Cited by 380Genetics, Aging, and Longevity in Model OrganismsGenetic Associations and EpidemiologyGenetics and Physical Performance

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Genetics of healthy aging and longevity

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Brooks-Wilson, Angela R.·2013·Human Genetics

DOI 10.1007/s00439-013-1342-zPMC PMC3898394

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Abstract

Longevity and healthy aging are among the most complex phenotypes studied to date. The heritability of age at death in adulthood is approximately 25 %. Studies of exceptionally long-lived individuals show that heritability is greatest at the oldest ages. Linkage studies of exceptionally long-lived families now support a longevity locus on chromosome 3; other putative longevity loci differ between studies. Candidate gene studies have identified variants at APOE and FOXO3A associated with longevity; other genes show inconsistent results. Genome-wide association scans (GWAS) of centenarians vs. younger controls reveal only APOE as achieving genome-wide significance (GWS); however, analyses of combinations of SNPs or genes represented among associations that do not reach GWS have identified pathways and signatures that converge upon genes and biological processes related to aging. The impact of these SNPs, which may exert joint effects, may be obscured by gene-environment interactions or inter-ethnic differences. GWAS and whole genome sequencing data both show that the risk alleles defined by GWAS of common complex diseases are, perhaps surprisingly, found in long-lived individuals, who may tolerate them by means of protective genetic factors. Such protective factors may 'buffer' the effects of specific risk alleles. Rare alleles are also likely to contribute to healthy aging and longevity. Epigenetics is quickly emerging as a critical aspect of aging and longevity. Centenarians delay age-related methylation changes, and they can pass this methylation preservation ability on to their offspring. Non-genetic factors, particularly lifestyle, clearly affect the development of age-related diseases and affect health and lifespan in the general population. To fully understand the desirable phenotypes of healthy aging and longevity, it will be necessary to examine whole genome data from large numbers of healthy long-lived individuals to look simultaneously at both common and rare alleles, with impeccable control for population stratification and consideration of non-genetic factors such as environment.

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Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248
Genome-wide methylation profiles reveal quantitative views of human aging rates
Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270
Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · cited 2×
“The use of principal components analysis (Price et al. 2006) or genomic controls (Devlin and Roeder 1999) can mitigate this problem, as can the conduct of studies within specific ethnic groups (Barzilai et al. 2001).”
Background
Hsp90 as a capacitor for morphological evolution
Rutherford, S. L., & Lindquist, S. (1998) · Nature · doi:10.1038/24550 · Cited by 2,270
Signals from the reproductive system regulate the lifespan of C. elegans
Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,014
The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900
Herskind, A. M., McGue, M., Holm, N. V., Sørensen, T. I. A., Harvald, B., & Vaupel, J. W. (1996) · Human Genetics · doi:10.1007/bf02185763 · Cited by 879
Distinct DNA methylomes of newborns and centenarians
Heyn, H., Li, N., Ferreira, H. J., Moran, S., Pisano, D. G., Gomez, A., Diez, J., Sanchez-Mut, J. V., Setien, F., Carmona, F. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120658109 · Cited by 802
Intra-individual Change Over Time in DNA Methylation With Familial Clustering
Bjornsson, H. T. (2008) · JAMA · doi:10.1001/jama.299.24.2877 · Cited by 702
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Bell, J. T., Tsai, P.-C., Yang, T.-P., Pidsley, R., Nisbet, J. P., Glass, D., Mangino, M., Zhai, G., Zhang, F., Valdes, A. M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002629 · Cited by 700
