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Cited by 382

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic

Open access
Luzi, Livio, Radaelli, Maria Grazia·2020·Acta Diabetologica

Abstract

Aims Analyze the relationship between obesity and influenza. Methods Basal hormone milieu, defective response of both innate and adaptive immune system and sedentariness are major determinants in the severity of influenza viral infection in obese patients. Being overweight not only increases the risk of infection and of complications for the single obese person, but a large prevalence of obese individuals within the population might increase the chance of appearance of more virulent viral strain, prolongs the virus shedding throughout the total population and eventually might increase overall mortality rate of an influenza pandemic. Results Waiting for the development of a vaccination against COVID-19, isolation of positive cases and social distancing are the primary interventions. Nonetheless, evidence from previous influenza pandemics suggests the following interventions aimed at improving immune response: (1) lose weight with a mild caloric restriction; (2) include AMPK activators and PPAR gamma activators in the drug treatment for obesity associated with diabetes; and (3) practice mild-to-moderate physical exercise. Conclusions Due to prolonged viral shedding, quarantine in obese subjects should likely be longer than normal weight individuals.

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Metadata

Authors
Luzi, L., & Radaelli, M. G.
Venue
Acta Diabetologica
Published
2020-04-05
Volume
57
Issue
6
Pages
759-764
ISSN
  • 0940-5429 (ISSN-L)
  • 1432-5233
OpenAlex
W3015049708
Cited by
382
References
45
FWCI
53.60
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic. https://app.cochat.ai/papers/10.1007/s00592-020-01522-8
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Luzi, L., & Radaelli, M. G. (2020). Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic. Acta Diabetologica. https://doi.org/10.1007/s00592-020-01522-8

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