Dopaminergic mechanisms in memory consolidation and antidepressant reversal of a chronic mild stress-induced cognitive impairment`

Papp, Mariusz; Gruca, Piotr; Lason-Tyburkiewicz, Magdalena; Litwa, Ewa; Niemczyk, Monika; Tota-Glowczyk, Katarzyna; Willner, Paul

doi:10.1007/s00213-017-4651-4

Cited by 40Neurotransmitter Receptor Influence on BehaviorMemory and Neural MechanismsTreatment of Major Depression

Dopaminergic mechanisms in memory consolidation and antidepressant reversal of a chronic mild stress-induced cognitive impairment`

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Papp, Mariusz, Gruca, Piotr, Lason-Tyburkiewicz, Magdalena, Litwa, Ewa, Niemczyk, Monika, Tota-Glowczyk, Katarzyna, Willner, Paul·2017·Psychopharmacology

DOI 10.1007/s00213-017-4651-4PMC PMC5548836

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Abstract

Cognitive deficits in depression can be modelled using the novel object recognition (NOR) test, performance in which is impaired by chronic mild stress (CMS). We aimed to examine the involvement of mesocorticolimbic DA terminal regions, and to establish the substrate for CMS-induced impairment of NOR and its reversal by chronic antidepressant treatment. In experiments 1 and 2, we examined the effect of infusions into medial PFC, dorsal hippocampus (HPC), and nucleus accumbens (NAc) shell of D1 and D2 antagonists and D3 agonist, which were predicted to impair NOR with a short (1 h) delay, and of D1 and D2 agonists and D3 antagonist, which were predicted to facilitate NOR with a long (24 h) delay. Using optimal doses identified in experiment 2, in experiments 3 and 4, we examined effects on drug-stimulated NOR of CMS and chronic treatment with venlafaxine (VFX) or risperidone (RSP). We found a wide involvement of DA systems in memory for NOR: D1 receptors in PFC, HPC, and NAc; D3 receptors in PFC and HPC; and D2 receptors in PFC. CMS impaired D2- and D3-mediated effects in PFC and HPC; antidepressants rescued those effects in PFC but not HPC. The involvement of DA in NOR is multifaceted, but the effects of CMS and antidepressants are more discrete, involving D2 and D3 receptors in PFC specifically. While raising many difficult questions, these results suggest that the D2 and D3 receptors in the medial PFC may be an important substrate for cognitive deficits in depression and their remediation.

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Post-sample microinjections of the D1-R agonist SKF81297, the D2-R agonist quinpirole or the D3-R antagonist SB277,011 into the PFC facilitated NOP memory when tested after 24 hours.
“Conversely, post-sample microinjections of the D1-R agonist SKF81297, the D2-R agonist quinpirole or the D3-R antagonist SB277,011 into the PFC facilitated NOP memory when tested after 24 hours (Papp et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Papp et al., 2017
Post-sample microinjections of the D1-R antagonist SCH23390, the D2-R antagonist L-741.626 or the D3-R agonist 7-OH-DPAT into the PFC dose-dependently impaired NOP memory when tested 1 hour later.
“Microinjections of the D1-R antagonist SCH23390, the D2-R antagonist L-741.626 or the D3-R agonist 7-OH-DPAT into the PFC after the sample trial dose-dependently impaired NOP memory when tested 1 hour later (Papp et al., 2017).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Papp et al., 2017
Post-sample microinjections of the D1-R agonist SKF81297, the D2-R agonist quinpirole and the D3-R antagonist SB277,011 into the dorsal hippocampus facilitated NOP when tested after 24 hours.
“Post-sample microinjections of the D1-R agonist SKF81297, the D2-R agonist quinpirole and the D3-R antagonist SB277,011 into the dorsal hippocampus facilitated NOP when tested after 24 hours”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Papp et al., 2017

