Brown seaweed fucoidan: Biological activity and apoptosis, growth signaling mechanism in cancer

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627 · see citing works

The biochemistry of apoptosis

Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,295 · see citing works

Death Receptors: Signaling and Modulation

Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · see citing works

Mammalian MAP kinase signalling cascades

Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961 · see citing works

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824 · see citing works

Journal of Food Science and Technology

(2013) · Journal of Food Science and Technology · doi:10.1007/13197.0975-8402 · Cited by 2,456 · see citing works

International Journal of Molecular Medicine

(2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm · Cited by 2,247 · see citing works

Apoptosis

Johnstone, R. W., Ruefli, A. A., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00625-6 · Cited by 2,236 · see citing works

Bioactive compounds in seaweed: functional food applications and legislation

Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135 · see citing works

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

Kaufmann, S. H., Desnoyers, S., Ottaviano, Y. L., Davidson, N. E., & Poirier, G. G. (1993) · PubMed · Cited by 1,889 · see citing works

Mitogen-activated protein kinases in apoptosis regulation

Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432 · see citing works

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

Desagher, S., Osen‐Sand, A., Nichols, A. C., Eskes, R., Montessuit, S., Lauper, S., Maundrell, K., Antonsson, B. E., & Martinou, J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.5.891 · Cited by 1,260 · see citing works

ANIMAL CELL CYCLES AND THEIR CONTROL

Norbury, C. J., & Nurse, P. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.002301 · Cited by 1,252 · see citing works

Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

Eskes, R., Desagher, S., Antonsson, B. E., & Martinou, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.929-935.2000 · Cited by 1,190 · see citing works

Macroscopic Mass and Energy Balance of a Pilot Plant Anaerobic Bioreactor Operated Under Thermophilic Conditions

Espinosa‐Solares, T., Bombardiere, J., Mark, C., Domaschko, M., Easter, M., David, A. S., Castillo-Angeles, S., & Castellanos-Hernandez, N. (2006) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:132:1:959 · Cited by 1,112 · see citing works

Caspases in apoptosis and beyond

Li, J., & Yuan, J. (2008) · Oncogene · doi:10.1038/onc.2008.297 · Cited by 1,090 · see citing works

Chemical structures and bioactivities of sulfated polysaccharides from marine algae

Jiao, G., Yu, G., Zhang, J., & Ewart, H. S. (2011) · Marine Drugs · doi:10.3390/md9020196 · Cited by 1,054 · see citing works

A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds

Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works

Regulators of Angiogenesis

Klagsbrun, M., & D'Amore, P. A. (1991) · Annual Review of Physiology · doi:10.1146/annurev.ph.53.030191.001245 · Cited by 961 · see citing works

Molecular Medicine Reports

(2026) · Molecular Medicine Reports · doi:10.3892/mmr · Cited by 920 · see citing works

Leaders in Social Networks, the Delicious Case

Lü, L., Zhang, Y., Yeung, C. H., & Zhou, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021202 · Cited by 863 · see citing works

Sulfated fucans, fresh perspectives: Structures, functions, and biological properties of sulfated fucans and an overview of enzymes active toward this class of polysaccharide

Berteau, O. (2003) · Glycobiology · doi:10.1093/glycob/cwg058 · Cited by 769 · see citing works

Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica

Wang, J., Zhang, Q., Zhang, Z., & Li, Z. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.003 · Cited by 745 · see citing works

Chemistry and enzymology of marine algal polysaccharides

Percival, E. E., & McDowell, R. H. (1967) · Cited by 686 · see citing works

Characterization of polysaccharides extracted from brown seaweeds

Rioux, L.-E., Turgeon, S. L., & Beaulieu, M. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.01.009 · Cited by 604 · see citing works

Potential Antioxidant Capacity of Sulfated Polysaccharides from the Edible Marine Brown Seaweed Fucus vesiculosus

Rupérez, P., Ahrazem, O., & Leal, J. A. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010908o · Cited by 599 · see citing works

Journal of Thrombosis and Haemostasis

Anne-marie Centre, Intercommunal, H., La, T., Mer, S. S., Medicale, G., Sylvia Centre, Ap-hp, H. U., Henri, G., Chenevier, M.-A., Emmanuelle Centre Hospitalier, et al. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1111/(issn)1538-7836 · Cited by 553 · see citing works

A revised structure for fucoidan may explain some of its biological activities.

Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531 · see citing works

Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities

Koyanagi, S., Tanigawa, N., Nakagawa, H., Soeda, S., & Shimeno, H. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01478-8 · Cited by 479 · see citing works

Recent developments in mushrooms as anti-cancer therapeutics: a review

Patel, S. V., & Goyal, A. (2011) · 3 Biotech · doi:10.1007/s13205-011-0036-2 · Cited by 462 · see citing works

Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica

Wang, J., Zhang, Q., Zhang, Z., Song, H., & Li, P. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2009.10.015 · Cited by 456 · see citing works

Major cell death pathways at a glance

Duprez, L., Wirawan, E., Berghe, T. V., & Vandenabeele, P. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.08.013 · Cited by 382 · see citing works

Antioxidant activity of different molecular weight sulfated polysaccharides from Ulva pertusa Kjellm (Chlorophyta)

Qi, H., Zhao, T., Zhang, Q., Li, Z., Zhao, Z., & Xing, R. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-9003-9 · Cited by 377 · see citing works

Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis

Kryczek, I., Wei, S., Keller, E. T., Liu, R., & Zou, W. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00406.2006 · Cited by 329 · see citing works

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

Smalley, K. S. M. (2003) · International Journal of Cancer · doi:10.1002/ijc.10978 · Cited by 320 · see citing works

Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum

Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00149-5 · Cited by 319 · see citing works

Production and utilization of products from commercial seaweeds

McHugh, D. J. (1987) · FAO eBooks · Cited by 312 · see citing works

Fucoidan induces apoptosis of human HS-Sultan cells accompanied by activation of caspase-3 and down-regulation of ERK Pathways

Aisa, Y., Miyakawa, Y., Nakazato, T., Shibata, H., Saito, K., Ikeda, Y., & Kizaki, M. (2005) · American Journal of Hematology · doi:10.1002/ajh.20182 · Cited by 307 · see citing works

A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae

Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 304 · see citing works

Algal biotechnology industries and research activities in China

Tseng, C. K. (2001) · Journal of Applied Phycology · doi:10.1023/a:1017972812576 · Cited by 284 · see citing works

Seaweeds as a source of nutritionally beneficial compounds - A review

Chandini, S., Ganesan, P., Suresh, P. V., & Bhaskar, N. (2008) · CFTRI Institutional Repository · Cited by 282 · see citing works

Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity

Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N. (2011) · Carbohydrate Research · doi:10.1016/j.carres.2011.09.034 · Cited by 267 · see citing works

Fucoidan from Sargassum sp. and Fucus vesiculosus reduces cell viability of lung carcinoma and melanoma cells in vitro and activates natural killer cells in mice in vivo

