Shaping Synapses by the Neural Extracellular Matrix
Open accessAbstract
Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a tetrapartite synapse. Here we outline the major mechanisms driving: (i) synaptogenesis by secreted extracellular scaffolding molecules, like thrombospondins (TSPs), neuronal pentraxins (NPs) and cerebellins, which respectively promote presynaptic, postsynaptic differentiation or both; (ii) maturation of synapses via reelin and integrin ligands-mediated signaling; and (iii) regulation of synaptic plasticity by ECM-dependent control of induction and consolidation of new synaptic configurations. Particularly, we focused on potential importance of activity-dependent concerted activation of multiple extracellular proteases, such as ADAMTS4/5/15, MMP9 and neurotrypsin, for permissive and instructive events in synaptic remodeling through localized degradation of perisynaptic ECM and generation of proteolytic fragments as inducers of synaptic plasticity.
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TNXB encodes tenascin proteins, which are extracellular matrix glycoproteins demonstrated to modulate synaptic plasticity in the brain.
“TNXB encodes tenascin proteins, which are extracellular matrix glycoproteins demonstrated to modulate synaptic plasticity in the brain [83].”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [83]
The “Tenascins and Synaptic Plasticity” section describes tenascins as extracellular-matrix glycoproteins that modulate synaptic plasticity, particularly tenascin-R and tenascin-C in the brain. It does not identify TNXB as encoding a tenascin or demonstrate a role for the TNXB product specifically. (LLM, conf=0.88)
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- Authors
- Ferrer-Ferrer, M., & Dityatev, A.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Corresponding author
- Dityatev, Alexander
- ORCID
- Dityatev, Alexander
- Venue
- Frontiers in Neuroanatomy
- Publisher
- Frontiers Media SA
- Published
- 2018-05-15
- Volume
- 12
- Pages
- 40-40
- ISSN
- 1662-5129 (ISSN-L)
- PMC
- PMC5962695
- OpenAlex
- W2804637583
- Cited by
- 169
- References
- 222
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 18 · 2023: 19 · 2022: 26 · 2021: 34 · 2020: 19 · 2019: 21 · 2018: 5
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neuroanatomy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DZNE Pub (submittedVersion, cc-by)
- Funders
- Seventh Framework Programme (Initial Training Network ExtraBrain)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- synaptogenesis, synaptic plasticity, thrombospondin, cerebellin, reelin, integrin signaling, extracellular protease, ADAMTS, MMP-9, synaptic remodeling
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