Determinants of shortened, disrupted, and mistimed sleep and associated metabolic health consequences in healthy humans
Abstract
Recent increases in the prevalence of obesity and type 2 diabetes mellitus (T2DM) in modern societies have been paralleled by reductions in the time their denizens spend asleep. Epidemiological studies have shown that disturbed sleep—comprising short, low-quality, and mistimed sleep—increases the risk of metabolic diseases, especially obesity and T2DM. Supporting a causal role of disturbed sleep, experimental animal and human studies have found that sleep loss can impair metabolic control and body weight regulation. Possible mechanisms for the observed changes comprise sleep loss–induced changes in appetite-signaling hormones (e.g., higher levels of the hunger-promoting hormone ghrelin) or hedonic brain responses, altered responses of peripheral tissues to metabolic signals, and changes in energy intake and expenditure. Even though the overall consensus is that sleep loss leads to metabolic perturbations promoting the development of obesity and T2DM, experimental evidence supporting the validity of this view has been inconsistent. This Perspective aims at discussing molecular to behavioral factors through which short, low-quality, and mistimed sleep may threaten metabolic public health. In this context, possible factors that may determine the extent to which poor sleep patterns increase the risk of metabolic pathologies within and across generations will be discussed (e.g., timing and genetics).
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The risk of T2DM and obesity is increased in subjects suffering from chronic sleep loss.
“The risk of T2DM and obesity – metabolic pathologies that have been linked to dysregulated gut microbiotas – has been found to be increased in subjects suffering from chronic sleep loss [24]”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [24]
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Self-citationSong, Z., Yang, R., Wang, W., Huang, N., Zhuang, Z., Han, Y., Qi, L., Xu, M., Tang, Y., & Huang, T. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01434-z · Cited by 78 · see citing works
“In addition to the common lifestyle factors, epidemiological studies have shown that sleep disturbances—comprising shorten time [8], difficulty in maintaining sleep [9], and mistimed sleep [10] increase the risk of T2DM.”
BackgroundCedernaes, J., Lampola, L., Axelsson, E. K., Liethof, L., Hassanzadeh, S., Yeganeh, A., Broman, J., Schiöth, H. B., & Benedict, C. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12340 · Cited by 67 · see citing works
Self-citationAssociation Between Inpatient Sleep Loss and Hyperglycemia of Hospitalization
DePietro, R. H., Knutson, K. L., Spampinato, L. M., Anderson, S. L. C., Meltzer, D. O., Cauter, E. V., & Arora, V. M. (2016) · Diabetes Care · doi:10.2337/dc16-1683 · Cited by 67 · see citing works
“Recent reviews have proposed mechanisms by which sleep affects metabolism, as it may affect both the brain and peripheral organs playing a pivotal role in metabolism, and thus sleepmay be a promising interventional point to treat obesity and type 2 diabetes (16,17).”
BackgroundSleep Deprivation Selectively Upregulates an Amygdala–Hypothalamic Circuit Involved in Food Reward
Rihm, J. S., Menz, M. M., Schultz, H., Bruder, L. R., Schilbach, L., Schmid, S. M., & Peters, J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0250-18.2018 · Cited by 64 · see citing works
Evidence for altered insulin receptor signaling in Alzheimer's disease
Griffith, C. M., Eid, T., Rose, G. M., & Patrylo, P. R. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.008 · Cited by 61 · see citing works
Cedernaes, J., Fanelli, F., Fazzini, A., Pagotto, U., Broman, J.-E., Vogel, H., Dickson, S. L., Schiöth, H. B., & Benedict, C. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.014 · Cited by 59 · see citing works
“For instance, there is some evidence that humans are more responsive to the effects of psychological stress when sleepdeprived compared to when they are well-rested (Cedernaes et al., 2015b; Minkel et al., 2014).”
BackgroundSelf-citationSleep and Wellbeing, Now and in the Future
Chow, C. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082883 · Cited by 52 · see citing works
“Indeed, short, low-quality and mistimed sleep may threaten metabolic public health [7].”