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A. (2011) · Nature · doi:10.1038/nature10572 · Cited by 660
Detectable clonal mosaicism from birth to old age and its relationship to cancer
Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2271 · Cited by 594
Detectable clonal mosaicism and its relationship to aging and cancer
Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2270 · Cited by 589
Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity
Barzilai, N. (2003) · JAMA · doi:10.1001/jama.290.15.2030 · Cited by 578
Morbidity Profiles of Centenarians: Survivors, Delayers, and Escapers
Evert, J., Lawler, E. V., Bogan, H., & Perls, T. T. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.m232 · Cited by 517
Genetic influence on human lifespan and longevity
Hjelmborg, J., Iachine, I. A., Skytthe, A., Vaupel, J. W., McGue, M. K., Koskenvuo, M. J., Kaprio, J. A., Pedersen, N. L., & Christensen, K. (2006) · Human Genetics · doi:10.1007/s00439-006-0144-y · Cited by 498
The quest for genetic determinants of human longevity: challenges and insights
Christensen, K., Johnson, T. E., & Vaupel, J. W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1871 · Cited by 494
Genetic signatures of exceptional longevity in humans
Sebastiani, P., Solovieff, N., DeWan, A. T., Walsh, K. M., Puca, A., Hartley, S. W., Melista, E., Andersen, S., Dworkis, D. A., Wilk, J. B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029848 · Cited by 464
Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
BENEDICTIS, G. D., Rose, G., Carrieri, G., Luca, M. D., Falcone, E., Passarino, G., Bonafè, M., Monti, D., Baggio, G., Bertolini, S., et al. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1532 · Cited by 390
Life-long sustained mortality advantage of siblings of centenarians
Perls, T. T., Wilmoth, J. R., Levenson, R., Shea-Drinkwater, M., Cohen, M., Bogan, H., Joyce, E., Brewster, S. J., Kunkel, L. M., & Puca, A. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122587599 · Cited by 378
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
Puca, A. A., Daly, M. J., Brewster, S. J., Matise, T. C., Barrett, J. C., Shea-Drinkwater, M., Kang, S., Joyce, E., Nicoli, J., Benson, E. K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181337598 · Cited by 347
Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span
Andersen, S. L., Sebastiani, P., Dworkis, D. A., Feldman, L., & Perls, T. T. (2012) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr223 · Cited by 331
Epigenetic factors in aging and longevity
Gravina, S., & Vijg, J. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0730-7 · Cited by 329
Mitochondrial genotype associated with longevity
Tanaka, M., Gong, J., Zhang, J., Yoneda, M., & Yagi, K. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78211-8 · Cited by 316
Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs
Talens, R. P., Christensen, K., Putter, H., Willemsen, G., Christiansen, L., Kremer, D., Suchiman, H. E. D., Slagboom, P. E., Boomsma, D. I., & Heijmans, B. T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00835.x · Cited by 300
Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited
Deelen, J., Beekman, M., Uh, H., Helmer, Q., Kuningas, M., Christiansen, L., Kremer, D., van der Breggen, R., Suchiman, H. E. D., Lakenberg, N., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00705.x · Cited by 285
Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly
Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V, Passarino, G., Feraco, E., Mari, V, Barbi, C., et al. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00209-2 · Cited by 282
Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study
Westendorp, R. G. J., van Heemst, D., Rozing, M. P., Frölich, M., Mooijaart, S. P., Blauw, G. J., Beekman, M., Heijmans, B. T., de Craen, A. J. M., Slagboom, P. E., et al. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02381.x · Cited by 257
Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
Atzmon, G., Cho, M., Cawthon, R., Budagov, T., Katz, M., Yang, X., Siegel, G., Bergman, A., Huffman, D. M., Schechter, C. B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906191106 · Cited by 252
Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life in Health, Aging, and Body Composition, a Population-Based Cohort Study
Njajou, O. T., Hsueh, W.-C., Blackburn, E. H., Newman, A. B., Wu, S.-H., Li, R., Simonsick, E. M., Harris, T. B., Cummings, S., & Cawthon, R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp061 · Cited by 249
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population
Niemi, A., Hervonen, A., Hurme, M., Karhunen, P. J., Jylhä, M. K., & Majamaa, K. (2003) · Human Genetics · doi:10.1007/s00439-002-0843-y · Cited by 245
Personality Predictors of Longevity: Activity, Emotional Stability, and Conscientiousness
Terracciano, A., Löckenhoff, C. E., Zonderman, A. B., Ferrucci, L., & Costa, P. T. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31817b9371 · Cited by 242
Inheritance of human longevity in Iceland
Gudmundsson, H., Gudbjartsson, D. F., Kong, A., Guðbjartsson, H., Frigge, M., Gulcher, J. R., & Stefánsson, K. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200527 · Cited by 231
Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians’ offspring
Gentilini, D., Mari, D., Castaldi, D., Remondini, D., Ogliari, G., Ostan, R., Bucci, L., Sirchia, S. M., Tabano, S. M., Cavagnini, F., et al. (2012) · AGE · doi:10.1007/s11357-012-9463-1 · Cited by 211
The Genetics of Extreme Longevity: Lessons from the New England Centenarian Study
Sebastiani, P., & Perls, T. T. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00277 · Cited by 207
Remarkable longevity and stress resistance of nematode PI3K‐null mutants
Ayyadevara, S., Alla, R., Thaden, J. J., & Reis, R. J. S. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00348.x · Cited by 205
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals
Nebel, A., Kleindorp, R., Caliebe, A., Nothnagel, M., Blanché, H., Junge, O., Wittig, M., Ellinghaus, D., Flachsbart, F., Wichmann, H. ‐., et al. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.06.008 · Cited by 201
The Search for Longevity and Healthy Aging Genes: Insights From Epidemiological Studies and Samples of Long-Lived Individuals
Murabito, J. M., Yuan, R., & Lunetta, K. L. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls089 · Cited by 200
Clinical Phenotype of Families with Longevity
Atzmon, G., Schechter, C. B., Greiner, W., Davidson, D. E., Rennert, G., & Barzilai, N. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52068.x · Cited by 197
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
Lunetta, K. L., D’Agostino, R. B., Karasik, D., Benjamin, E. J., Guo, C., Govindaraju, R., Kiel, D. P., Kelly‐Hayes, M., Massaro, J. M., Pencina, M. J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s13 · Cited by 193
Health and function of participants in the Long Life Family Study: A comparison with other cohorts
Newman, A. B., Glynn, N. W., Taylor, C. A., Sebastiani, P., Perls, T. T., Mayeux, R. P., Christensen, K., Zmuda, J. M., Barral, S., Lee, J. H., et al. (2011) · Aging · doi:10.18632/aging.100242 · Cited by 192
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study
Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., et al. (2013) · Aging Cell · doi:10.1111/acel.12039 · Cited by 190
Lifestyle Factors of People with Exceptional Longevity
Rajpathak, S. N., Liu, Y., Ben‐David, O., Reddy, S., Atzmon, G., Crandall, J. P., & Barzilai, N. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03498.x · Cited by 187
Mitochondrial DNA polymorphism: its role in longevity of the Irish population
Ross, O. A. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00094-8 · Cited by 181
Siblings of Okinawan Centenarians Share Lifelong Mortality Advantages
Willcox, B. J., Willcox, D. C., He, Q., Curb, J. D., & Suzuki, M. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.4.345 · Cited by 169
Lower All‐Cause, Cardiovascular, and Cancer Mortality in Centenarians' Offspring
Terry, D. F., Wilcox, M., McCormick, M. A., Pennington, J. Y., Sharp, E. S., Andersen, S. L., & Perls, T. T. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52561.x · Cited by 169
Healthy aging and disease: role for telomere biology?
