Psychiatric Polygenic Risk Scores as Predictor for Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Clinical Child and Adolescent Sample
Open accessAbstract
Neurodevelopmental disorders such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are highly heritable and influenced by many single nucleotide polymorphisms (SNPs). SNPs can be used to calculate individual polygenic risk scores (PRS) for a disorder. We aim to explore the association between the PRS for ADHD, ASD and for Schizophrenia (SCZ), and ADHD and ASD diagnoses in a clinical child and adolescent population. Based on the most recent genome wide association studies of ADHD, ASD and SCZ, PRS of each disorder were calculated for individuals of a clinical child and adolescent target sample (N = 688) and for adult controls (N = 943). We tested with logistic regression analyses for an association with (1) a single diagnosis of ADHD (N = 280), (2) a single diagnosis of ASD (N = 295), and (3) combining the two diagnoses, thus subjects with either ASD, ADHD or both (N = 688). Our results showed a significant association of the ADHD PRS with ADHD status (OR 1.6, P = 1.39 × 10 −07 ) and with the combined ADHD/ASD status (OR 1.36, P = 1.211 × 10 −05 ), but not with ASD status (OR 1.14, P = 1). No associations for the ASD and SCZ PRS were observed. In sum, the PRS of ADHD is significantly associated with the combined ADHD/ASD status. Yet, this association is primarily driven by ADHD status, suggesting disorder specific genetic effects of the ADHD PRS.
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With the exception of ADHD and autism spectrum disorder, there is a paucity of well-powered GWASs in pediatric populations, especially for aggressive behaviors and related phenotypes.
“With the exception of ADHD and autism spectrum disorder, there is a paucity of well-powered GWASs in pediatric populations [150, 151], especially for aggressive behaviors and related phenotypes such as disruptive behavior disorders, conduct disorders, as well as externalizing and internalizing behaviors.”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [151]
The Introduction (page unavailable) identifies GWAS findings for ADHD and autism spectrum disorder. It does not establish that well-powered pediatric GWAS are scarce for other conditions; the cited passage does not address aggressive behavior or the related phenotypes named in the sentence. (LLM, conf=0.76)
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Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
- Authors
- Jansen, A. G., Dieleman, G. C., Jansen, P. R., Verhulst, F. C., Posthuma, D., & Polderman, T. J. C.
- Affiliations
- Erasmus MC (NL)
- University of Copenhagen (DK)
- Amsterdam Neuroscience (NL)
- Corresponding author
- Jansen, Arija G.
- Polderman, Tinca J. C.
- Venue
- Behavior Genetics
- Published
- 2019-07-25
- Volume
- 50
- Issue
- 4
- Pages
- 203-212
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- PMC
- PMC7355275
- OpenAlex
- W2963245083
- Cited by
- 58
- References
- 46
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 16 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 10 · 2019: 1
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Behavior Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (acceptedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Sophia Stichting voor Wetenschappelijk Onderzoek (593, S14-27)
- NWO (VICI 453-14-005)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- polygenic risk score, attention deficit hyperactivity disorder, autism spectrum disorder, schizophrenia, neurodevelopmental disorders, single nucleotide polymorphisms, genetic risk prediction, child and adolescent psychiatry, comorbidities, heritability
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Family, Female, Humans, Infant, Male, Risk Factors, Schizophrenia, Genetic Predisposition to Disease, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Genome-Wide Association Study
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