BackgroundUnderstanding Natural Cognition in Everyday Settings: 3 Pressing Challenges
Parada, F. J. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00386 · Cited by 48 · see citing works
“…with demographical, lifestyle, and social information such as eating (McGarel et al., 2014; Ojha et al., 2015; Zuker, 2015) and sleeping habits (Cedernaes et al., 2015; Dashti et al., 2015; Irwin, 2015), current employment situation/satisfaction (Faragher et al., 2013; Benach et al., 2014),…”
BackgroundCollado, M. C., Katila, M. K., Vuorela, N., Saarenpää‐Heikkilä, O., Salminen, S., & Isolauri, E. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002161 · Cited by 49 · see citing works
Sleep, circadian dysrhythmia, obesity and diabetes
Sridhar, G. R., & Sanjana, N. S. N. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i19.515 · Cited by 44 · see citing works
RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020
Chawla, R., Madhu, S. V., Makkar, B. M., Ghosh, S. K., Saboo, B., Kalra, S., & On behalf of RSSDI-ESI Consensus Group (2020) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-020-00819-2 · Cited by 43 · see citing works
Some implications of melatonin use in chronopharmacology of insomnia
Golombek, D. A., Pandi-Perumal, S. R., Brown, G. M., & Cardinali, D. P. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.032 · Cited by 42 · see citing works
“obesity and type 2 diabetes mellitus (Cedernaes et al., 2015) as well as in neurodegenerative disorders (Landry and Liu-Ambrose,”
BackgroundTsuneki, H., Wada, T., & Sasaoka, T. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.12.010 · Cited by 40 · see citing works
Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome
Wilms, B., Leineweber, E., Mölle, M., Chamorro, R., Pommerenke, C., Salinas, G., Sina, C., Lehnert, H., Oster, H., & Schmid, S. M. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01663 · Cited by 40 · see citing works
“Although it has to be shown to which extent this translates into an obesogenic effect under conditions of chronic sleep restriction, such molecular changes may represent the first symptoms preluding the physiological and appetite effects observed in several human sleep studies (4, 26).”
BackgroundAssessing the efficacy of melatonin to curtail benzodiazepine/Z drug abuse
Cardinali, D. P., Golombek, D. A., Rosenstein, R. E., Brusco, L. I., & Vigo, D. E. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.08.016 · Cited by 38 · see citing works
“Epidemiological studies have shown that disturbed sleep - comprising short, low-quality, and mistimed sleep - increases the risk of metabolic diseases, especially obesity and type 2 diabetes mellitus [5], as well as of neurodegenerative disorders [6].”
BackgroundTsuneki, H., Kon, K., Ito, H., Yamazaki, M., Takahara, S., Toyooka, N., Ishii, Y., Sasahara, M., Wada, T., Yanagisawa, M., et al. (2016) · Endocrinology · doi:10.1210/en.2016-1404 · Cited by 38 · see citing works
Sleep Control, GPCRs, and Glucose Metabolism
Tsuneki, H., Sasaoka, T., & Sakurai, T. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.011 · Cited by 34 · see citing works
“Evidence for the impact of sleep restriction or circadian misalignment on daytime physical activity and energy expenditure is also inconsistent; this may be due to different protocols and/or backgrounds of subjects enrolled in each trial and the differential influences of sleep on multiple components of energy expendi…”
BackgroundLehner, R., Balsters, J. H., Bürgler, A., Hare, T. A., & Wenderoth, N. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00230 · Cited by 32 · see citing works
“org November 2017 | Volume 8 | Article 230 FigUre 1 | Continued which can alter the incentive value of food (77) and performance on visual and cognitive tasks (78, 79).”
BackgroundSkúladóttir, G. V., Nilsson, E., Mwinyi, J., & Schiöth, H. B. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0309-1 · Cited by 32 · see citing works
“Several studies have indicated associations between insufficient sleep and alterations in circulating hormones involved in feeding behavior, glucose metabolism, hunger, and appetite, which are probably involved in the development of metabolic disorders, such as obesity and diabetes [9, 10].”
