Antipsychotic Drugs Alter Functional Connectivity between the Medial Frontal Cortex, Hippocampus, and Nucleus Accumbens as Measured by H215O PET
Open accessAbstract
To evaluate changes in functional connectivity as a result of treatment with antipsychotic drugs (APDs) in subjects with schizophrenia (SZ), we identified a limited number of regions that have been implicated in the mechanism of action of APDs and that are part of a neuronal network known to be modulated by dopamine (DA). These regions consisted of the nucleus accumbens (NAcc), the hippocampus (Hip), and the medial frontal cortex (MFC). SZ participants were blindly randomized into a haloperidol treatment group (n = 12) and an olanzapine treatment group (n = 17). Using PET with 15O, we evaluated changes in functional connectivity between these regions during rest and task performance at three treatment time points: (1) at baseline, after withdrawal of all psychotropic medication (2 weeks), (2) after 1 week on medication, and (3) after 6 weeks on medication. Results from the two treatment groups were combined during analysis to investigate the common effects of APDs on functional connectivity. We found that the functional connectivity between MFC and NAcc significantly increased at week one, and then significantly decreased from week one to week 6. The functional connectivity between MFC and Hip significantly decreased at week one and week 6 relative to baseline. Critically, the strength of the functional connectivity between the MFC and Hip after 1 week of treatment was predictive of treatment response. This pattern of changes may represent an important biomarker for indexing treatment response. The regulation by APDs of the balance between prefrontal and limbic inputs to the striatum may be crucial to restoring adaptive behavior.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Cortico-striatal synchrony is disrupted by treatment with phencyclidine.
“Moreover, cortico-striatal synchrony is disrupted by treatment with phencyclidine [96], and anti-psychotic drugs that act on dopamine also alter the functional connectivity between these regions and the hippocampus [97].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090 · see citing works
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812 · see citing works
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · see citing works
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892 · see citing works
Maldjian, J., Laurienti, P., Kraft, R., & Burdette, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,453 · see citing works
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336 · see citing works
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331 · see citing works
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220 · see citing works
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works
Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., Shenton, M. E., Green, A. I., Nieto-Castanon, A., LaViolette, P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809141106 · Cited by 1,435 · see citing works
Functional Connectivity and Brain Networks in Schizophrenia
Lynall, M.-E., Bassett, D. S., Kerwin, R., McKenna, P. J., Kitzbichler, M. G., Müller, U., & Bullmore, E. T. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0333-10.2010 · Cited by 1,366 · see citing works
(1995) · PubMed · Cited by 1,320 · see citing works
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · see citing works
Dichotomous dopaminergic control of striatal synaptic plasticity
Shen, W., Flajolet, M., Greengard, P., & Surmeier, D. J. (2008) · Science · doi:10.1126/science.1160575 · Cited by 1,190 · see citing works
Aberrant “Default Mode” Functional Connectivity in Schizophrenia
Garrity, A. G., Pearlson, G. D., McKiernan, K., Lloyd, D., Kiehl, K. A., & Calhoun, V. D. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.450 · Cited by 1,114 · see citing works
McEvoy, J. M., Lieberman, J. A., Stroup, T. S., Thomas, S., Meltzer, H. Y., Rosenheck, R. A., Swartz, M. S., Perkins, D. O., Keefe, R. S. E., Davis, C. E., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.4.600 · Cited by 1,019 · see citing works
Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
Raichle, M. E., Martin, W. R. W., Herscovitch, P., Mintun, M. A., & Markham, J. (1983) · PubMed · Cited by 1,015 · see citing works
van den Heuvel, M. P., Mandl, R. C. W., Kahn, R. S., & Hulshoff Pol, H. E. (2009) · Human Brain Mapping · doi:10.1002/hbm.20737 · Cited by 987 · see citing works
Variational free energy and the Laplace approximation
Friston, K., Mattout, J., Trujillo-Barreto, N., Ashburner, J., & Penny, W. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.035 · Cited by 880 · see citing works
Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
Goto, Y., & Grace, A. A. (2005) · Nature Neuroscience · doi:10.1038/nn1471 · Cited by 576 · see citing works
Meyer-Lindenberg, A. S., Olsen, R. K., Kohn, P. D., Brown, T., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.4.379 · Cited by 574 · see citing works
Bluhm, R. L., Miller, J., Lanius, R. A., Osuch, E. A., Boksman, K., Neufeld, R. W. J., Théberge, J., Schaefer, B., & Williamson, P. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm052 · Cited by 568 · see citing works
Gating of information flow within the limbic system and the pathophysiology of schizophrenia.
