The DOI matches its Crossref record; 146 of the 147 references it cites were found in a registry or an index.
Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging
Abstract
Aging is associated with mitochondrial dysfunctions, which trigger membrane leakage, release of reactive species from oxygen and nitrogen and subsequent induction of peroxidative reactions that result in biomolecules' damaging and releasing of metals with amplification of free radicals discharge. Free radicals induce neuronal cell death increasing tissue loss, which could be associated with memory detriment. These pathological events are involved in cardiovascular, neurodegenerative and carcinogenic processes. Dietary bioactive compounds from different functional foods, herbs and nutraceuticals (ginseng, ginkgo, nuts, grains, tomato, soy phytoestrogens, curcumin, melatonin, polyphenols, antioxidant vitamins, carnitine, carnosine, ubiquinone, etc.) can ameliorate or even prevent diseases. Protection from chronic diseases of aging involves antioxidant activities, mitochondrial stabilizing functions, metal chelating activities, inhibition of apoptosis of vital cells, and induction of cancer cell apoptosis. Functional foods and nutraceuticals constitute a great promise to improve health and prevent aging-related chronic diseases.
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“These food compounds, mainly found in plant-based foods and fatty fish, have been implicated in offering physiological health benefits over and above basic nutritional requirements (126–128).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [127]
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Metadata
- Authors
- Ferrari, C. K. B.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Ferrari, Carlos K. B.
- Venue
- Biogerontology
- Published
- 2004-10
- Volume
- 5
- Issue
- 5
- Pages
- 275-290
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W2025236117
- Cited by
- 227
- References
- 147
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 17 · 2015: 6 · 2014: 11 · 2013: 17 · 2012: 10
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
- Keywords
- healthy aging, functional foods, nutraceuticals, herbs, mitochondrial dysfunction, free radicals, oxidative stress, neurodegeneration, cardiovascular disease, cancer prevention, bioactive compounds, antioxidants, polyphenols, melatonin, curcumin, soy phytoestrogens, ginseng, Ginkgo biloba, metal chelation, apoptosis, memory impairment
- MeSH terms
- Aging, Antioxidants, Chelating Agents, Food, Heart Diseases, Homocysteine, Humans, Lipoproteins, LDL, Oxidative Stress, Mitochondrial Diseases, Herbal Medicine
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