BackgroundSelf-citationGao, X., & Hermes, G. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00142 · Cited by 30 · see citing works
“It is well known that sleep loss is a risk factor for the development of obesity and diabetes (Copinschi et al., 2014; Cedernaes et al., 2015).”
BackgroundGodin, O., Henry, C., Leboyer, M., Azorin, J., Aubin, V., Bellivier, F., Polosan, M., Courtet, P., Gard, S., Kahn, J., et al. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1332071 · Cited by 30 · see citing works
“Other sleep parameters tended to correlate with metabolic disturbances such as low sleep quality and mistimed sleep (Cedernaes et al., 2015).”
BackgroundKelly, N. R., Shomaker, L. B., Radin, R. M., Thompson, K. A., Cassidy, O. L., Brady, S. M., Mehari, R. D., Courville, A. B., Chen, K. Y., Galescu, O. A., et al. (2016) · Eating Behaviors · doi:10.1016/j.eatbeh.2016.06.019 · Cited by 29 · see citing works
Liu, R.-Q., Qian, Z. M., Wang, S.-Q., Vaughn, M. G., Geiger, S. D., Xian, H., Lin, S., Paul, G. E., Zeng, X., Yang, B., et al. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6544 · Cited by 28 · see citing works
Freyberg, Z., & McCarthy, M. J. (2017) · Schizophrenia · doi:10.1038/s41537-017-0018-4 · Cited by 27 · see citing works
An international study of post-COVID sleep health
Alzueta, E., Perrin, P. B., Yüksel, D., Ramos‐Usuga, D., Kiss, O., Iacovides, S., de Zambotti, M., Cortes, M., Olabarrieta‐Landa, L., Arango‐Lasprilla, J. C., et al. (2022) · Sleep Health · doi:10.1016/j.sleh.2022.06.011 · Cited by 25 · see citing works
Vejražková, D., Lischkova, O., Vaňková, M., Stanická, S., Vrbíková, J., LUKASOVA, P., Včelák, J., Vacínová, G., & Bendlová, B. (2017) · Physiological Research · doi:10.33549/physiolres.933366 · Cited by 24 · see citing works
Zeng, Y., Wu, J., Yin, J., Chen, J., Yang, S., & Fang, Y. (2018) · Quality of Life Research · doi:10.1007/s11136-018-1942-0 · Cited by 21 · see citing works
Zhang, J., Zhang, J., Wu, H., & Wang, R. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02504-y · Cited by 20 · see citing works
Lee, H., Kim, B., & Park, T. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01706-x · Cited by 18 · see citing works
Yassıbaş, E., Bölükbaşı, H., Turan, İ. E., Demirel, A. M., & Gürler, E. (2024) · Journal of Eating Disorders · doi:10.1186/s40337-024-00980-7 · Cited by 17 · see citing works
“Because of limited sleep activity in individuals, ghrelin levels increase; leptin levels decrease; and this situation raises not only the total amount of food intake within 24 h but also the consumption of snacks [11].”
BackgroundZhan, S., Wu, Y., Sun, P. G., Lin, H., Zhu, Y., & Han, X. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122102 · Cited by 17 · see citing works
“Several reports have demonstrated that sleep deficiency induces obesity [14,15], whereas others have found that it attenuates weight gain [16,17].”
BackgroundAssociations Between the Prevalence of Metabolic Syndrome and Sleep Parameters Vary by Age
Titova, O. E., Lindberg, E., Elmståhl, S., Lind, L., Schiöth, H. B., & Benedict, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00234 · Cited by 17 · see citing works
“, during daytime because of night shift work) has been shown to adversely affect metabolic health (33, 34).”
