Amygdala core nuclei volumes are decreased in recurrent major depression

Sheline, Yvette I.; Gado, Mokhtar H.; Price, Joseph L.

doi:10.1097/00001756-199806220-00021

Cited by 472Stress Responses and CortisolTreatment of Major DepressionNeural and Behavioral Psychology Studies

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Amygdala core nuclei volumes are decreased in recurrent major depression

Sheline, Yvette I., Gado, Mokhtar H., Price, Joseph L.·1998·NeuroReport

DOI 10.1097/00001756-199806220-00021

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Abstract

The amygdala is a key structure in the brain's integration of emotional meaning with perception and experience. Patients with depression have impaired functioning in emotional tasks involving the amygdala, and have abnormal resting amygdala blood flow. To better understand the anatomical basis for these functional changes we measured the volumes of the total amygdala and of the core amygdala nuclei in 20 patients with a history of depression and 20 pair-wise matched controls. Depressed subjects had bilaterally reduced amygdala core nuclei volumes and no significant differences in total amygdala volumes or in whole brain volumes. Since patients with a depression history have bilateral hippocampal volume reduction the volume loss in this closely related structure suggests a shared effect on both structures, potentially glucocorticoid-induced neurotoxicity mediated by the extensive reciprocal glutamatergic connections.

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Dysfunction in the activity of the hippocampus, amygdala and PFC is strongly implicated in major depressive disorder.
“Dysfunction in the activity of these regions is strongly implicated in major depressive disorder (Sheline et al., 1998; Videbech and Ravnkilde, 2004).”
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Authors: Sheline, Y. I., Gado, M. H., & Price, J. L.
Affiliations: Washington University in St. Louis (US)
ORCID: Sheline, Yvette I.
Venue: NeuroReport
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1998-06
Volume: 9
Issue: 9
Pages: 2023-2028
ISSN: 0959-4965 (ISSN-L)
DOI: 10.1097/00001756-199806220-00021
OpenAlex: W2048738245
Semantic Scholar: a28790d3fb604932494489fedfac499bb0911161
Cited by: 472
References: 7
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 9 · 2021: 14 · 2020: 8 · 2019: 12 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 13 · 2014: 27 · 2013: 13 · 2012: 29
FWCI: 7.05
Type: journal article
Language: en
Open access: closed
Locations: Neuroreport (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: amygdala, recurrent major depressive disorder, brain atrophy, hippocampus, emotional processing
MeSH terms: Adult, Aged, Aged, 80 and over, Amygdala, Brain, Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Recurrence

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Amygdala core nuclei volumes are decreased in recurrent major depression

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