Determination of N ɛ-(carboxymethyl)lysine in food systems by ultra performance liquid chromatography-mass spectrometry
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We report the use of ultra pressure liquid chromatography (UPLC), coupled to a tandem mass spectrometer operated in multiple reaction monitoring mode to determine the advanced glycation endproduct, Nepsilon-(carboxymethyl)lysine (CML). The procedure was applied to acid hydrolyzates of protein isolated from a range of foods (milks processed at different temperatures, butter, cheese, infant formulae, bread, raw and cooked minced beef and olive oil). Highest levels of CML were determined in white bread crust (15.2 +/- 0.63 mmol/mol Lys), wholemeal bread crust (13.1 +/- 0.61 mmol/mol Lys) and evaporated full-fat milk (4.86 +/- 0.77 mmol/mol Lys). Lowest levels of CML were measured in raw minced beef beef (0.03 +/- 002 mmol/mol Lys), raw full-fat cow's milk (0.08 +/- 0.03 mmol/mol Lys) and pasteurized skimmed cow's milk (0.09 +/- 0.002 mmol/mol Lys). CML could not be detected in olive oil.
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The absorptive process may allow translocation of LPS from gut bacteria into the systemic circulation.
“Related to this effect, the absorptive process may allow translocation of LPS from gut bacteria into the systemic circulation (168) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [168]
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- Authors
- Assar, S. H., Moloney, C., Lima, M., Magee, R., & Ames, J. M.
- Affiliations
- Queen's University Belfast (GB)
- Corresponding author
- Ames, Jennifer M.
- Venue
- Amino Acids
- Published
- 2008-04-04
- Volume
- 36
- Issue
- 2
- Pages
- 317-326
- ISSN
- 0939-4451 (ISSN-L)
- 1438-2199
- OpenAlex
- W1999234525
- Cited by
- 206
- References
- 50
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 14 · 2022: 9 · 2021: 21 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 20 · 2014: 14 · 2013: 17 · 2012: 3
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Amino Acids (publishedVersion)
- PubMed (publishedVersion)
- UWE Research Repository (UWE Bristol) (submittedVersion, cc-by)
- Funders
- Food Standards Agency
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
- Keywords
- carboxymethyllysine, advanced glycation end products, food proteins, milk, bread, cheese, infant formula, beef, olive oil, thermal processing, UPLC-MS/MS
- MeSH terms
- Animals, Bread, Chromatography, High Pressure Liquid, Food Analysis, Lysine, Meat, Milk, Tandem Mass Spectrometry
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