Zhu, H., Belcher, M. D., & van der Harst, P. (2011) · Clinical Science · doi:10.1042/cs20100385 · Cited by 169
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes
Zhang, J., Asin-Cayuela, J., Fish, J. L., Michikawa, Y., Bonafè, M., Olivieri, F., Passarino, G., Benedictis, G. D., Franceschi, C., & Attardi, G. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242719399 · Cited by 166
Genome‐wide miRNA signatures of human longevity
ElSharawy, A., Keller, A., Flachsbart, F., Wendschlag, A., Jacobs, G., Kefer, N., Brefort, T., Leidinger, P., Backes, C., Meese, E. U., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00824.x · Cited by 156
Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity
Beekman, M., Nederstigt, C., Suchiman, H. E. D., Kremer, D., van der Breggen, R., Lakenberg, N., Alemayehu, W. G., de Craen, A. J. M., Westendorp, R. G. J., Boomsma, D. I., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003540107 · Cited by 153
A genome-wide association study of aging
Walter, S., Atzmon, G., Demerath, E. W., Garcia, M. E., Kaplan, R. C., Meena Kumari, B., Lunetta, K. L., Milaneschi, Y., Tanaka, T., Tranah, G. J., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.026 · Cited by 151
Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan
Geesaman, B. J., Benson, E. K., Brewster, S. J., Kunkel, L. M., Blanché, H., Thomas, G. D., Perls, T. T., Daly, M. J., & Puca, A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936249100 · Cited by 149
If you would live long, choose your parents well
Cournil, A., & Kirkwood, T. B. L. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02306-x · Cited by 144
Mice as a Mammalian Model for Research on the Genetics of Aging
Yuan, R., Peters, L. L., & Paigen, B. J. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.4 · Cited by 142
A Meta-analysis of Four Genome-Wide Association Studies of Survival to Age 90 Years or Older: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Newman, A. B., Walter, S., Lunetta, K. L., Garcia, M. E., Slagboom, P. E., Christensen, K., Arnold, A. M., Aspelund, T., Aulchenko, Y. S., Benjamin, E. J., et al. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq028 · Cited by 139
Model Organisms as a Guide to Mammalian Aging
Tissenbaum, H. A., & Guarente, L. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00098-3 · Cited by 128
Exceptional Familial Clustering for Extreme Longevity in Humans
Perls, T. T., Shea-Drinkwater, M., Bowen-Flynn, J., Ridge, S. B., Kang, S., Joyce, E., Daly, M. J., Brewster, S. J., Kunkel, L. M., & Puca, A. A. (2000) · Journal of the American Geriatrics Society · doi:10.1111/jgs.2000.48.11.1483 · Cited by 128
Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross‐sectional and longitudinal analysis
Soerensen, M., Thinggaard, M., Nygaard, M., Dato, S., Tan, Q., Hjelmborg, J., Andersen‐Ranberg, K., Stevnsner, T., Bohr, V. A., Kimura, M., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00775.x · Cited by 126
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
Deelen, J., Uh, H., Monajemi, R., van Heemst, D., Thijssen, P. E., Böhringer, S., van den Akker, E. B., de Craen, A. J. M., Rivadeneira, F., Uitterlinden, A. G., et al. (2011) · AGE · doi:10.1007/s11357-011-9340-3 · Cited by 126
The Epidemiology of Longevity and Exceptional Survival
Newman, A. B., & Murabito, J. M. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs013 · Cited by 126
Gene expression analysis of mTOR pathway: association with human longevity
Passtoors, W. M., Beekman, M., Deelen, J., van der Breggen, R., Maier, A. B., Guigas, B., Derhovanessian, E., van Heemst, D., de Craen, A. J. M., Gunn, D. A., et al. (2012) · Aging Cell · doi:10.1111/acel.12015 · Cited by 125
Offspring of Centenarians Have a Favorable Lipid Profile
Barzilai, N., Gabriely, I., Gabriely, M., Iankowitz, N., & Sorkin, J. D. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49013.x · Cited by 119
Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging
Bergman, A., Atzmon, G., Ye, K. Q., MacCarthy, T., & Barzilai, N. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030170 · Cited by 117
A genotype of exceptional longevity is associated with preservation of cognitive function
Barzilai, N., Atzmon, G., Derby, C. A., Bauman, J., & Lipton, R. B. (2006) · Neurology · doi:10.1212/01.wnl.0000249116.50854.65 · Cited by 111
The Oldest Human
Robine, J., & Allard, M. (1998) · Science · doi:10.1126/science.279.5358.1831h · Cited by 105
