The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Cost of healthcare for patients with migraine in five European countries: results from the International Burden of Migraine Study (IBMS)
Open accessAbstract
Migraine is a disabling neurological disease that affects 14.7 % of Europeans. Studies evaluating the economic impact of migraine are complex to conduct adequately and with time become outdated as healthcare systems evolve. This study sought to quantify and compare direct medical costs of chronic migraine (CM) and episodic migraine (EM) in five European countries. Cross-sectional data collected via a web-based survey were screened for migraine and classified as CM (≥15 headache days/month) or EM (<15 headache days/month), and included sociodemographics, resource use data and medication use. Unit cost data, gathered using publicly available sources, were analyzed for each type of service, stratified by migraine status. Univariate and multivariate log-normal regression models were used to examine the relationship between various factors and their impact on total healthcare costs. This economic analysis included data from respondents with migraine in the UK, France, Germany, Italy, and Spain. CM participants had higher level of disability and more prevalent psychiatric disorders compared to EM. CM participants had more provider visits, emergency department/hospital visits, and diagnostic tests; the medical costs were three times higher for CM than EM. Per patient annual costs were highest in the UK and Spain and lower in France and Germany. CM was associated with higher medical resource use and total costs compared to EM in all study countries, suggesting that treatments that reduce headache frequency could decrease the clinical and economic burden of migraine in Europe. Comparing patterns of care and outcomes among countries may facilitate the development of more cost-effective care, and bring greater recognition to patients affected by migraine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Specifically, no detailed assessment of the current treatment pathway, impact on work productivity, or burden associated with premonitory and postdromal phases of migraine is available in individuals experiencing ≥4 MMDs who have had previous prophylactic treatments that failed and continue to experience frequent migraines.”
From My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed (2018) · cites this paper as [6]
In the citing paper
“However, the current understanding of migraine burden among individuals with the highest unmet needs, specifically those experiencing ≥4 monthly migraine days (MMDs) and prior prophylaxis failure, is limited.”
From My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed (2018) · cites this paper as [6]
In the citing paper
“These findings are consistent with the results of the IBMS study, which found that for each of the five European countries studied, chronic migraine (per ICHD-2 criteria, persons with ≥15 MMDs) was associated with additional healthcare costs attributable to an increased use of medical services and associated cost [6].”
From My Migraine Voice survey: a global study of disease burden among individuals with migraine for whom preventive treatments have failed (2018) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Prevalence and Burden of Migraine in the United States: Data From the American Migraine Study II
Lipton, R. B., Stewart, W. F., Diamond, S., Diamond, M. L., & Reed, M. (2001) · Headache: The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.041007646.x · Cited by 2,268
Self-citationStewart, W. F., Lipton, R. B., Dowson, A. J., & Sawyer, J. (2001) · Neurology · doi:10.1212/wnl.56.suppl_1.s20 · Cited by 1,210
Self-citationNew Appendix Criteria Open for a Broader Concept of Chronic Migraine
Olesen, J., Bousser, M.-G., Diener, H.-C., Dodick, D., First, M., Goadsby, P., Göbel, H., Lainez, M., Lance, J., Lipton, R., et al. (2006) · Cephalalgia · doi:10.1111/j.1468-2982.2006.01172.x · Cited by 909 · cited 1×
“1 defines chronic migraine as C15 headache days per month for at least 3 months, with C8 days per month fulfilling criteria for migraine without aura, in the absence of medication overuse and that cannot be attributed to another causative disorder [6].”
BackgroundSelf-citationBIGAL, M. E., Serrano, D., Buse, D. C., Scher, I., Stewart, W. F., & Lipton, R. B. (2008) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2008.01217.x · Cited by 848
Self-citationThe cost of headache disorders in Europe: the Eurolight project
Linde, M., Gustavsson, A., Stovner, L. J., Steiner, T. J., Barré, J., Katsarava, Z., Lainez, J. M., Lampl, C., Lantéri‐Minet, M., Rastenyte, D., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03612.x · Cited by 741
Self-citationGlobal prevalence of chronic migraine: A systematic review
Natoli, J. L., Manack, A., Dean, B. B., Butler, Q. R., Turkel, C., Stovner, L., & Lipton, R. B. (2009) · Cephalalgia · doi:10.1111/j.1468-2982.2009.01941.x · Cited by 693
