Brain monoamine receptors in a chronic unpredictable stress model in rats
Abstract
Antidepressant drugs are devoid of mood-elevating effects in normal (non-depressed) human subjects, thus, it is necessary to evaluate the antidepressant property of compounds (drugs) in animal models of depression. Several animal models of depression have been introduced, however, only a few have been extensively validated. In the present study we report the results of investigations into monoaminergic receptors in the brain of rats subjected to chronic unpredictable stress (CUS) procedure (one of the well validated animal models of depression). We have examined the dopaminergic (D-1, D-2), adrenergic (alpha-1, beta-1) and serotonergic (5HT-1A, 5HT-2A) receptors in different brain regions by a saturation radioligand binding method in rats subjected to CUS paradigm and control animals. CUS procedure resulted in a significant 29% increase in the D-1 receptor density in the limbic system and 52% increase of the density of 5HT-2A receptors in the cerebral cortex. The present data indicate that the increase of the density of brain D-1 and 5HT-2A receptors of rats subjected to CUS might be involved in the pathophysiology of "animal depression" (since chronic antidepressant treatment produced opposite changes i.e. decrease in the density of these receptors) and thus in pathophysiology of human depression.
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Altered DA function may be related to changes in D1 receptors, which alter functional output in the rat limbic system after chronic unpredictable stress.
“Altered DA function may also be related to changes in D1 receptors, which have been shown to alter functional output in the rat limbic system after chronic unpredictable stress [199].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [199]
Cites
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · cited 9× · see citing works
“amined for their, face, construct and predictive validity and introduced to preclinical drug evaluation (Katz et al., 1981; Van Riezen and Leonard, 1991; Willner et al., 1992).”
BackgroundMethodInfluentialKatz, R. J., Roth, K. A., & Carroll, B. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90005-1 · Cited by 889 · see citing works
Weiss, J. M., Goodman, P. A., Losito, B. G., Corrigan, S. A., Charry, J. M., & Bailey, W. H. (1981) · Brain Research Reviews · doi:10.1016/0165-0173(81)90005-9 · Cited by 660 · see citing works
Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment
Charney, D. S. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780350094011 · Cited by 649 · see citing works
Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims
Mann, J. J. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800100048007 · Cited by 549 · see citing works
Depression: The predisposing influence of stress
Anisman, H., & Zacharko, R. M. (1982) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00010633 · Cited by 433 · see citing works
Arango, V. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810230054009 · Cited by 420 · see citing works
Heel, R. C., Morley, P. A., Brogden, R. N., Carmine, A., Speight, T. M., & Avery, G. S. (1982) · Drugs · doi:10.2165/00003495-198224030-00001 · Cited by 384 · see citing works
Heninger, G. R., Delgado, P. L., & Charney, D. S. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979535 · Cited by 381 · see citing works
Brown, A. S., & Gershon, S. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245227 · Cited by 359 · see citing works
Stress, depression and the mesolimbic dopamine system
Cabib, S., & Puglisi‐Allegra, S. (1996) · Psychopharmacology · doi:10.1007/s002130050142 · Cited by 314 · see citing works
Arora, R. C., & Meltzer, H. Y. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.6.730 · Cited by 313 · see citing works
5HT2 receptor changes in major depression
Yates, M., Leake, A., Candy, J., FAIRBAIRN, A. F., McKeith, I. G., & Ferrier, I. N. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90440-d · Cited by 265 · see citing works
Effects of psychotropic drugs on the behavior and neurochemistry of olfactory bulbectomized rats
van Riezen, H., & Leonard, B. E. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90043-2 · Cited by 218 · see citing works
Platelet serotonin-2 receptor binding sites in depression and suicide
Pandey, G. N., Pandey, S. C., Janicak, P. G., Marks, R., & Davis, J. M. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90576-n · Cited by 212 · see citing works
Pharmacological validation of the chronic mild stress model of depression
Papp, M., Moryl, E., & Willner, P. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00697-4 · Cited by 205 · see citing works
Papp, M., Klimek, V., & Willner, P. (1994) · Psychopharmacology · doi:10.1007/bf02245566 · Cited by 202 · see citing works
Multiple neurochemical and behavioral consequences of stressors: Implications for depression
Anisman, H., & Zacharko, R. M. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90039-5 · Cited by 196 · see citing works
Watanabe, Y., Sakai, R. R., McEwen, B. S., & Mendelson, S. D. (1993) · Brain Research · doi:10.1016/0006-8993(93)91117-b · Cited by 189 · see citing works
Arora, R., & Meltzer, H. Y. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90384-6 · Cited by 176 · see citing works
Serotonin 5-HT2 receptor binding on blood platelets - a peripheral marker for depression?
