Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch
Open accessAbstract
The function of neural circuits depends on the generation of specific classes of neurons. Neural identity is typically established near the time when neurons exit the cell cycle to become postmitotic cells, and it is generally accepted that, once the identity of a neuron has been established, its fate is maintained throughout life. Here, we show that network activity dynamically modulates the properties of fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator Er81. In the adult cortex, Er81 protein levels define a spectrum of FS basket cells with different properties, whose relative proportions are, however, continuously adjusted in response to neuronal activity. Our findings therefore suggest that interneuron properties are malleable in the adult cortex, at least to a certain extent.
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In supragranular PV+ basket cells, neuronal activity modulates expression and subcellular location of Etv1, which induces Kv1.1.
“In supragranular PV+ basket cells, neuronal activity modulates the expression and subcellular location (cytoplasmic or nuclear) of the transcription factor Etv1 (Dehorter et al., 2015), which in turn induces the expression of Kv1.1.”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Dehorter et al., 2015
Some cell types have been quantified, but those studies often relied on extra labels such as individual gene markers to define the types beforehand.
“Specific cell types have been characterized quantitatively9–11, but these studies frequently have used additional labels (individual gene markers) to pre-define cell types.”
From Classification of electrophysiological and morphological neuron types in the mouse visual cortex (2019) · cites this paper as [11]
Activity-dependent mechanisms influence development, maturation and plasticity of cortical interneurons, but most aspects directly linked to functional diversity seem intrinsically determined.
“Activity-dependent mechanisms undoubtedly influence development, maturation and plasticity of cortical interneurons (24–26), but most aspects that are directly linked to the functional diversity of cortical interneurons seem to be intrinsically determined (14, 27).”
From Early emergence of cortical interneuron diversity in the mouse embryo (2018) · cites this paper as [26]
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“For example, Nkx6-2+ progenitor cells produce several types of SST+ neurons along with some PV+ basket cells and chandelier cells, and a mixed progeny of interneurons from the SST+ and PV+ classes has also been described for Etv1+ progenitor cells (He et al., 2016).”
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- Authors
- Dehorter, N., Ciceri, G., Bartolini, G., Lim, L., del Pino, I., & Marín, O.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- MRC Centre for Developmental Neurobiology, Medical Research Council, New Hunt's House, Guy's Campus, King’s College London, London SE1 1UL, UK.
- Venue
- Science
- Published
- 2015-09-11
- Volume
- 349
- Issue
- 6253
- Pages
- 1216-1220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4702376
- OpenAlex
- W1599788775
- Cited by
- 169
- References
- 42
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 17 · 2023: 18 · 2022: 11 · 2021: 17 · 2020: 15 · 2019: 16 · 2018: 21 · 2017: 16 · 2016: 17 · 2015: 3
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Wellcome Trust (103714MA)
- European Research Council (ERC-2011-AdG 293683)
- Spanish Ministry of Science and Innovation (SAF2011-28845)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- fast-spiking interneurons, ER81, basket cells, activity-dependent plasticity, transcriptional regulation, postmitotic neurons, neuronal identity, interneuron heterogeneity, network activity
- MeSH terms
- Animals, Cerebral Cortex, DNA-Binding Proteins, Interneurons, Mice, Mutant Strains, Mitosis, Mutation, Nerve Net, Transcription Factors, Transcription, Genetic, Mice
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