BackgroundSelf-citationChen, Z., Feng, Y., Li, S., Hua, K., Fu, S., Chen, F., Chen, H., Pan, L., Wu, C., & Jiang, G. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1050403 · Cited by 16 · see citing works
Investigating sleep, stress, and mood dynamics via temporal network analysis
Jordan, D. G., Slavish, D. C., Dietch, J. R., Messman, B., Ruggero, C. J., Kelly, K. S., & Taylor, D. J. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.01.007 · Cited by 17 · see citing works
Cedernaes, J., Sand, F., Liethof, L., Lampola, L., Hassanzadeh, S., Axelsson, E. K., Yeganeh, A., Ros, O., Broman, J., Schiöth, H. B., et al. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.03.012 · Cited by 16 · see citing works
Self-citationPaulino, D. S. M., Pinho‐Pompeu, M., Raikov, F., Freitas-Jesus, J. V., Machado, H. D. C., & Surita, F. G. (2020) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0040-1712132 · Cited by 14 · see citing works
No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial
Larsen, A. U., Hopstock, L. A., Jorde, R., & Grimnes, G. (2021) · Sleep Medicine X · doi:10.1016/j.sleepx.2021.100040 · Cited by 14 · see citing works
“Specifically, poor sleep health has been associated with metabolic [3], endocrine [4] and psychiatric [5] diseases, as well as all-cause mortality [6].”
BackgroundLina, J., O’Callaghan, E. K., & Mongrain, V. (2018) · Clocks & Sleep · doi:10.3390/clockssleep1010006 · Cited by 10 · see citing works
“The study of topographic patterns of scale-free activity of the sleep EEG and of the underlying molecular mechanisms will further the knowledge on the established role for sleep in memory consolidation and in physiological health [13,14].”
Kaar, J. L., Schmiege, S. J., Kalkwarf, H. J., Woo, J. G., Daniels, S. R., & Simon, S. L. (2019) · Childhood Obesity · doi:10.1089/chi.2019.0126 · Cited by 13 · see citing works
Moulin, T. C., Ferro, F., Berkins, S., Hoyer, A., Williams, M. J., & Schiöth, H. B. (2020) · Brain Sciences · doi:10.3390/brainsci10080487 · Cited by 12 · see citing works
“Importantly, the overall activity and sleep/wake behavior assessment showed no differences between groups, indicating that the increase in food ingestion was not related to modifications in locomotion or disturbed sleep, which could by itself cause behavioral or metabolic consequences [26].”
BackgroundSelf-citationDelaying time to first nocturnal void may have beneficial effects on reducing blood glucose levels
Juul, K. V., Jessen, N., Bliwise, D. L., van der Meulen, E., & Nørgaard, J. P. (2016) · Endocrine · doi:10.1007/s12020-016-0920-y · Cited by 11 · see citing works
“An increasing body of literature indicates that adequate sleep is vital for metabolic health [1, 2].”
Backgroundde la Fuente-Muñoz, M., Roman, M. N., Amor, S., Garcı́a-Villalón, Á. L., Espinel, A. E., González‐Hedström, D., & Granado, M. (2023) · Antioxidants · doi:10.3390/antiox12081619 · Cited by 10 · see citing works
“The long-term consequences include an increased risk of suffering cardiovascular diseases, such as hypertension, atherosclerosis, myocardial ischemia [18], metabolic diseases, such as obesity and type II diabetes [19], cancer [20,21], and psychiatric disorders, such as anxiety or depression [16].”
BackgroundSiddalingaiah, H. S., Chandrakala, D., & Singh, A. (2017) · International Journal of Community Medicine and Public Health · doi:10.18203/2394-6040.ijcmph20175165 · Cited by 12 · see citing works
World Diabetes Day 2015: Healthy living & diabetes
Madhu, S. (2015) · The Indian Journal of Medical Research · doi:10.4103/0971-5916.171263 · Cited by 10 · see citing works
Sleep deprivation and dendritic architecture: a systematic review and meta-analysis
Brodin, A., Liesecke, F., Spielbauer, J., & Karlsson, T. E. (2025) · SLEEP · doi:10.1093/sleep/zsaf146 · Cited by 8 · see citing works
Savvidis, C., Maggio, V., Rizzo, M., Zabulienė, L., & Ilias, Ι. (2025) · Medicina · doi:10.3390/medicina61091630 · Cited by 12 · see citing works
“This misalignment disrupts key metabolic processes [19–21].”