Ale, M. T., Maruyama, H., Tamauchi, H., Mikkelsen, J. D., & Meyer, A. S. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2011.05.009 · Cited by 267 · see citing works

Activator protein 1 (AP-1)– and nuclear factor κB (NF-κB)–dependent transcriptional events in carcinogenesis

Hsu, T.-C., Young, M. R., Cmarik, J. L., & Colburn, N. H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00220-3 · Cited by 265 · see citing works

Relationship between sulfate groups and biological activities of fucans

Haroun-Bouhedja, F., Ellouali, M., Sinquin, C., & Boisson-Vidal, C. (2000) · Thrombosis Research · doi:10.1016/s0049-3848(00)00338-8 · Cited by 256 · see citing works

In vivo antioxidant activity of polysaccharide fraction from Porphyra haitanesis (Rhodephyta) in aging mice

Zhang, Q., Li, N., Zhou, G., Lu, X., Xu, Z., & Li, Z. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00103-8 · Cited by 253 · see citing works

The current status of natural products from marine fungi and their potential as anti-infective agents

Bhadury, P., Mohammad, B. T., & Wright, P. C. (2006) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-005-0070-3 · Cited by 250 · see citing works

Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga

Alekseyenko, T. V., Zhanayeva, S. Y., Venediktova, A. A., Zvyagintseva, T. N., Kuznetsova, T. A., Besednova, N. N., & Korolenko, T. A. (2007) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-007-0226-4 · Cited by 244 · see citing works

Apoptosis in the absence of caspase 3

Liang, Y. S., Yan, C., & Schor, N. F. (2001) · Oncogene · doi:10.1038/sj.onc.1204815 · Cited by 235 · see citing works

Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity

Ermakova, S., Sokolova, R., Kim, S.-M., Um, B.-H., Isakov, V., & Zvyagintseva, T. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9178-2 · Cited by 229 · see citing works

Production and Use of Marine AIgae in Japan

Murata, M., & Nakazoe, J.-I. (2001) · Japan Agricultural Research Quarterly JARQ · doi:10.6090/jarq.35.281 · Cited by 219 · see citing works

The interplay between the Bcl-2 family and death receptor-mediated apoptosis

Sprick, M. R., & Walczak, H. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.11.002 · Cited by 206 · see citing works

Structural Features and Antiviral Activity of Sulphated Fucans from the Brown Seaweed Cystoseira Indica

Mandal, P., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2007) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020701800305 · Cited by 205 · see citing works

Cell death in health and disease

Lockshin, R. A., & Zakeri, Z. F. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00150.x · Cited by 199 · see citing works

Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways

Lee, H., Kim, J.-S., & Kim, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050624 · Cited by 191 · see citing works

Antitumor Active Fucoidan from the Brown Seaweed,<i>Umitoranoo</i>(<i>Sargassum thunbergii</i>)

Zhuang, C., Itoh, H., Mizuno, T., & Ito, H. (1995) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.59.563 · Cited by 184 · see citing works

Ex Vivo Priming of Endothelial Progenitor Cells With SDF-1 Before Transplantation Could Increase Their Proangiogenic Potential

Zemani, F., Silvestre, J., Fauvel-Lafève, F., Bruel, A., Vilar, J., Bièche, I., Laurendeau, I., Galy–Fauroux, I., Fischer, A. M., & Boisson‐Vidal, C. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160044 · Cited by 183 · see citing works

Zur Biochemie der Meeresalgen.

Kylin, H. (1913) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1913.83.3.171 · Cited by 183 · see citing works

Fucoidan Induces Apoptosis through Activation of Caspase-8 on Human Breast Cancer MCF-7 Cells

Yamasaki-Miyamoto, Y., Yamasaki, M., Tachibana, H., & Yamada, K. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9010406 · Cited by 181 · see citing works

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

Wu, W.-S., Wu, J.-R., & Hu, C.-T. (2008) · Cancer Metastasis Review · doi:10.1007/s10555-008-9112-4 · Cited by 172 · see citing works

Affinity of low molecular weight fucoidan for P-selectin triggers its binding to activated human platelets

Bachelet, L., Bertholon, I., Lavigne, D., Vassy, R., Jandrot‐Perrus, M., Chaubet, F., & Letourneur, D. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.10.008 · Cited by 170 · see citing works

Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis

Senni, K., Gueniche, F., Foucault-Bertaud, A., Igondjo-Tchen, S., Fioretti, F., Colliec-Jouault, S., Durand, P., Guezennec, J., Godeau, G., & Letourneur, D. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.11.001 · Cited by 163 · see citing works

Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation

Rouzet, F., Bachelet-Violette, L., Alsac, J.-M., Suzuki, M., Meulemans, A., Louedec, L., Petiet, A., Jandrot‐Perrus, M., Chaubet, F., Michel, J., et al. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.085852 · Cited by 159 · see citing works

Role of mitogen-activated protein kinase kinase 4 in cancer

Whitmarsh, A. J., & Davis, R. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210410 · Cited by 157 · see citing works

Anti-proliferative activity of oversulfated fucoidan from commercially cultured Cladosiphon okamuranus TOKIDA in U937 cells

Teruya, T., Konishi, T., Uechi, S., Tamaki, H., & Tako, M. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.02.010 · Cited by 156 · see citing works

The Role of NK cells in Antitumor Activity of Dietary Fucoidan from <i>Undaria pinnatifida</i> Sporophylls (Mekabu)

Maruyama, H., Tamauchi, H., Iizuka, M., & Nakano, T. (2006) · Planta Medica · doi:10.1055/s-2006-951703 · Cited by 151 · see citing works

Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells

Hyun, J.-H., Kim, S.-C., Kang, J.-I., Kim, M.-K., Boo, H.-J., Kwon, J.-M., Koh, Y.-S., Hyun, J.-W., Park, D.-B., Yoo, E.-S., et al. (2009) · Biological &amp; Pharmaceutical Bulletin · doi:10.1248/bpb.32.1760 · Cited by 150 · see citing works

Enzyme-digested fucoidan extracts derived from seaweed Mozuku of Cladosiphon novae-caledoniae kylin inhibit invasion and angiogenesis of tumor cells

Ye, J., Li, Y., Teruya, K., Katakura, Y., Ichikawa, A., Eto, H., Hosoi, M., Hosoi, M., Nishimoto, S., & Shirahata, S. (2005) · Cytotechnology · doi:10.1007/s10616-005-3761-8 · Cited by 146 · see citing works

Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGF receptor degradation in breast cancer

Hsu, H.-Y., Lin, T., Hwang, P., Tseng, L., Chen, R., Tsao, S.-M., & Hsu, J. L. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs396 · Cited by 141 · see citing works

Fucoidan Extracted From Cladosiphon Okamuranus Tokida Induces Apoptosis of Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells

Haneji, K., Matsuda, T., Tomita, M., Kawakami, H., Ohshiro, K., Uchihara, J., Masuda, M., Takasu, N., Tanaka, Y., Ohta, T., et al. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5202_9 · Cited by 132 · see citing works

Low Molecular Weight Fucoidan Increases VEGF165-induced Endothelial Cell Migration by Enhancing VEGF165 Binding to VEGFR-2 and NRP1

Lake, A. C., Vassy, R., Benedetto, M. D., Lavigne, D., Visage, C. L., Perret, G. Y., & Letourneur, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600686200 · Cited by 129 · see citing works

Hoppe-Seyler's zeitschrift fur physiologische chemie

Karlson, P. (1977) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(77)90076-7 · Cited by 127 · see citing works

How do patients with inflammatory bowel disease want their biological therapy administered?

