Cited by 170Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsGenetics and Neurodevelopmental Disorders

Shaping Synapses by the Neural Extracellular Matrix

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Ferrer-Ferrer, Maura, Dityatev, Alexander·2018·Frontiers in Neuroanatomy

Abstract

Accumulating data support the importance of interactions between pre- and postsynaptic neuronal elements with astroglial processes and extracellular matrix (ECM) for formation and plasticity of chemical synapses, and thus validate the concept of a tetrapartite synapse. Here we outline the major mechanisms driving: (i) synaptogenesis by secreted extracellular scaffolding molecules, like thrombospondins (TSPs), neuronal pentraxins (NPs) and cerebellins, which respectively promote presynaptic, postsynaptic differentiation or both; (ii) maturation of synapses via reelin and integrin ligands-mediated signaling; and (iii) regulation of synaptic plasticity by ECM-dependent control of induction and consolidation of new synaptic configurations. Particularly, we focused on potential importance of activity-dependent concerted activation of multiple extracellular proteases, such as ADAMTS4/5/15, MMP9 and neurotrypsin, for permissive and instructive events in synaptic remodeling through localized degradation of perisynaptic ECM and generation of proteolytic fragments as inducers of synaptic plasticity.

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Crossref · 10.3389/fnana.2018.00040

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  • TNXB encodes tenascin proteins, which are extracellular matrix glycoproteins demonstrated to modulate synaptic plasticity in the brain.

    “TNXB encodes tenascin proteins, which are extracellular matrix glycoproteins demonstrated to modulate synaptic plasticity in the brain [83].”

    From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [83]

    The “Tenascins and Synaptic Plasticity” section describes tenascins as extracellular-matrix glycoproteins that modulate synaptic plasticity, particularly tenascin-R and tenascin-C in the brain. It does not identify TNXB as encoding a tenascin or demonstrate a role for the TNXB product specifically. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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1 of the 222 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Jones F. S. Jones P. L. (2000). The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling. Dev. Dyn. 218, 235– 259. 10.1002/(SICI)1097-0177(200006)218:2<235::AID-DVDY2>3.0.CO;2-G 10842355 · DOI

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Authors
Ferrer-Ferrer, M., & Dityatev, A.
Affiliations
German Center for Neurodegenerative Diseases (DE)
Corresponding author
Dityatev, Alexander
Venue
Frontiers in Neuroanatomy
Published
2018-05-15
Volume
12
Pages
40-40
ISSN
1662-5129 (ISSN-L)
OpenAlex
W2804637583
Cited by
169
References
222
Citations by year
2026: 11 · 2025: 16 · 2024: 18 · 2023: 19 · 2022: 26 · 2021: 34 · 2020: 19 · 2019: 21 · 2018: 5
FWCI
2.59
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Neuroanatomy (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DZNE Pub (submittedVersion, cc-by)
Funders
Seventh Framework Programme (Initial Training Network ExtraBrain)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
synaptogenesis, synaptic plasticity, thrombospondin, cerebellin, reelin, integrin signaling, extracellular protease, ADAMTS, MMP-9, synaptic remodeling

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