Alkozei, A., Killgore, W. D. S., Smith, R. S., Dailey, N. S., Bajaj, S., Raikes, A. C., & Haack, M. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12629 · Cited by 9 · see citing works
“Importantly, sleep restriction is a risk factor for futureweight gain, especially for men (Cedernaes et al., 2015; Copinschi et al., 2014; Spaeth et al., 2013, 2014; Wu et al., 2014).”
BackgroundWyst, K. B. V., Whisner, C. M., Reifsnider, E., & Petrov, M. E. R. (2019) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000636 · Cited by 9 · see citing works
Chronotherapeutic effect of orexin antagonists on glucose metabolism in diabetic mice
Kon, K., Tsuneki, H., Ito, H., Takemura, Y., Sato, K., Yamazaki, M., Ishii, Y., Sasahara, M., Rudich, A., Maeda, T., et al. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0708 · Cited by 8 · see citing works
An, J. H., Park, M. J., Fava, M., Mischoulon, D., Kim, H., Jang, J., Hong, J. P., Park, J. S., & Jeon, H. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00444 · Cited by 7 · see citing works
“Several epidemiological studies also revealed that insomnia increases the risk of type 2 diabetes mellitus, neurocognitive disorders, and obesity (2, 3).”
BackgroundClark, E., Gutierrez‐Colina, A. M., Ruzicka, E. B., Sánchez, N., Bristol, M., Gulley, L. D., Broussard, J. L., Kelsey, M. M., Simon, S. L., & Shomaker, L. B. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2399756 · Cited by 5 · see citing works
“…been associated with greater insulin sensitivity in studies with adolescents and adults, whereas insufficient or short sleep may relate to acute and longer-term declines in insulin sensitivity, as well as decreased insulin secretory capacity, and consequently, a greater risk for T2D [26, 94,95].”
BackgroundXu, D., Cardell, E., Xu, M., Ji, Y., Lou, Z., Sun, J., & Li, L. (2023) · International Journal of Cognitive Therapy · doi:10.1007/s41811-023-00189-7 · Cited by 4 · see citing works
“Previous studies also mentioned that sleep problems are closely linked to the alterations of cardiometabolic conditions (Bathgate & Fernandez-Mendoza, 2018; Cedernaes et al., 2015; Tan et al., 2018).”
Colour design and non‐image‐forming effects in humans: An open issue
Rossi, M. (2020) · Coloration Technology · doi:10.1111/cote.12501 · Cited by 5 · see citing works
Sleep disorders in patients with endometriosis; a cross-sectional study
Chaichian, S., Mehdizadehkashi, A., Haghgoo, A., Ajdary, M., Derakhshan, R., Rokhgireh, S., Sarhadi, S., & Nikfar, B. (2024) · BMC Women s Health · doi:10.1186/s12905-024-03185-x · Cited by 4 · see citing works
“According to the negative health consequences of sleep disorders mentioned above [14–16,”
BackgroundDoes vital exhaustion increase the risk of type 2 diabetes? A prospective study
Volden, S., Wimmelmann, C. L., & Flensborg‐Madsen, T. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.06.001 · Cited by 4 · see citing works
Rossi, M. (2019) · Research for development · doi:10.1007/978-3-030-11087-1_2 · Cited by 4 · see citing works
Knowles, O., Soria, M., Saner, N. J., Trewin, A. J., Alexander, S. E., Roberts, S., Hiam, D., GARNHAM, A. P., Drinkwater, E. J., Aisbett, B., et al. (2024) · Physiological Genomics · doi:10.1152/physiolgenomics.00010.2024 · Cited by 3 · see citing works
Tan, X. W., Cedernaes, J., Risérus, U., & Benedict, C. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.227 · Cited by 3 · see citing works
“These sleep parameters have all been linked to impaired insulin sensitivity (Tan et al., 2018b; Cedernaes et al., 2018; Cedernaes et al., 2015; Strand et al., 2015).”