Biegon, A. R., Weizman, A., Karp, L., Ram, A., Tiano, S., & Wolff, M. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90675-8 · Cited by 166 · see citing works
Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning
Sugrue, M. F. (1983) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(83)90065-7 · Cited by 160 · see citing works
Klimek, V., & Nielsen, M. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90248-2 · Cited by 118 · see citing works
Weiss, J. M., Bailey, W. H., Pohorecky, L. A., Korzeniowski, D., & Grillione, G. (1980) · Neurochemical Research · doi:10.1007/bf00964456 · Cited by 115 · see citing works
Cabib, S., Giardino, L., Calzà, L., Zanni, M., Mele, A., & Puglisi-Allegra, S. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00468-5 · Cited by 98 · see citing works
The neuroendocrine response to fenfluramine in depressives and normal controls
Asnis, G. M., Eisenberg, J., van Praag, H. M., Lemus, C. Z., Harkavy‐Friedman, J., & Miller, A. H. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90133-3 · Cited by 65 · see citing works
D’Aquila, P. S., Collu, M., Pani, L., Gessa, G. L., & Serra, G. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90033-7 · Cited by 63 · see citing works
Katz, R. J., & Sibel, M. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90055-7 · Cited by 62 · see citing works
Wolfe, N., Katz, D. I., Albert, M. L., Almozlino, A., Durso, R., Smith, M. C., & Volicer, L. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.10.915 · Cited by 58 · see citing works
A role for 5-HT in the action of antidepressant drugs
Cowen, P. J. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90033-x · Cited by 56 · see citing works
Weizman, A., Mark, M., Gil‐Ad, I., Tyano, S., & Laron, Z. (1988) · Clinical Neuropharmacology · doi:10.1097/00002826-198806000-00007 · Cited by 52 · see citing works
Repeated Administration of Antidepressants Enhances Agonist Affinity for Mesolimbic D2-Receptors
Klimek, V., & Maj, J. (1989) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1989.tb06525.x · Cited by 49 · see citing works
Berendsen, H. H. G., & Broekkamp, C. L. E. (1991) · Psychopharmacology · doi:10.1007/bf02244313 · Cited by 48 · see citing works
Giardino, L., Zanni, M., Pozza, M., Bettelli, C., & Covelli, V. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01608-7 · Cited by 23 · see citing works
Chronic stress reduces fighting behavior of rats: The effect of antidepressants
Zebrowska-Łupina, I., Ossowska, G., & Klenk-Majewska, B. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90182-2 · Cited by 21 · see citing works
Self-citationSerotonin neuroscience discoveries usher in a new era of novel drug therapies for psychiatry.
Sm, S. (1992) · PubMed · Cited by 16 · see citing works
The influence of antidepressants on aggressive behavior in stressed rats: the role of dopamine.
Zebrowska-Łupina, I., Ossowska, G., & Klenk-Majewska, B. (1993) · PubMed · Cited by 10 · see citing works
Self-citation
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Sorted by citations
Stress and the dopaminergic reward system
Baik, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00532-4 · Cited by 446 · see citing works
Neurobiology of chronic mild stress: parallels to major depression
Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B., & Weinberg, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.001 · Cited by 420 · see citing works
Hill, M. N., Patel, S., Carrier, E. J., Rademacher, D. J., Ormerod, B. K., Hillard, C. J., & Gorzalka, B. B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300601 · Cited by 363 · see citing works
Anisman, H., Merali, Z., & Hayley, S. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.01.004 · Cited by 334 · see citing works
Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000016 · Cited by 304 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.005 · Cited by 281 · see citing works
Anisman, H. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0902 · Cited by 292 · see citing works
Hill, M. N., Carrier, E. J., McLaughlin, R. J., Morrish, A. C., Meier, S. E., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05567.x · Cited by 246 · see citing works
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
Holmes, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.006 · Cited by 264 · see citing works
The behavioral pharmacology of hallucinogens
Fantegrossi, W. E., Murnane, K. S., & Reissig, C. J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.018 · Cited by 226 · see citing works
Brouwer, A., & Carhart-Harris, R. L. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959637 · Cited by 159 · see citing works