Grace, A. (2000) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(99)00049-1 · Cited by 532 · see citing works
Lawrie, S. M., Buechel, C., Whalley, H. C., Frith, C. D., Friston, K. J., & Johnstone, E. C. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01316-1 · Cited by 529 · see citing works
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.0207e04 · Cited by 521 · see citing works
Spatial Remapping of Cortico-striatal Connectivity in Parkinson's Disease
Helmich, R. C. G., Derikx, L. C. E. M., Bakker, M., Scheeringa, R., Bloem, B. R., & Toni, I. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp178 · Cited by 418 · see citing works
Delayed-Onset Hypothesis of Antipsychotic Action: A Hypothesis Tested and Rejected
Agid, O., Kapur, S., Arenovich, T., & Zipursky, R. B. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1228 · Cited by 408 · see citing works
Liang, M., Zhou, Y., Jiang, T., Liu, Z., Tian, L., Liu, H., & Hao, Y. (2006) · Neuroreport · doi:10.1097/01.wnr.0000198434.06518.b8 · Cited by 402 · see citing works
Lui, S., Li, T., Deng, W., Jiang, L., Wu, Q., Tang, H., Yue, Q., Huang, X., Chan, R. C. K., Collier, D. A., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.84 · Cited by 364 · see citing works
Limbic and cortical information processing in the nucleus accumbens
Goto, Y., & Grace, A. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.08.002 · Cited by 332 · see citing works
Aberrant “Default Mode” Functional Connectivity in Schizophrenia
Garrity, A. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.3.450 · Cited by 290 · see citing works
Zhou, Y., Liang, M., Jiang, T., Tian, L., Liu, Y., Liu, Z., Liu, H., & Kuang, F. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.081 · Cited by 289 · see citing works
Probing the human hippocampus using rCBF: Contrasts in schizophrenia
Medoff, D. R., Holcomb, H. H., Lahti, A. C., & Tamminga, C. A. (2001) · Hippocampus · doi:10.1002/hipo.1070 · Cited by 257 · see citing works
Self-citationSchlösser, R. G. M., Gesierich, T., Kaufmann, B., Vučurević, G., Hunsche, S., Gawehn, J., & Stoeter, P. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00106-x · Cited by 254 · see citing works
Holcomb, H. H., Cascella, N. G., Thaker, G. K., Medoff, D. R., Dannals, R. F., & Tamminga, C. A. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.1.41 · Cited by 234 · see citing works
Self-citationDopamine depletion impairs frontostriatal functional connectivity during a set-shifting task
Nagano-Saito, A., Leyton, M., Monchi, O., Goldberg, Y. K., He, Y., & Dagher, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3921-07.2008 · Cited by 222 · see citing works
Glutamate/dopamine D1/D2 balance in the basal ganglia and its relevance to Parkinson' disease
Starr, M. S. (1995) · Synapse · doi:10.1002/syn.890190405 · Cited by 214 · see citing works
Sambataro, F., Blasi, G., Fazio, L., Caforio, G., Taurisano, P., Romano, R., Giorgio, A. D., Gelao, B., Bianco, L. L., Papazacharias, A., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.192 · Cited by 192 · see citing works
Postsynaptic integration of glutamatergic and dopaminergic signals in the striatum
Kötter, R. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90037-x · Cited by 186 · see citing works
Striatal Metabolic Rate and Clinical Response to Neuroleptics in Schizophrenia
Buchsbaum, M. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120054008 · Cited by 182 · see citing works
A multivariate analysis of PET activation studies
Friston, K. J., Poline, J., Holmes, A. P., Frith, C., & Frackowiak, R. S. J. (1996) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1996)4:2 · Cited by 166 · see citing works
Functional connectivity in the thalamus and hippocampus studied with functional MR imaging.