Self-citationFrom symbiosis to dysbiosis in gut-consequence includes metabolic syndrome
Mohan, N., & Sunder, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95715-1.00005-4 · Cited by 3 · see citing works
The experience of a Power Nap Center in the largest city of Brazil
Santos‐Silva, R., Jankavski, C., & Lorenzi‐Filho, G. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.06.006 · Cited by 3 · see citing works
“2).”
Associations between paediatric fatigue and eating behaviours
Bensignor, M. O., Northrop, E. F., Bramante, C. T., Rudser, K. D., Gross, A. C., & Kelly, A. S. (2020) · Obesity Science & Practice · doi:10.1002/osp4.422 · Cited by 2 · see citing works
Immune, neuroendocrine, and metabolic functions in insomnia disorder
Engert, L. C., & Haack, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00120-1 · Cited by 3 · see citing works
Sleep quality among clinical postgraduate students: a cross-sectional study in Kerala, India
Gopika, G. B., Mini, G., Ameera, A., Parvathi, R., Malavika, George, R., Swarnam, K., & Marthanda Pillai, A. (2025) · BMC Public Health · doi:10.1186/s12889-025-23719-8 · Cited by 3 · see citing works
“Sleep disturbances are caused by several internal factors, such as obesity, neurological conditions, chronic illnesses, anxiety disorders, depression, and restless legs syndrome [2].”
Yoshikawa, F., Kumashiro, N., Shigiyama, F., Miyagi, M., Ando, Y., Uchino, H., & Hirose, T. (2021) · Diabetology International · doi:10.1007/s13340-021-00516-3 · Cited by 2 · see citing works
Melatonin and Benzodiazepine/Z-Drug Abuse
Vigo, D. E., & Cardinali, D. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-95360-1_34 · Cited by 2 · see citing works
Comparison and prediction of sleep quality in users of bed or hammock as sleeping device
Estrella, J. M., & Arankowsky‐Sandoval, G. (2020) · Sleep Health · doi:10.1016/j.sleh.2020.06.002 · Cited by 2 · see citing works
Kunorozva, L., Rae, D. E., & Roden, L. C. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2139184 · Cited by 1 · see citing works
“Other studies have reported a reduction in glucose uptake by peripheral tissues in favour of fat oxidation following sleep deprivation (Cedernaes et al. 2015; Knutson et al. 2007; Tasali et al. 2008).”
BackgroundAnalysis of the role of clock genes in the sleep-wake cycle and other biological processes
Xu, J. (2023) · Theoretical and Natural Science · doi:10.54254/2753-8818/23/20231067 · Cited by 1 · see citing works
Insomnia in stimulant use disorders: Prevalence and associations with negative affect
Bourtin, I. G., de Dios, C., Vincent, J. N., Schmitz, J. M., Lane, S. D., & Webber, H. E. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.108689 · Cited by 1 · see citing works
Kovalchuk, L. S., González‐Romá, V., Balducci, C., Molinaro, D., & Spagnoli, P. (2025) · Anxiety Stress & Coping · doi:10.1080/10615806.2025.2601226 · Cited by 1 · see citing works
“…physical and mental health problems, such as hypertension, cardiovascular disease, type 2 diabetes, depression, anxiety, and performance deficits (Cedernaes et al., 2015; McCoy & Strecker, 2011; Meerlo et al., 2015; Narang et al., 2012; Phillips & Mannino, 2007; Tem-pesta et al., 2015; Tkachenko…”
Chermon, D., Busi, O., Haikin, S., & Birk, R. Z. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.109082 · Cited by 1 · see citing works
Evidence-based Ways to Promote Metabolic Health
Outland, L. (2018) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2018.02.010 · Cited by 1 · see citing works
Obstruktive Schlafapnoe und Diabetes
Fietze, I. (2020) · Der Diabetologe · doi:10.1007/s11428-020-00613-y · Cited by 1 · see citing works
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Integrated respirometry and metabolomics unveil circadian metabolic dynamics in DrosophilaPreprint
Akhtar, F., Malik, D. M., Sengupta, A., Haynes, P. R., Nguyen, A. D., Klok, J., Sehgal, A., & Weljie, A. M. (2025) · eLife · doi:10.7554/elife.108681 · Cited by 1 · see citing works
“This is a critical advancement, as dissecting time- of- day-dependent metabolic regulation in mammals is often confounded by overlapping effects of sleep, activity, and feeding rhythms ( Cedernaes et al., 2015 ; Katayose et al., 2009 ).”