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Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
Neurobiology of emotion perception II: implications for major psychiatric disorders
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00171-9 · Cited by 1,736 · see citing works
Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis
Cipriani, A., Furukawa, T. A., Salanti, G., Geddes, J. R., Higgins, J. P., Churchill, R., Watanabe, N., Nakagawa, A., Omori, I. M., McGuire, H., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60046-5 · Cited by 1,654 · see citing works
Cognitive deficits in depression: Possible implications for functional neuropathology
Austin, M.-P., Mitchell, P., & Goodwin, G. M. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.178.3.200 · Cited by 1,154 · see citing works
The chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works
Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin.
Lévesque, D., Díaz, J., Pilon, C., Martres, M., Bruno Giros, A., Souil, E., Schott, D., Morgat, J. L., Schwartz, J., & Sokoloff, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8155 · Cited by 674 · see citing works
Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory
Kempadoo, K. A., Mosharov, E. V., Choi, S. J., Sulzer, D., & Kandel, E. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616515114 · Cited by 647 · see citing works
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
Guillin, O., Díaz, J., Carroll, P., Griffon, N., Schwartz, J.-C., & Sokoloff, P. (2001) · Nature · doi:10.1038/35075076 · Cited by 573 · see citing works
Neurobiology of Decision Making: A Selective Review from a Neurocognitive and Clinical Perspective
Monique Ernst, D., & Paulus, M. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.004 · Cited by 567 · see citing works
Targeted electrode-based modulation of neural circuits for depression.
Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542 · see citing works
The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue
Brisch, R., Saniotis, A., Wolf, R. J., Bielau, H., Bernstein, H., Steiner, J. H., Bogerts, B., Braun, A. K., Jankowski, Z., Kumaritlake, J., et al. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00047 · Cited by 520 · see citing works
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Self-citation
The subcallosal cingulate gyrus in the context of major depression
Hamani, C., Mayberg, H., Stone, S., Laxton, A., Haber, S., & Lozano, A. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.034 · Cited by 508 · see citing works
Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans
Chudasama, Y., & Robbins, T. W. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.005 · Cited by 484 · see citing works
D1Receptor Modulation of Hippocampal–Prefrontal Cortical Circuits Integrating Spatial Memory with Executive Functions in the Rat
Seamans, J. K., Floresco, S., & Phillips, A. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01613.1998 · Cited by 472 · see citing works
Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting
Floresco, S. B., Magyar, O., Ghods-Sharifi, S., Vexelman, C., & Tse, M. T. L. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300825 · Cited by 395 · see citing works
Pramipexole for bipolar II depression: a placebo-controlled proof of concept study
Zarate, C. A., Payne, J. L., Singh, J. B., Quiroz, J. A., Luckenbaugh, D. A., Denicoff, K. D., Charney, D. S., & Manji, H. K. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.013 · Cited by 342 · see citing works
BindingDB Entry 4838: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.
BindingDB (2011) · PubMed · doi:10.7270/q2cr5rw8 · Cited by 334 · see citing works
Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A
Reavill, C., Taylor, S. G., Wood, M. D., Ashmeade, T., Austin, N. E., Avenell, K. Y., Boyfield, I., Branch, C. L., Cilia, J., Coldwell, M. C., et al. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39184-0 · Cited by 287 · see citing works
Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression.
Chiara, G. D., Loddo, P., & Tanda, G. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00236-x · Cited by 266 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
Spine synapse remodeling in the pathophysiology and treatment of depression
Duman, C. H., & Duman, R. S. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.022 · Cited by 257 · see citing works
Cellular and molecular basis for stress-induced depression
Seo, J.-S., Wei, J., Qin, L., Kim, Y., Yan, Z., & Greengard, P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.118 · Cited by 235 · see citing works
The dopamine D3 receptor, a quarter century later
Sokoloff, P., & Foll, B. L. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13390 · Cited by 223 · see citing works
The mesolimbic dopamine system as a target for rapid antidepressant action
Willner, P. (1997) · International Clinical Psychopharmacology · doi:10.1097/00004850-199707003-00002 · Cited by 209 · see citing works
An 8-Week Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Cariprazine in Patients With Bipolar I Depression
Durgam, S., Earley, W., Lipschitz, A., Guo, H., Laszlovszky, I., Németh, G., Vieta, E., Calabrese, J. R., & Yatham, L. N. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020164 · Cited by 209 · see citing works
KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID‐ACTING ANTIDEPRESSANTS
Abdallah, C. G., Adams, T. G., Kelmendi, B., Esterlis, I., Sanacora, G., & Krystal, J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22501 · Cited by 206 · see citing works
Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine
Papp, M., Klimek, V., & Willner, P. (1994) · Psychopharmacology · doi:10.1007/bf02245566 · Cited by 202 · see citing works
Long-lasting behavioral effects and recognition memory deficit induced by chronic mild stress in mice: effect of antidepressant treatment
Elizalde, N., Gil-Bea, F. J., Ramírez, M. J., Aisa, B., Lasheras, B., del Rı́o, J. A., & Tordera, R. M. (2008) · Psychopharmacology · doi:10.1007/s00213-007-1035-1 · Cited by 195 · see citing works
The Relationship Between Neurocognitive and Psychosocial Functioning in Major Depressive Disorder: A Systematic Review
Evans, V. C., Iverson, G. L., Yatham, L. N., & Lam, R. W. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13r08939 · Cited by 185 · see citing works
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex
Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., et al. (2007) · Learning & Memory · doi:10.1101/lm.461407 · Cited by 184 · see citing works
Depression: from psychopathology to pathophysiology
Belzung, C., Willner, P., & Philippot, P. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.013 · Cited by 179 · see citing works
The potential role of dopamine D3 receptor neurotransmission in cognition
Nakajima, S., Gerretsen, P., Takeuchi, H., Caravaggio, F., Chow, T. W., Foll, B. L., Mulsant, B. H., Pollock, B. G., & Graff‐Guerrero, A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.05.006 · Cited by 179 · see citing works
Differential Roles of Dopamine D1 and D2 Receptors in the Nucleus Accumbens in Attentional Performance on the Five-Choice Serial Reaction Time Task
Pezze, M.-A., Dalley, J. W., & Robbins, T. W. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301073 · Cited by 170 · see citing works
Dopaminergic mechanism of antidepressant action in depressed patients
Willner, P., Hale, A. S., & Argyropoulos, S. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.12.010 · Cited by 169 · see citing works
Repeated Methamphetamine Treatment Impairs Recognition Memory Through a Failure of Novelty-Induced ERK1/2 Activation in the Prefrontal Cortex of Mice
Kamei, H., Nagai, T., Nakano, H., Togan, Y., Takayanagi, M., Takahashi, K., Kobayashi, K., Yoshida, S., Maeda, K., Takuma, K., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.006 · Cited by 165 · see citing works
Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats
Wilkerson, A., & Levin, E. D. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00346-7 · Cited by 160 · see citing works
Dopamine D2-Like Receptors and the Antidepressant Response
Gershon, A. A., Vishne, T. H., & Grunhaus, L. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.031 · Cited by 159 · see citing works
Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments
Lammers, C.-H., Díaz, J., Jc, S., & Sokoloff, P. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000754 · Cited by 155 · see citing works
Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex
Watson, D. J., Loiseau, F., Ingallinesi, M., Millan, M. J., Marsden, C. A., & Fone, K. C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.254 · Cited by 151 · see citing works
Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine
Wohleb, E. S., Gerhard, D. M., Thomas, A., & Duman, R. S. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160309114549 · Cited by 151 · see citing works
Repeated exposure to social stress has long-term effects on indirect markers of dopaminergic activity in brain regions associated with motivated behavior
Lucas, L., Celen, Z., Tamashiro, K. L., Blanchard, R. J., Blanchard, D. C., Markham, C. M., Sakai, R. R., & McEwen, B. S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.009 · Cited by 145 · see citing works
Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia
Arnsten, A., Girgis, R. R., Gray, D. L., & Mailman, R. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.028 · Cited by 144 · see citing works
Reversal of stress-induced anhedonia by the dopamine receptor agonist, pramipexole
Willner, P., Lappas, S., Cheeta, S., & Muscat, R. (1994) · Psychopharmacology · doi:10.1007/bf02245568 · Cited by 142 · see citing works
Plasticity at hippocampal to prefrontal cortex synapses is impaired by loss of dopamine and stress: Importance for psychiatric diseases
Jay, T. M., Rocher, C., Hotte, M., Naudon, L., Gurden, H., & Spedding, M. (2004) · Neurotoxicity Research · doi:10.1007/bf03033225 · Cited by 141 · see citing works
Prefrontal dopamine in associative learning and memory
Puig, M. V., Antzoulatos, E. G., & Miller, E. K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.026 · Cited by 138 · see citing works
Selective blockade of dopamine D3versus D2receptors enhances frontocortical cholinergic transmission and social memory in rats: a parallel neurochemical and behavioural analysis
Millan, M. J., Cara, B. D., Dekeyne, A., Panayi, F., de Groote, L., Sicard, D., Cistarelli, L., Billiras, R., & Gobert, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04262.x · Cited by 125 · see citing works
Dopamine D2 receptor binding before and after treatment of major depression measured by [123I]IBZM SPECT
Klimke, A. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00009-8 · Cited by 125 · see citing works
Maintenance therapy with second generation antipsychotics for bipolar disorder: a systematic review and meta-analysis
Lindström, L., Lindström, E., Nilsson, M., & Höistad, M. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.012 · Cited by 122 · see citing works
TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression
ŞAHİN, T. D., Karson, A., Balcı, F., Yazır, Y., Bayramgürler, D., & Utkan, T. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.062 · Cited by 119 · see citing works
Antidepressant-like effects of dopamine agonists in an animal model of depression
Muscat, R., Papp, M., & Willner, P. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90119-k · Cited by 119 · see citing works
Dopamine D1, receptor ligands modulate cognitive performance and hippocampal acetylcholine release in memory-impaired aged rats
Hersi, A. I., Rowe, W. B., Gaudreau, P., & Quirion, R. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00319-e · Cited by 119 · see citing works
S33005, a Novel Ligand at Both Serotonin and Norepinephrine Transporters: II. Behavioral Profile in Comparison with Venlafaxine, Reboxetine, Citalopram, and Clomipramine
Millan, M. J., Dekeyne, A., Papp, M., Rochelle, C. D. L., MacSweeny, C., Péglion, J.-L., & Brocco, M. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29416-7 · Cited by 117 · see citing works
Reversal of antidepressant action by dopamine antagonists in an animal model of depression
Sampson, D., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02245655 · Cited by 115 · see citing works
Object recognition testing: Statistical considerations
Akkerman, S., Prickaerts, J., Steinbusch, H. W. M., & Blokland, A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.024 · Cited by 114 · see citing works
Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets
Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works
In VivoEvidence for the Involvement of Dopamine-D2Receptors in Striatum and Anterior Cingulate Gyrus in Major Depression
Larisch, R., Klimke, A., Vosberg, H., Löffler, S., Gäebel, W., & Müller-Gärtner, H.-W. (1997) · NeuroImage · doi:10.1006/nimg.1997.0267 · Cited by 106 · see citing works
Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models
Lyon, L., Saksida, L. M., & Bussey, T. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2536-5 · Cited by 105 · see citing works
Modulatory influence of dopamine receptors on consolidation of object recognition memory
de Lima, M. N. M., Presti-Torres, J., Dornelles, A. D. S., Scalco, F. S., Roesler, R., Garcia, V. A., & Schröder, N. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.12.007 · Cited by 102 · see citing works
Long Term Sex-Dependent Psychoneuroendocrine Effects of Maternal Deprivation and Juvenile Unpredictable Stress in Rats
Llorente, R., Miguel-Blanco, C., Aisa, B., Lachize, S., Borcel, É., Meijer, O. C., Ramírez, M. J., de Kloet, E. R., & Viveros, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02109.x · Cited by 101 · see citing works
Pramipexole in treatment-resistant depression: An extended follow-up
Cassano, P., Lattanzi, L., Soldani, F., Navari, S., Battistini, G., Gemignani, A., & Cassano, G. B. (2004) · Depression and Anxiety · doi:10.1002/da.20038 · Cited by 101 · see citing works
Changes in dopamine receptor mRNA expression following chronic mild stress and chronic antidepressant treatment
Dziedzicka‐Wasylewska, M., Willner, P., & Papp, M. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00017 · Cited by 101 · see citing works
Effects of cariprazine, a novel antipsychotic, on cognitive deficit and negative symptoms in a rodent model of schizophrenia symptomatology
Neill, J. C., Grayson, B., Kiss, B., Gyertyán, I., FERGUSON, P. W., & Adham, N. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.016 · Cited by 93 · see citing works
D1/D5 dopamine receptors modulate spatial memory formation
da Silva, W. C. N., Köhler, C. A., Radiske, A., & Cammarota, M. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.01.005 · Cited by 92 · see citing works
Modulation of recognition and temporal order memory retrieval by dopamine D1 receptor in rats
Hotte, M., Naudon, L., & Jay, T. M. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.04.002 · Cited by 89 · see citing works
Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats
Liu, D., Zhang, Q., Gu, J., Wang, X., Xie, K., Xian, X., Wang, J., Jiang, H., & Wang, Z. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.017 · Cited by 87 · see citing works
Effect of antidepressant drugs administered repeatedly on the dopamine D3 receptors in the rat brain
Maj, J., Dziedzicka‐Wasylewska, M., Rogoż, R., & Rogóż, Z. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00297-0 · Cited by 85 · see citing works
Augmentation with Atypical Antipsychotics for Depression: A Review of Evidence‐Based Support from the Medical Literature
Wright, B. M., Eiland, E. H., & Lorenz, R. A. (2013) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1204 · Cited by 84 · see citing works
What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory
Brown, M. W., Barker, G. R. I., Aggleton, J. P., & Warburton, E. C. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.07.034 · Cited by 84 · see citing works
Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment
Watson, D. J., Marsden, C. A., Millan, M. J., & Fone, K. C. F. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000435 · Cited by 81 · see citing works
Attenuation of anhedonia by cariprazine in the chronic mild stress model of depression
Papp, M., Gruca, P., Łasoń, M., Adham, N., Kiss, B., & Gyertyán, I. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000070 · Cited by 80 · see citing works
Functional Significance of Central D1 Receptors in Cognition: Beyond Working Memory
Takahashi, H., Yamada, M., & Suhara, T. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.194 · Cited by 79 · see citing works
Dopamine D1 but not D3 receptor is critical for spatial learning and related signaling in the hippocampus
Xing, B., Kong, H., Meng, X., Wei, S., Xu, M., & Li, S. B. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.034 · Cited by 78 · see citing works
Dopamine vs Noradrenaline: Inverted-U Effects and ADHD Theories
Lévy, F. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802607238 · Cited by 77 · see citing works
D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex
Hotte, M., Thuault, S., Lachaise, F., Dineley, K. T., Hemmings, H. C., Nairn, A. C., & Jay, T. M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.026 · Cited by 76 · see citing works
Dopamine D1 and D2 receptor binding sites in brain samples from depressed suicides and controls
Bowden, C., Theodorou, A. E., Cheetham, S. C., Lowther, S., Katona, C., Crompton, M. R., & Horton, R. W. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01460-6 · Cited by 76 · see citing works
Brain monoamine receptors in a chronic unpredictable stress model in rats
Ossowska, G., Nowak, G., Kata, R., Klenk-Majewska, B., Danilczuk, Z., & Żebrowska-Łupina, I. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170077 · Cited by 76 · see citing works
Increased vulnerability to cocaine in mice lacking dopamine D 3 receptors
Song, R., Zhang, H., Li, X., Bi, G., Gardner, E. L., & Xi, Z. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205297109 · Cited by 76 · see citing works
Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus
Rossato, J. I., Radiske, A., Kohler, C. A., Gonzalez, C., Bevilaqua, L. R., Medina, J. H., & Cammarota, M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.012 · Cited by 75 · see citing works
Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors
Darvas, M., & Palmiter, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907299106 · Cited by 75 · see citing works
Influences of chronic venlafaxine, olanzapine and nicotine on the hippocampal and cortical concentrations of brain-derived neurotrophic factor (BDNF)
Czubak, A., Nowakowska, E., Kus, K., Burda, K., Metelska, J., Baer‐Dubowska, W., & Cichocki, M. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70163-x · Cited by 71 · see citing works
The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures
Millan, M. J., Buccafusco, J. J., Loiseau, F., Watson, D. J., Decamp, E., Fone, K. C. F., Thomasson, N., Hill, M. P., Mocaër, E., & Schneider, J. S. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000775 · Cited by 70 · see citing works
Blockade of dopamine D3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: Similar actions of D1 receptor agonists, but not of D2 antagonists
Loiseau, F., & Millan, M. J. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.07.012 · Cited by 69 · see citing works
Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant
D’Aquila, P. S., Monleón, S., Borsini, F., Brain, P. F., & Willner, P. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01412-x · Cited by 69 · see citing works
Systematic review of randomized controlled trials of candidate treatments for cognitive impairment in depression and methodological challenges in the field
Miskowiak, K. W., Ott, C. V., Petersen, J. Z., & Kessing, L. V. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.09.641 · Cited by 69 · see citing works
Epigallocatechin-3-Gallate Attenuates Impairment of Learning and Memory in Chronic Unpredictable Mild Stress-Treated Rats by Restoring Hippocampal Autophagic Flux
Gu, H., Nie, Y., Tong, Q., Tang, Y., Zeng, Y., Jing, K.-Q., Zheng, X., & Liao, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112683 · Cited by 68 · see citing works
Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats
Papp, M., Gruca, P., Łasoń, M., & Willner, P. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4206-0 · Cited by 68 · see citing works
Inactivation of dopamine D-1 or D-2 receptors differentially inhibits stereotypies induced by dopamine agonists in rats
Arnt, J., Hyttel, J., & Meier, E. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90400-1 · Cited by 65 · see citing works
Neuroadaptations to hyperdopaminergia in dopamine D3 receptor-deficient mice
Foll, B. L., Díaz, J., & Sokoloff, P. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.09.018 · Cited by 63 · see citing works
The dopamine D 3 -preferring D 2 /D 3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia
Watson, D. J., King, M. V., Gyertyán, I., Kiss, B., Adham, N., & Fone, K. C. F. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.020 · Cited by 63 · see citing works
Antidepressant, anxiolytic and procognitive effects of subacute and chronic ketamine in the chronic mild stress model of depression
Papp, M., Gruca, P., Łasoń, M., & Willner, P. (2016) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000259 · Cited by 63 · see citing works
Models of Affective Illness: Chronic Mild Stress in the Rat
Papp, M. (2012) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0509s57 · Cited by 61 · see citing works
D1 and D5 dopamine receptors participate on the consolidation of two different memories
Furini, C. R. G., Myskiw, J. C., Schmidt, B. E., Marcondes, L. A., & Izquierdo, I. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.027 · Cited by 60 · see citing works
Modification of spatial recognition memory and object discrimination after chronic administration of haloperidol, amitriptyline, sodium valproate or olanzapine in normal and anhedonic rats
Orsetti, M., Colella, L., Dellarole, A., Canonico, P. L., & Ghi, P. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145706006705 · Cited by 60 · see citing works
The effects of social defeat on behavior and dopaminergic markers in mice
Jin, H.-M., Muna, S. S., Bagalkot, T. R., Cui, Y., Yadav, B. K., & Chung, Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.043 · Cited by 59 · see citing works
Consolidation and reconsolidation of object recognition memory
Balderas, I., Rodríguez‐Ortiz, C. J., & Bermúdez‐Rattoni, F. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.049 · Cited by 58 · see citing works
Mood disorders: neurocognitive models
Malhi, G. S., Byrow, Y., Fritz, K., Das, P., Baune, B. T., Porter, R., & Outhred, T. (2015) · Bipolar Disorders · doi:10.1111/bdi.12353 · Cited by 58 · see citing works
The Role of α1- and α2-Adrenoreceptors on Venlafaxineinduced Elevation of Extracellular Serotonin, Noradrenaline and Dopamine Levels in the Rat Prefrontal Cortex and Hippocampus
Weikop, P., Kehr, J., & Scheel-Krüger, J. (2004) · Journal of Psychopharmacology · doi:10.1177/026988110401800311 · Cited by 57 · see citing works
Selective modifications in the nucleus accumbens of dopamine synaptic transmission in rats exposed to chronic stress
Scheggi, S., Leggio, B., Masi, F., Grappi, S., Gambarana, C., Nanni, G., Rauggi, R., & Montis, M. G. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01193.x · Cited by 53 · see citing works
Cognitive functioning in depression: a review of theory and research
Willner, P. (1984) · Psychological Medicine · doi:10.1017/s0033291700019784 · Cited by 52 · see citing works
Dissociable roles of dopamine within the core and medial shell of the nucleus accumbens in memory for objects and place.