Stein, T. D., Moritz, C. H., Quigley, M., Cordes, D., Haughton, V. H., & Meyerand, M. E. (2000) · PubMed Central · Cited by 160 · see citing works
Overall brain connectivity maps show cortico‐subcortical abnormalities in schizophrenia
Salvador, R. M., Sarró, S., Gomar, J. J., Ortiz‐Gil, J., Vila‐Rodriguez, F., Capdevila, A., Bullmore, E. T., McKenna, P. J., & Pomarol‐Clotet, E. (2010) · Human Brain Mapping · doi:10.1002/hbm.20993 · Cited by 138 · see citing works
Liu, H., Kaneko, Y. A., Ouyang, X., Li, L., Hao, Y., Chen, E. Y. H., Jiang, T., Zhou, Y., & Liu, Z. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq074 · Cited by 135 · see citing works
Functional effects of antipsychotic drugs: comparing clozapine with haloperidol
Lahti, A. C., Holcomb, H. H., Weiler, M. A., Medoff, D. R., & Tamminga, C. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01602-5 · Cited by 134 · see citing works
Self-citationLahti, A. C., Weiler, M. A., Holcomb, H. H., Tamminga, C. A., Carpenter, W. T., & McMahon, R. P. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300837 · Cited by 133 · see citing works
Self-citationEffectiveness of Antipsychotic Drugs in Patients With Chronic Schizophrenia
Kennedy, L. (2006) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70268-3 · Cited by 128 · see citing works
The Nucleus Accumbens: A Switchboard for Goal-Directed Behaviors
Gruber, A. J., Hussain, R. J., & O’Donnell, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005062 · Cited by 119 · see citing works
Lahti, A. C., Weiler, M. A., Holcomb, H. H., Tamminga, C. A., & Cropsey, K. L. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.94 · Cited by 106 · see citing works
Self-citationDopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1996) · Journal of Neuropsychiatry · doi:10.1176/jnp.8.2.223 · Cited by 100 · see citing works
Immediate effects of risperidone on cortico–striato–thalamic loops and the hippocampus
Liddle, P. F., Lane, C. J., & Ngan, E. T. C. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.177.5.402 · Cited by 96 · see citing works
The Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective
Goto, Y., & Grace, A. A. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(06)78002-3 · Cited by 94 · see citing works
Lahti, A. C., Weiler, M. A., Medoff, D. R., Tamminga, C. A., & Holcomb, H. H. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.02.006 · Cited by 65 · see citing works
Self-citationNgan, E. T. C. (2002) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.72.1.106 · Cited by 63 · see citing works
Holcomb, H. H., Lahti, A. C., Medoff, D. R., Weiler, M. A., Dannals, R. F., & Tamminga, C. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1634 · Cited by 59 · see citing works
Self-citationWolf, M. E. (2003) · Molecular Interventions · doi:10.1124/mi.3.5.248 · Cited by 51 · see citing works
Fox, A. S., Oakes, T. R., Shelton, S. E., Converse, A. K., Davidson, R. J., & Kalin, N. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409470102 · Cited by 36 · see citing works
A systematic method for estimating individual responses to treatment with antipsychotics in CATIE
van den Oord, E. J. C. G., Adkins, D. E., McClay, J. L., Lieberman, J. A., & Sullivan, P. F. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.09.009 · Cited by 35 · see citing works
Liang, H., & Wong‐Riley, M. T. T. (2006) · Neuroreport · doi:10.1097/01.wnr.0000204980.98876.11 · Cited by 31 · see citing works
Thought disorder and nucleus accumbens in childhood: a structural MRI study