Bakır, B. O. (2017) · Advances in Obesity Weight Management & Control · doi:10.15406/aowmc.2017.06.00146
Influência do padrão de sono sobre o ganho de peso ao longo da gestação
Balieiro, L. C. T. (2017) · doi:10.14393/ufu.di.2017.79
Az alvászavar és a metabolikus szindróma kapcsolata
Rafael, B., Perényi, D. R., & Kósa, I. (2019) · Cardiologia Hungarica · doi:10.26430/chungarica.2019.49.5.349
“Lehetséges, hogy ez a magyarázata annak, hogy idősebb korban gyakoribb a metabolikus szindróma előfordulása (13).”
InfluentialO’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_8
ระบบสองสวางอจฉรยะสำหรบการเลยนแบบแสงในรอบวนและแสงจา
สันติมาลัย, ส. (2021) · doi:10.58837/chula.the.2021.949
Factorizing social advanced aspects in modern life on human health
Nguyen, P. Y. N., Dinh, H. D., & Tran, H. N. (2023) · CTU Journal of Innovation and Sustainable Development · doi:10.22144/ctujoisd.2023.034
“This is primarily related to the body being more sensitive to insulin and an increase in appetite, which motivates higher levels of food intake (Cedernaes et al., 2015).”
BackgroundComportamentos relacionados à saúde na perspectiva do cuidado obstétrico
Paulino, D. S. M. (2020) · doi:10.47749/t/unicamp.2020.1246517
Integrated respirometry and metabolomics unveil circadian metabolic dynamics in Drosophila
Akhtar, F., Malik, D. M., Sengupta, A., Haynes, P. R., Nguyen, A. D., Klok, J., Sehgal, A., & Weljie, A. M. (2026) · eLife · doi:10.7554/elife.108681.3
Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in DrosophilaPreprint
Akhtar, F., Malik, D. M., Sengupta, A., Haynes, P. R., Klok, J., Sehgal, A., & Weljie, A. M. (2025) · eLife · doi:10.7554/elife.108681.1
Lee, H.-S., Kim, B., & Park, T. (2024) · Figshare · doi:10.6084/m9.figshare.26315522
Bourtin, I. G., Calvillo, D. J., Badawi, J. C., Schmitz, J. M., Lane, S. D., Yoon, J. H., & Webber, H. E. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113125
- Authors
- Cedernaes, J., Schiöth, H. B., & Benedict, C.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Cedernaes, Jonathan
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2015-03-17
- Volume
- 64
- Issue
- 4
- Pages
- 1073-1080
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2121355707
- Semantic Scholar
- 36131c74e99a735465a2f0f5b7ca175768a02d56
- Cited by
- 103
- References
- 76
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 12 · 2019: 6 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 6
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Novo Nordisk Fonden (NNF14OC0009349)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep disruption, short sleep duration, sleep deprivation, obesity, type 2 diabetes, metabolic health, ghrelin, appetite-regulating hormones, energy balance, body weight regulation, sleep timing, genetic susceptibility
- MeSH terms
- Diabetes Mellitus, Type 2, Female, Humans, Male, Obesity, Sleep Deprivation
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