Self-citationAn international study to assess reliability of the Migraine Disability Assessment (MIDAS) score
Stewart, W. F., Lipton, R. B., Whyte, J., Dowson, A. J., Kolodner, K. B., Liberman, J. N., & Sawyer, J. P. C. (1999) · Neurology · doi:10.1212/wnl.53.5.988 · Cited by 629
Self-citationBlumenfeld, A., Varon, S., Wilcox, T., Buse, D., Kawata, A., Manack, A., Goadsby, P., & Lipton, R. (2011) · Cephalalgia · doi:10.1177/0333102410381145 · Cited by 627
Self-citationSociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers
Buse, D. C., Manack, A., Serrano, D., Turkel, C., & Lipton, R. B. (2010) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.192492 · Cited by 622
Self-citationClassification of daily and near-daily headaches
Silberstein, S. D., Lipton, R. B., & Sliwinski, M. J. (1996) · Neurology · doi:10.1212/wnl.47.4.871 · Cited by 613
Self-citationPrevalence of headache in Europe: a review for the Eurolight project
Stovner, L. J., & Andree, C. (2010) · The Journal of Headache and Pain · doi:10.1007/s10194-010-0217-0 · Cited by 580
Stewart, W., Lipton, R. B., Kolodner, K., Liberman, J. N., & Sawyer, J. P. C. (1999) · Cephalalgia · doi:10.1046/j.1468-2982.1999.019002107.x · Cited by 558
Self-citationBuse, D. C., Manack, A. N., Fanning, K. M., Serrano, D., Reed, M. L., Turkel, C. C., & Lipton, R. B. (2012) · Headache: The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2012.02223.x · Cited by 549
Self-citationChronic migraine in the population
BIGAL, M. E., Serrano, D., Reed, M. L., & Lipton, R. B. (2008) · Neurology · doi:10.1212/01.wnl.0000323925.29520.e7 · Cited by 488
Self-citationAfridi, S. K., Shields, K. G., Bhola, R., & Goadsby, P. J. (2006) · Pain · doi:10.1016/j.pain.2006.01.016 · Cited by 394
Self-citationChronic daily headache with analgesic overuse
Colás, R., Muñoz, P., Temprano, R. P., Gómez, C., & Pascual, J. (2004) · Neurology · doi:10.1212/01.wnl.0000120545.45443.93 · Cited by 264
Self-citationStokes, M., Becker, W. J., Lipton, R. B., Sullivan, S. D., Wilcox, T. K., Wells, L., Manack, A. N., Proskorovsky, I., Gladstone, J. P., Buse, D. C., et al. (2011) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.01945.x · Cited by 258
Self-citationBIGAL, M. E., Rapoport, A. M., Lipton, R. B., Tepper, S. J., & Sheftell, F. D. (2003) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2003.03068.x · Cited by 242
Self-citationBuse, D. C., Manack, A. N., Serrano, D., Reed, M. L., Varon, S. F., Turkel, C. C., & Lipton, R. B. (2011) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.02046.x · Cited by 239
Self-citationEmployment and Work Impact of Chronic Migraine and Episodic Migraine
Stewart, W. F., Wood, G. C., Manack, A. N., Varon, S. F., Buse, D. C., & Lipton, R. B. (2010) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e3181c1dc56 · Cited by 194
Self-citationQuality‐of‐Life Differences Between Patients With Episodic and Transformed Migraine
Meletiche, D. M., Lofland, J. H., & Young, W. B. (2001) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2001.041006573.x · Cited by 165
Quality of life in chronic daily headache
Guitera, V., Muñoz, P., Castillo, J., & Pascual, J. (2002) · Neurology · doi:10.1212/wnl.58.7.1062 · Cited by 160
Self-citationStewart, W. F., Lipton, R. B., & Kolodner, K. (2003) · Headache The Journal of Head and Face Pain · doi:10.1046/j.1526-4610.2003.03050.x · Cited by 158
Self-citationImpact of headache in Europe: a review for the Eurolight project
Stovner, L. J., Andrée, C., & On behalf of the Eurolight Steering Committee (2008) · The Journal of Headache and Pain · doi:10.1007/s10194-008-0038-6 · Cited by 154
Intravenous dihydroergotamine for inpatient management of refractory primary headaches
Nagy, A. J., Gandhi, S., Bhola, R., & Goadsby, P. J. (2011) · Neurology · doi:10.1212/wnl.0b013e3182377dbb · Cited by 134
Self-citationCost of migraine and other headaches in Europe
Berg, J., & Stovner, L. J. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01192.x · Cited by 117
Societal Perspective on the Burden of Migraine in The Netherlands
Roijen, L. H., Essink‐Bot, M., Koopmanschap, M. A., Michel, B. C., & Rutten, F. (1995) · PharmacoEconomics · doi:10.2165/00019053-199507020-00008 · Cited by 98
Economic Impact of Migraine and Other Episodic Headaches in France
Pradalier, A., Auray, J., Hasnaoui, A. E., Alzahouri, K., Dartigues, J., Duru, G., Henry, P., Lantéri‐Minet, M., Lucas, C., Chazot, G., et al. (2004) · PharmacoEconomics · doi:10.2165/00019053-200422150-00003 · Cited by 92
A review of current European treatment guidelines for migraine
Antonaci, F., Dumitrache, C., Cillis, I. D., & Allena, M. (2009) · The Journal of Headache and Pain · doi:10.1007/s10194-009-0179-2 · Cited by 84
Payne, K. A., Varon, S. F., Kawata, A. K., Yeomans, K., Wilcox, T. K., Manack, A., Buse, D. C., Lipton, R. B., Goadsby, P. J., & Blumenfeld, A. M. (2011) · Cephalalgia · doi:10.1177/0333102411410610 · Cited by 74 · cited 1×
“A full description of the survey methods as well as the inclusion/exclusion criteria have been described elsewhere [26].”
