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Cited by 62Muscle metabolism and nutritionSports Performance and TrainingExercise and Physiological Responses

Ten weeks of branched-chain amino acid supplementation improves select performance and immunological variables in trained cyclists

Kephart, Wesley C., Wachs, Taylor D., Mac Thompson, R., Brooks Mobley, C., Fox, Carlton D., McDonald, James R., Ferguson, Brian S., Young, Kaelin C. +7 more·2016·Amino Acids
DOI 10.1007/s00726-015-2125-8
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Abstract

We examined if supplementing trained cyclists (32 ± 2 year, 77.8 ± 2.6 kg, and 7.4 ± 1.2 year training) with 12 g/day (6 g/day L-Leucine, 2 g/day L-Isoleucine and 4 g/day L-Valine) of either branched-chain amino acids (BCAAs, n = 9) or a maltodextrin placebo (PLA, n = 9) over a 10-week training season affected select body composition, performance, and/or immune variables. Before and after the 10-week study, the following was assessed: (1) 4-h fasting blood draws; (2) dual X-ray absorptiometry body composition; (3) Wingate peak power tests; and (4) 4 km time-trials. No group × time interactions existed for total lean mass (P = 0.27) or dual-leg lean mass (P = 0.96). A significant interaction existed for body mass-normalized relative peak power (19 % increase in the BCAA group pre- to post-study, P = 0.01), and relative mean power (4 % increase in the BCAA group pre- to post-study, P = 0.01). 4 km time-trial time to completion approached a significant interaction (P = 0.08), as the BCAA group improved in this measure by 11 % pre- to post-study, though this was not significant (P = 0.15). There was a tendency for the BCAA group to present a greater post-study serum BCAA: L-Tryptophan ratio compared to the PLA group (P = 0.08). A significant interaction for neutrophil number existed (P = 0.04), as there was a significant 18 % increase within the PLA group from the pre- to post-study time point (P = 0.01). Chronic BCAA supplementation improves sprint performance variables in endurance cyclists. Additionally, given that BCAA supplementation blunted the neutrophil response to intense cycling training, BCAAs may benefit immune function during a prolonged cycling season.

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Authors
Kephart, W. C., Wachs, T. D., Mac Thompson, R., Brooks Mobley, C., Fox, C. D., McDonald, J. R., Ferguson, B. S., Young, K. C., Nie, B., Martin, J. S., Company, J. M., Pascoe, D. D., Arnold, R. D., Moon, J. R., & Roberts, M. D.
Affiliations
  • Auburn University (US)
  • Wichita State University (US)
  • MusclePharm Sports Science Institute (United States) (US)
Corresponding author
Roberts, Michael D.
ORCID
Venue
Amino Acids
Publisher
Springer Science and Business Media LLC
Published
2015-11-09
Volume
48
Issue
3
Pages
779-789
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
DOI
10.1007/s00726-015-2125-8
OpenAlex
W2610490788
Cited by
62
References
37
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 6 · 2018: 15 · 2017: 5 · 2016: 1
FWCI
3.73
Type
journal article
Language
en
Update notices
correction (2018-08-11)
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
  • Holmes Museum Of Anthropology (Wichita State University) (submittedVersion)
Funders
  • MusclePharm Corp. (FY2014)
  • NIH R01 (EB016100)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
branched-chain amino acids, leucine, L-isoleucine, valine, endurance cyclists, sprint performance, peak power, time trial performance, body composition, lean body mass, immune function, neutrophils, tryptophan, maltodextrin placebo, training season
MeSH terms
Adult, Amino Acids, Branched-Chain, Body Composition, Humans, Male, Middle Aged, Neutrophils, Physical Endurance, Muscle, Skeletal, Dietary Supplements, Young Adult, Athletes

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