Allen, P. B., Lindsay, H., & Tham, T. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-1 · Cited by 127 · see citing works

Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats

Huang, L., Wen, K., Gao, X., & Liu, Y. (2010) · Pharmaceutical Biology · doi:10.3109/13880200903150435 · Cited by 125 · see citing works

Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line.

Riou, D., Colliec‐Jouault, S., du Sel, D. P., Bösch, S., Siavoshian, S., Bert, V. L., Tomasoni, C., Sinquin, C., Durand, P., & Roussakis, C. (1996) · PubMed · Cited by 124 · see citing works

Polysaccharides of Algae: 55. Polysaccharide Composition of Several Brown Algae from Kamchatka

Usov, A. I., Smirnova, G. P., & Клочкова, Н. Г. (2001) · Russian Journal of Bioorganic Chemistry · doi:10.1023/a:1012992820204 · Cited by 124 · see citing works

Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells

Liu, F., Wang, J., Chang, A. K., Liu, B., Yang, L., Li, Q., Wang, P., & Zou, X. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.03.015 · Cited by 115 · see citing works

Correction: Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice

Zhang, L., Reidy, S. P., Bogachev, O., Hall, B. K., & Majdalawieh, H.-S. A. (2011) · PLoS ONE · doi:10.1371/annotation/4056d03c-20ed-4eca-9568-3e9400e2312e · Cited by 111 · see citing works

Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells

Matsubara, K., Xue, C.-H., Zhao, X., Mori, M., Sugawara, T., & Hirata, T. (2005) · International Journal of Molecular Medicine · doi:10.3892/ijmm.15.4.695 · Cited by 109 · see citing works

Higher specificity of the activity of low molecular weight fucoidan for thrombin-induced platelet aggregation

Zhu, Z., Zhang, Q., Chen, L., Ren, S., Xu, P., Tang, Y. P., & Luo, D. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.02.011 · Cited by 108 · see citing works

硫酸化フカン,最新の展望 硫酸化フカンの構造,機能,及び生物学的性質とこのクラスの多糖類に対して活性を示す酵素の概要

Berteau, O., & Mulloy, B. (2003) · Glycobiology · Cited by 106 · see citing works

Nutrients removed by Kappaphycus alvarezii (Rhodophyta, Solieriaceae) in integrated cultivation with fishes in re-circulating water

Hayashi, L., Yokoya, N. S., Ostini, S., Pereira, R. T. L., Braga, E. D. S., & de Oliveira, E. C. (2008) · Aquaculture · doi:10.1016/j.aquaculture.2008.02.024 · Cited by 103 · see citing works

Low-molecular-weight fucoidan enhances the proangiogenic phenotype of endothelial progenitor cells

Zemani, F., Benisvy, D., Galy–Fauroux, I., Lokajczyk, A., Colliec‐Jouault, S., Uzan, G., Fischer, A. M., & Boisson‐Vidal, C. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.07.014 · Cited by 99 · see citing works

Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence

Sweeney, E. A., Priestley, G. V., Nakamoto, B., Collins, R. G., Beaudet, A. L., & Papayannopoulou, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6544 · Cited by 96 · see citing works

Antithrombotic and Anticoagulant Activities of a Low Molecular Weight Fucoidan by the Subcutaneous Route

Colliec‐Jouault, S., Mauray, S., Theveniaux, J., Sternberg, C., Vidal, B., Fischer, A., & Millet, J. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614484 · Cited by 95 · see citing works

Potential effects of a low‐molecular‐weight fucoidan extracted from brown algae on bone biomaterial osteoconductive properties

Changotade, S., Korb, G., Bassil, J., Barroukh, B., Willig, C., Colliec‐Jouault, S., Durand, P., Godeau, G., & Senni, K. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31819 · Cited by 95 · see citing works

The mechanism of fucoidan-induced apoptosis in leukemic cells: Involvement of ERK1/2, JNK, glutathione, and nitric oxide

Jin, J., Song, M., Kim, Y., Park, J., & Kwak, J. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20654 · Cited by 91 · see citing works

Inhibitory Effect of Fucoidan on Huh7 Hepatoma Cells Through Downregulation of CXCL12

Nagamine, T., Hayakawa, K., Kusakabe, T., Takada, H., Nakazato, K., Hisanaga, E., & Iha, M. (2009) · Nutrition and Cancer · doi:10.1080/01635580802567133 · Cited by 87 · see citing works

ESIMS analysis of fucoidan preparations from Costaria costata, extracted from alga at different life-stages

Anastyuk, S. D., Imbs, T. I., Шевченко, Н. М., Dmitrenok, P. S., & Николаевна, З. Т. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.06.033 · Cited by 85 · see citing works

Chinese Journal of Cancer

(2011) · 癌症：英文版 · doi:10.5732/cjc · Cited by 84 · see citing works

mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3

Busch, S., Renaud, S. J., Schleußner, E., Graham, C. H., & Markert, U. R. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.01.026 · Cited by 82 · see citing works

Clinical Importance and Therapeutic Implications of the Pivotal CXCL12-CXCR4 (Chemokine Ligand-Receptor) Interaction in Cancer Cell Migration

Arya, M., Ahmed, H. U., Silhi, N., Williamson, M. P., & Patel, H. (2007) · Tumor Biology · doi:10.1159/000102979 · Cited by 81 · see citing works

Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells

Zhang, Z., Teruya, K., Hiroshi, E. T. O., & Shirahata, S. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120631 · Cited by 77 · see citing works

Inhibitors of Angiogenesis Enter Phase III Testing

Nelson, N. J. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.13.960a · Cited by 75 · see citing works

Inhibitory effects of fucoidan on activation of epidermal growth factor receptor and cell transformation in JB6 Cl41 cells

Lee, N. Y., Ermakova, S. P., Zvyagintseva, T. N., Kang, K. W., Dong, Z., & Choi, H. S. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.01.025 · Cited by 75 · see citing works

Hydroxyapatite-fucoidan nanocomposites for bone tissue engineering

Jeong, H., Venkatesan, J., & Kim, S. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.03.011 · Cited by 73 · see citing works

Chemical Characterization of Acetyl Fucoidan and Alginate from Commercially Cultured Cladosiphon okamuranus

Tako, M., Yoza, E., & Tohma, S. (2000) · Botanica Marina · doi:10.1515/bot.2000.040 · Cited by 72 · see citing works