Melatonin profiles and sleep characteristics in boys with fragile X syndrome: A preliminary study
Gould, E. L., Loesch, D. Z., Martin, M. J., Hagerman, R. J., Armstrong, S. M., & Huggins, R. (2000) · American Journal of Medical Genetics · doi:10.1002/1096-8628(20001211)95:4 · Cited by 101
Neutral mitochondrial heteroplasmy and the influence of aging
Sondheimer, N., Glatz, C. E., Tirone, J. E., Deardorff, M. A., Krieger, A. Μ., & Hakonarson, H. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr043 · Cited by 100
Dissecting the genetics of longevity inDrosophila melanogaster
Paaby, A. B., & SCHMIDT, P. S. (2009) · Fly · doi:10.4161/fly.3.1.7771 · Cited by 100
Genetics and genomics of human ageing
Wheeler, H. E., & Kim, S. K. (2010) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0259 · Cited by 98
Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
Kim, S., Bi, X.-H., Czarny‐Ratajczak, M., Dai, J., Welsh, D. A., Myers, L., Welsch, M. A., Cherry, K. E., Arnold, J., Poon, L. W., et al. (2011) · Biogerontology · doi:10.1007/s10522-011-9360-5 · Cited by 97
No association between microsomal triglyceride transfer protein ( MTP ) haplotype and longevity in humans
Nebel, A., Croucher, P. J. P., Stiegeler, R., Nikolaus, S., Krawczak, M., & Schreiber, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408670102 · Cited by 96
The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe
Haddy, N., Bacquer, D. D., Chemaly, M. M., Maurice, M., Ehnholm, C., Evans, A., Sans, S., Martins, M. D. C., Backer, G. D., Siest, G., et al. (2002) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200864 · Cited by 92
Genome-Wide Association Study of Personality Traits in the Long Life Family Study
Bae, H. T., Sebastiani, P., Sun, F. X., Andersen, S. L., Daw, E. W., Terracciano, A., Ferrucci, L., & Perls, T. T. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00065 · Cited by 85
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Huebbe, P., Nebel, A., Siegert, S., Moehring, J., Boesch, C., Most, E., Pallauf, J., Egert, S., Müller, M. J., Schreiber, S., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-180935 · Cited by 83
Family patterns of coronary heart disease mortality: The Framingham Longevity Study
Brand, F. N., Kiely, D. K., Kannel, W. B., & Myers, R. H. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90009-c · Cited by 81
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Gombar, S., Jung, H. J., Dong, F., Calder, B. R., Atzmon, G., Barzilai, N., Tian, X., Pothof, J., Hoeijmakers, J. H. J., Campisi, J., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-353 · Cited by 81
Joint influence of small-effect genetic variants on human longevity
Yashin, A. I., Wu, D., Arbeev, K. G., & Ukraintseva, S. V. (2010) · Aging · doi:10.18632/aging.100191 · Cited by 81
Sex Differences in the Association of Apolipoprotein E and Angiotensin-Converting Enzyme Gene Polymorphisms With Healthy Aging and Longevity: A Population-Based Study From Southern Italy
Seripa, D., Franceschi, M., Matera, M. G., Panza, F., Kehoe, P. G., Gravina, C., Orsitto, G., Solfrizzi, V., Minno, G. D., Dallapiccola, B., et al. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.9.918 · Cited by 78
Mitochondrial DNA involvement in human longevity
Santoro, A., Salvioli, S., Raule, N., Capri, M., Sevini, F., Valensin, S., Monti, D., Bellizzi, D., Passarino, G., Rose, G., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.040 · Cited by 76
Inherited Variability of the Mitochondrial Genome and Successful Aging in Humans
BENEDICTIS, G. D., Carrieri, G., Varcasia, O., Bonafè, M., & Franceschi, C. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06648.x · Cited by 73
Association Study on Long-Living Individuals from Southern Italy Identifies rs10491334 in the CAMKIV Gene That Regulates Survival Proteins
Malovini, A. L., Illario, M., Iaccarino, G., Villa, F., Ferrario, A., Roncarati, R., Anselmi, C. V., Novelli, V., Cipolletta, E., Leggiero, E., et al. (2011) · Rejuvenation Research · doi:10.1089/rej.2010.1114 · Cited by 72
Reduced telomere length variation in healthy oldest old
Halaschek-Wiener, J., Vulto, I. M., Fornika, D., Collins, J. A., Connors, J. M., Le, N. D., Lansdorp, P. M., & Brooks-Wilson, A. R. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.07.004 · Cited by 70
Self-citation
Epigenetic Genome-Wide Association Methylation in Aging and Longevity
Ben‐Avraham, D., Muzumdar, R. H., & Atzmon, G. (2012) · Epigenomics · doi:10.2217/epi.12.41 · Cited by 69
Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts
BENEDICTIS, G. D., Carotenuto, L., Carrieri, G., Luca, M. D., FALCONE, E., Rose, G., Yashin, A. I., Bonafè, M., & Franceschi, C. (1998) · Annals of Human Genetics · doi:10.1046/j.1469-1809.1998.6220115.x · Cited by 66
Whole Genome Sequences of a Male and Female Supercentenarian, Ages Greater than 114 Years
Sebastiani, P., Riva, A., Montano, M. A., Pham, P., Torkamani, A., Scherba, E., Benson, G., Milton, J. N., Baldwin, C. T., Andersen, S. L., et al. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2011.00090 · Cited by 64
How genetic analysis tests theories of animal aging
Hekimi, S. (2006) · Nature Genetics · doi:10.1038/ng1881 · Cited by 63
First autopsy study of an Okinawan centenarian: Absence of many age-related diseases
Bernstein, A. M., Willcox, B. J., Tamaki, H., Kunishima, N., Suzuki, M., Craig Willcox, D., Kristen Yoo, J.-S., & Perls, T. T. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.11.1195 · Cited by 56
Mitochondrial–nuclear epistasis: Implications for human aging and longevity
Tranah, G. J. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.06.003 · Cited by 55
A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians
Nebel, A., Flachsbart, F., Till, A., Caliebe, A., Blanché, H., Arlt, A., Häsler, R., Jacobs, G., Kleindorp, R., & Franke, A. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.08.004 · Cited by 53
Leukocyte Telomere Length Is Associated with Disability in Older U.S. Population
Risques, R. A., Arbeev, K. G., Yashin, A. I., Ukraintseva, S. V., Martin, G. M., Rabinovitch, P. S., & Oshima, J. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02948.x · Cited by 48
Flies selected for longevity retain a young gene expression profile
Sarup, P. M., Sørensen, P., & Loeschcke, V. (2010) · AGE · doi:10.1007/s11357-010-9162-8 · Cited by 48
Chromosome 4q25, Microsomal Transfer Protein Gene, and Human Longevity: Novel Data and a Meta-Analysis of Association Studies
Beekman, M., Blauw, G. J., Houwing‐Duistermaat, J. J., Brandt, B. W., Westendorp, R. G. J., & Slagboom, P. E. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.4.355 · Cited by 48
The Study ofAPOA1,APOC3andAPOA4Variability in Healthy Ageing People Reveals Another Paradox in the Oldest Old Subjects
Garasto, S., Rose, G., Rango, F. D., Berardelli, M., Corsonello, A., Feraco, E., Mari, V., Maletta, R., Bruni, A. C., Franceschi, C., et al. (2003) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2003.00008.x · Cited by 47
Genome-Wide Scan for a Healthy Aging Phenotype Provides Support for a Locus Near D4S1564 Promoting Healthy Aging
Reed, T., Dick, D. M., Uniacke, S. K., Foroud, T., & Nichols, W. C. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.3.b227 · Cited by 42
Large common deletions associate with mortality at old age
Kuningas, M., Estrada, K., Hsu, Y., Nandakumar, K., Uitterlinden, A. G., Lunetta, K. L., van Duijn, C. M., Karasik, D., Albert Hofman, D., Murabito, J. M., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr340 · Cited by 40
Human longevity and common variations in the LMNA gene: a meta‐analysis
Conneely, K. N., Capell, B. C., Erdos, M. R., Sebastiani, P., Solovieff, N., Swift, A. J., Baldwin, C. T., Budagov, T., Barzilai, N., Atzmon, G., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00808.x · Cited by 40
Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish
Edwards, D. R. V., Gilbert, J. R., Jiang, L., Gallins, P. J., Caywood, L. J., Creason, M., Fuzzell, D., Knebusch, C., Jackson, C. E., Pericak‐Vance, M. A., et al. (2011) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2011.00658.x · Cited by 36
Leukocyte telomere length and physical ability among Danish Twins age 70+
Bendix, L., Gade, M. M., Staun, P. W., Kimura, M., Jeune, B., Hjelmborg, J., Aviv, A., & Christensen, K. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.10.003 · Cited by 36
‘Positive biology’ as a new paradigm for the medical sciences
Farrelly, C. (2012) · EMBO Reports · doi:10.1038/embor.2011.256 · Cited by 36
Linkage and association of successful aging to the 6q25 region in large Amish kindreds
Edwards, D. R. V., Gilbert, J. R., Hicks, J. E., Myers, J. L., Jiang, L., Cummings, A. C., Guo, S., Gallins, P. J., Konidari, I., Caywood, L. J., et al. (2012) · AGE · doi:10.1007/s11357-012-9447-1 · Cited by 31
The molecular genetics of sirtuins: association with human longevity and age-related diseases.
