Cited by 206Advanced Glycation End Products researchPotato Plant ResearchFood Nutrient Composition and Product Development

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Determination of N ɛ-(carboxymethyl)lysine in food systems by ultra performance liquid chromatography-mass spectrometry

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Assar, Shima H., Moloney, Catherine, Lima, Maria, Magee, Ronald, Ames, Jennifer M.·2009·Amino Acids

DOI 10.1007/s00726-008-0071-4

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Abstract

We report the use of ultra pressure liquid chromatography (UPLC), coupled to a tandem mass spectrometer operated in multiple reaction monitoring mode to determine the advanced glycation endproduct, Nepsilon-(carboxymethyl)lysine (CML). The procedure was applied to acid hydrolyzates of protein isolated from a range of foods (milks processed at different temperatures, butter, cheese, infant formulae, bread, raw and cooked minced beef and olive oil). Highest levels of CML were determined in white bread crust (15.2 +/- 0.63 mmol/mol Lys), wholemeal bread crust (13.1 +/- 0.61 mmol/mol Lys) and evaporated full-fat milk (4.86 +/- 0.77 mmol/mol Lys). Lowest levels of CML were measured in raw minced beef beef (0.03 +/- 002 mmol/mol Lys), raw full-fat cow's milk (0.08 +/- 0.03 mmol/mol Lys) and pasteurized skimmed cow's milk (0.09 +/- 0.002 mmol/mol Lys). CML could not be detected in olive oil.

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Authors: Assar, S. H., Moloney, C., Lima, M., Magee, R., & Ames, J. M.
Affiliations: Queen's University Belfast (GB)
Corresponding author: Ames, Jennifer M.
ORCID: Lima, Maria
Ames, Jennifer M.
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2008-04-04
Volume: 36
Issue: 2
Pages: 317-326
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-008-0071-4
OpenAlex: W1999234525
Cited by: 206
References: 50
Citations by year: 2026: 3 · 2025: 9 · 2024: 9 · 2023: 14 · 2022: 9 · 2021: 21 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 20 · 2014: 14 · 2013: 17 · 2012: 3
FWCI: 6.42
Type: journal article
Language: en
Open access: green
uwe-repository.worktribe.com
Licence: cc-by
www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
UWE Research Repository (UWE Bristol) (submittedVersion, cc-by)
Funders: Food Standards Agency
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
Keywords: carboxymethyllysine, advanced glycation end products, food proteins, milk, bread, cheese, infant formula, beef, olive oil, thermal processing, UPLC-MS/MS
MeSH terms: Animals, Bread, Chromatography, High Pressure Liquid, Food Analysis, Lysine, Meat, Milk, Tandem Mass Spectrometry

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Determination of N ɛ-(carboxymethyl)lysine in food systems by ultra performance liquid chromatography-mass spectrometry

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