signaling deployment across the animal kingdom, we have examined the presence and expression of genes encoding FGF pathway components in the anthozoan cnidarian Nematostella vectensis. We isolated three FGF ligands (NvFGF8A, NvFGF8B, and NvFGF1A), two FGF receptors (NvFGFRa and NvFGFRb), and two orthologs of vertebrate FGF responsive genes, Sprouty (NvSprouty), an inhibitor of FGF signaling, and Churchill (NvChurchill), a Zn finger transcription factor. We found these FGF ligands, receptors, and response gene expressed asymmetrically along the oral/aboral axis during gastrulation and in a developing chemosensory structure of planula stages known as the apical tuft. These results suggest a conserved role for FGF signaling molecules in coordinating both gastrulation and neural induction that predates the Cambrian explosion and the origins of the Bilateria.
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Choanoflagellates and sponges possess some of these signaling systems, and they are all found in cnidarian genomes.
“Even choanoflagellates possess some of these signaling systems (King et al. 2003, 2008; Erwin 2009; Marshall and Valentine 2009) as do sponges, and they are all found in cnidarian genomes (Matus et al. 2007).”
From An integrated view of precambrian eumetazoan evolution (2009) · cites this paper as Matus et al. 2007
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- Authors
- Matus, D. Q., Thomsen, G. H., & Martindale, M. Q.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Stony Brook University (US)
- Corresponding author
- Martindale, Mark Q.
- Venue
- Development Genes and Evolution
- Published
- 2007-01-20
- Volume
- 217
- Issue
- 2
- Pages
- 137-148
- ISSN
- 0043-5546 (ISSN-L)
- 0949-944X
- 1432-041X
- PMC
- PMC4580332
- OpenAlex
- W2161580764
- Cited by
- 92
- References
- 6
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 6 · 2013: 10 · 2012: 5
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Development Genes and Evolution (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM076599)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- FGF signaling, gastrulation, neural induction, Nematostella vectensis, FGF ligands, fibroblast growth factor receptor, Sprouty, apical tuft, oral-aboral axis, epithelial-mesenchymal transition, planula
- MeSH terms
- Animals, Embryonic Induction, Fibroblast Growth Factors, Gastrula, Ligands, Genetic Linkage, Nervous System, Phylogeny, Sea Anemones, Signal Transduction, Receptors, Fibroblast Growth Factor, Gene Expression Regulation, Developmental, Evolution, Molecular
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