The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery
Open accessAbstract
Additive manufacturing, also known as 3D printing, has emerged over the past 3 decades as a disruptive technology for rapid prototyping and manufacturing. Vat polymerization, powder bed fusion, material extrusion, and binder jetting are distinct technologies of additive manufacturing, which have been used in a wide variety of fields, including biomedical research and tissue engineering. The ability to print biocompatible, patient-specific geometries with controlled macro- and micro-pores, and to incorporate cells, drugs and proteins has made 3D-printing ideal for orthopaedic applications, such as bone grafting. Herein, we performed a systematic review examining the fabrication of calcium phosphate (CaP) ceramics by 3D printing, their biocompatibility in vitro, and their bone regenerative potential in vivo, as well as their use in localized delivery of bioactive molecules or cells. Understanding the advantages and limitations of the different 3D printing approaches, CaP materials, and bioactive additives through critical evaluation of in vitro and in vivo evidence of efficacy is essential for developing new classes of bone graft substitutes that can perform as well as autografts and allografts or even surpass the performance of these clinical standards.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Xu, S., Xu, S., Zhou, P., Cheng, X., Xie, Y., Liang, C., & Li, C. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s50685 · Cited by 160
Retracted3D bioprinting of tissues and organs
Murphy, S. V., & Atala, A. (2014) · Nature Biotechnology · doi:10.1038/nbt.2958 · Cited by 7,034
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
Kang, H.-W., Lee, S. J., Ko, I. K., Kengla, C., Yoo, J. J., & Atala, A. (2016) · Nature Biotechnology · doi:10.1038/nbt.3413 · Cited by 2,622
Continuous liquid interface production of 3D objects
Tumbleston, J. R., Shirvanyants, D., Ermoshkin, N., Janusziewicz, R., Johnson, A. R., Kelly, D., Chen, K., Pinschmidt, R., Rolland, J. P., Ermoshkin, A., et al. (2015) · Science · doi:10.1126/science.aaa2397 · Cited by 2,278
Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering
Williams, J. M., Adewunmi, A., Schek, R. M., Flanagan, C. L., Krebsbach, P. H., Feinberg, S. E., Hollister, S. J., & Das, S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.057 · Cited by 1,563
Bose, S., & Tarafder, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.11.017 · Cited by 958
3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration
Inzana, J. A., Olvera, D., Fuller, S. M., Kelly, J. P., Graeve, O. A., Schwarz, E. M., Kates, S. L., & Awad, H. A. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.064 · Cited by 840
Self-citationHandbook of Biomaterial Properties
(1998) · Springer eBooks · doi:10.1007/978-1-4615-5801-9 · Cited by 639
Evaluation of polycaprolactone scaffold degradation for 6 months in vitro and in vivo
Lam, C. X. F., Hutmacher, D. W., Schantz, J., Woodruff, M. A., & Teoh, S. H. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32052 · Cited by 599
Sobral, J. M., Caridade, S. G., Sousa, R. A., Mano, J. F., & Reis, R. L. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.11.003 · Cited by 561
Cited by
Binder jetting: A review of process, materials, and methods
Ziaee, M., & Crane, N. B. (2019) · Additive Manufacturing · doi:10.1016/j.addma.2019.05.031 · Cited by 819
A Review of 3D Printing Technology for Medical Applications
Yan, Q., Dong, H., Su, J., Han, J., Song, B., Wei, Q., & Shi, Y. (2018) · Engineering · doi:10.1016/j.eng.2018.07.021 · Cited by 720
Recent advances in bioprinting techniques: approaches, applications and future prospects
Li, J., Chen, M., Fan, X., & Zhou, H. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1028-0 · Cited by 608
3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy.
Ma, H., Feng, C., Chang, J., & Wu, C. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.08.026 · Cited by 512
Additive Manufacturing of Biomaterials, Tissues, and Organs
Zadpoor, A. A., & Malda, J. (2017) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1719-y · Cited by 462
Metadata
- Authors
- Trombetta, R., Inzana, J. A., Schwarz, E. M., Kates, S. L., & Awad, H. A.
- Venue
- Annals of Biomedical Engineering
- Published
- 2016-06-20
- Volume
- 45
- Issue
- 1
- Pages
- 23-44
- ISSN
- 0090-6964 (ISSN-L)
- 1573-9686
- OpenAlex
- W2467652405
- Cited by
- 377
- References
- 89
- FWCI
- 15.81
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: 3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery. https://app.cochat.ai/papers/10.1007/s10439-016-1678-3
- The paper
- Trombetta, R., Inzana, J. A., Schwarz, E. M., Kates, S. L., & Awad, H. A. (2017). 3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery. Annals of Biomedical Engineering. https://doi.org/10.1007/s10439-016-1678-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.