Ballmaier, M., Toga, A. W., Siddarth, P., Blanton, R. E., Levitt, J. G., Lee, M., & Caplan, R. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2003.10.001 · Cited by 27 · see citing works
Delayed onset hypothesis of antipsychotic action — a hypothesis tested and rejected
Agid, O., Kapur, S., Arenovich, T., & Zipursky, R. B. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)80242-6 · Cited by 24 · see citing works
Kelly, D., Weiner, E., Ball, M. P., McMahon, R. P., Carpenter, W. T., & Rw, B. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108093883 · Cited by 24 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Lahti A. C. Lahti R. A. Tamminga C. A. (1996). “New neuroleptics and experimental antipsychotics: future roles,” in The New Pharmacotherapy of Schizophrenia, ed. Breier A. (Washington: APA Press), 57– 87
- Tamminga C. Dannals R. F. Frost J. Wong D. Wagner H. N. (1993). “Neuroreceptor and neurochemistry studies with positron emission tomography in psychiatric illness: promise and progress,” in Review of Psychiatry, eds Oldham J. Riba M. Tasman A. (Washington, DC: American Psychiatric Press), 487– 510
Cited by
Sorted by citations
Antipsychotic Treatment and Functional Connectivity of the Striatum in First-Episode Schizophrenia
Sarpal, D. K., Robinson, D. G., Lencz, T., Árgyelán, M., Ikuta, T., Karlsgodt, K. H., Gallego, J. A., Kane, J. M., Szeszko, P. R., & Malhotra, A. K. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1734 · Cited by 328 · see citing works
Khadka, S., Meda, S. A., Stevens, M. C. G., Glahn, D. C., Calhoun, V. D., Sweeney, J. A., Tamminga, C. A., Keshavan, M. S., O'Neil, K. M., Schretlen, D. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.024 · Cited by 219 · see citing works
Baseline Striatal Functional Connectivity as a Predictor of Response to Antipsychotic Drug Treatment
Sarpal, D. K., Argyelan, M., Robinson, D. G., Szeszko, P. R., Karlsgodt, K. H., John, M., Weissman, N., Gallego, J. A., Kane, J. M., Lencz, T., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14121571 · Cited by 212 · see citing works
Alderson-Day, B., McCarthy-Jones, S., & Fernyhough, C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.04.016 · Cited by 165 · see citing works
Floris, D. L., Barber, A. D., Nebel, M. B., Martinelli, M., Lai, M., Crocetti, D., Baron‐Cohen, S., John Suckling, A., Pekar, J. J., & Mostofsky, S. H. (2016) · Molecular Autism · doi:10.1186/s13229-016-0096-6 · Cited by 148 · see citing works
Millan, M. J., Goodwin, G. M., Meyer-Lindenberg, A., & Ove Ögren, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.016 · Cited by 132 · see citing works
Lo, C. Z., Su, T.-W., Huang, C., Hung, C., Chen, W.-L., Lan, T., Lin, C., & Bullmore, E. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502052112 · Cited by 130 · see citing works
Egerton, A., Broberg, B. V., van Haren, N. E. M., Merritt, K., Barker, G. J., Lythgoe, D. J., Pérez‐Iglesias, R., Baandrup, L., Düring, S. W., Sendt, K.-V., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0082-9 · Cited by 127 · see citing works
Dysconnectivity of Large-Scale Functional Networks in Early Psychosis: A Meta-analysis
O’Neill, A., Mechelli, A., & Bhattacharyya, S. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby094 · Cited by 127 · see citing works
Kraguljac, N. V., White, D. M., Hadley, N. T., Hadley, J. A., Hoef, L. V., Davis, E., & Lahti, A. C. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv228 · Cited by 123 · see citing works
Self-citationHutcheson, N. L., Sreenivasan, K. R., Deshpande, G., Reid, M. A., Hadley, J., White, D. M., Ver Hoef, L., & Lahti, A. C. (2015) · Human Brain Mapping · doi:10.1002/hbm.22714 · Cited by 79 · see citing works