Hammack, S. E., Guo, J.-D., Hazra, R., Dabrowska, J., Myers, K. M., & Rainnie, D. G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.05.013 · Cited by 103 · see citing works
“An increase in cortical 5-HT2 receptor function is observed after chronic variable stress (Ferretti et al., 1995; Ossowska et al., 2001), social stress (McKittrick et al., 1995), and swim stress (Takao et al., 1997), and similar stressors have been shown to decrease 5-HT1A function in the…”
BackgroundMethamphetamine-induced toxicity: An updated review on issues related to hyperthermia
Matsumoto, R. R., Seminerio, M. J., Turner, R. C., Robson, M. J., Nguyen, L., Miller, D. B., & O'Callaghan, J. P. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.05.001 · Cited by 99 · see citing works
Ma, S., & Morilak, D. A. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01372.x · Cited by 94 · see citing works
Neurochemical, hormonal, and behavioral effects of chronic unpredictable stress in the rat
Cox, B. M., Alsawah, F., McNeill, P. C., Galloway, M. P., & Perrine, S. A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.038 · Cited by 86 · see citing works
Serotonin 2A receptors are a stress response system: implications for post-traumatic stress disorder
Murnane, K. S. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000459 · Cited by 85 · see citing works
Torres, I. L. D. S., Gamaro, G. D., de Vasconcellos, A. P. S., Silveira, R., & Dalmaz, C. (2002) · Neurochemical Research · doi:10.1023/a:1019856821430 · Cited by 84 · see citing works
A final common pathway for depression? Progress toward a general conceptual framework
Stone, E. A., Lin, Y., & Quartermain, D. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.08.007 · Cited by 82 · see citing works
Guo, J.-D., Hammack, S. E., Hazra, R., Levita, L., & Rainnie, D. G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.028 · Cited by 67 · see citing works
Randomized Controlled Trials of the D1/D5 Antagonist Ecopipam for Weight Loss in Obese Subjects
Astrup, A. V., Greenway, F. L., Ling, W. W., Pedicone, L. D., Lachowicz, J. E., Strader, C. D., Kwan, R., & Ecopipam Obesity Study Group (2007) · Obesity · doi:10.1038/oby.2007.205 · Cited by 65 · see citing works
Stone, E. A., Lin, Y., Rosengarten, H., Kramer, H. K., & Quartermain, D. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300222 · Cited by 60 · see citing works
Jacobson‐Pick, S., Audet, M., McQuaid, R. J., Kalvapalle, R., & Anisman, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060133 · Cited by 58 · see citing works
Chronic stress augments the long-term and acute effects of methamphetamine
Matuszewich, L., & Yamamoto, B. K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.007 · Cited by 49 · see citing works
Czopek, A., Byrtus, H., Kołaczkowski, M., Pawłowski, M., Dybała, M., Nowak, G., Tatarczynska, E., Wesołowska, A., & Chojnacka-Wójcik, E. (2009) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2009.11.053 · Cited by 46 · see citing works
Self-citationJuvenile stress affects anxiety-like behavior and limbic monoamines in adult rats
Luo, X.-M., Yuan, S., Guan, X., Xie, X., Shao, F., & Wang, W. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.035 · Cited by 43 · see citing works
Liu, H., Ma, L.-L., Li, C., Cao, B., Jiang, Y., Han, L., Xu, R., Lin, J., & Zhang, D. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101281 · Cited by 43 · see citing works
Tata, D. Α., Raudensky, J., & Yamamoto, B. K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05688.x · Cited by 41 · see citing works
Hazra, R., Guo, J. D., Dabrowska, J., & Rainnie, D. G. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.014 · Cited by 42 · see citing works
Papp, M., Gruca, P., Lason-Tyburkiewicz, M., Litwa, E., Niemczyk, M., Tota-Glowczyk, K., & Willner, P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4651-4 · Cited by 40 · see citing works
Long-lasting effects of chronic stress on DOI-induced hyperthermia in male rats
Matuszewich, L., & Yamamoto, B. K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1498-7 · Cited by 40 · see citing works
Steinbusch, H. W. M., Dolatkhah, M. A., & Hopkins, D. A. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.02.003 · Cited by 39 · see citing works
Lages, Y., Rossi, Á. D., Krahe, T. E., & Landeira-Fernández, J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.01.020 · Cited by 35 · see citing works
5-HT1A/1B Receptors as Targets for Optimizing Pigmentary Responses in C57BL/6 Mouse Skin to Stress
Wu, H., Pang, S., Liu, Q., Wang, Q., Cai, M., & Shang, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089663 · Cited by 34 · see citing works
