Cited by 152Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCerebrospinal fluid and hydrocephalus

Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer’s disease

Open access
Welge, Volker, Fiege, Oliver, Lewczuk, Piotr, Mollenhauer, Brit, Esselmann, Hermann, Klafki, Hans-Wolfgang, Wolf, Stefanie, Trenkwalder, Claudia +4 more·2009·Journal of Neural Transmission

Abstract

Cerebrospinal fluid (CSF) concentrations of amyloid-beta (Abeta) 1-38, 1-40, 1-42, total-tau and phospho-tau in samples from 156 patients with Alzheimer's disease (AD) (n = 44), depressive cognitive complainers (DCC, n = 25) and various other forms of non-Alzheimer dementias (NAD, n = 87) were analyzed by electrochemiluminescence and enzyme linked immunosorbent assay, respectively. A significant decrease of CSF Abeta1-42 was the most powerful single marker for differentiation of AD from DCC, yielding accuracies of beyond 85%. Increased p-tau and the ratio Abeta1-42/Abeta1-38 yielded accuracies of beyond 80 and 85%, respectively, to discriminate AD versus NAD. Combining p-tau with Abeta1-42/Abeta1-38 resulted in a sensitivity of 94% for detection of AD and 85% specificity for excluding NAD. Decreased CSF Abeta1-42 represents a core biomarker for AD. The lack of specificity for exclusion of NAD can be most effectively compensated by the ratio Abeta1-42/Abeta1-38. The ratio Abeta1-42/Abeta1-38/p-tau powerfully discriminates AD versus NAD and fulfils the accuracy requirements for an applicable screening and differential diagnostic AD biomarker.

Integrity signals

Registry

Crossref · 10.1007/s00702-008-0177-6

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Welge, V., Fiege, O., Lewczuk, P., Mollenhauer, B., Esselmann, H., Klafki, H.-W., Wolf, S., Trenkwalder, C., Otto, M., Kornhuber, J., Wiltfang, J., & Bibl, M.
Affiliations
  • University of Duisburg-Essen (DE)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
  • University of Göttingen (DE)
  • Paracelsus Elena Klinik Kassel (DE)
  • Universität Ulm (DE)
Corresponding author
Bibl, Mirko
Venue
Journal of Neural Transmission
Published
2009-01-14
Volume
116
Issue
2
Pages
203-212
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2041245991
Cited by
152
References
42
Citations by year
2026: 2 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 6 · 2021: 10 · 2020: 17 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 13 · 2014: 14 · 2013: 13 · 2012: 10
FWCI
7.63
Type
journal article
Language
en
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • GRO (submittedVersion, cc-by)
Funders
  • Baden-Württemberg Stiftung
  • Bundesministerium für Bildung und Forschung
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords
Alzheimer's disease, cerebrospinal fluid biomarkers, amyloid-beta 42, phosphorylated tau, total tau, differential diagnosis of dementia, non-Alzheimer's dementia, diagnostic accuracy, screening biomarkers
MeSH terms
Aged, Alzheimer Disease, Enzyme-Linked Immunosorbent Assay, Female, Humans, Luminescent Measurements, Male, Middle Aged, Phosphorylation, ROC Curve, Biomarkers, Amyloid beta-Peptides, tau Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review