Future Scenarios for the Treatment of Advanced Non-Small Cell Lung Cancer: Focus on Taxane-Containing Regimens

Grossi, F., Kubota, K., Cappuzzo, F., de Marinis, F., Gridelli, C., Aita, M., & Douillard, J. (2010) · The Oncologist · doi:10.1634/theoncologist.2010-0322 · Cited by 70 · see citing works

The sulfate-content dependence of the anticoagulant activity of a fucan sulfate from the brown seaweed Ecklonia kurome

Nishino, T., & Nagumo, T. (1991) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90542-1 · Cited by 69 · see citing works

Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro

Fukahori, S., Yano, H., Akiba, J., Ogasawara, S., Momosaki, S., Sanada, S., Kuratomi, K., Ishizaki, Y., Moriya, F., Yagi, M., et al. (2008) · Molecular Medicine Reports · doi:10.3892/mmr.1.4.537 · Cited by 67 · see citing works

AnIn VitroStudy of the Structure-Activity Relationships of Sulfated Polysaccharide from Brown Algae to its Antioxidant Effect

Hu, J., Geng, M. Y., Zhang, J. T., & Jiang, H. (2001) · Journal of Asian Natural Products Research · doi:10.1080/10286020108040376 · Cited by 65 · see citing works

Renal peroxidative changes mediated by oxalate: The protective role of fucoidan

Veena, C. K., Josephine, A., Preetha, S. P., Varalakshmi, P., & Sundarapandiyan, R. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.014 · Cited by 60 · see citing works

Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits

Østergaard, C., Yieng-Kow, R. V., Benfield, T., Møller, J. K., Espersen, F., & Lundgren, J. D. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3153-3157.2000 · Cited by 59 · see citing works

Effect of Low Molecular Weight Fucoidan and Low Molecular Weight Heparin in a Rabbit Model of Arterial Thrombosis

Durand, É., Helley, D., Zen, A. A. H., Dujols, C., Bruneval, P., Colliec‐Jouault, S., Fischer, A., & Lafont, A. M. (2008) · Journal of Vascular Research · doi:10.1159/000129687 · Cited by 54 · see citing works

Chemical Diversity of Bioactive Marine Natural Products: An Illustrative Case Study

Costantino, V., Fattorusso, E., Menna, M., & Taglialatela‐Scafati, O. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043364973 · Cited by 52 · see citing works

Immunological analysis of inhibition of lung metastases by fucoidan (GIV-A) prepared from brown seaweed Sargassum thunbergii.

(1995) · PubMed · Cited by 50 · see citing works

Effects of Polysaccharide Fucoidin on Cerebrospinal Fluid Interleukin-1 and Tumor Necrosis Factor Alpha in Pneumococcal Meningitis in the Rabbit

Granert, C., Raud, J., Waage, A., & Lindquist, L. (1999) · Infection and Immunity · doi:10.1128/iai.67.5.2071-2074.1999 · Cited by 49 · see citing works

Antitumor effect of seaweeds. IV. Enhancement of antitumor activity by sulfation of a crude fucoidan fraction from Sargassum kjellmanianum.

Yamamoto, I., Takahashi, M., Suzuki, T., Seino, H., & Mori, H. (1984) · PubMed · Cited by 46 · see citing works

Fucoidan inhibits the development of proteinuria in active Heymann nephritis

Zhang, Q., Li, N., Zhao, T., Qi, H., Xu, Z., & Li, Z. (2005) · Phytotherapy Research · doi:10.1002/ptr.1623 · Cited by 39 · see citing works

[Antiviral activity of sulfated polysaccharide from the brown algae Laminaria japonica against avian influenza A (H5N1) virus infection in the cultured cells].

Макаренкова, И. Д., Deryabin, P. G., Dk, L., Николаевна, З. Т., & Besednova, N. N. (2010) · PubMed · Cited by 39 · see citing works

Effect of fucoidan on the biotinidase kinetics in human hepatocellular carcinoma.

Hayakawa, K., & Nagamine, T. (2009) · PubMed · Cited by 31 · see citing works

Effect of low-molecular-weight fucoidan on experimental arterial thrombosis in the rabbit and rat

Colliec‐Jouault, S., Millet, J., Helley, D., Sinquin, C., & Fischer, A. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.t01-1-00215.x · Cited by 30 · see citing works

Dose-response relationship for lung cancer induction at radiotherapy dose

Schneider, U., Stipper, A., & Besserer, J. (2010) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2010.03.008 · Cited by 28 · see citing works

Fucoidin, a potent inhibitor of l-selectin function, reduces contact hypersensitivity reaction in mice

Nasu, T., Fukuda, Y., Nagahira, K., Kawashima, H., Noguchi, C., & Nakanishi, T. (1997) · Immunology Letters · doi:10.1016/s0165-2478(97)00100-4 · Cited by 28 · see citing works

Comparison of the effects of marchantin C and fucoidan on sFlt-1 and angiogenesis in glioma microenvironment

Lv, Y., Song, Q., Shao, Q., Gao, W., Mao, H., Lou, H., Qu, X., & Li, X. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01430.x · Cited by 24 · see citing works

Induction of hepatocyte growth factor by fucoidan and fucoidan-derived oligosaccharides

Fukuta, K., & Nakamura, T. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.4.0013 · Cited by 21 · see citing works

Involvement of ERK1/2 in Invasiveness and Metastatic Development of Rat Prostatic Adenocarcinoma

Suthiphongchai, T., Promyart, P., Virochrut, S., Tohtong, R., & Wilairat, P. (2003) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504003108748302 · Cited by 21 · see citing works

Antioxidative activities of low molecular fucoidans from kelp laminaria japonica

Xue, C., Chen, L., Li, Z., Yuepiao, C., Lin, H., & Fang, Y. (2004) · Developments in food science · doi:10.1016/s0167-4501(04)80016-5 · Cited by 15 · see citing works

Molecular Carcinogenesis

Zachariadis, M., Evangelou, K., Kastrinakis, N. G., Papanagnou, P., & Gorgoulis, V. G. (2010) · Springer eBooks · doi:10.1007/978-3-540-71915-1_74 · Cited by 13 · see citing works

[Expression and significance of PTEN/PI3K signal transduction-related proteins in non-small cell lung cancer].