Nelson, A. J. D., Thur, K. E., Marsden, C. A., & Cassaday, H. J. (2010) · Behavioral Neuroscience · doi:10.1037/a0021114 · Cited by 50 · see citing works
Attenuation of social interaction-associated ultrasonic vocalizations and spatial working memory performance in rats exposed to chronic unpredictable stress
Riaz, M. S., Bohlen, M. O., Gunter, B. W., Henry, Q., Stockmeier, C. A., & Paul, I. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.09.005 · Cited by 49 · see citing works
Direct and indirect interactions of the dopamine D3 receptor with glutamate pathways: implications for the treatment of schizophrenia
Sokoloff, P., Leriche, L., Díaz, J., Louvel, J., & Pumain, R. (2012) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-012-0797-0 · Cited by 47 · see citing works
Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake
Castro‐Hernández, J., Afonso‐Oramas, D., Cruz‐Muros, I., Salas-Hernández, J., Barroso‐Chinea, P., Moratalla, R., Millan, M. J., & González‐Hernández, T. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.007 · Cited by 47 · see citing works
Dopamine D2 receptor plays a role in memory function: implications of dopamine–acetylcholine interaction in the ventral hippocampus
Fujishiro, H., Umegaki, H., Suzuki, Y., Kurotani, S., Yamaguchi, Y., & Iguchi, A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0072-x · Cited by 47 · see citing works
Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors
Bristow, L. J., Cook, G. P., Patel, S. S., Curtis, N. R., Mawer, I. M., & Kulagowski, J. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00066-5 · Cited by 45 · see citing works
D2 dopamine receptor regulation of learning, sleep and plasticity
França, A. S. C., Soares, B. L., Muratori, L., Nascimento, G., Winne, J., Pereira, C. M., Jerônimo, S. M. B., & Ribeiro, S. T. G. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.011 · Cited by 43 · see citing works
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation
Cuadrado‐Tejedor, M., Ricobaraza, A., Río, J. D., Frechilla, D., Franco, R., Pérez‐Mediavilla, A., & García‐Osta, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.01.005 · Cited by 42 · see citing works
EVALUATION OF THE EFFECTS OF SKF 82526 AND LY 171555 ON PRESYNAPTIC (DA2) AND POSTSYNAPTIC (DA1) DOPAMINE RECEPTORS IN RAT KIDNEY
Lokhandwala, M. F., & Steenberg, M. L. (1984) · Journal of Autonomic Pharmacology · doi:10.1111/j.1474-8673.1984.tb00105.x · Cited by 41 · see citing works
Activation of Dopaminergic D2/D3 Receptors Modulates Dorsoventral Connectivity in the Hippocampus and Reverses the Impairment of Working Memory after Nerve Injury
Cardoso-Cruz, H., Dourado, M., Monteiro, C., Matos, M. R., & Galhardo, V. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0021-14.2014 · Cited by 39 · see citing works
Hippocampal and prefrontal dopamine D1/5 receptor involvement in the memory-enhancing effect of reboxetine
De Bundel, D., Femenía, T., DuPont, C. M., Konradsson-Geuken, Å., Feltmann, K., Schilström, B., & Lindskog, M. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000370 · Cited by 37 · see citing works
Increased sensitivity to antidepressants of D3 dopamine receptor-deficient mice in the forced swim test (FST)
Leggio, G. M., Micale, V., & Drago, F. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.07.003 · Cited by 37 · see citing works
Elevated Aggression and Reduced White Matter Integrity in Mild Traumatic Brain Injury: A DTI Study
Dailey, N. S., Smith, R. S., Bajaj, S., Alkozei, A., Gottschlich, M., Raikes, A. C., Satterfield, B. C., & Killgore, W. D. S. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00118 · Cited by 35 · see citing works
Venlafaxine inhibits apoptosis of hippocampal neurons by up-regulating brain-derived neurotrophic factor in a rat depression model
Huang, X., Mao, Y.-S., Li, C., Wang, H., & Jian-lin, J. (2014) · Die Pharmazie · doi:10.31083/ph.2014.4661 · Cited by 33 · see citing works
D2 dopamine receptor blockade prevents cognitive effects of Ang IV and des-Phe6 Ang IV
Braszko, J. J. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.03.025 · Cited by 32 · see citing works
In Vivo Occupancy of Dopamine D3 Receptors by Antagonists Produces Neurochemical and Behavioral Effects of Potential Relevance to Attention-Deficit–Hyperactivity Disorder
Barth, V., Need, A. B., Tzavara, E. T., Bruno Giros, A., Overshiner, C. D., Gleason, S. D., Wade, M. R., Johansson, A., Perry, K. W., Nomikos, G. G., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.198895 · Cited by 32 · see citing works
Impact of Untreated Major Depressive Disorder on Cognition and Daily Function
Culpepper, L. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13086tx4c · Cited by 30 · see citing works
Effects of immobilization stress on emotional behaviors in dopamine D3 receptor knockout mice
Xing, B., Liu, P., Jiang, W., Liu, F., Zhang, H., Cao, G., Chen, T., & Dang, Y. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.019 · Cited by 29 · see citing works
Attenuation of chronic mild stress-induced ‘anhedonia’ by asenapine is not associated with a ‘hedonic’ profile in intracranial self-stimulation
Marston, H. M., Martin, F., Papp, M., Gold, L. H., Wong, E. H. F., & Shahid, M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110376684 · Cited by 27 · see citing works
Characterisation of Gs activation by dopamine D1 receptors using an antibody capture assay: antagonist properties of clozapine
Cussac, D., Pasteau, V., & Millan, M. J. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.11.077 · Cited by 24 · see citing works
The dopamine D1 receptor agonist SKF 38393 improves temporal order memory performance in maternally deprived rats
Lejeune, S., Dourmap, N., Martres, M., Bruno Giros, A., Daugé, V., & Naudon, L. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.10.005 · Cited by 23 · see citing works
Y-QA31, a novel dopamine D3 receptor antagonist, exhibits antipsychotic-like properties in preclinical animal models of schizophrenia
Sun, X., Gou, H., Li, F. R., Lu, G.-Y., Song, R., Yang, R., Wu, N., Su, R., Cong, B., & Li, J. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.105 · Cited by 22 · see citing works
Antidepressants and Their Effect on Cognition in Major Depressive Disorder
Papakostas, G. I. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13086tx5c · Cited by 19 · see citing works
Dopamine D1 receptor modulation of set shifting
Nikiforuk, A. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328356522f · Cited by 17 · see citing works
Dopamine D3 Receptor Mediates Preadolescent Stress-Induced Adult Psychiatric Disorders
Seo, J. H., & Kuzhikandathil, E. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143908 · Cited by 14 · see citing works
Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice
França, A. S. C., Muratori, L., Nascimento, G., Pereira, C. M., Ribeiro, S. T. G., & Soares, B. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.04.009 · Cited by 14 · see citing works
Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters
Delis, F., Rombola, C., Bellezza, R., Rosko, L. M., Grandy, D. K., Volkow, N. D., & Thanos, P. K. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00118 · Cited by 13 · see citing works
The influence of antidepressants on aggressive behavior in stressed rats: the role of dopamine.
Zebrowska-Łupina, I., Ossowska, G., & Klenk-Majewska, B. (1993) · PubMed · Cited by 10 · see citing works
The touchscreen operant platform for assessing cognitive functions in a rat model of depression
Tran, T. P., Christensen, H. L., Bertelsen, F., Bouzinova, E. V., Møller, A., & Wiborg, O. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.032 · Cited by 9 · see citing works
[Effect of Risperidone on BDNF-TrkB Signaling Pathway in Rat Brain].
Yu, B., Wang, X., Wei, J., Ni, P.-Y., Liang, L.-H., Zhao, L., Ma, X., Li, T., & Wang, Y. (2015) · PubMed · Cited by 3 · see citing works
Comparison of pramipexole, fluoxetine, and placebo in patients with major depression
(2000) · doi:10.1002/(sici)1520-6394(2000)11:2

