Cited by 100Neurotransmitter Receptor Influence on BehaviorPsychopathy, Forensic Psychiatry, Sexual OffendingAttention Deficit Hyperactivity Disorder

Dopamine D3 receptor gene polymorphism and violent behavior: Relation to impulsiveness and ADHD-related psychopathology

Retz, W., R�sler, M., Supprian, T., Retz-Junginger, P., Thome, J.·2003·Journal of Neural Transmission

Abstract

Several lines of evidence indicate that dopaminergic neurotransmission is involved in the regulation of impulsive aggression and violence and that genetically determined variability in dopaminergic gene expression modifies complex traits including that of impulsivity and aggression. In this study we report an association of the dopamine D3 receptor (DRD3) polymorphism with impulsiveness according to Eysenck's EIQ and scores on the German short version of the Wender Utah Rating Scale (WURS-k), which we used for the assessment of a history of ADHD-related symptoms. This association was detected in a group of violent offenders, but not in non-violent individuals. Highest scores of EIQ impulsiveness and of the WURS-k were found in heterozygous violent individuals, while homozygotes showed significant lower rating scores, suggesting an heterosis effect. The results of our study suggest that variations of the DRD3 gene are likely involved in the regulation of impulsivity and some psychopathological aspects of ADHD related to violent behavior.

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Crossref · 10.1007/s00702-002-0805-5

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  • The DRD3 polymorphism has been found to be associated with impulsivity, with the association significant in violent but not nonviolent individuals, and no association between DRD3 and violence per se.

    “The DRD3 polymorphism has been found to be associated with impulsivity. This association was significant in violent, but not in nonviolent individuals, and there were no association between DRD3 and violence per se (Retz et al., 2003).”

    From Human Aggression Across the Lifespan (2011) · cites this paper as Retz et al., 2003

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Authors
Retz, W., R�sler, M., Supprian, T., Retz-Junginger, P., & Thome, J.
Affiliations
  • Saarland University (DE)
  • Central Institute of Mental Health (DE)
Venue
Journal of Neural Transmission
Published
2003-05-01
Volume
110
Issue
5
Pages
561-572
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2009658853
Cited by
100
References
46
Citations by year
2026: 1 · 2025: 4 · 2022: 2 · 2021: 1 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 8
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords
dopamine D3 receptor, violent behavior, impulsivity, violent offenders, dopamine signaling, aggression, Wender Utah Rating Scale
MeSH terms
Adult, Aged, Alleles, Attention Deficit Disorder with Hyperactivity, Genotype, Humans, Disruptive, Impulse Control, and Conduct Disorders, Impulsive Behavior, Male, Middle Aged, Polymorphism, Genetic, Violence, Receptors, Dopamine D2, Receptors, Dopamine D3

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