Polito, L., Kehoe, P. G., Forloni, G., & Albani, D. (2010) · PubMed Central · Cited by 30
Mitochondrial Haplogroup X is associated with successful aging in the Amish
Courtenay, M. D., Gilbert, J. R., Jiang, L., Cummings, A. C., Gallins, P. J., Caywood, L. J., Reinhart‐Mercer, L., Fuzzell, D., Knebusch, C., Laux, R. A., et al. (2011) · Human Genetics · doi:10.1007/s00439-011-1060-3 · Cited by 30
High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci
Boyden, S. E., & Kunkel, L. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012432 · Cited by 29
Heritability and Validity of Healthy Physical Aging (Wellness) in Elderly Male Twins
Reed, T., & Dick, D. M. (2003) · Twin Research · doi:10.1375/136905203765693889 · Cited by 27
Distinguishing Between Longevity and Buffered-Deleterious Genotypes for Exceptional Human Longevity: The Case of the MTP Gene
Huffman, D. M., Deelen, J., Ye, K. Q., Bergman, A., Slagboom, P. E., Barzilai, N., & Atzmon, G. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls103 · Cited by 27
No evidence for an association between extreme longevity and Microsomal Transfer Protein polymorphisms in a longitudinal study of 1651 nonagenarians
Bathum, L., Christiansen, L., Tan, Q., Vaupel, J. W., Jeune, B., & Christensen, K. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201468 · Cited by 26
Impact of genetic variations in the WRN gene on age related pathologies and mortality
Kuningas, M., Slagboom, P. E., Westendorp, R. G. J., & van Heemst, D. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.005 · Cited by 23
Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study
Mooijaart, S. P., van Heemst, D., Noordam, R., Rozing, M. P., Wijsman, C. A., de Craen, A. J. M., Westendorp, R. G. J., Beekman, M., & Slagboom, P. E. (2010) · Aging · doi:10.18632/aging.100250 · Cited by 22
The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations
Ferrario, A., Villa, F., Malovini, A. L., Araniti, F., & Puca, A. A. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-7 · Cited by 21
Genomics of human health and aging
Kulminski, A. M., & Culminskaya, I. V. (2011) · AGE · doi:10.1007/s11357-011-9362-x · Cited by 21
A Genome-Wide Study Replicates Linkage of 3p22-24 to Extreme Longevity in Humans and Identifies Possible Additional Loci
Kerber, R. A., O’Brien, E., Boucher, K. M., Smith, K. R., & Cawthon, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034746 · Cited by 20
Mitochondrial Polymorphisms Are Associated Both with Increased and Decreased Longevity
Castrì, L., Meléndez‐Obando, M., Villegas‐Palma, R., Barrantes, R., Raventós, H., Pereira, R., Luiselli, D., Pettener, D., & Madrigal, L. (2008) · Human Heredity · doi:10.1159/000181152 · Cited by 20
Ashkenazi Jewish Centenarians Do Not Demonstrate Enrichment in Mitochondrial Haplogroup J
Shlush, L. I., Atzmon, G., Weisshof, R., Behar, D. M., Yudkovsky, G., Barzilai, N., & Skorecki, K. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003425 · Cited by 19
Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians
Iwata, N., Zhang, J., Atzmon, G., Leanza, S. M., Cho, J., Chomyn, A., Burk, R. D., Barzilai, N., & Attardi, G. M. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.001 · Cited by 19
Relationship between case-control studies and the transmission/disequilibrium test