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Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability
Antoniuk, S., Bijata, M., Ponimaskin, E., & Wlodarczyk, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.002 · Cited by 750 · see citing works
The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties
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Neuronal Dopamine D3 Receptors: Translational Implications for Preclinical Research and CNS Disorders
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Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial
Zhu, M., Liu, Z.-J., Hu, Q.-Y., Yang, J., Jin, Y., Zhu, N., Huang, Y., Shi, D.-H., Liu, M.-J., Tan, H.-Y., et al. (2022) · Military Medical Research · doi:10.1186/s40779-022-00420-0 · Cited by 65 · see citing works
Rapid antidepressant effects of deep brain stimulation of the pre-frontal cortex in an animal model of treatment-resistant depression
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Models of Affective Illness: Chronic Mild Stress in the Rat
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Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model
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Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway
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Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress
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Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats
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Effects of venlafaxine on the expression level and methylation status of genes involved in oxidative stress in rats exposed to a chronic mild stress
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The activity of brain and liver cytochrome P450 2D (CYP2D) is differently affected by antidepressants in the chronic mild stress (CMS) model of depression in the rat
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Galanin (1–15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats
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AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar–Kyoto rats
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Genomic Screening of Wistar and Wistar-Kyoto Rats Exposed to Chronic Mild Stress and Deep Brain Stimulation of Prefrontal Cortex
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Anti-stress Properties of Atypical Antipsychotics
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Chronic Mild Stress and Venlafaxine Treatment Were Associated with Altered Expression Level and Methylation Status of New Candidate Inflammatory Genes in PBMCs and Brain Structures of Wistar Rats
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Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving
Weber, S. J., Kawa, A. B., Beutler, M. M., Kuhn, H. M., Moutier, A. L., Westlake, J. G., Koyshman, L. M., Moreno, C. D., Wunsch, A. M., & Wolf, M. E. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01992-2 · Cited by 14 · see citing works
Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization
Looveren, K. V., Boxelaere, M. V., Callaerts‐Vegh, Z., & Libert, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226753 · Cited by 14 · see citing works
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Browne, C. A., Smith, T., & Lucki, I. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172948 · Cited by 13 · see citing works
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Martis, L., Brision, C., Holmes, M. C., & Wiborg, O. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.08.014 · Cited by 13 · see citing works
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Shi, X., Barr, J. L., von Weltin, E., Wolsh, C. C., & Unterwald, E. M. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.119.259283 · Cited by 9 · see citing works
The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
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Ma, J.-C., Che, X., Zhu, X.-N., Ren, A.-X., Hu, Y., Yang, C.-L., Xu, Z.-T., Li, Y., Wu, C., & Yang, J. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01321-9 · Cited by 2 · see citing works
The Basis For A Neurobiological-Associative Model of Personality and Group Cohesion: The Evolutionary And System Biological Origins Of Social Exclusion, Hierarchy, and StructurePreprint
Thomas, M. E. (2020) · Preprints.org · doi:10.20944/preprints202007.0003.v1 · Cited by 2 · see citing works
Effects on brain-derived neurotrophic factor signalling of chronic mild stress, chronic risperidone and acute intracranial dopamine receptor challenges
Papp, M., Gruca, P., Łasoń, M., Litwa, E., Niemczyk, M., Tota-Glowczyk, K., Faron‐Górecka, A., Kuśmider, M., Solich, J., Szlachta, M., et al. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000392 · Cited by 1 · see citing works
Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization
Looveren, K. V., Boxelaere, M. V., Callaerts‐Vegh, Z., & Libert, C. (2020) · Yearbook of pediatric endocrinology · doi:10.1530/ey.17.8.2
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Li, Z., Zhu, M., Liu, Z., Hu, Q., Yang, J., Jin, Y., Zhu, N., Huang, Y., Shi, D., Liu, M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1213529/v1
In-silico and in-vivo evaluation of comparative enhanced neurogenic performance by energy drinks
Das, S., Khan, I., Debnath, A., Singh, R., & Dhasmana, S. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns6.10822
Additional file 1 of Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress
Kim, H. R., Lee, Y.-J., Kim, T.-W., Lim, R.-N., Hwang, D. Y., Moffat, J. J., Kim, S., Seo, J.-W., & Ka, M. (2020) · Figshare · doi:10.6084/m9.figshare.13152013
Subregion‐specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment
Brivio, P., Palumbo, A., Gallo, M. T., Veronesi, F. U. T., Cortinovis, G., Gruca, P., Łasoń, M., Litwa, E., Biała, D., Fumagalli, F., et al. (2026) · British Journal of Pharmacology · doi:10.1111/bph.70594 · Cited by 1 · see citing works