Liao, D.-W., Wang, L., Zhang, X.-G., & Liu, M. (2006) · PubMed · Cited by 12 · see citing works

ChemInform Abstract: Structural Analysis of Fucoidans

Bilan, M. I., & Usov, A. I. (2009) · ChemInform · doi:10.1002/chin.200934275 · Cited by 5 · see citing works

Untitled work

Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

Cunha, L., & Grenha, A. (2016) · Marine Drugs · doi:10.3390/md14030042 · Cited by 619 · see citing works

Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification

Garcia-Vaquero, M., Rajauria, G., O'Doherty, J. V., & Sweeney, T. (2017) · Food Research International · doi:10.1016/j.foodres.2016.11.016 · Cited by 364 · see citing works

Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms

van Weelden, G. H., Bobiński, M. S., Okła, K., van Weelden, W. J., Romano, A., & Pijnenborg, J. M. A. (2019) · Marine Drugs · doi:10.3390/md17010032 · Cited by 336 · see citing works

Current Trends on Seaweeds: Looking at Chemical Composition, Phytopharmacology, and Cosmetic Applications

Salehi, B., Sharifi‐Rad, J., Seca, A. M. L., Pinto, D. C. G. A., Michalak, I., Trincone, A., Mishra, A. P., Nigam, M., Zam, W., & Martins, N. A. (2019) · Molecules · doi:10.3390/molecules24224182 · Cited by 315 · see citing works

The seasonal variation of fucoidan within three species of brown macroalgae

Fletcher, H. R., Biller, P., Ross, A. B., & Adams, J. M. M. (2016) · Algal Research · doi:10.1016/j.algal.2016.10.015 · Cited by 270 · see citing works

Carbohydrates From Seaweeds

Stiger‐Pouvreau, V., Bourgougnon, N., & Deslandes, É. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802772-1.00008-7 · Cited by 226 · see citing works

Fucoidan as a Marine Anticancer Agent in Preclinical Development

Kwak, J. (2014) · Marine Drugs · doi:10.3390/md12020851 · Cited by 219 · see citing works

The relationship between polysaccharide structure and its antioxidant activity needs to be systematically elucidated

Chen, N., Jiang, T., Xu, J., Xi, W., Shang, E., Xiao, P., & Duan, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132391 · Cited by 206 · see citing works

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

Venkatesan, J., Anil, S., Kim, S., & Shim, M. S. (2016) · Polymers · doi:10.3390/polym8020030 · Cited by 203 · see citing works

Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels

Zhang, Y., Zhou, T., Wang, H., Cui, Z., Cheng, F., & Wang, K. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.04.002 · Cited by 192 · see citing works

Anti-Cancer Activity of Porphyran and Carrageenan from Red Seaweeds

Liu, Z., Gao, T., Yang, Y. R., Meng, F., Zhan, F., Jiang, Q., & Sun, X. L. (2019) · Molecules · doi:10.3390/molecules24234286 · Cited by 163 · see citing works

Advances in dietary polysaccharides as anticancer agents: Structure-activity relationship

Li, N., Wang, C., Georgiev, M. I., Bajpai, V. K., Tundis, R., Simal‐Gándara, J., Lu, X., Xiao, J., Tang, X., & Qiao, X. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.008 · Cited by 162 · see citing works

Polysaccharides—Naturally Occurring Immune Modulators

Murphy, E. J., Fehrenbach, G. W., Abidin, I. Z., Buckley, C., Montgomery, T., Pogue, R. E., Murray, P., Major, I., & Rezoagli, E. (2023) · Polymers · doi:10.3390/polym15102373 · Cited by 167 · see citing works

Anti-HIV activity of fucoidans from three brown seaweed species

Thủy, T. T. T., Lý, B. M., Vân, T. T. T., Quang, N. V., Tu, H. C., Zheng, Y., Seguin‐Devaux, C., Mi, B., & Ai, U. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.08.068 · Cited by 158 · see citing works

Physico-chemical characterization and pharmacological evaluation of sulfated polysaccharides from three species of Mediterranean brown algae of the genus Cystoseira

Ammar, H. H., Lajili, S., Said, R. B., Cerf, D. L., Bouraoui, A., & Majdoub, H. (2015) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/s40199-015-0089-6 · Cited by 158 · see citing works

Structural characterization and effect on anti-angiogenic activity of a fucoidan from Sargassum fusiforme

Cong, Q., Chen, H., Liao, W., Xiao, F., Wang, P., Qin, Y., Dong, Q., & Ding, K. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.09.087 · Cited by 156 · see citing works

Marine prebiotics: Polysaccharides and oligosaccharides obtained by using microbial enzymes

Gurpilhares, D. D. B., Cinelli, L. P., Simas, N. K., Pessoa, A., & Sette, L. D. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.12.023 · Cited by 156 · see citing works

Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non-Communicable Diseases

Collins, K., Fitzgerald, G. F., Stanton, C., & Ross, R. P. (2016) · Marine Drugs · doi:10.3390/md14030060 · Cited by 156 · see citing works

Anticancer activity of seaweeds

Gutiérrez, A. G., Juárez-Portilla, C. J., Olivares-Bañuelos, T. N., & Zepeda, R. C. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.10.019 · Cited by 153 · see citing works

The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems

Zhong, H., Gao, X., Cheng, C., Chun, L., Wang, Q., & Han, X. (2020) · Marine Drugs · doi:10.3390/md18120658 · Cited by 134 · see citing works

Characterization of antibacterial activity from protein hydrolysates of the macroalga Saccharina longicruris and identification of peptides implied in bioactivity

Beaulieu, L., Bondu, S., Doiron, K., Rioux, L., & Turgeon, S. L. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.026 · Cited by 128 · see citing works

A review on phytoconstituents of marine brown algae

Hakim, M. M., & Patel, I. (2020) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-020-00147-6 · Cited by 130 · see citing works

Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Bilal, M., & Iqbal, H. M. N. (2019) · Marine Drugs · doi:10.3390/md18010007 · Cited by 126 · see citing works

A comprehensive review on the health benefits and nutritional significance of fucoidan polysaccharide derived from brown seaweeds in human, animals and aquatic organisms

Saeed, M., Arain, M. A., Fazlani, S. A., Marghazani, I. B., Umar, M., Soomro, J., Bhutto, Z. A., Soomro, F., Noreldin, A. E., El-Hack, M. E. A., et al. (2021) · Aquaculture Nutrition · doi:10.1111/anu.13233 · Cited by 126 · see citing works

Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating

Venkatesan, J., Singh, S. K., Anil, S., Kim, S., & Shim, M. S. (2018) · Molecules · doi:10.3390/molecules23061429 · Cited by 119 · see citing works

Antioxidant and Signal‐Modulating Effects of Brown Seaweed‐Derived Compounds against Oxidative Stress‐Associated Pathology

Begum, R., Saurav, H., Mamun-Or-Rashid, A. N. M., Rafiquzzaman, S. M., Ashraf, G. M., Albadrani, G. M., Sayed, A. A., Peluso, I., Abdel‐Daim, M. M., & Uddin, M. S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9974890 · Cited by 126 · see citing works

Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease

Eom, T.-K., Kim, Y. S., Choi, C. H., Sadowsky, M. J., & Unno, T. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-8049-8 · Cited by 116 · see citing works

Health benefits and potential applications of fucoidan (FCD) extracted from brown seaweeds in aquaculture: An updated review

Abdel‐Latif, H. M. R., Dawood, M. A. O., Alagawany, M. M., Faggio, C., Nowosad, J., & Kucharczyk, D. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.01.039 · Cited by 118 · see citing works

Encapsulation of curcumin using fucoidan stabilized zein nanoparticles: Preparation, characterization, and in vitro release performance