Self-citationSubcortical Dopamine and Cognition in Schizophrenia: Looking Beyond Psychosis in Preclinical Models
Conn, K., Burne, T. H. J., & Kesby, J. P. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00542 · Cited by 63 · see citing works
Blessing, E., Murty, V. P., Zeng, B., Wang, J., Davachi, L., & GOFF, D. C. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz076 · Cited by 55 · see citing works
Psychotropic Medication Use in Autism Spectrum Disorders May Affect Functional Brain Connectivity
Linke, A. C., Olson, L., Gao, Y., Fishman, I., & Müller, R. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.06.008 · Cited by 56 · see citing works
Palaniyappan, L. K., Marques, T. R., Taylor, H., Mondelli, V., Reinders, A. A. T. S., Bonaccorso, S., Giordano, A., Forti, M. D., Simmons, A., David, A. S., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw069 · Cited by 50 · see citing works
Chang, X., Collin, G., Xi, Y.-B., Cui, L.-B., Scholtens, L. H., Sommer, I., Wang, H.-N., Yin, H., Kahn, R., & van den Heuvel, M. P. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.01.024 · Cited by 51 · see citing works
Sankar, A., Scheinost, D., Goldman, D. A., Drachman, R., Čolić, L., Villa, L. M., Kim, J. A., Gonzalez, Y., Marcelo, I., Shinomiya, M., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01767-z · Cited by 38 · see citing works
Bryant, J. E., Frölich, M. A., Tran, S., Reid, M. A., Lahti, A. C., & Kraguljac, N. V. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.07.008 · Cited by 29 · see citing works
Self-citationWang, J., Jiang, Y., Tang, Y., Xia, M., Curtin, A., Li, J., Sheng, J., Zhang, T., Li, C., Hui, L., et al. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2019.12.044 · Cited by 25 · see citing works
Li, J., Ishiwari, K., Conway, M. W., François, J., Huxter, J. R., Lowry, J. P., Schwarz, A. J., Tricklebank, M. D., & Gilmour, G. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.10 · Cited by 22 · see citing works
Millan, M. J., Goodwin, G. M., Hamon, M., Meyer‐Lindenberg, A., & Ögren, S. O. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.015 · Cited by 22 · see citing works
Tang, Y., Zhou, Q., Chang, M., Chekroud, A. M., Gueorguieva, R. V., Jiang, X., Zhou, Y., He, G. S., Rowland, M. A., Wang, D., et al. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.12.041 · Cited by 20 · see citing works
Rossi, P. D., Chiapponi, C., & Spalletta, G. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150507223542 · Cited by 19 · see citing works
Asif-Malik, A., Dautan, D., Young, A. M. J., & Gerdjikov, T. V. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1393-3 · Cited by 18 · see citing works
Neuroimaging as a Window Into the Pathophysiological Mechanisms of Schizophrenia
Kraguljac, N. V., & Lahti, A. C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.613764 · Cited by 17 · see citing works
Self-citationRichards, S., Hughes, M., Woodward, T., Rossell, S., & Carruthers, S. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.006 · Cited by 14 · see citing works
Openshaw, R. L., Thomson, D. M., Thompson, R., Penninger, J. M., Pratt, J. A., MORRIS, B. J., & Dawson, N. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz044 · Cited by 14 · see citing works
Brunelin, J., & Fecteau, S. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.11.021 · Cited by 14 · see citing works
Variability of structurally constrained and unconstrained functional connectivity in schizophrenia
Yao, Y., Palaniyappan, L. K., Liddle, P. F., Zhang, J., Francis, S., & Feng, J. (2015) · Human Brain Mapping · doi:10.1002/hbm.22932 · Cited by 11 · see citing works