The role of prefrontal cortex dopamine D2 and D3 receptors in the mechanism of action of venlafaxine and deep brain stimulation in animal models of treatment-responsive and treatment-resistant depression
Papp, M., Gruca, P., Łasoń, M., Niemczyk, M., & Willner, P. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119827889 · Cited by 25 · see citing works
D1 receptor agonists reverse the subchronic phencyclidine (PCP)-induced novel object recognition (NOR) deficit in female rats
Horiguchi, M., Hannaway, K. E., Adelekun, A. E., Huang, M., Jayathilake, K., & Meltzer, H. Y. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.030 · Cited by 40 · see citing works
Antidepressant drugs specifically inhibiting noradrenaline reuptake enhance recognition memory in rats.
Feltmann, K., Konradsson‐Geuken, Å., Bundel, D. D., Lindskog, M., & Schilström, B. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000100 · Cited by 17 · see citing works
AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar–Kyoto rats
Papp, M., Gruca, P., Łasoń, M., Litwa, E., Solecki, W., & Willner, P. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120967857 · Cited by 21 · see citing works
Changes in dopamine receptor mRNA expression following chronic mild stress and chronic antidepressant treatment
Dziedzicka‐Wasylewska, M., Willner, P., & Papp, M. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00017 · Cited by 101 · see citing works