Zhang, H., Jiang, L., Tong, M., Lu, Y., Ouyang, X., & Ling, J. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2021.115586 · Cited by 116 · see citing works

Fucoidan as bio-functional molecule: Insights into the anti-inflammatory potential and associated molecular mechanisms

Phull, A. R., & Kim, S. J. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.09.051 · Cited by 115 · see citing works

“Fucoidan, a natural biopolymer in cancer combating: From edible algae to nanocarrier tailoring”

Etman, S. M., Elnaggar, Y. S. R., & Abdallah, O. Y. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.191 · Cited by 115 · see citing works

Promoting Wound Healing Using Low Molecular Weight Fucoidan in a Full-Thickness Dermal Excision Rat Model

Park, J., Choi, S.-H., Park, S.-J., Lee, Y. J., Park, J. S., Song, P. H., Cho, C.-M., Ku, S., & Song, C. (2017) · Marine Drugs · doi:10.3390/md15040112 · Cited by 114 · see citing works

An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients

Takahashi, H., Kawaguchi, M., Kitamura, K., Narumiya, S., Kawamura, M., Tengan, I., Nishimoto, S., Hanamure, Y., MAJIMA, Y., Tsubura, S., et al. (2017) · Integrative Cancer Therapies · doi:10.1177/1534735417692097 · Cited by 113 · see citing works

Fucoidan from Ecklonia maxima is a powerful inhibitor of the diabetes-related enzyme, α-glucosidase

Daub, C. D., Mabate, B., Malgas, S., & Pletschke, B. I. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.161 · Cited by 109 · see citing works

Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells

Yan, M., Yao, C., Chow, J., Chang, C.-L., Hwang, P., Chuang, S., Whang‐Peng, J., & Lai, G. (2015) · Marine Drugs · doi:10.3390/md13106099 · Cited by 107 · see citing works

The Key Role of Sulfation and Branching on Fucoidan Antitumor Activity

Oliveira, C., Ferreira, A. S., Novoa-Carballal, R., Nunes, C., Pashkuleva, I., Neves, N. M., Coimbra, M. A., Reis, R. L., Martins, A. M., & Silva, T. H. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600340 · Cited by 105 · see citing works

Comparison Study on Polysaccharide Fractions from Laminaria japonica: Structural Characterization and Bile Acid Binding Capacity.

Gao, J., Lin, L.-Z., Sun, B.-G., & Zhao, M.-M. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04033 · Cited by 94 · see citing works

Phyto-mediated synthesis of silver nanoparticles using fucoidan isolated from Spatoglossum asperum and assessment of antibacterial activities

Anjali, R., Palanisamy, S., Vinosha, M., Muthu, T., Rajasekar, P., Marudhupandi, T., Ponnuchamy, K., Boomi, P., & Marimuthu, P. N. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.05.031 · Cited by 103 · see citing works

Fucoidan isolated from Padina commersonii inhibit LPS-induced inflammation in macrophages blocking TLR/NF-κB signal pathway

Asanka Sanjeewa, K. K., Jayawardena, T. U., Kim, H.-S., Kim, S.-Y., Shanura Fernando, I. P., Wang, L., Abetunga, D. T. U., Kim, W.-S., Lee, D.-S., & Jeon, Y.-J. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115195 · Cited by 102 · see citing works

Optimal nutrition and the ever-changing dietary landscape: a conference report

Shao, A., Drewnowski, A., Willcox, D. C., Krämer, L., Lausted, C. G., Eggersdorfer, M. L., Mathers, J. C., Bell, J. D., Randolph, R. K., Witkamp, R. F., et al. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1460-9 · Cited by 97 · see citing works

Gradual degradation of fucoidan from Fucus vesiculosus and its effect on structure, antioxidant and antiproliferative activities

Lahrsen, E., Liewert, I., & Alban, S. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.03.056 · Cited by 96 · see citing works

Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades

Chen, S., Zhao, Y., Zhang, Y., & Zhang, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108157 · Cited by 95 · see citing works

Primary structure and chain conformation of fucoidan extracted from sea cucumber Holothuria tubulosa

Chang, Y., Hu, Y., Yu, L., McClements, D. J., Xu, X., Liu, G., & Xue, C. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.10.016 · Cited by 93 · see citing works

Extraction and Yield Optimisation of Fucose, Glucans and Associated Antioxidant Activities from Laminaria digitata by Applying Response Surface Methodology to High Intensity Ultrasound-Assisted Extraction

García‐Vaquero, M., Rajauria, G., Tiwari, B. K., Sweeney, T., & O’Doherty, J. V. (2018) · Marine Drugs · doi:10.3390/md16080257 · Cited by 93 · see citing works

Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy

Mabate, B., Daub, C. D., Malgas, S., Edkins, A. L., & Pletschke, B. I. (2021) · Marine Drugs · doi:10.3390/md19010030 · Cited by 92 · see citing works

Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications

Willcox, B. J., & Willcox, D. C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000019 · Cited by 92 · see citing works

The potential of seaweed as a source of drugs for use in cancer chemotherapy

Murphy, C., Hotchkiss, S., Worthington, J., & McKEOWN, S. R. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0245-2 · Cited by 92 · see citing works

In Vitro Photodynamic Effect of Phycocyanin against Breast Cancer Cells

Bharathiraja, S., Seo, H., Manivasagan, P., Santhamoorthy, M., Park, S. H., & Oh, J. (2016) · Molecules · doi:10.3390/molecules21111470 · Cited by 89 · see citing works

Seaweed bioactives potential as nutraceuticals and functional ingredients: A review

Matos, J., Cardoso, C. L., Serralheiro, M. L., Bandarra, N. M., & Afonso, C. M. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106453 · Cited by 95 · see citing works

Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

Cho, M. H., Yan, L., Lo, P., Lee, H., & Choi, Y. (2020) · Nano-Micro Letters · doi:10.1007/s40820-020-0384-8 · Cited by 85 · see citing works

Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells

Kasai, A., Arafuka, S., Koshiba, N., Takahashi, D., & Toshima, K. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01634g · Cited by 83 · see citing works

Primary structure, conformation in aqueous solution, and intestinal immunomodulating activity of fucoidan from two brown seaweed species Sargassum crassifolium and Padina australis

Yuguchi, Y., Vân, T. T. T., Bui, L. M., Shizuka, T., Suzuki, S., Nobukazu, N., Kitamura, S., & Thanh, T. T. T. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.03.101 · Cited by 82 · see citing works

Cellulase-assisted extraction of polysaccharides from Malva sylvestris : Process optimization and potential functionalities

Rostami, H., & Gharibzahedi, S. M. T. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.03.078 · Cited by 81 · see citing works

Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells

Park, H. M., Park, S., Jeong, J., Yoon, D., Han, M. H., Lee, D.-S., Choi, G., Yim, M., Lee, J. E., Kim, D., et al. (2017) · Marine Drugs · doi:10.3390/md15060154 · Cited by 79 · see citing works