MethodSelf-citationImproving care through health economics analyses: cost of illness and headache
Mennini, F. S., Gitto, L., & Martelletti, P. (2008) · The Journal of Headache and Pain · doi:10.1007/s10194-008-0051-9 · Cited by 67
Self-citationEconomic evidence in migraine and other headaches: a review
Berg, J. (2004) · The European Journal of Health Economics · doi:10.1007/s10198-005-0288-z · Cited by 65
The Burden of Migraine in Spain
Badia, X. C., Magaz, S., rrez, L. G., & n, J. G. (2004) · PharmacoEconomics · doi:10.2165/00019053-200422090-00004 · Cited by 48
Cost of scheduled and unscheduled asthma management in seven European Union countries
Williams, A., Lloyd, A., Watson, L., & Rabe, K. F. (2006) · European Respiratory Review · doi:10.1183/09059180.06.00009801 · Cited by 46
Epidemiology of chronic daily headache.
Kavuk, I., Yavuz, A., Cetindere, U., Agelink, M. W., & Diener, H. (2003) · PubMed · Cited by 44
Bateman, E. D. (2006) · European Respiratory Review · doi:10.1183/09059180.06.00009800 · Cited by 16
Migräne - eine Volkskrankheit und ihre Kosten: Indirekte Kosten überwiegen
Neubauer, G., & Ujlaky, R. (2002) · Pharmazie in unserer Zeit · doi:10.1002/1615-1003(200209)31:5 · Cited by 9
Manack, A., Serrano, D., Turkel, C., Lipton, R. B., & Buse, D. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-s1-p9 · Cited by 7
Self-citation
Research works printed but not linked: 2
- Reed ML, Buse DC, Manack AN, Fanning KM, Serrano D, Turkel CC, Lipton RB (2011) Prevalence of chronic migraine (CM), headache-related disability and sociodemographic factors in the US population. Headache 51(S1):28
- Michel P, Auray J, Chicoye A, Dartigues J, Lamure M, Duru G, Henry P, Salamon R (1993) Prise en charge des migraineux en France: coût et recours aux soins. J d’Econ Méd 11:71–80
Cited by
Sorted by citations
Adherence to oral migraine-preventive medications among patients with chronic migraine
Hepp, Z., Dodick, D. W., Varon, S. F., Gillard, P. J., Hansen, R. N., & Devine, E. B. (2014) · Cephalalgia · doi:10.1177/0333102414547138 · Cited by 438
Self-citationAdams, A. M., Serrano, D., Buse, D. C., Reed, M. L., Marske, V., Fanning, K. M., & Lipton, R. B. (2015) · Cephalalgia · doi:10.1177/0333102414552532 · Cited by 305
Self-citationA narrative review on the burden of migraine: when the burden is the impact on people’s life
Leonardi, M., & Raggi, A. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-0993-0 · Cited by 303
European headache federation consensus on the definition of resistant and refractory migraine
Sacco, S., Braschinsky, M., Ducros, A., Lampl, C., Little, P., MaassenVanDenBrink, A., Pozo‐Rosich, P., Reuter, U., de la Torre, E. R., del Río, M. S., et al. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01130-5 · Cited by 272
Self-citationBonafede, M., Sapra, S. J., Shah, N. A., Tepper, S. J., Cappell, K. A., & Desai, P. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13275 · Cited by 248
Metadata
- Authors
- Bloudek, L. M., Stokes, M., Buse, D. C., Wilcox, T. K., Lipton, R. B., Goadsby, P. J., Varon, S. F., Blumenfeld, A. M., Katsarava, Z., Pascual, J., Lanteri-Minet, M., Cortelli, P., & Martelletti, P.
- Affiliations
- Allergan (United States) (US)
- Albert Einstein College of Medicine (US)
- University of California, San Francisco (US)
- Essen University Hospital (DE)
- Hospital Universitario Central de Asturias (ES)
- University of Bologna (IT)
- Azienda Ospedaliera Sant'Andrea (IT)
- Corresponding author
- Bloudek, L. M.
- ORCID
- Venue
- The Journal of Headache and Pain
- Published
- 2012-05-29
- Volume
- 13
- Issue
- 5
- Pages
- 361-378
- ISSN
- 1129-2369 (ISSN-L)
- 1129-2377
- PMC
- PMC3381065
- OpenAlex
- W2094473459
- Cited by
- 339
- References
- 38
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 26 · 2023: 19 · 2022: 18 · 2021: 38 · 2020: 36 · 2019: 34 · 2018: 25 · 2017: 25 · 2016: 17 · 2015: 17 · 2014: 30 · 2013: 25 · 2012: 6
- FWCI
- 17.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Journal of Headache and Pain (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- University of Washington
- Allergan
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- migraine, chronic migraine, episodic migraine, health care costs, direct medical costs, health care utilization, disability, psychiatric comorbidity, emergency department visits, hospital visits, diagnostic testing, medication use, cross-national comparison
- MeSH terms
- Cross-Sectional Studies, Europe, Female, Persons with Disabilities, Health Surveys, Humans, Male, Migraine Disorders, Health Care Costs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