Bojarski, A. J., Kowalski, P., Kowalska, T., Duszyńska, B., Charakchieva‐Minol, S., Tatarczynska, E., Kłodzińska, A., & Chojnacka-Wójcik, E. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00349-8 · Cited by 32 · see citing works
The renaissance in psychedelic research: What do preclinical models have to offer
Murnane, K. S. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.08.003 · Cited by 31 · see citing works
A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex
Luppi, A. I., Girn, M., Rosas, F. E., Timmermann, C., Roseman, L., Erritzøe, D., Nutt, D., Stamatakis, E. A., Spreng, R. N., Xing, L., et al. (2023) · Brain · doi:10.1093/brain/awad311 · Cited by 30 · see citing works
Johnson, B. N., & Yamamoto, B. K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.067 · Cited by 26 · see citing works
Wesołowska, A., Paluchowska, M. H., Gołembiowska, K., & Chojnacka-Wójcik, E. (2003) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021017 · Cited by 25 · see citing works
Bojarski, A. J., Paluchowska, M. H., Duszyńska, B., Kłodzińska, A., Tatarczynska, E., & Chojnacka-Wójcik, E. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.12.041 · Cited by 24 · see citing works
Tang, H., Zhang, Y., Yang, L., Chen, H., Chen, K., Li, Y., & Wu, H. (2023) · The FASEB Journal · doi:10.1096/fj.202201352rr · Cited by 23 · see citing works
Jaggar, M., Weisstaub, N., Gingrich, J. A., & Vaidya, V. A. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.06.001 · Cited by 23 · see citing works
Papiez, M. A., Dybała, M., Sowa-Kućma, M., Krzyściak, W., Taha, H., Józkowicz, A., & Nowak, G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.02.015 · Cited by 22 · see citing works
Self-citationRubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms
Yi, J. H., Jeon, J., Kwon, H., Cho, E., Yun, J., Lee, Y. C., Ryu, J. H., Park, S. J., Cho, J. H., & Kim, D. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103454 · Cited by 18 · see citing works
Ossowska, G., Nowak, G., Klenk-Majewska, B., Danilczuk, Z., & Zebrowska-Łupina, I. (2002) · PubMed · Cited by 21 · see citing works
Self-citationLewis, M. W., Jones, R. T., & Davis, M. T. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00915-1 · Cited by 20 · see citing works
Synthesis and 5-HT1A, 5-HT2A receptor activity of new β-tetralonohydantoins
Byrtus, H., Pawłowski, M., Czopek, A., Bojarski, A. J., Duszyńska, B., Nowak, G., Kłodzińska, A., Tatarczynska, E., Wesołowska, A., & Chojnacka-Wójcik, E. (2005) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2004.07.013 · Cited by 19 · see citing works
Self-citationHuzarska, M., Zieliński, M., & Herman, Z. S. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.069 · Cited by 19 · see citing works
SUMNER, B. E. H., D’Eath, R. B., Farnworth, M. J., Robson, S. K., Russell, J. A., Lawrence, A. B., & Jarvis, S. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.05.004 · Cited by 17 · see citing works
Zajdel, P., Subra, G., Bojarski, A. J., Duszyńska, B., Pawłowski, M., & Martínez, J. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.01.060 · Cited by 18 · see citing works
Cheng, Z., Zhao, F., Piao, J., Yang, W., Cui, R., & Li, B. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02684-5 · Cited by 18 · see citing works
Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives
Zagórska, A., Jurczyk, S., Pawłowski, M., Dybała, M., Nowak, G., Tatarczynska, E., Nikiforuk, A., & Chojnacka-Wójcik, E. (2009) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2009.07.014 · Cited by 17 · see citing works
Self-citationMetabolomic analysis of animal models of depression
Tian, L., Pu, J., Liu, Y., Gui, S., Zhong, X., Song, X., Xu, S., Zhang, H., Wang, H., Zhou, W., et al. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00574-7 · Cited by 16 · see citing works
Rasul, A., El‐Nour, H., Blakely, R., Lonne‐Rahm, S., Forsberg, J., Johansson, B. A., Theodorsson, E., & Nordlind, K. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1138-8 · Cited by 14 · see citing works
Matrov, D., Vonk, A., Herm, L., Rinken, A., & Harro, J. (2011) · Neuropsychobiology · doi:10.1159/000325224 · Cited by 14 · see citing works
García‐Gutiérrez, M. S., Navarro, D., Austrich-Olivares, A., & Manzanares, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1171646 · Cited by 12 · see citing works
Psychedelic-Induced Serotonin 2A Receptor Downregulation Does Not Predict Swim Stress Coping in Mice
Pędzich, B. D., Medrano, M., Buckinx, A., Smolders, I. J., & Bundel, D. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315284 · Cited by 11 · see citing works
Prior stress interferes with the anxiolytic effect of exercise in c57bl/6j mice.
