Does the left superior longitudinal fascicle subserve language semantics? A brain electrostimulation study
Abstract
Recent diffusion tensor imaging (DTI) tractography studies indicate that the supramarginal gyrus (SMG) represents a relay between frontal and temporal language sites. Some authors postulate that pathways connecting SMG to the posterior temporal lobe, i.e., the posterior part of the superior longitudinal fascicle (SLF) subserve semantic aspects of language. However, DTI provides only anatomic but not functional data. Therefore, it is impossible to conclude. Interestingly, intra-operative electrical mapping of cortical and subcortical language structures during tumor surgery is recognized as a reliable technique in functional neuroanatomy research. We mapped the underlying white matter of the SMG, especially the SLF, in 11 patients who underwent awake surgery for a glioma involving the left inferior parietal lobule. Using direct electrostimulation, we investigated the exact role of the SLF in language. Our findings indicate that the white matter under the inferior parietal lobule is highly involved in the dorsal phonological system. First, the SMG, connected to the ventral premotor cortex by horizontal fibers of the SLF, subserves articulatory processing, as demonstrated by dysarthria elicited by stimulation. Second, long arcuate fibers, found deeper in the white matter, subserve phonological processing, as supported by phonemic paraphasia induced by electrostimulation. Third, the most important result is that no semantic disturbances were elicited by stimulating the SLF, inclu…
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Maldonado et al. confirmed the left SLF III role in speech through a brain electrostimulation study.
“This view has been confirmed by Maldonado et al. (78) through a brain electrostimulation study.”
From Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates (2022) · cites this paper as [78]
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- Authors
- Maldonado, I. L., Moritz-Gasser, S., & Duffau, H.
- Affiliations
- Hôpital Gui de Chauliac (FR)
- Inserm (FR)
- Corresponding author
- Duffau, Hugues
- Venue
- Brain Structure and Function
- Published
- 2011-03-16
- Volume
- 216
- Issue
- 3
- Pages
- 263-274
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2053696939
- Cited by
- 161
- References
- 6
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 7 · 2023: 9 · 2022: 13 · 2021: 16 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 14 · 2013: 12 · 2012: 9
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Keywords
- superior longitudinal fasciculus, language semantics, supramarginal gyrus, inferior parietal lobule, direct electrical stimulation, intraoperative language mapping, arcuate fasciculus, phonological processing, phonemic paraphasia, dysarthria, left hemisphere language, white matter tracts
- MeSH terms
- Adult, Brain Mapping, Brain Neoplasms, Electric Stimulation, Female, Glioma, Humans, Intraoperative Period, Language, Male, Middle Aged, Neural Pathways, Parietal Lobe, Semantics
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