Therapeutic and nutraceutical potentials of a brown seaweed Sargassum fusiforme

Liu, J., Luthuli, S., Yang, Y., Cheng, Y., Zhang, Y., Wu, M., Choi, J., & Tong, H. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1835 · Cited by 76 · see citing works

The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica

Jin, W., Zhang, W., Mitra, D., McCandless, M. G., Sharma, P., Tandon, R., Zhang, F., & Linhardt, R. J. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.184 · Cited by 77 · see citing works

Anti-Photoaging Effects of Low Molecular-Weight Fucoidan on Ultraviolet B-Irradiated Mice

Kim, Y., Oh, W., Song, P. H., Yun, S., Kwon, Y.-S., Lee, Y. J., Ku, S., Song, C., & Oh, T. (2018) · Marine Drugs · doi:10.3390/md16080286 · Cited by 76 · see citing works

Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis

Park, H., Kim, G., Moon, S., Kim, W., Yoo, Y. H., & Choi, Y. H. (2014) · Molecules · doi:10.3390/molecules19055981 · Cited by 77 · see citing works

Beneficial effects of three brown seaweed polysaccharides on gut microbiota and their structural characteristics: An overview

You, L., Gong, Y., Li, C., Hu, X., Brennan, C. S., & Kulikouskaya, V. I. (2019) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14408 · Cited by 75 · see citing works

Isolation, Structural characterization, and antiproliferative activity of phycocolloids from the red seaweed Laurencia papillosa on MCF-7 human breast cancer cells

Ghannam, A., Murad, H., Jazzara, M., Odeh, A., & Allaf, A. W. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.11.001 · Cited by 74 · see citing works

Development of a bio-refinery process for the production of speciality chemical, biofuel and bioactive compounds from Laminaria digitata

Kostas, E. T., White, D. A., & Cook, D. J. (2017) · Algal Research · doi:10.1016/j.algal.2017.10.022 · Cited by 72 · see citing works

In Vitro Digestion and Fermentation of Three Polysaccharide Fractions from Laminaria japonica and Their Impact on Lipid Metabolism-Associated Human Gut Microbiota

Gao, J., Lin, L., Chen, Z., Cai, Y., Xiao, C., Zhou, F., Sun, B., & Zhao, M. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00970 · Cited by 72 · see citing works

Seaweed-Derived Sulfated Polysaccharides; The New Age Chemopreventives: A Comprehensive Review

Bhuyan, P. P., Nayak, R., Patra, S., Abdulabbas, H. S., Jena, M., & Pradhan, B. (2023) · Cancers · doi:10.3390/cancers15030715 · Cited by 81 · see citing works

Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products

Juliano, C., & Magrini, G. (2018) · Cosmetics · doi:10.3390/cosmetics5010019 · Cited by 76 · see citing works

Cancer-fighting potentials of algal polysaccharides as nutraceuticals

Ouyang, Y., Qiu, Y., Liu, Y., Zhu, R., Chen, Y., El-Seedi, H. R., Chen, X., & Zhao, C. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110522 · Cited by 71 · see citing works

Combined Administration of Fucoidan Ameliorates Tumor and Chemotherapy-Induced Skeletal Muscle Atrophy in Bladder Cancer-Bearing Mice

Chen, M.-C., Hsu, W.-L., Hwang, P.-A., Chen, Y.-L., & Chou, T.-C. (2016) · Oncotarget · doi:10.18632/oncotarget.9958 · Cited by 69 · see citing works

In vitro enzyme inhibitory properties, antioxidant activities, and phytochemical fingerprints of five Moroccan seaweeds

Grina, F., Ullah, Z., Kaplaner, E., Moujahid, A., Eddoha, R., Nasser, B., Terzioğlu, P., Yılmaz, M. A., Ertaş, A., Öztürk, M., et al. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2019.10.021 · Cited by 73 · see citing works

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

Wu, S., Yan, M., Wu, A. T. H., Yuan, K. S., & Liu, S. (2016) · Journal of Cancer · doi:10.7150/jca.15703 · Cited by 69 · see citing works

Novel fucoidan based bioactive targeted nanoparticles from Undaria Pinnatifida for treatment of pancreatic cancer

Etman, S. M., Abdallah, O. Y., & Elnaggar, Y. S. R. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.177 · Cited by 69 · see citing works

Characterization of polysaccharides from different species of brown seaweed using saccharide mapping and chromatographic analysis

Chen, S., Sathuvan, M., Xiao, Z., Zhang, W., Tang, S., Liu, Y., & Cheong, K. (2021) · BMC Chemistry · doi:10.1186/s13065-020-00727-w · Cited by 67 · see citing works

Bioactivity and Applications of Polysaccharides from Marine Microalgae

Raposo, M. F. D. J., Morais, A. M. M. B., & Morais, R. M. S. C. (2015) · Springer eBooks · doi:10.1007/978-3-319-16298-0_47 · Cited by 67 · see citing works

Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Guo, C., Li, J., Chen, K., Li, S., Feng, J., Liu, T., Wang, F., Zhang, R., Xu, S., Zhou, Y., et al. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s98740 · Cited by 66 · see citing works

The structure-activity relationship between polysaccharides from Sargassum thunbergii and anti-tumor activity

Jin, W., Zhang, W., Liu, G., Yao, J., Shan, T., Sun, C., & Zhang, Q. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.07.089 · Cited by 66 · see citing works

Anticancer effect of fucoidan on cell proliferation, cell cycle progression, genetic damage and apoptotic cell death in HepG2 cancer cells

Arumugam, P., Arunkumar, K., Loganathan, S., Murugan, M., & Murugan, K. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.06.005 · Cited by 64 · see citing works

Fucoidan protects mesenchymal stem cells against oxidative stress and enhances vascular regeneration in a murine hindlimb ischemia model

Han, Y., Lee, J. H., Jung, J. S., Noh, H., Baek, M. J., Ryu, J. M., Yoon, Y. M., Han, H. J., & Lee, S. H. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.070 · Cited by 63 · see citing works

Recent advances in breast cancer immunotherapy: The promising impact of nanomedicines

Hashemzadeh, N., Dolatkhah, M., Adibkia, K., Aghanejad, A., Barzegar-Jalali, M., Omidi, Y., & Barar, J. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119110 · Cited by 63 · see citing works

Opportunities and challenges of algal fucoidan for diabetes management

Wen, Y., Gao, L., Zhou, H., Ai, C., Huang, X., Wang, M.-F., Zhang, Y., & Zhao, C. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.028 · Cited by 62 · see citing works

Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives

Hélissey, C., Cavallero, S., Brossard, C., Dusaud, M., Chargari, C., & François, S. (2020) · Cells · doi:10.3390/cells10010021 · Cited by 60 · see citing works

Polysaccharides from the leaves of Polygonatum sibiricum Red. regulate the gut microbiota and affect the production of short-chain fatty acids in mice