Mitchell, L. E. (2000) · Genetic Epidemiology · doi:10.1002/1098-2272(200010)19:3 · Cited by 19
MITOCHONDRIAL DNA HAPLOGROUPS IN A CHINESE UYGUR POPULATION AND THEIR POTENTIAL ASSOCIATION WITH LONGEVITY
Wei-Hong, R. E. N., Li, X., Zhang, H., Deng, F., Liao, W., Pang, Y., Liu, Y., Qiu, M., Zhang, G., & Zhang, Y. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05028.x · Cited by 19
Association Analyses of Insulin Signaling Pathway Gene Polymorphisms With Healthy Aging and Longevity in Americans of Japanese Ancestry
Morris, B. J., Donlon, T. A., He, Q., Grove, J., Masaki, K., Elliott, A., Willcox, D. C., & Willcox, B. J. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt082 · Cited by 15
Study Designs to Enhance Identification of Genetic Factors in Healthy Aging
Manolio, T. A. (2007) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00368.x · Cited by 13
Allelic Variation and Human Longevity
Nebel, A., & Schreiber, S. (2005) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2005.29.pe23 · Cited by 11
Runs of Homozygosity Do Not Influence Survival to Old Age
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Manolio, T. A. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.s228-s233 · Cited by 10
Association of heat shock proteins with all-cause mortality
Broer, L., Demerath, E. W., Garcia, M., Homuth, G., Kaplan, R. C., Lunetta, K. L., Tanaka, T., Tranah, G. J., Walter, S., Arnold, A. M., et al. (2012) · AGE · doi:10.1007/s11357-012-9417-7 · Cited by 5
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Andersson (1999) · doi:10.1002/(sici)1096-8628(19990219)82:5 · Cited by 1

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Deelen J, Uh HW, Monajemi R, van Heemst D, Thijssen PE, Bohringer S, van den Akker EB, de Craen AJ, Rivadeneira F, Uitterlinden AG, Westendorp RG, Goeman JJ, Slagboom PE, Houwing-Duistermaat JJ, Beekman M (2013) Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways. Age (Dordr) 35:235–249 · DOI

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Authors: Brooks-Wilson, A. R.
Affiliations: BC Cancer Agency (CA)
Corresponding author: Brooks-Wilson, Angela R.
ORCID: Brooks-Wilson, Angela R.
Venue: Human Genetics
Publisher: Springer Science and Business Media LLC
Published: 2013-08-08
Volume: 132
Issue: 12
Pages: 1323-1338
ISSN: 0018-7348 (ISSN-L)
0340-6717
1432-1203
DOI: 10.1007/s00439-013-1342-z
PMC: PMC3898394
OpenAlex: W2072130124
Cited by: 380
References: 123
Citations by year: 2026: 17 · 2025: 31 · 2024: 40 · 2023: 33 · 2022: 34 · 2021: 43 · 2020: 25 · 2019: 26 · 2018: 30 · 2017: 24 · 2016: 23 · 2015: 35 · 2014: 19
FWCI: 1.58
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/2.0 (unspecified)
Locations: Human Genetics (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords: healthy aging, longevity, centenarians, apolipoprotein E, FOXO3, chromosome 3, genome-wide association study, candidate genes, gene-environment interaction, rare alleles, epigenetics, DNA methylation, lifestyle factors, age-related diseases, population stratification
MeSH terms: Aging, Health, Humans, Life Expectancy, Genetic Linkage, Longevity, Genetic Variation, Epigenesis, Genetic, Genome-Wide Association Study, Gene-Environment Interaction

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