Authors: Papp, M., Gruca, P., Lason-Tyburkiewicz, M., Litwa, E., Niemczyk, M., Tota-Glowczyk, K., & Willner, P.
Affiliations: Maj Institute of Pharmacology (PL)
Swansea University (GB)
Corresponding author: Papp, Mariusz
ORCID: Papp, Mariusz
Gruca, Piotr
Litwa, Ewa
Willner, Paul
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2017-05-31
Volume: 234
Issue: 17
Pages: 2571-2585
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-017-4651-4
PMC: PMC5548836
OpenAlex: W2616931289
Cited by: 40
References: 135
Citations by year: 2026: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 7 · 2018: 6
FWCI: 3.35
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Psychopharmacology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Science Centre (NCN) (2013/09/B/NZ7/04098)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: dopaminergic mechanisms, memory consolidation, chronic mild stress, cognitive impairment, depression, novel object recognition, medial prefrontal cortex, dorsal hippocampus, nucleus accumbens shell, dopamine D1 receptor, dopamine D2 receptor, dopamine D3 receptor, venlafaxine, risperidone
MeSH terms: Memory Consolidation, Animals, Antidepressive Agents, Depression, Hippocampus, Male, Nucleus Accumbens, Stress, Psychological, Rats, Wistar, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Cognitive Dysfunction

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Dopaminergic mechanisms in memory consolidation and antidepressant reversal of a chronic mild stress-induced cognitive impairment`

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