Luo, Y. H., Fang, Q., Lai, Y. R., Lei, H., Zhang, D., Niu, H., Wang, R., & Song, C. (2022) · AMB Express · doi:10.1186/s13568-022-01376-z · Cited by 60 · see citing works

Interference with the CXCL12/CXCR4 axis as potential antitumor strategy: superiority of a sulfated galactofucan from the brown algaSaccharina latissimaand Fucoidan over heparins

Schneider, T., Ehrig, K., Liewert, I., & Alban, S. (2015) · Glycobiology · doi:10.1093/glycob/cwv022 · Cited by 58 · see citing works

The effects of chosen plant extracts and compounds on mesenchymal stem cells—a bridge between molecular nutrition and regenerative medicine‐ concise review

Kornicka, K., Kocherova, I., & Marycz, K. (2017) · Phytotherapy Research · doi:10.1002/ptr.5812 · Cited by 58 · see citing works

Production Inhibition and Excretion Promotion of Urate by Fucoidan from Laminaria japonica in Adenine-Induced Hyperuricemic Mice

Zhang, D., Liu, H., Luo, P., & Li, Y. (2018) · Marine Drugs · doi:10.3390/md16120472 · Cited by 58 · see citing works

The Quest for Phenolic Compounds from Seaweed: Nutrition, Biological Activities and Applications

Subbiah, V., Xie, C., Dunshea, F. R., Barrow, C. J., & Suleria, H. A. R. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2094406 · Cited by 60 · see citing works

Fucoidan Inhibits Radiation-Induced Pneumonitis and Lung Fibrosis by Reducing Inflammatory Cytokine Expression in Lung Tissues

Yu, H., Ko, E. C., Chang, C., Yuan, K. S., Wu, A. T. H., Shan, Y., & Wu, S. (2018) · Marine Drugs · doi:10.3390/md16100392 · Cited by 57 · see citing works

Molecular characterization and immunomodulatory activity of sulfated fucans from Agarum cribrosum

Cho, M., Lee, D., Kim, J., & You, S. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.07.055 · Cited by 54 · see citing works

Therapeutic Application of Diverse Marine-derived Natural Products in Cancer Therapy

Yun, C. W., Kim, H., & Lee, S. H. (2019) · Anticancer Research · doi:10.21873/anticanres.13721 · Cited by 55 · see citing works

The Sulfated Polysaccharide Fucoidan Rescues Senescence of Endothelial Colony-Forming Cells for Ischemic Repair

Lee, J. H., Lee, S. H., Choi, S. H., Asahara, T., & Kwon, S. (2015) · Stem Cells · doi:10.1002/stem.1973 · Cited by 54 · see citing works

Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis

Li, J., Chen, K., Li, S., Liu, T., Wang, F., Xia, Y., Lu, J., Zhou, Y., & Guo, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152570 · Cited by 54 · see citing works

Sulfated polysaccharides from Padina tetrastromatica induce apoptosis in HeLa cells through ROS triggered mitochondrial pathway

Jose, G. M., Raghavankutty, M., & Kurup, G. M. (2018) · Process Biochemistry · doi:10.1016/j.procbio.2018.02.014 · Cited by 55 · see citing works

Effect of carboxymethylation on properties of fucoidan from Laminaria japonica: Antioxidant activity and preservative effect on strawberry during cold storage

Duan, Z., Duan, W., Li, F., Li, Y., Luo, P., & Liu, H. (2019) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2019.02.008 · Cited by 54 · see citing works

Effects of fucoidan and ferulic acid on potato starch: Pasting, rheological and retrogradation properties and their interactions

Meng, N., Kang, Z., Jiang, P., Liu, Y., Liu, M., & Li, Q. (2023) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2023.109635 · Cited by 52 · see citing works

Biopolymer-Based Nanomedicine for Cancer Therapy: Opportunities and Challenges

Wu, X., Xin, Y., Zhang, H., Liang, Q., & Ao, Q. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s460047 · Cited by 56 · see citing works

Seaweeds as potential therapeutic interventions for the metabolic syndrome

Kumar, S. A., & Brown, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9254-8 · Cited by 51 · see citing works

Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines

Isnansetyo, A., Lutfia, F. N. L., Nursid, M., Trijoko, T., & Susidarti, R. A. (2016) · Pharmacognosy Journal · doi:10.5530/pj.2017.1.3 · Cited by 52 · see citing works

Fucoidan Promotes Apoptosis and Inhibits EMT of Breast Cancer Cells

He, X., Xue, M., Jiang, S., Li, W., Yu, J., & Xiang, S. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00777 · Cited by 51 · see citing works

Anti-Metastasis Effect of Fucoidan from Undaria pinnatifida Sporophylls in Mouse Hepatocarcinoma Hca-F Cells

Wang, P., Liu, Z., Liu, X., Teng, H., Zhang, C., Hou, L., & Zou, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106071 · Cited by 50 · see citing works

Influence of Ascophyllum nodosum Extract Foliar Spray on the Physiological and Biochemical Attributes of Okra under Drought Stress

Ali, J., Jan, I., Ullah, H., Ahmed, N., Alam, M., Ullah, R., El-sharnouby, M. E., Kesba, H., Shukry, M., Sayed, S. M. H., et al. (2022) · Plants · doi:10.3390/plants11060790 · Cited by 49 · see citing works

Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species

Wei, C., Xiao, Q., Kuang, X., Zhang, T., Yang, Z., & WANG, L. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4252 · Cited by 49 · see citing works

An Overview of Antitumour Activity of Polysaccharides

Jin, H., Li, M., Feng, T., Yu, F. D., & Zhao, W. G. (2022) · Molecules · doi:10.3390/molecules27228083 · Cited by 48 · see citing works

Antioxidant, anti-inflammatory and anticancer potential of natural bioactive compounds from seaweeds

Ravi, S., & Devi, K. P. (2019) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817901-7.00005-8 · Cited by 48 · see citing works

Fucoidan, A Sulfated Polysaccharides from Brown Algae as Therapeutic Target for Cancer

Kalimuthu, S., & Kim, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_7 · Cited by 26 · see citing works

In vitro anticancer activity of fucoidan extracted from Sargassum cinereum against Caco-2 cells

Narayani, S. S., Saravanan, S., Jaganathan, R., Ramasamy, M. S., & Chitra, J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.07.127 · Cited by 105 · see citing works

Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro

Fukahori, S., Yano, H., Akiba, J., Ogasawara, S., Momosaki, S., Sanada, S., Kuratomi, K., Ishizaki, Y., Moriya, F., Yagi, M., et al. (2008) · Molecular Medicine Reports · doi:10.3892/mmr.1.4.537 · Cited by 67 · see citing works

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

Atashrazm, F., Lowenthal, R. M., Woods, G. M., Holloway, A. F., & Dickinson, J. L. (2015) · Marine Drugs · doi:10.3390/md13042327 · Cited by 361 · see citing works

98P Seaweed extract and fucoidan on breast cancer cell proliferation

Chavoshi, S. H., & Chavoshi, M. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw575.037