Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study
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Melatonin administration prior to bedtime in children with ADHD and insomnia leads to a rapid onset decrease in sleep latency that is significantly sustained at three-month follow-up.
“Tjon Pian Gi et al. (2003) examined the efficacy of melatonin administration prior to bedtime in 24 children with ADHD and insomnia in a prospective open quasi-experimental study and report that such treatment lead to a rapid onset decrease in sleep latency, which was significantly sustained at three-month follow-up.”
From A systematic review of circadian function, chronotype and chronotherapy in attention deficit hyperactivity disorder (2017) · cites this paper as Tjon Pian Gi et al. (2003)
Two randomized, double-blind, placebo-controlled trials and a preliminary open-label study have indicated that melatonin treatment is effective in reducing sleep onset delay in children with ADHD.
“Two randomized, double-blind, placebo-controlled trials (Van der Heijden et al. 2007; Weiss et al. 2006) and a preliminary open-label study (Tjon Pian Gi et al. 2003) have indicated that melatonin treatment is effective in reducing sleep onset delay in children with ADHD (Cortese et al. 2013a).”
From Associations of sleep disturbance with ADHD: implications for treatment (2015) · cites this paper as Tjon Pian Gi et al. 2003
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“The diagnostic procedures included clinical history, 1-week 24-hour actigraphy measurement, Dutch Sleep Disorders Questionnaire ( Sweere et al., 1998 ), and Children`s Sleep Hygiene Scale (Harsh et al., 2002).”
BackgroundMethodAssociations of sleep disturbance with ADHD: implications for treatment
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“This corresponds with the results of a small open label study of melatonin treatment in children with ADHD reporting that the effect of melatonin persisted for at least 3 months [11].”
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“Melatonin has also been investigated for the treatment of DSPD in children with attention deficit hyperactivity disorder (ADHD), and has been found to be effective and well tolerated, except for the rare occurrence of new-onset seizures [31].”
BackgroundMelatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder
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“…Van der Heijden et al., 2005, 2007), and other studies have indirectly looked at the effect of stimulant medication on daily rhythms by demonstrating the effectiveness of melatonin for the treatment of SOI in children being treated with methylphenidate (Pian Gi et al., 2003; Weiss et al., 2006).”
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“This approach could be especially useful in relation to ADHD given that SOI problems occur in up to 54% of ADHD cases affecting daily functioning and quality of life (Tjon Pian Gi et al., 2003).”
BackgroundSleep Characteristics of Children and Adolescents with Attention Deficit-Hyperactivity Disorder
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“Tjon Pian Gi and colleagues [56] described short-term (1–4 weeks; n = 24) and long-term (3 months; n = 13) effects of melatonin in 27 MPH-treated children who had ADHD and sleep disturbances [56].”
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“In addition, the sleep of patients with ADHD is greatly improved by the use of melatonin as a medication [8–12], suggesting that the endogenous level of melatonin is not sufficient to reset the biologic clock.”
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“Melatonin and small doses of Clonidine have been advocated for the treatment of sleep problems in ADHD (Prince et al., 1996 [92] ; Tjon Pian Gi et al., 2003 [122] ).”
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“In relation to ADHD, the working group retrieved a total of five trials of melatonin [12–16], including three randomized controlled trials [13,14,16], all showing positive effects of melatonin on sleep disturbances, with, overall, a safe tolerability profile.”
MethodManaging the Risks of ADHD Treatments
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- Authors
- Tjon Pian Gi, C. V., Broeren, J. P. A., Starreveld, J. S., & A. Versteegh, F. G.
- Affiliations
- Groene Hart Ziekenhuis (NL)
- Venue
- European Journal of Pediatrics
- Published
- 2003-06-03
- Volume
- 162
- Issue
- 7-8
- Pages
- 554-555
- ISSN
- 0340-6199 (ISSN-L)
- 1432-1076
- OpenAlex
- W2056563307
- Cited by
- 85
- References
- 6
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- melatonin, sleep disorders, attention deficit hyperactivity disorder, children
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Central Nervous System Depressants, Child, Circadian Rhythm, Humans, Sleep Initiation and Maintenance Disorders, Melatonin, Methylphenidate, Sleep
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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