Cited by 593Folate and B Vitamins ResearchSulfur Compounds in BiologyBiochemical effects in animals

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The role of methionine on metabolism, oxidative stress, and diseases

Martínez, Yordan, Li, Xue, Liu, Gang, Bin, Peng, Yan, Wenxin, Más, Dairon, Valdivié, Manuel, Hu, Chien-An Andy, Ren, Wenkai, Yin, Yulong·2017·Amino Acids

DOI 10.1007/s00726-017-2494-2

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Abstract

Methionine is an aliphatic, sulfur-containing, essential amino acid, and a precursor of succinyl-CoA, homocysteine, cysteine, creatine, and carnitine. Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digestive functioning in mammals. It also intervenes in lipid metabolism, activation of endogenous antioxidant enzymes such as methionine sulfoxide reductase A, and the biosynthesis of glutathione to counteract oxidative stress. In addition, methionine restriction prevents altered methionine/transmethylation metabolism, thereby decreasing DNA damage and carcinogenic processes and possibly preventing arterial, neuropsychiatric, and neurodegenerative diseases. This review focuses on the role of methionine in metabolism, oxidative stress, and related diseases.

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Authors: Martínez, Y., Li, X., Liu, G., Bin, P., Yan, W., Más, D., Valdivié, M., Hu, C.-A. A., Ren, W., & Yin, Y.
Affiliations: Chinese Academy of Sciences (CN)
University of New Mexico (US)
Hunan Normal University (CN)
Corresponding author: Liu, Gang
ORCID: Martínez, Yordan
Li, Xue
Liu, Gang
Bin, Peng
Yan, Wenxin
Hu, Chien-An Andy
Ren, Wenkai
Yin, Yulong
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2017-09-19
Volume: 49
Issue: 12
Pages: 2091-2098
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-017-2494-2
OpenAlex: W2754863196
Cited by: 583
References: 76
Citations by year: 2026: 66 · 2025: 93 · 2024: 89 · 2023: 92 · 2022: 80 · 2021: 56 · 2020: 56 · 2019: 32 · 2018: 15 · 2017: 2
FWCI: 4.63
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
Funders: International Partnership Program of Chinese Academy of Sciences (161343KYSB20160008)
National Key Research and Development Program of China (2016YFD0500504)
National Natural Science Foundation of China (31570114, 31330075, 31110103909)
Chinese Academy of Sciences visiting professorship for senior international scientists (2016VBB007)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
Keywords: methionine, methionine metabolism, oxidative stress, methionine restriction, transmethylation, homocysteine, MsrA, glutathione synthesis, antioxidant enzymes, lipid metabolism, innate immunity, DNA damage, carcinogenesis, neurodegenerative diseases, cardiovascular disease, neuropsychiatric disorders
MeSH terms: Animals, Cardiovascular Diseases, Humans, Immunity, Innate, Kidney Diseases, Liver Diseases, Methionine, Neoplasms, Nervous System Diseases, Oxidative Stress, Lipid Metabolism

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The role of methionine on metabolism, oxidative stress, and diseases

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