Fan, Y., Li, H., Guo, J., Pang, Y., Li, L., Hu, M., Li, M., Wang, C., Sheng, W., Liu, H., et al. (2021) · Brain Connectivity · doi:10.1089/brain.2021.0061 · Cited by 11 · see citing works
Luo, L., Dimitrovski, M., Wise, T., & Iniesta, R. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106309 · Cited by 10 · see citing works
Yao, C., Hu, N., Cao, H., Tang, B., Zhang, W., Xiao, Y., Zhao, Y., Gong, Q., & Lui, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.737179 · Cited by 8 · see citing works
Haddon, J. E., Titherage, D., Heckenast, J. R., Carter, J., Owen, M. J., Hall, J., Wilkinson, L. S., & Jones, M. W. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02969-x · Cited by 6 · see citing works
“Moreover, cortico-striatal synchrony is disrupted by treatment with phencyclidine [96], and anti-psychotic drugs that act on dopamine also alter the functional connectivity between these regions and the hippocampus [97].”
BackgroundAnterior hippocampal dysfunction in early psychosis: a 2-year follow-up study
McHugo, M., Avery, S. N., Armstrong, K., Rogers, B. P., Vandekar, S., Woodward, N. D., Blackford, J. U., & Heckers, S. (2021) · Psychological Medicine · doi:10.1017/s0033291721001318 · Cited by 5 · see citing works
Ibragimov, K., Keane, G., Glaría, C. C., Cheng, J. J., & Llosa, A. E. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013425.pub2 · Cited by 4 · see citing works
Discovery of early schizophrenia through neuroimaging
Lahti, A. C. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114993 · Cited by 5 · see citing works
Self-citationMolecular connectivity studies of cerebral glucose metabolism and blood flow: A scoping review
Cavaliere, C., Galli, A., Meneghini, C., Severino, M., Peretti, D. E., Nørgaard, M., Tang, C., Martini, A. L., Bardiau, M., Doyen, M., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106623 · Cited by 4 · see citing works
Park, H. Y., Bang, M., Seo, E., Koo, S. J., Lee, E. M., Lee, S., & An, S. K. (2022) · Schizophrenia · doi:10.1038/s41537-022-00258-4 · Cited by 4 · see citing works
Gifford, G., Crossley, N. A., Morgan, S. E., Kempton, M. J., Dazzan, P., Modinos, G., Azis, M., Samson, C., Bonoldi, I., Quinn, B., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25235 · Cited by 2 · see citing works
Lute, N., Lemmers-Jansen, I. L. J., A, L. K. M., & van Buuren, M. (2025) · Neuroimage Reports · doi:10.1016/j.ynirp.2025.100248 · Cited by 1 · see citing works
Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art
Postnov, A. A., Kalaeva, D. B., Balakhonov, A. B., & Pronin, I. (2023) · Medical Visualization · doi:10.24835/1607-0763-1297
- Authors
- Bolding, M. S., White, D. M., Hadley, J. A., Weiler, M., Holcomb, H. H., & Lahti, A. C.
- Affiliations
- University of Alabama at Birmingham (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Lahti, Adrienne C.
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2012
- Volume
- 3
- Pages
- 105-105
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC3515723
- OpenAlex
- W1967938101
- Cited by
- 41
- References
- 64
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 1
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Mental Health (R01MH102951, R01MH057971)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- antipsychotic drugs, schizophrenia, functional connectivity, medial frontal cortex, hippocampus, nucleus accumbens, haloperidol, olanzapine, treatment response prediction, treatment response biomarkers, dopamine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
