Cited by 150Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

Learning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity

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Coddington, Luke T., Dudman, Joshua T.·2019·Neuron

Abstract

Animals infer when and where a reward is available from experience with informative sensory stimuli and their own actions. In vertebrates, this is thought to depend upon the release of dopamine from midbrain dopaminergic neurons. Studies of the role of dopamine have focused almost exclusively on their encoding of informative sensory stimuli; however, many dopaminergic neurons are active just prior to movement initiation, even in the absence of sensory stimuli. How should current frameworks for understanding the role of dopamine incorporate these observations? To address this question, we review recent anatomical and functional evidence for action-related dopamine signaling. We conclude by proposing a framework in which dopaminergic neurons encode subjective signals of action initiation to solve an internal credit assignment problem.

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Crossref · 10.1016/j.neuron.2019.08.036

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  • DA neurotransmission is essential for diverse behavioral outputs, including motivation, cognition, reward learning, decision making, salience attribution, and voluntary motor control.

    “DA neurotransmission is essential for diverse behavioral outputs, including motivation, cognition, reward learning, decision making, salience attribution, and voluntary motor control [121–127].”

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Authors
Coddington, L. T., & Dudman, J. T.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
  • Coddington, Luke T.
  • Dudman, Joshua T.
Venue
Neuron
Publisher
Elsevier BV
Published
2019-10
Volume
104
Issue
1
Pages
63-77
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2979619911
Cited by
150
References
186
Citations by year
2026: 18 · 2025: 24 · 2024: 27 · 2023: 19 · 2022: 24 · 2021: 24 · 2020: 14
FWCI
2.06
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dopamine, midbrain dopaminergic neurons, movement initiation, reward prediction, credit assignment
MeSH terms
Animals, Humans, Learning, Mesencephalon, Movement, Reward, Dopaminergic Neurons

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