Hare, B. D., D’Onfro, K. C., Hammack, S. E., & Falls, W. A. (2012) · Behavioral Neuroscience · doi:10.1037/a0030617 · Cited by 11 · see citing works
Muraoka, H., Oshibuchi, H., Kawano, M., Kawano, T., Tsutsumi, T., Yamada, M., Ishigooka, J., Nishimura, K., & Inada, K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.06.033 · Cited by 11 · see citing works
Stupin, K. N., Zenko, M. Y., & Rybnikova, E. A. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921060109 · Cited by 9 · see citing works
Dubrovina, N. I. (2006) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-006-0073-1 · Cited by 9 · see citing works
Matuszewich, L., Carter, S., Anderson, E. M., Friedman, R. D., & McFadden, L. M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.013 · Cited by 8 · see citing works
Muthmainah, M., Sari, W. A., Wiyono, N., Ghozali, D. A., Yudhani, R. D., & Wasita, B. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6396 · Cited by 7 · see citing works
A final common pathway for depression: implications for therapy
Stone, E. A. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.8.1019 · Cited by 6 · see citing works
Imipramine-Induced Antinociception in the Formalin Test
Zarrindast, M., Vousooghi, N., & Sahebgharani, M. (2003) · Pharmacology · doi:10.1159/000070173 · Cited by 4 · see citing works
Iskra‐Jopa, J., Gołembiowska, K., Dziubina, A., Cybulski, M., Duszyńska, B., & Chilmończyk, Z. (2005) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357055425 · Cited by 3 · see citing works
Zaky, D. A., Mehny, K. A., Abdelrahman, S. S. M., El-Yamany, M. F., & Kamel, A. S. E. D. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176869 · Cited by 3 · see citing works
Pauwelyn, G., Laeken, N. V., Verhoeven, J., Vos, F. D., Peremans, K. Y., Dockx, R., Baeken, C., Descamps, B., Vanhove, C., Kersemans, K., et al. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000468 · Cited by 2 · see citing works
Stupin, K. N., Зенько, М. Ю., & Rybnikova, E. A. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521060105 · Cited by 2 · see citing works
Miner, L. A. H., & Sesack, S. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-72256-6_3 · Cited by 2 · see citing works
Lu, H., Roeder, N. M., Richardson, B., Hamilton, J. A., Lagamjis, G., Owada, Y., Kagawa, Y., Sharma, A., & Thanos, P. K. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04753-3 · Cited by 1 · see citing works
Ganesh, V. S., Reddy, K. S., Raghuveer varma., P., & Balaraju, J. (2019) · World Journal of Current Medical and Pharmaceutical Research · Cited by 1 · see citing works
SEROTONERGIC MECHANISMS IN ATOPIC DERMATITIS
Rasul, A. (2012) · Figshare
3, 4-methylenedioximethamphetamin reverses anxiety induced by chronic mild stress
León, L. A., & Cárdenas, F. P. (2013) · DOAJ (DOAJ: Directory of Open Access Journals)
RAPPORT DE STAGE D'OPTION SCIENTIFIQUE Rewards, Punishment and the Brain
Boureau, Y.-L., & Dayan, P. (2005)
Li, B., Han, X., Song, J., Cheng, Z., & Geng, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-9045113/v1
- Authors
- Ossowska, G., Nowak, G., Kata, R., Klenk-Majewska, B., Danilczuk, Z., & Żebrowska-Łupina, I.
- Affiliations
- Medical University of Lublin (PL)
- Maj Institute of Pharmacology (PL)
- Jagiellonian University (PL)
- Venue
- Journal of Neural Transmission
- Published
- 2001-03-20
- Volume
- 108
- Issue
- 3
- Pages
- 311-319
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2006608223
- Cited by
- 76
- References
- 38
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 2 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- chronic unpredictable mild stress, animal models of depression, monoamine receptors, dopamine D1 receptor, 5-HT2A receptor, serotonin receptors, adrenergic receptors, receptor density, limbic system, cerebral cortex, antidepressant treatment, depression pathophysiology
- MeSH terms
- Adrenergic Agonists, Animals, Brain, Brain Chemistry, Chronic Disease, Depression, Disease Models, Animal, Male, Neurons, Radioligand Assay, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Receptors, Serotonin, Stress, Physiological, Biogenic Monoamines, Rats, Wistar, Serotonin Receptor Agonists, Receptors, Dopamine D1, Receptors, Dopamine D2, Receptors, Neurotransmitter, Dopamine Agonists, Receptors, Serotonin, 5-HT1, Receptor, Serotonin, 5-HT2A, Rats
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